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Term Detail
GO term:phosphatidylinositol 3-kinase complex
Synonym: 1-phosphatidylinositol 3-kinase complex
Synonym: phosphoinositide 3-kinase complex
Synonym: PI3K complex
Synonym: PI3-kinase p85-subunit alpha- PI3-kinase p110 complex
Synonym: PIK3C3-PIK3R4 complex
Synonym: PIK3CA-PIK3R1 complex
GO id:GO:0005942
Definition:A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
CommentsFor discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-acatalytic complex
                                        is-atransferase complex
                                                is-atransferase complex, transferring phosphorus-containing groups
                                                        is-a6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
                                                        is-a6-phosphofructokinase complex
                                                        is-aadenylyltransferase complex +
                                                        is-aalpha-D-ribose 1-methylphosphonate 5-triphosphate synthase complex
                                                        is-acreatine kinase complex +
                                                        is-aDNA polymerase complex +
                                                        is-aphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                                                is-aphosphatidylinositol 3-kinase complex, class I +
                                                                is-aphosphatidylinositol 3-kinase complex, class II
                                                                is-aphosphatidylinositol 3-kinase complex, class III +
                                                        is-apolyphosphate kinase complex
                                                        is-aprotein kinase complex +
                                                        is-aprotein-N(PI)-phosphohistidine-sugar phosphotransferase complex
                                                        is-apyruvate kinase complex +
                                                        is-aribose phosphate diphosphokinase complex
                                                        is-aRNA polymerase complex +
                                                        is-aUDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex


obsolete Gene_Ontology
        is-acellular_component
                is-amacromolecular complex
                        is-aprotein complex
                                is-amembrane protein complex
                                        is-a5-lipoxygenase complex
                                        is-aalpha-1,6-mannosyltransferase complex
                                        is-aAP-type membrane coat adaptor complex +
                                        is-aAsi complex
                                        is-aBam protein complex
                                        is-achloroplast outer membrane translocon
                                        is-achloroplast thylakoid membrane protein complex +
                                        is-achromosome segregation-directing complex
                                        is-aclathrin complex
                                        is-acytochrome o ubiquinol oxidase complex
                                        is-aDerlin-1 retrotranslocation complex
                                        is-aDerlin-1-VIMP complex
                                        is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                        is-aDsc E3 ubiquitin ligase complex
                                        is-aEGO complex
                                        is-aendoplasmic reticulum palmitoyltransferase complex +
                                        is-aendoplasmic reticulum Sec complex +
                                        is-aendosomal scaffold complex
                                        is-aER membrane protein complex
                                        is-aER ubiquitin ligase complex +
                                        is-aESCRT I complex
                                        is-aESCRT II complex
                                        is-aESCRT III complex
                                        is-afatty acid elongase complex
                                        is-aGPI-anchor transamidase complex
                                        is-aHOPS complex +
                                        is-ainner mitochondrial membrane protein complex +
                                        is-aIre1 complex
                                        is-aIRE1-TRAF2-ASK1 complex
                                        is-alipopolysaccharide receptor complex
                                        is-amembrane coat +
                                        is-ameprin A complex
                                        is-aMHC class I peptide loading complex +
                                        is-aNAD(P)H dehydrogenase complex (plastoquinone)
                                        is-aNADH dehydrogenase complex +
                                        is-aNem1-Spo7 phosphatase complex
                                        is-anuclear pore central transport channel
                                        is-anuclear pore cytoplasmic filaments
                                        is-anuclear pore inner ring
                                        is-anuclear pore linkers
                                        is-anuclear pore nuclear basket
                                        is-anuclear pore outer ring
                                        is-anuclear pore transmembrane ring
                                        is-aoligosaccharyltransferase complex +
                                        is-aouter mitochondrial membrane protein complex +
                                        is-aphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class I +
                                                is-aphosphatidylinositol 3-kinase complex, class II
                                                is-aphosphatidylinositol 3-kinase complex, class III +
                                        is-aphospholamban complex
                                        is-aphotosystem +
                                        is-aphotosystem I antenna complex
                                        is-aphotosystem I reaction center
                                        is-aphotosystem II antenna complex
                                        is-aphotosystem II oxygen evolving complex
                                        is-aphotosystem II reaction center
                                        is-aphycobilisome
                                        is-aplasma membrane protein complex +
                                        is-apore complex +
                                        is-apre-B cell receptor complex
                                        is-aprotein C inhibitor-acrosin complex
                                        is-aproton-transporting ATP synthase, catalytic core +
                                        is-aproton-transporting ATP synthase, central stalk +
                                        is-aproton-transporting ATP synthase, stator stalk +
                                        is-aproton-transporting two-sector ATPase complex +
                                        is-aproton-transporting two-sector ATPase complex, catalytic domain +
                                        is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                                        is-aRagulator complex
                                        is-arespiratory chain complex +
                                        is-aretromer complex +
                                        is-aretromer complex, inner shell
                                        is-aretromer complex, outer shell
                                        is-aSec62/Sec63 complex
                                        is-asignal peptidase complex
                                        is-asignal recognition particle receptor complex
                                        is-aSNARE complex +
                                        is-asodium ion-transporting two-sector ATPase complex +
                                        is-aSREBP-SCAP complex
                                        is-aSREBP-SCAP-Insig complex
                                        is-astarch utilization system complex
                                        is-aSTING complex
                                        is-aTAP complex
                                        is-aTic complex
                                        is-aToc complex
                                        is-atranslocon complex +
                                        is-atransmembrane transporter complex +
                                        is-aUDP-N-acetylglucosamine transferase complex
                                        is-aVCP-NPL4-UFD1 AAA ATPase complex
                                        is-aVps4-Vta1 complex
                                        is-aVps55/Vps68 complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-aextrinsic component of membrane
                                        is-aextrinsic component of cell outer membrane +
                                        is-aextrinsic component of organelle membrane +
                                        is-aextrinsic component of plasma membrane +
                                        is-aextrinsic component of thylakoid membrane +
                                        part-ofphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class I +
                                                is-aphosphatidylinositol 3-kinase complex, class II
                                                is-aphosphatidylinositol 3-kinase complex, class III +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane part
                                is-amembrane protein complex
                                        is-a5-lipoxygenase complex
                                        is-aalpha-1,6-mannosyltransferase complex
                                        is-aAP-type membrane coat adaptor complex +
                                        is-aAsi complex
                                        is-aBam protein complex
                                        is-achloroplast outer membrane translocon
                                        is-achloroplast thylakoid membrane protein complex +
                                        is-achromosome segregation-directing complex
                                        is-aclathrin complex
                                        is-acytochrome o ubiquinol oxidase complex
                                        is-aDerlin-1 retrotranslocation complex
                                        is-aDerlin-1-VIMP complex
                                        is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                        is-aDsc E3 ubiquitin ligase complex
                                        is-aEGO complex
                                        is-aendoplasmic reticulum palmitoyltransferase complex +
                                        is-aendoplasmic reticulum Sec complex +
                                        is-aendosomal scaffold complex
                                        is-aER membrane protein complex
                                        is-aER ubiquitin ligase complex +
                                        is-aESCRT I complex
                                        is-aESCRT II complex
                                        is-aESCRT III complex
                                        is-afatty acid elongase complex
                                        is-aGPI-anchor transamidase complex
                                        is-aHOPS complex +
                                        is-ainner mitochondrial membrane protein complex +
                                        is-aIre1 complex
                                        is-aIRE1-TRAF2-ASK1 complex
                                        is-alipopolysaccharide receptor complex
                                        is-amembrane coat +
                                        is-ameprin A complex
                                        is-aMHC class I peptide loading complex +
                                        is-aNAD(P)H dehydrogenase complex (plastoquinone)
                                        is-aNADH dehydrogenase complex +
                                        is-aNem1-Spo7 phosphatase complex
                                        is-anuclear pore central transport channel
                                        is-anuclear pore cytoplasmic filaments
                                        is-anuclear pore inner ring
                                        is-anuclear pore linkers
                                        is-anuclear pore nuclear basket
                                        is-anuclear pore outer ring
                                        is-anuclear pore transmembrane ring
                                        is-aoligosaccharyltransferase complex +
                                        is-aouter mitochondrial membrane protein complex +
                                        is-aphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                                is-aphosphatidylinositol 3-kinase complex, class I +
                                                is-aphosphatidylinositol 3-kinase complex, class II
                                                is-aphosphatidylinositol 3-kinase complex, class III +
                                        is-aphospholamban complex
                                        is-aphotosystem +
                                        is-aphotosystem I antenna complex
                                        is-aphotosystem I reaction center
                                        is-aphotosystem II antenna complex
                                        is-aphotosystem II oxygen evolving complex
                                        is-aphotosystem II reaction center
                                        is-aphycobilisome
                                        is-aplasma membrane protein complex +
                                        is-apore complex +
                                        is-apre-B cell receptor complex
                                        is-aprotein C inhibitor-acrosin complex
                                        is-aproton-transporting ATP synthase, catalytic core +
                                        is-aproton-transporting ATP synthase, central stalk +
                                        is-aproton-transporting ATP synthase, stator stalk +
                                        is-aproton-transporting two-sector ATPase complex +
                                        is-aproton-transporting two-sector ATPase complex, catalytic domain +
                                        is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                                        is-aRagulator complex
                                        is-arespiratory chain complex +
                                        is-aretromer complex +
                                        is-aretromer complex, inner shell
                                        is-aretromer complex, outer shell
                                        is-aSec62/Sec63 complex
                                        is-asignal peptidase complex
                                        is-asignal recognition particle receptor complex
                                        is-aSNARE complex +
                                        is-asodium ion-transporting two-sector ATPase complex +
                                        is-aSREBP-SCAP complex
                                        is-aSREBP-SCAP-Insig complex
                                        is-astarch utilization system complex
                                        is-aSTING complex
                                        is-aTAP complex
                                        is-aTic complex
                                        is-aToc complex
                                        is-atranslocon complex +
                                        is-atransmembrane transporter complex +
                                        is-aUDP-N-acetylglucosamine transferase complex
                                        is-aVCP-NPL4-UFD1 AAA ATPase complex
                                        is-aVps4-Vta1 complex
                                        is-aVps55/Vps68 complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane
                        part-ofmembrane protein complex
                                is-a5-lipoxygenase complex
                                is-aalpha-1,6-mannosyltransferase complex
                                is-aAP-type membrane coat adaptor complex +
                                is-aAsi complex
                                is-aBam protein complex
                                is-achloroplast outer membrane translocon
                                is-achloroplast thylakoid membrane protein complex +
                                is-achromosome segregation-directing complex
                                is-aclathrin complex
                                is-acytochrome o ubiquinol oxidase complex
                                is-aDerlin-1 retrotranslocation complex
                                is-aDerlin-1-VIMP complex
                                is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                is-aDsc E3 ubiquitin ligase complex
                                is-aEGO complex
                                is-aendoplasmic reticulum palmitoyltransferase complex +
                                is-aendoplasmic reticulum Sec complex +
                                is-aendosomal scaffold complex
                                is-aER membrane protein complex
                                is-aER ubiquitin ligase complex +
                                is-aESCRT I complex
                                is-aESCRT II complex
                                is-aESCRT III complex
                                is-afatty acid elongase complex
                                is-aGPI-anchor transamidase complex
                                is-aHOPS complex +
                                is-ainner mitochondrial membrane protein complex +
                                is-aIre1 complex
                                is-aIRE1-TRAF2-ASK1 complex
                                is-alipopolysaccharide receptor complex
                                is-amembrane coat +
                                is-ameprin A complex
                                is-aMHC class I peptide loading complex +
                                is-aNAD(P)H dehydrogenase complex (plastoquinone)
                                is-aNADH dehydrogenase complex +
                                is-aNem1-Spo7 phosphatase complex
                                is-anuclear pore central transport channel
                                is-anuclear pore cytoplasmic filaments
                                is-anuclear pore inner ring
                                is-anuclear pore linkers
                                is-anuclear pore nuclear basket
                                is-anuclear pore outer ring
                                is-anuclear pore transmembrane ring
                                is-aoligosaccharyltransferase complex +
                                is-aouter mitochondrial membrane protein complex +
                                is-aphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                        is-aphosphatidylinositol 3-kinase complex, class II
                                        is-aphosphatidylinositol 3-kinase complex, class III +
                                is-aphospholamban complex
                                is-aphotosystem +
                                is-aphotosystem I antenna complex
                                is-aphotosystem I reaction center
                                is-aphotosystem II antenna complex
                                is-aphotosystem II oxygen evolving complex
                                is-aphotosystem II reaction center
                                is-aphycobilisome
                                is-aplasma membrane protein complex +
                                is-apore complex +
                                is-apre-B cell receptor complex
                                is-aprotein C inhibitor-acrosin complex
                                is-aproton-transporting ATP synthase, catalytic core +
                                is-aproton-transporting ATP synthase, central stalk +
                                is-aproton-transporting ATP synthase, stator stalk +
                                is-aproton-transporting two-sector ATPase complex +
                                is-aproton-transporting two-sector ATPase complex, catalytic domain +
                                is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                                is-aRagulator complex
                                is-arespiratory chain complex +
                                is-aretromer complex +
                                is-aretromer complex, inner shell
                                is-aretromer complex, outer shell
                                is-aSec62/Sec63 complex
                                is-asignal peptidase complex
                                is-asignal recognition particle receptor complex
                                is-aSNARE complex +
                                is-asodium ion-transporting two-sector ATPase complex +
                                is-aSREBP-SCAP complex
                                is-aSREBP-SCAP-Insig complex
                                is-astarch utilization system complex
                                is-aSTING complex
                                is-aTAP complex
                                is-aTic complex
                                is-aToc complex
                                is-atranslocon complex +
                                is-atransmembrane transporter complex +
                                is-aUDP-N-acetylglucosamine transferase complex
                                is-aVCP-NPL4-UFD1 AAA ATPase complex
                                is-aVps4-Vta1 complex
                                is-aVps55/Vps68 complex


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-aextrinsic component of membrane
                                is-aextrinsic component of cell outer membrane +
                                is-aextrinsic component of organelle membrane +
                                is-aextrinsic component of plasma membrane +
                                is-aextrinsic component of thylakoid membrane +
                                part-ofphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                        is-aphosphatidylinositol 3-kinase complex, class II
                                        is-aphosphatidylinositol 3-kinase complex, class III +


obsolete Gene_Ontology
        is-acellular_component
                is-amembrane part
                        is-amembrane protein complex
                                is-a5-lipoxygenase complex
                                is-aalpha-1,6-mannosyltransferase complex
                                is-aAP-type membrane coat adaptor complex +
                                is-aAsi complex
                                is-aBam protein complex
                                is-achloroplast outer membrane translocon
                                is-achloroplast thylakoid membrane protein complex +
                                is-achromosome segregation-directing complex
                                is-aclathrin complex
                                is-acytochrome o ubiquinol oxidase complex
                                is-aDerlin-1 retrotranslocation complex
                                is-aDerlin-1-VIMP complex
                                is-adolichyl-phosphate-mannose-protein mannosyltransferase complex +
                                is-aDsc E3 ubiquitin ligase complex
                                is-aEGO complex
                                is-aendoplasmic reticulum palmitoyltransferase complex +
                                is-aendoplasmic reticulum Sec complex +
                                is-aendosomal scaffold complex
                                is-aER membrane protein complex
                                is-aER ubiquitin ligase complex +
                                is-aESCRT I complex
                                is-aESCRT II complex
                                is-aESCRT III complex
                                is-afatty acid elongase complex
                                is-aGPI-anchor transamidase complex
                                is-aHOPS complex +
                                is-ainner mitochondrial membrane protein complex +
                                is-aIre1 complex
                                is-aIRE1-TRAF2-ASK1 complex
                                is-alipopolysaccharide receptor complex
                                is-amembrane coat +
                                is-ameprin A complex
                                is-aMHC class I peptide loading complex +
                                is-aNAD(P)H dehydrogenase complex (plastoquinone)
                                is-aNADH dehydrogenase complex +
                                is-aNem1-Spo7 phosphatase complex
                                is-anuclear pore central transport channel
                                is-anuclear pore cytoplasmic filaments
                                is-anuclear pore inner ring
                                is-anuclear pore linkers
                                is-anuclear pore nuclear basket
                                is-anuclear pore outer ring
                                is-anuclear pore transmembrane ring
                                is-aoligosaccharyltransferase complex +
                                is-aouter mitochondrial membrane protein complex +
                                is-aphosphatidylinositol 3-kinase complex [GO:0005942] (19 genes, 35 annotations)
                                        is-aphosphatidylinositol 3-kinase complex, class I +
                                        is-aphosphatidylinositol 3-kinase complex, class II
                                        is-aphosphatidylinositol 3-kinase complex, class III +
                                is-aphospholamban complex
                                is-aphotosystem +
                                is-aphotosystem I antenna complex
                                is-aphotosystem I reaction center
                                is-aphotosystem II antenna complex
                                is-aphotosystem II oxygen evolving complex
                                is-aphotosystem II reaction center
                                is-aphycobilisome
                                is-aplasma membrane protein complex +
                                is-apore complex +
                                is-apre-B cell receptor complex
                                is-aprotein C inhibitor-acrosin complex
                                is-aproton-transporting ATP synthase, catalytic core +
                                is-aproton-transporting ATP synthase, central stalk +
                                is-aproton-transporting ATP synthase, stator stalk +
                                is-aproton-transporting two-sector ATPase complex +
                                is-aproton-transporting two-sector ATPase complex, catalytic domain +
                                is-aproton-transporting two-sector ATPase complex, proton-transporting domain +
                                is-aRagulator complex
                                is-arespiratory chain complex +
                                is-aretromer complex +
                                is-aretromer complex, inner shell
                                is-aretromer complex, outer shell
                                is-aSec62/Sec63 complex
                                is-asignal peptidase complex
                                is-asignal recognition particle receptor complex
                                is-aSNARE complex +
                                is-asodium ion-transporting two-sector ATPase complex +
                                is-aSREBP-SCAP complex
                                is-aSREBP-SCAP-Insig complex
                                is-astarch utilization system complex
                                is-aSTING complex
                                is-aTAP complex
                                is-aTic complex
                                is-aToc complex
                                is-atranslocon complex +
                                is-atransmembrane transporter complex +
                                is-aUDP-N-acetylglucosamine transferase complex
                                is-aVCP-NPL4-UFD1 AAA ATPase complex
                                is-aVps4-Vta1 complex
                                is-aVps55/Vps68 complex


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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory