About   Help   FAQ
Pdpk1
Gene Detail
Symbol

Name
ID
Pdpk1
3-phosphoinositide dependent protein kinase 1
MGI:1338068
Synonyms
Pdk1, Pkb kinase
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.23 cM, cytoband A3.3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:24073680-24150924 bp, - strand
From VEGA annotation of GRCm38

  77245 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37643  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PDPK1
Protein SuperFamily: 3-phosphoinositide-dependent protein kinase 1
Gene Tree: Pdpk1

Human
homologs
PDPK1, 3-phosphoinositide dependent protein kinase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5170
neXtProt AC: NX_O15530

Human Synonyms: PDK1, PDPK2, PDPK2P, PRO0461

Human Chr (Location): 16p13.3; chr16:2537964-2603191 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(201) : Gene trapped(189) Targeted(12)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Pdpk1 interacts with 462 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process activation of protein kinase B activity, calcium-mediated signaling, ...
Component cell junction, cell projection, ...
Function 3-phosphoinositide-dependent protein kinase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (115)    Tissues (52)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 89
Northern blot 16
Western blot 8
RT-PCR 2
cDNA source data(137)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase pdpk1 ; ZFIN pdpk1a, pdpk1b    NEW 
Molecular
reagents
All nucleic(139) cDNA(138) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016280 (Evidence)
Ensembl Gene Model ENSMUSG00000024122 (Evidence)
Entrez Gene 18607 (Evidence)
UniGene 10504
DFCI TC1578105, TC1602059, TC1642701, TC1612459, TC1621505
DoTS DT.97371476, DT.91582349, DT.91401094, DT.528394
NIA Mouse Gene Index U037516
EC 2.7.11.1
Consensus CDS Project CCDS28474.1, CCDS37483.1, CCDS70767.1
International Mouse Phenotyping Consortium Status Pdpk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016280 VEGA Gene Model | MGI Sequence Detail 77245 C57BL/6J ±  kb
transcript OTTMUST00000039074 VEGA | MGI Sequence Detail 7161 Not Applicable 
polypeptide OTTMUSP00000017452 VEGA | MGI Sequence Detail 559 Not Applicable 

For the selected sequences
All sequences(98) RefSeq(6) UniProt(12)
Polymorphisms
SNPs within 2kb(338 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000012515 3-phosphoinositide-dependent protein kinase 1
References
(Earliest) J:53564 Dong LQ, et al., Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta. J Biol Chem. 1999 Mar 19;274(12):8117-22
(Latest) J:218155 Schonhuber N, et al., A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. Nat Med. 2014 Nov;20(11):1340-7
All references(122)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory