Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Pik3ca

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes PIK3CA
- Mouse genes Pik3ca
- Rat genes Pik3ca
- Zfish genes pik3ca
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pik3ca

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	PIK3CA	IDA		Human	PMID:2174051
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3ca	IMP	MGI:MGI:3691486	Mouse	PMID:20197055
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3ca	IDA		Mouse	PMID:11784871
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3ca	IMP		Mouse	PMID:26872540
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3ca	IDA		Mouse	PMID:14657280
Molecular Function	GO:0016303	1-phosphatidylinositol-3-kinase activity	Pik3ca	IDA		Rat	PMID:12882977\|RGD:4144086
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3ca	IPI	PR:P35569	Mouse	PMID:12486171
Molecular Function	GO:0043560	insulin receptor substrate binding	Pik3ca	IPI	MGI:MGI:109334	Mouse	PMID:12486171
Molecular Function	GO:0016301	kinase activity	PIK3CA	IDA		Human	PMID:25327288
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q9UKG1	Human	PMID:10490823
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:16043515
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q96FE7	Human	PMID:17475214
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:18079394
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:O00459	Human	PMID:19380743
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P21860	Human	PMID:19411071
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:19574958
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:19805105
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:20018188
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:20713702
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P62993	Human	PMID:21706016
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:O00459	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q92569	Human	PMID:22402981
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P35568	Human	PMID:23643389
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q5T0W9	Human	PMID:23676467
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P21860	Human	PMID:24189400
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:O00459	Human	PMID:25253337
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:25253337
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q92569	Human	PMID:25814554
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:O00459	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q92569	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P62993	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q92569	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P06396	Human	PMID:30568254
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P01100	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P42858	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P54252	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P54253	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P62993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:O00459	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P27986	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:P35568	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	PIK3CA	IPI	UniProtKB:Q92569	Human	PMID:34591612
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P13020	Mouse	MGI:MGI:6450443\|PMID:30568254
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3795660\|PMID:18449193
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P26450	Mouse	MGI:MGI:3688344\|PMID:15102471
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P01112	Mouse	MGI:MGI:3715668\|PMID:17540175
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P41241	Mouse	MGI:MGI:5825410\|PMID:27474268
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	PR:Q64143	Mouse	PMID:7542745
Molecular Function	GO:0005515	protein binding	Pik3ca	IPI	UniProtKB:P63033	Rat	PMID:14724584\|RGD:1304287
Molecular Function	GO:0030295	protein kinase activator activity	Pik3ca	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Pik3ca	IMP	MGI:MGI:3691486	Mouse	PMID:20197055
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Pik3ca	IDA		Mouse	PMID:11784871
Molecular Function	GO:0043539	protein serine/threonine kinase activator activity	Pik3ca	IMP		Mouse	PMID:26872540
Cellular Component	GO:0014704	intercalated disc	Pik3ca	IDA		Mouse	MGI:MGI:6450443\|PMID:30568254
Cellular Component	GO:0030027	lamellipodium	Pik3ca	IDA		Mouse	PMID:14657280
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3ca	IPI	PR:Q64143	Mouse	PMID:7542745
Cellular Component	GO:0005942	phosphatidylinositol 3-kinase complex	Pik3ca	IDA		Rat	PMID:12882977\|RGD:4144086
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA	IPI		Human	PMID:19805105
Cellular Component	GO:0005943	phosphatidylinositol 3-kinase complex, class IA	PIK3CA	IDA		Human	PMID:22402981
Biological Process	GO:0030036	actin cytoskeleton organization	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0060612	adipose tissue development	Pik3ca	IMP	MGI:MGI:4845856	Mouse	PMID:24691033
Biological Process	GO:0086003	cardiac muscle cell contraction	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0071333	cellular response to glucose stimulus	Pik3ca	IMP	MGI:MGI:4845856	Mouse	PMID:24691033
Biological Process	GO:0071464	cellular response to hydrostatic pressure	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0097009	energy homeostasis	Pik3ca	IMP	MGI:MGI:4845856	Mouse	PMID:24691033
Biological Process	GO:0006006	glucose metabolic process	Pik3ca	IMP	MGI:MGI:3628805	Mouse	PMID:16625210
Biological Process	GO:0008286	insulin receptor signaling pathway	Pik3ca	IMP	MGI:MGI:3691486	Mouse	PMID:20197055
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pik3ca	IDA		Mouse	PMID:11784871
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pik3ca	IMP		Mouse	PMID:26872540
Biological Process	GO:0001889	liver development	Pik3ca	IMP	MGI:MGI:4845856	Mouse	PMID:24691033
Biological Process	GO:0030835	negative regulation of actin filament depolymerization	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:2000811	negative regulation of anoikis	PIK3CA	IMP		Human	PMID:22402981
Biological Process	GO:2000270	negative regulation of fibroblast apoptotic process	Pik3ca	IDA		Mouse	PMID:15192701
Biological Process	GO:0010629	negative regulation of gene expression	Pik3ca	IGI	UniProtKB:D4A5Q1	Rat	PMID:28947594\|RGD:13524616
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Pik3ca	IMP		Mouse	PMID:12904469
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	PIK3CA	IGI	UniProtKB:P15692	Human	PMID:30496354
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0046854	phosphatidylinositol phosphate biosynthetic process	Pik3ca	IDA		Rat	PMID:12882977\|RGD:4144086
Biological Process	GO:0016310	phosphorylation	PIK3CA	IDA		Human	PMID:25327288
Biological Process	GO:0044029	positive regulation of gene expression via CpG island demethylation	Pik3ca	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0033138	positive regulation of peptidyl-serine phosphorylation	Pik3ca	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	PIK3CA	IGI	UniProtKB:P15692	Human	PMID:30496354
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Pik3ca	IMP		Rat	PMID:25908763\|RGD:13207417
Biological Process	GO:0043491	protein kinase B signaling	Pik3ca	IMP	MGI:MGI:3628805	Mouse	PMID:16625210
Biological Process	GO:0110053	regulation of actin filament organization	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0043457	regulation of cellular respiration	Pik3ca	IMP	MGI:MGI:4845856	Mouse	PMID:24691033
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	pik3ca	IMP	ZFIN:ZDB-MRPHLNO-140703-6	Zfish	PMID:24218155
Biological Process	GO:0048696	regulation of collateral sprouting in absence of injury	pik3ca	IGI	ZFIN:ZDB-MRPHLNO-140703-6,ZFIN:ZDB-MRPHLNO-140703-7	Zfish	PMID:24218155
Biological Process	GO:0010468	regulation of gene expression	Pik3ca	IMP		Mouse	PMID:17475835
Biological Process	GO:2000653	regulation of genetic imprinting	Pik3ca	IDA		Mouse	MGI:MGI:5009774\|PMID:21047779
Biological Process	GO:0040014	regulation of multicellular organism growth	Pik3ca	IMP	MGI:MGI:3628805	Mouse	PMID:16625210
Biological Process	GO:0001932	regulation of protein phosphorylation	Pik3ca	IDA		Mouse	PMID:15192701
Biological Process	GO:0055119	relaxation of cardiac muscle	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0014823	response to activity	Pik3ca	IEP		Rat	PMID:23812090\|RGD:12801494
Biological Process	GO:1903544	response to butyrate	Pik3ca	IEP		Rat	PMID:24124592\|RGD:10045951
Biological Process	GO:0071548	response to dexamethasone	Pik3ca	IEP		Rat	PMID:24124592\|RGD:10045951
Biological Process	GO:0043201	response to leucine	Pik3ca	IEP		Rat	PMID:24124592\|RGD:10045951
Biological Process	GO:0014870	response to muscle inactivity	Pik3ca	IEP		Rat	PMID:24124592\|RGD:10045951
Biological Process	GO:0035994	response to muscle stretch	Pik3ca	IMP		Mouse	MGI:MGI:6450443\|PMID:30568254
Biological Process	GO:0038084	vascular endothelial growth factor signaling pathway	PIK3CA	IGI	UniProtKB:P15692	Human	PMID:30496354

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.