Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes PDPK1,PDPK2P
  • Mouse genes Pdpk1
  • Rat genes Pdpk1
  • Zfish genes pdpk1a,pdpk1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Pdpk1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	PDPK1	IDA		Human	PMID:9368760
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IDA		Mouse	PMID:19047061
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IMP	MGI:MGI:3795190	Mouse	PMID:18347057
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IDA		Mouse	PMID:15116068
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IMP	MGI:MGI:3043781	Mouse	PMID:15116068
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IMP	MGI:MGI:3628819	Mouse	PMID:16642023
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IDA		Mouse	PMID:10075713
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IDA		Rat	PMID:14585963|RGD:1581775
Molecular Function	GO:0004676	3-phosphoinositide-dependent protein kinase activity	Pdpk1	IDA		Rat	PMID:16314505|RGD:1581774
Molecular Function	GO:0005158	insulin receptor binding	Pdpk1	IDA		Rat	PMID:16314505|RGD:1581774
Molecular Function	GO:0019209	kinase activator activity	Pdpk1	IDA		Mouse	PMID:19047061
Molecular Function	GO:0019209	kinase activator activity	Pdpk1	IMP	MGI:MGI:3795190	Mouse	PMID:18347057
Molecular Function	GO:0016004	phospholipase activator activity	PDPK1	IMP		Human	PMID:22454520
Molecular Function	GO:0043274	phospholipase binding	PDPK1	IPI	UniProtKB:P19174	Human	PMID:22454520
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:P31749	Human	PMID:11438723
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:Q8WTW4	Human	PMID:18616680
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:Q00005	Human	PMID:21075311
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:P31749	Human	PMID:21775285
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:P31749	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:P31749	Human	PMID:26256536
Molecular Function	GO:0005515	protein binding	PDPK1	IPI	UniProtKB:O75385	Human	PMID:26593251
Molecular Function	GO:0005515	protein binding	Pdpk1	IPI	PR:Q2VEB4	Mouse	PMID:16337591
Molecular Function	GO:0030295	protein kinase activator activity	Pdpk1	IDA		Mouse	PMID:15116068
Molecular Function	GO:0030295	protein kinase activator activity	Pdpk1	IMP	MGI:MGI:3043781	Mouse	PMID:15116068
Molecular Function	GO:0030295	protein kinase activator activity	Pdpk1	IMP	MGI:MGI:3628819	Mouse	PMID:16642023
Molecular Function	GO:0030295	protein kinase activator activity	Pdpk1	IDA		Mouse	PMID:10075713
Molecular Function	GO:0019901	protein kinase binding	Pdpk1	IDA		Rat	PMID:14585963|RGD:1581775
Molecular Function	GO:0004674	protein serine/threonine kinase activity	PDPK1	IDA		Human	PMID:9368760
Cellular Component	GO:0042995	cell projection	PDPK1	IDA		Human	PMID:22454520
Cellular Component	GO:0005737	cytoplasm	PDPK1	IDA		Human	PMID:9637919
Cellular Component	GO:0005737	cytoplasm	Pdpk1	IDA		Mouse	PMID:12783890
Cellular Component	GO:0031410	cytoplasmic vesicle	Pdpk1	IDA		Mouse	PMID:12783890
Cellular Component	GO:0005829	cytosol	PDPK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	Pdpk1	IDA		Rat	PMID:16314505|RGD:1581774
Cellular Component	GO:0043204	perikaryon	Pdpk1	IDA		Rat	PMID:18971483|RGD:10449508
Cellular Component	GO:0005886	plasma membrane	PDPK1	IDA		Human	PMID:14749367
Cellular Component	GO:0005886	plasma membrane	PDPK1	IDA		Human	PMID:22454520
Cellular Component	GO:0005886	plasma membrane	PDPK1	IDA		Human	PMID:9637919
Cellular Component	GO:0005886	plasma membrane	Pdpk1	IDA		Rat	PMID:16314505|RGD:1581774
Cellular Component	GO:0014069	postsynaptic density	Pdpk1	IDA		Mouse	PMID:17114649
Biological Process	GO:0032148	activation of protein kinase B activity	PDPK1	IDA		Human	PMID:9368760
Biological Process	GO:0019722	calcium-mediated signaling	PDPK1	IMP		Human	PMID:22454520
Biological Process	GO:0016477	cell migration	PDPK1	IMP		Human	PMID:22454520
Biological Process	GO:1990416	cellular response to brain-derived neurotrophic factor stimulus	Pdpk1	IEP		Rat	PMID:18971483|RGD:10449508
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	PDPK1	IMP		Human	PMID:22454520
Biological Process	GO:0032869	cellular response to insulin stimulus	PDPK1	IMP		Human	PMID:10567711
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	PDPK1	IMP		Human	PMID:22454520
Biological Process	GO:0097191	extrinsic apoptotic signaling pathway	PDPK1	IMP		Human	PMID:16207722
Biological Process	GO:0048041	focal adhesion assembly	Pdpk1	IMP		Rat	PMID:14585963|RGD:1581775
Biological Process	GO:0006972	hyperosmotic response	Pdpk1	IDA		Mouse	PMID:12783890
Biological Process	GO:0008286	insulin receptor signaling pathway	Pdpk1	IMP	MGI:MGI:3795190	Mouse	PMID:18347057
Biological Process	GO:0008286	insulin receptor signaling pathway	Pdpk1	IDA		Mouse	PMID:19047061
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pdpk1	IMP		Mouse	PMID:33377210
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pdpk1	IDA		Mouse	PMID:23472139
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Pdpk1	IDA		Mouse	PMID:33567274
Biological Process	GO:0035556	intracellular signal transduction	PDPK1	IDA		Human	PMID:14749367
Biological Process	GO:0010667	negative regulation of cardiac muscle cell apoptotic process	Pdpk1	IMP		Mouse	MGI:MGI:3849539|PMID:19429709
Biological Process	GO:2000352	negative regulation of endothelial cell apoptotic process	PDPK1	IMP		Human	PMID:26235810
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	Pdpk1	IMP		Rat	PMID:18971483|RGD:10449508
Biological Process	GO:0006469	negative regulation of protein kinase activity	PDPK1	IDA		Human	PMID:9373175
Biological Process	GO:0034122	negative regulation of toll-like receptor signaling pathway	Pdpk1	IMP		Mouse	MGI:MGI:4821539|PMID:20584979
Biological Process	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	PDPK1	IDA		Human	PMID:17327236
Biological Process	GO:0018107	peptidyl-threonine phosphorylation	PDPK1	IDA		Human	PMID:9368760
Biological Process	GO:0045766	positive regulation of angiogenesis	PDPK1	IMP		Human	PMID:23802567
Biological Process	GO:0043536	positive regulation of blood vessel endothelial cell migration	PDPK1	IMP		Human	PMID:23802567
Biological Process	GO:0010518	positive regulation of phospholipase activity	PDPK1	IMP		Human	PMID:22454520
Biological Process	GO:1903078	positive regulation of protein localization to plasma membrane	PDPK1	IMP		Human	PMID:10567711
Biological Process	GO:0051281	positive regulation of release of sequestered calcium ion into cytosol	PDPK1	IDA		Human	PMID:22454520
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	PDPK1	IMP		Human	PMID:26235810
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	PDPK1	IMP		Human	PMID:23802567
Biological Process	GO:0006468	protein phosphorylation	PDPK1	IDA		Human	PMID:14585963
Biological Process	GO:0010594	regulation of endothelial cell migration	Pdpk1	IMP		Mouse	MGI:MGI:3789556|PMID:17371830
Biological Process	GO:0043122	regulation of I-kappaB kinase/NF-kappaB signaling	PDPK1	IMP		Human	PMID:16207722
Biological Process	GO:0043304	regulation of mast cell degranulation	Pdpk1	IMP		Mouse	MGI:MGI:5298334|PMID:21063107
Biological Process	GO:0003323	type B pancreatic cell development	Pdpk1	IMP		Mouse	MGI:MGI:4365695|PMID:19635472

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern