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Pdpk1
Gene Detail
Symbol

Name
ID
Pdpk1
3-phosphoinositide dependent protein kinase 1
MGI:1338068
Synonyms
Pdk1, Pkb kinase
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.23 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:24073680-24150924 bp, - strand
From VEGA annotation of GRCm38

  77245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 3-phosphoinositide-dependent protein kinase 1
Gene Tree: Pdpk1

Human
homologs
Human Homolog PDPK1, 3-phosphoinositide dependent protein kinase 1
NCBI Gene ID 5170
neXtProt AC  NX_O15530
Human Synonyms  PDK1, PDPK2, PRO0461
Human Chr (Location)  16p13.3; chr16:2537964-2603190 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(201) : Gene trapped(189) Targeted(12)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure.
 
Human Diseases Modeled Using Mouse Pdpk1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Pdpk1 interacts with 463 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process activation of protein kinase B activity, calcium-mediated signaling, ...
Component cell junction, cell projection, ...
Function 3-phosphoinositide-dependent protein kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (115)    Tissues (52)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
Northern blot 16
Western blot 8
RT-PCR 2
cDNA source data(137)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(139) cDNA(138) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000016280 (Evidence)
Ensembl Gene ModelENSMUSG00000024122 (Evidence)
Entrez Gene18607 (Evidence)
UniGene10504
DFCITC1578105, TC1612459, TC1602059, TC1621505, TC1642701
DoTSDT.91582349, DT.91401094, DT.97371476, DT.528394
NIA Mouse Gene IndexU037516
EC2.7.11.1
Consensus CDS ProjectCCDS28474.1, CCDS37483.1, CCDS70767.1
International Mouse Knockout Project StatusPdpk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016280 VEGA Gene Model | MGI Sequence Detail 77245 C57BL/6J ±  kb
transcript OTTMUST00000039074 VEGA | MGI Sequence Detail 7161 Not Applicable 
polypeptide OTTMUSP00000017452 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(124) RefSeq(22) UniProt(23)
Polymorphisms
SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012515 3-phosphoinositide-dependent protein kinase 1
References
(Earliest) J:53564 Dong LQ, et al., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 1999 Mar 19;274(12):8117-22
(Latest) J:214355 Scortegagna M, et al., Genetic inactivation or pharmacological inhibition of Pdk1 delays development and inhibits metastasis of Braf(V600E)::Pten(-/-) melanoma. Oncogene. 2014 Aug 21;33(34):4330-9
All references(121)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory