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Gene Ontology Browser
Term Detail
GO term:phosphatidylinositol 3-kinase complex
Synonym: 1-phosphatidylinositol 3-kinase complex
Synonym: phosphoinositide 3-kinase complex
Synonym: PI3K complex
Synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
Synonym: PIK3C3-PIK3R4 complex
Synonym: PIK3CA-PIK3R1 complex
GO id:GO:0005942
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
CommentsFor discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Number of paths to term: 5

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-acatalytic complex
                                is-atransferase complex
                                        is-atransferase complex, transferring phosphorus-containing groups
                                                is-a6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
                                                is-a6-phosphofructokinase complex
                                                is-aadenylyltransferase complex +
                                                is-aalpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
                                                is-acreatine kinase complex +
                                                is-aDNA polymerase complex +
                                                is-aphosphatidylinositol 3-kinase complex [GO:0005942] (18 genes, 32 annotations)
                                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                                        is-aphosphatidylinositol 3-kinase complex, class II
                                                        is-aphosphatidylinositol 3-kinase complex, class III +
                                                is-apolyphosphate kinase complex
                                                is-aprotein kinase complex +
                                                is-aprotein-N(PI)-phosphohistidine-sugar phosphotransferase complex
                                                is-apyruvate kinase complex +
                                                is-aribose phosphate diphosphokinase complex
                                                is-aRNA polymerase complex +
                                                is-aUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aextrinsic component of membrane
                                        is-aextrinsic component of cell outer membrane +
                                        is-aextrinsic component of organelle membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aextrinsic component of thylakoid membrane +
                                        part-ofphosphatidylinositol 3-kinase complex [GO:0005942] (18 genes, 32 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class I +
                                                is-aphosphatidylinositol 3-kinase complex, class II
                                                is-aphosphatidylinositol 3-kinase complex, class III +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aalpha-1,6-mannosyltransferase complex
                                is-achaperone-mediated autophagy translocation complex
                                is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                is-aDsc E3 ubiquitin ligase complex
                                is-aendoplasmic reticulum membrane +
                                is-aendoplasmic reticulum palmitoyltransferase complex +
                                is-aER ubiquitin ligase complex +
                                is-aextrinsic component of membrane +
                                is-afatty acid elongase complex
                                is-aGPI-anchor transamidase complex
                                is-aintrinsic component of membrane +
                                is-aIre1 complex
                                is-aleaflet of membrane bilayer
                                is-alipopolysaccharide receptor complex
                                is-amembrane protein complex +
                                is-amembrane region +
                                is-amitochondrial membrane part +
                                is-aNADH dehydrogenase complex +
                                is-aNem1-Spo7 phosphatase complex
                                is-anuclear membrane part +
                                is-anuclear outer membrane +
                                is-aoligosaccharyltransferase complex +
                                is-aperinuclear endoplasmic reticulum membrane
                                is-aphosphatidylinositol 3-kinase complex [GO:0005942] (18 genes, 32 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                        is-aphosphatidylinositol 3-kinase complex, class II
                                        is-aphosphatidylinositol 3-kinase complex, class III +
                                is-aphotosystem II oxygen evolving complex
                                is-aplasma membrane part +
                                is-aprospore membrane spindle pole body attachment site
                                is-arespiratory chain +
                                is-aside of membrane +
                                is-asuccinate dehydrogenase complex +
                                is-atransmembrane transporter complex +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aextrinsic component of membrane
                                is-aextrinsic component of cell outer membrane +
                                is-aextrinsic component of organelle membrane +
                                is-aextrinsic component of plasma membrane +
                                is-aextrinsic component of thylakoid membrane +
                                part-ofphosphatidylinositol 3-kinase complex [GO:0005942] (18 genes, 32 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                        is-aphosphatidylinositol 3-kinase complex, class II
                                        is-aphosphatidylinositol 3-kinase complex, class III +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aalpha-1,6-mannosyltransferase complex
                        is-achaperone-mediated autophagy translocation complex
                        is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                        is-aDsc E3 ubiquitin ligase complex
                        is-aendoplasmic reticulum membrane +
                        is-aendoplasmic reticulum palmitoyltransferase complex +
                        is-aER ubiquitin ligase complex +
                        is-aextrinsic component of membrane +
                        is-afatty acid elongase complex
                        is-aGPI-anchor transamidase complex
                        is-aintrinsic component of membrane +
                        is-aIre1 complex
                        is-aleaflet of membrane bilayer
                        is-alipopolysaccharide receptor complex
                        is-amembrane protein complex +
                        is-amembrane region +
                        is-amitochondrial membrane part +
                        is-aNADH dehydrogenase complex +
                        is-aNem1-Spo7 phosphatase complex
                        is-anuclear membrane part +
                        is-anuclear outer membrane +
                        is-aoligosaccharyltransferase complex +
                        is-aperinuclear endoplasmic reticulum membrane
                        is-aphosphatidylinositol 3-kinase complex [GO:0005942] (18 genes, 32 annotations)
                                is-aphosphatidylinositol 3-kinase complex, class I +
                                is-aphosphatidylinositol 3-kinase complex, class II
                                is-aphosphatidylinositol 3-kinase complex, class III +
                        is-aphotosystem II oxygen evolving complex
                        is-aplasma membrane part +
                        is-aprospore membrane spindle pole body attachment site
                        is-arespiratory chain +
                        is-aside of membrane +
                        is-asuccinate dehydrogenase complex +
                        is-atransmembrane transporter complex +


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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory