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Pik3ca
Gene Detail
Symbol

Name
ID
Pik3ca
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
MGI:1206581
Synonyms
6330412C24Rik, caPI3K, p110alpha
Feature Type
protein coding gene
Genetic Map
Chromosome 3
15.70 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:32397671-32466107 bp, + strand
From VEGA annotation of GRCm38

  68437 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PIK3CA
Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3ca

Human
homologs
PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5290
neXtProt AC: NX_P42336

Human Synonyms: CLOVE, CWS5, MCAP, MCM, MCMTC, p110-alpha, PI3K

Human Chr (Location): 3q26.3; chr3:179148114-179240084 (+)  GRCh38.p2

Disease Associations: (11) Diseases Associated with Human PIK3CA

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(12) Targeted(19) Transgenic(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null or knock-in mutations of this gene lead to embryonic death associated with growth retardation, vascular defects and hemorrhage. Surviving mice homozygous for a knock-in allele show impaired lymphangiogenesis, ascites, reduced weight, and resistance to Ras-driven skin tumorigenesis.
 
Human Diseases Modeled in Mice Using Pik3ca (1)    Mutations Annotated to Human Diseases (4)    Phenotype Images(5)
Interactions
Pik3ca interacts with 485 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (164)    Tissues (115)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 119
Northern blot 3
RT-PCR 42
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pik3ca ; ZFIN pik3ca    NEW 
Molecular
reagents
All nucleic(30) Genomic(2) cDNA(22) Primer pair(5) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000021191 (Evidence)
Ensembl Gene Model ENSMUSG00000027665 (Evidence)
Entrez Gene 18706 (Evidence)
DFCI TC1598985, TC1600575, TC1605332, TC1670344
DoTS DT.101134889, DT.490199
NIA Mouse Gene Index U003127
EC 2.7.11.1, 2.7.1.153
PDB 4A55
Consensus CDS Project CCDS38409.1
International Mouse Phenotyping Consortium Status Pik3ca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021191 VEGA Gene Model | MGI Sequence Detail 68437 C57BL/6J ±  kb
transcript OTTMUST00000050202 VEGA | MGI Sequence Detail 6689 Not Applicable 
polypeptide OTTMUSP00000023403 VEGA | MGI Sequence Detail 1068 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(388 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016024 Armadillo-type fold
InterPro IPR000008 C2 domain
InterPro IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
InterPro IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro IPR002420 Phosphatidylinositol 3-kinase, C2 domain
InterPro IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro IPR015433 Phosphatidylinositol Kinase
InterPro IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR029071 Ubiquitin-related domain
Protein Ontology PR:000012719 phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
References
(Earliest) J:47211 Klippel A, et al., The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol Cell Biol. 1994 Apr;14(4):2675-85
(Latest) J:222915 Stratikopoulos EE, et al., Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy. Cancer Cell. 2015 Jun 8;27(6):837-51
All references(135)
Disease annotation references (3)
Other
accession IDs
MGI:1917992

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory