Pdpk1
Gene Detail

Symbol Name ID

Pdpk1 3-phosphoinositide dependent protein kinase 1 MGI:1338068

Synonyms

Pdk1, Pkb kinase

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.23 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:24073680-24150924 bp, - strand From VEGA annotation of GRCm38   77245 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Pdpk1 ± 2 cM)

Gene Tree: Pdpk1

Human ortholog

PDPK1 3-phosphoinositide dependent protein kinase-1 NCBI Gene ID 5170
Human Synonyms: PDK1, PDPK2, PRO0461
Human Chr16:2587970-2653189 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(201) : Targeted(12) Gene trapped(189)
 

Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure.

 
Human Diseases Modeled Using Mouse Pdpk1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (43 annotations)

Process	activation of protein kinase B activity, cellular response to insulin stimulus, ...
Component	cell junction, cytoplasm, ...
Function	3-phosphoinositide-dependent protein kinase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (115)    Tissues (52)    Images (34)
Theiler Stages: 10, 17, 18, 19, 20, 23, 25, 28

Assay Type	Results
RNA in situ	89
Northern blot	16
Western blot	8
RT-PCR	2

cDNA source data(136)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) cDNA(137) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000016280 (Evidence)
Ensembl Gene Model	ENSMUSG00000024122 (Evidence)
Entrez Gene	18607 (Evidence)
UniGene	10504
DFCI	TC1578105, TC1602059, TC1612459, TC1621505
DoTS	DT.528394, DT.91401094, DT.91582349, DT.97371476
NIA Mouse Gene Index	U037516
EC	2.7.11.1
Consensus CDS Project	CCDS28474.1, CCDS37483.1
International Mouse Knockout Project Status	Pdpk1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016280	VEGA Gene Model | MGI Sequence Detail	77245	C57BL/6J
transcript	OTTMUST00000039074	VEGA | MGI Sequence Detail	7161	Not Applicable
polypeptide	OTTMUSP00000017452	VEGA | MGI Sequence Detail	559	Not Applicable

All sequences(93) RefSeq(4) UniProt(12)

Polymorphisms

SNPs(212 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000012515	3-phosphoinositide-dependent protein kinase 1

References

(Earliest) J:53564 Dong LQ, et al., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 1999 Mar 19;274(12):8117-22
(Latest) J:194209 Finlay DK, et al., PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells. J Exp Med. 2012 Dec 17;209(13):2441-53
All references(108)