Pik3ca
Gene Detail

Symbol Name ID

Pik3ca phosphatidylinositol 3-kinase, catalytic, alpha polypeptide MGI:1206581

Synonyms

6330412C24Rik, caPI3K, p110alpha

Feature Type

protein coding gene

Genetic Map

Chromosome 3

15.70 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:32397671-32466107 bp, + strand From VEGA annotation of GRCm38   68437 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21249  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: phosphatidylinositol 3-kinase
Gene Tree: Pik3ca

Human homologs

Human Homolog		PIK3CA, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
NCBI Gene ID		5290
neXtProt AC		NX_P42336
Human Synonyms		CLOVE, CWS5, MCAP, MCM, MCMTC, p110-alpha, PI3K
Human Chr (Location)		3q26.3; chr3:178866311-178952500 (+)  GRCh37.p10
Disease Associations		(7) Diseases Associated with Human PIK3CA

Alleles and phenotypes

All alleles(26) : Targeted(14) Gene trapped(12)
 

Homozygous null or knock-in mutations of this gene lead to embryonic death associated with growth retardation, vascular defects and hemorrhage. Surviving mice homozygous for a knock-in allele show impaired lymphangiogenesis, ascites, reduced weight, and resistance to Ras-driven skin tumorigenesis.

 
Human Diseases Modeled Using Mouse Pik3ca (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (39 annotations)

Process	angiogenesis, glucose metabolic process, ...
Component	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex, lamellipodium, ...
Function	1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (164)    Tissues (115)    Images (10)
Theiler Stages: 2, 3, 10, 15, 22, 23, 25, 28

Assay Type	Results
RNA in situ	119
Northern blot	3
RT-PCR	42

cDNA source data(114)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) Genomic(2) cDNA(115) Primer pair(5) Other(1)
Microarray probesets(9)

Other database links

VEGA Gene Model	OTTMUSG00000021191 (Evidence)
Ensembl Gene Model	ENSMUSG00000027665 (Evidence)
Entrez Gene	18706 (Evidence)
UniGene	260521
DFCI	TC1598985, TC1600575, TC1605332, TC1670344
DoTS	DT.101134889, DT.490199
NIA Mouse Gene Index	U003127
EC	2.7.1.153, 2.7.11.1
PDB	4A55
Consensus CDS Project	CCDS38409.1
International Mouse Knockout Project Status	Pik3ca

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021191	VEGA Gene Model | MGI Sequence Detail	68437	C57BL/6J
transcript	OTTMUST00000050202	VEGA | MGI Sequence Detail	6689	Not Applicable
polypeptide	OTTMUSP00000023403	VEGA | MGI Sequence Detail	1068	Not Applicable

All sequences(43) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(110 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain
InterPro	IPR018936	Phosphatidylinositol 3/4-kinase, conserved site
InterPro	IPR003113	Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
InterPro	IPR002420	Phosphatidylinositol 3-kinase C2 (PI3K C2) domain
InterPro	IPR000341	Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
InterPro	IPR015433	Phosphatidylinositol Kinase
InterPro	IPR001263	Phosphoinositide 3-kinase, accessory (PIK) domain
InterPro	IPR011009	Protein kinase-like domain
Protein Ontology	PR:000012719	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

References

(Earliest) J:47211 Klippel A, et al., The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol Cell Biol. 1994 Apr;14(4):2675-85
(Latest) J:194362 Jia S, et al., Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 2013 Jan;3(1):44-51
All references(114)

Other accession IDs

MGI:1917992