101 phenotypes from 10 alleles in 11 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Pdpk1Gt(OST82857)Lex/Pdpk1Gt(OST82857)Lex involves: 129S5/SvEvBrd * C57BL/6J	prenatal lethality, complete penetrance	J:103485
Pdpk1tm1.1Daca/Pdpk1tm1.1Daca involves: 129P2/OlaHsd * BALB/c	embryonic lethality during organogenesis, complete penetrance	J:165626
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw involves: BALB/c	no abnormal phenotype detected	J:85894
Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw Tg(Ckmm-cre)5Khn/? involves: BALB/c	abnormal cardiovascular system morphology	J:85498
	abnormal cardiovascular system physiology	J:85498
	abnormal heart morphology	J:85498
	abnormal heart right ventricle morphology	J:85498
	abnormal heart ventricle morphology	J:85498
	abnormal myocardial fiber morphology	J:85498
	abnormal Z line morphology	J:85498
	decreased body weight	J:85498
	decreased cardiac muscle contractility	J:85498
	dilated cardiomyopathy	J:85498
	heart right ventricle hypertrophy	J:85498
	increased heart atrium size	J:85498
	myocardium hypoplasia	J:85498
	premature death	J:85498
	small heart	J:85498
	thin ventricular wall	J:85498
Pdpk1tm1.2Mlw/Pdpk1tm1.2Mlw involves: BALB/c	abnormal allantois morphology	J:85894
	abnormal cephalic neural fold morphology	J:85894
	abnormal embryonic tissue morphology	J:85894
	abnormal endoderm development	J:85894
	abnormal head development	J:85894
	abnormal neural crest cell physiology	J:85894
	abnormal presomitic mesoderm morphology	J:85894
	abnormal rostral-caudal body axis extension	J:85894
	absent dorsal root ganglion	J:85894
	absent forebrain	J:85894
	absent heart	J:85894
	absent heart tube	J:85894
	absent pharyngeal arches	J:85894
	absent somites	J:85894
	anophthalmia	J:85894
	decreased embryo size	J:85894
	embryonic lethality during organogenesis, complete penetrance	J:85894
	incomplete embryo turning	J:85894
	small allantois	J:85894
Pdpk1tm1Dral/Pdpk1tm1Dral B6.129P2-Pdpk1tm1Dral	abnormal kidney size	J:136089
	decreased adrenal gland zona fasciculata size	J:136089
	decreased body weight	J:136089
	decreased brain size	J:136089
	impaired glucose tolerance	J:136089
	increased circulating insulin level	J:136089
	insulin resistance	J:136089
	pancreatic islet hyperplasia	J:136089
	pancreatic islet hypoplasia	J:136089
	small pancreas	J:136089
	small spleen	J:136089
	small testis	J:136089
Pdpk1tm1Ejm/Pdpk1tm1Ejm involves: 129P2/OlaHsd * BALB/c	abnormal brain development	J:90081
	abnormal embryo development	J:90081
	abnormal extraembryonic tissue morphology	J:90081
	abnormal first pharyngeal arch morphology	J:90081
	abnormal forebrain morphology	J:90081
	abnormal placenta development	J:90081
	abnormal vasculogenesis	J:90081
	absent dorsal root ganglion	J:90081
	decreased embryo size	J:90081
	decreased forebrain size	J:90081
	embryonic lethality during organogenesis, complete penetrance	J:90081
Pdpk1tm1Jcbr/Pdpk1tm1Jcbr Tg(Pomc1-cre)16Lowl/0 involves: C57BL/6 * FVB/N	abnormal circulating leptin level	J:134336
	abnormal glucose homeostasis	J:134336
	abnormal melanotroph morphology	J:134336
	decreased circulating corticosterone level	J:134336
	decreased circulating glucose level	J:134336
	decreased corticotroph cell number	J:134336
	decreased gonadal fat pad weight	J:134336
	decreased insulin secretion	J:134336
	improved glucose tolerance	J:134336
	increased body weight	J:134336
	increased circulating glucose level	J:134336
	increased insulin sensitivity	J:134336
	polyphagia	J:134336
Pdpk1tm1Maka/Pdpk1tm1Maka Tg(Alb1-cre)1Dlr/0 involves: 129S4/SvJae * FVB/N	abnormal glucose homeostasis	J:109359
	impaired glucose tolerance	J:109359
	increased circulating glucose level	J:109359
	increased circulating insulin level	J:109359
Pdpk1tm1Maka/Pdpk1tm1Maka Tg(CAG-cat,-lacZ)11Miya/0 Tg(Pomc1-cre)16Lowl/0 involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	abnormal homeostasis	J:162892
	abnormal neuron physiology	J:162892
	abnormal pituitary intermediate lobe morphology	J:162892
	decreased circulating corticosterone level	J:162892
	hypoglycemia	J:162892
	increased corticotroph apoptosis	J:162892
	increased food intake	J:162892
	increased insulin sensitivity	J:162892
	increased melanotroph apoptosis	J:162892
	increased pituitary gland apoptosis	J:162892
	increased total body fat amount	J:162892
Pdpk1tm1Maka/Pdpk1tm1Maka Tg(Ins2-cre)23Herr/0 involves: 129S4/SvJae * C57BL/6J * CBA/J	abnormal pancreas physiology	J:109010
	abnormal pancreatic beta cell morphology	J:109010
	decreased body weight	J:109010
	decreased circulating insulin level	J:109010
	hyperglycemia	J:109010
	increased circulating glucose level	J:109010
	premature death	J:109010
	small pancreatic islets	J:109010
Pdpk1tm1Maka/Pdpk1tm1Maka Tg(Zp3-cre)93Knw/0 involves: 129S4/SvJae * C57BL/6J	female infertility	J:165798
	maternal effect	J:165798
Pdpk1tm1Mlw/Pdpk1tm1.1Daca Tg(Cd4-cre)1Cwi/0 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2	abnormal CD8-positive, alpha beta T cell morphology	J:165626
	decreased NK T cell number	J:165626
	decreased T cell number	J:165626
Pdpk1tm1Mlw/Pdpk1tm1.2Mlw involves: BALB/c	decreased body size	J:85894
	prenatal lethality, incomplete penetrance	J:85894
Pdpk1tm1Mlw/Pdpk1tm1Mlw involves: BALB/c	decreased birth body size	J:85894
	decreased body size	J:85894
	decreased body weight	J:85894
	prenatal lethality, incomplete penetrance	J:85894
Pdpk1tm1Mlw/Pdpk1tm1Mlw Tg(Cd4-cre)1Cwi/0 involves: C57BL/6 * DBA/2	abnormal CD8-positive, alpha beta T cell morphology	J:165626
	abnormal NK T cell morphology	J:165626
	abnormal T cell differentiation	J:165626
	absent NK T cells	J:165626
	decreased NK T cell number	J:165626
	decreased T cell number	J:165626
	decreased T cell proliferation	J:165626
	normal immune system phenotype	J:165626
Pdpk1tm2Ejm/Pdpk1+ involves: 129P2/OlaHsd * BALB/c	prenatal lethality, incomplete penetrance	J:90081
Pdpk1tm2Ejm/Pdpk1tm2Ejm involves: 129P2/OlaHsd * BALB/c	abnormal brain development	J:90081
	abnormal developmental patterning	J:90081
	normal cardiovascular system phenotype	J:90081
	decreased forebrain size	J:90081
	normal embryo phenotype	J:90081
	embryonic growth retardation	J:90081
	embryonic lethality during organogenesis, complete penetrance	J:90081
	normal nervous system phenotype	J:90081
Gt(ROSA)26Sor/Gt(ROSA)26Sor+ Not Specified	abnormal glucose homeostasis	J:170965
	hyperglycemia	J:170965
	increased circulating insulin level	J:170965