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Pdpk1 Gene Detail
Summary
  • Symbol
    Pdpk1
  • Name
    3-phosphoinositide dependent protein kinase 1
  • Synonyms
    Pdk1, Pkb kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338068
    NCBI Gene: 18607
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24073680-24150924 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.23 cM, cytoband A3.3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    348 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338068
protein coding gene Chr17:24073680-24155621 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023288
protein coding gene Chr17:23024040-23103695 (-)
A/J MGP_AJ_G0023248
protein coding gene Chr17:22426073-22502615 (-)
AKR/J MGP_AKRJ_G0023215
protein coding gene Chr17:22486132-22565326 (-)
BALB/cJ MGP_BALBcJ_G0023253
protein coding gene Chr17:22601879-22678773 (-)
C3H/HeJ MGP_C3HHeJ_G0023013
protein coding gene Chr17:22817128-22900167 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023696
protein coding gene Chr17:24065508-24147385 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021173
protein coding gene Chr17:19882329-19962534 (-)
CAST/EiJ MGP_CASTEiJ_G0022515
protein coding gene Chr17:22661574-22743634 (-)
CBA/J MGP_CBAJ_G0022989
protein coding gene Chr17:24879827-24975848 (-)
DBA/2J MGP_DBA2J_G0023118
protein coding gene Chr17:21998373-22076852 (-)
FVB/NJ MGP_FVBNJ_G0023088
protein coding gene Chr17:21714339-21792452 (-)
LP/J MGP_LPJ_G0023195
protein coding gene Chr17:23339914-23421150 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023107
protein coding gene Chr17:24611983-24694274 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023734
protein coding gene Chr17:22749633-22832557 (-)
PWK/PhJ MGP_PWKPhJ_G0022264
protein coding gene Chr17:20751938-20833778 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022083
protein coding gene Chr17:20772158-20852066 (-)
WSB/EiJ MGP_WSBEiJ_G0022578
protein coding gene Chr17:22811982-22892200 (-)



Homology
more
  • Human Ortholog
    PDPK1, 3-phosphoinositide dependent protein kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PDPK1, 3-phosphoinositide dependent protein kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PDK1, PDPK2, PDPK2P, PRO0461
  • Links
    NCBI Gene ID: 5170
    neXtProt AC: NX_O15530
    UniProt: O15530, Q6A1A2

  • Chr Location
    16p13.3; chr16:2537964-2603190 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 11 alleles in 12 genetic backgrounds
    37 phenotypes from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024122 Ensembl Gene Model | MGI Sequence Detail 77245 C57BL/6J ±  kb
    transcript ENSMUST00000102927 Ensembl | MGI Sequence Detail 7161 Not Applicable  
    polypeptide ENSMUSP00000099991 Ensembl | MGI Sequence Detail 559 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 139
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 18
      Gene Ontology 15
      Phenotypes 85
    • Earliest
      J:53564 Dong LQ, et al., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 1999 Mar 19;274(12):8117-22
    • Latest
      J:251423 Zhao J, et al., ADP-ribosylation factor-like GTPase 15 enhances insulin-induced AKT phosphorylation in the IR/IRS1/AKT pathway by interacting with ASAP2 and regulating PDPK1 activity. Biochem Biophys Res Commun. 2017 May 13;486(4):865-871

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory