Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mmp2

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes MMP2
- Mouse genes Mmp2
- Rat genes Mmp2
- Zfish genes mmp2
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0004175	endopeptidase activity	MMP2	IDA		Human	PMID:23845380
Molecular Function	GO:0001968	fibronectin binding	Mmp2	IPI	RGD:2624	Rat	PMID:18039280\|RGD:2296060
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp2	IDA		Mouse	PMID:12419962
Molecular Function	GO:0004222	metalloendopeptidase activity	Mmp2	IDA		Mouse	PMID:15212943
Molecular Function	GO:0008237	metallopeptidase activity	MMP2	IDA		Human	PMID:24236012
Molecular Function	GO:0008233	peptidase activity	Mmp2	IDA		Rat	PMID:20110414\|RGD:4142798
Molecular Function	GO:0008233	peptidase activity	Mmp2	IDA		Rat	PMID:20518849\|RGD:2325681
Molecular Function	GO:0008233	peptidase activity	Mmp2	IDA		Rat	PMID:8531210\|RGD:7207198
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P16035	Human	PMID:12032297
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P20908	Human	PMID:20979576
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:Q8IX30	Human	PMID:21441952
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:Q8NBP7	Human	PMID:25613181
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:25897080
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P05067:PRO_0000000093	Human	PMID:25897080
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P05067:PRO_0000000092	Human	PMID:28106549
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P16035	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P20908	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:Q04864-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MMP2	IPI	UniProtKB:P05067	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mmp2	IPI	UniProtKB:P98158	Rat	PMID:28659595\|RGD:13210547
Molecular Function	GO:0004252	serine-type endopeptidase activity	MMP2	EXP		Human	PMID:17428795
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MMP2	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	MMP2	HDA		Human	PMID:23979707
Cellular Component	GO:0005737	cytoplasm	Mmp2	IDA		Rat	PMID:16740171\|RGD:1582597
Cellular Component	GO:0005737	cytoplasm	Mmp2	IDA		Rat	PMID:20213142\|RGD:2325692
Cellular Component	GO:0005615	extracellular space	MMP2	IDA		Human	PMID:18492766
Cellular Component	GO:0005615	extracellular space	MMP2	HDA		Human	PMID:20551380
Cellular Component	GO:0005615	extracellular space	MMP2	IDA		Human	PMID:24236012
Cellular Component	GO:0005615	extracellular space	MMP2	IDA		Human	PMID:24784232
Cellular Component	GO:0005615	extracellular space	Mmp2	HDA		Mouse	MGI:MGI:5640941\|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Mmp2	IDA		Rat	PMID:23911909\|RGD:8657085
Cellular Component	GO:0005886	plasma membrane	Mmp2	IDA		Mouse	PMID:17349656
Cellular Component	GO:0030017	sarcomere	Mmp2	IDA		Mouse	PMID:17349656
Cellular Component	GO:0030017	sarcomere	mmp2	IDA		Zfish	PMID:31795436
Biological Process	GO:0007568	aging	Mmp2	IEP		Rat	PMID:16208432\|RGD:8694091
Biological Process	GO:0007568	aging	Mmp2	IDA		Rat	PMID:23281803\|RGD:13207329
Biological Process	GO:0001525	angiogenesis	Mmp2	IEP		Rat	PMID:12234794\|RGD:625663
Biological Process	GO:0001955	blood vessel maturation	Mmp2	IGI	MGI:MGI:1855698	Mouse	PMID:11747814
Biological Process	GO:0060346	bone trabecula formation	Mmp2	IGI	MGI:MGI:88467	Mouse	PMID:17440987
Biological Process	GO:0016477	cell migration	Mmp2	IMP		Rat	PMID:20371087\|RGD:2325687
Biological Process	GO:0071230	cellular response to amino acid stimulus	Mmp2	IDA		Mouse	PMID:20548288
Biological Process	GO:0071345	cellular response to cytokine stimulus	Mmp2	IEP		Rat	PMID:19909738\|RGD:2325816
Biological Process	GO:0071392	cellular response to estradiol stimulus	Mmp2	IMP		Rat	PMID:19861308\|RGD:2325711
Biological Process	GO:0071498	cellular response to fluid shear stress	Mmp2	IEP		Rat	PMID:21637818\|RGD:7207287
Biological Process	GO:0071347	cellular response to interleukin-1	Mmp2	IEP		Rat	PMID:16046515\|RGD:2313720
Biological Process	GO:0071347	cellular response to interleukin-1	Mmp2	IEP		Rat	PMID:20371087\|RGD:2325687
Biological Process	GO:0034614	cellular response to reactive oxygen species	Mmp2	IMP		Mouse	PMID:17561096
Biological Process	GO:0071492	cellular response to UV-A	MMP2	IDA		Human	PMID:31380578
Biological Process	GO:0030574	collagen catabolic process	Mmp2	IMP	MGI:MGI:2386252	Mouse	PMID:17440987
Biological Process	GO:0030574	collagen catabolic process	Mmp2	IDA		Rat	PMID:22410640\|RGD:7207278
Biological Process	GO:0007566	embryo implantation	Mmp2	IDA		Mouse	PMID:18556655
Biological Process	GO:0035987	endodermal cell differentiation	MMP2	IEP		Human	PMID:23154389
Biological Process	GO:0060325	face morphogenesis	Mmp2	IGI	MGI:MGI:88467	Mouse	PMID:17440987
Biological Process	GO:0007565	female pregnancy	Mmp2	IEP		Rat	PMID:15044600\|RGD:2325965
Biological Process	GO:0021782	glial cell development	mmp2	IMP	ZFIN:ZDB-CRISPR-191009-76,ZFIN:ZDB-CRISPR-191009-77	Zfish	PMID:30924555
Biological Process	GO:0007507	heart development	Mmp2	IDA		Rat	PMID:12061388\|RGD:10043157
Biological Process	GO:0035701	hematopoietic stem cell migration	mmp2	IMP	ZFIN:ZDB-MRPHLNO-081029-8	Zfish	PMID:28416284
Biological Process	GO:0001957	intramembranous ossification	Mmp2	IGI	MGI:MGI:88467	Mouse	PMID:17440987
Biological Process	GO:0001553	luteinization	Mmp2	IEP		Rat	PMID:10537164\|RGD:7207086
Biological Process	GO:0001945	lymph vessel development	mmp2	IMP	ZFIN:ZDB-MRPHLNO-130607-2	Zfish	PMID:22490679
Biological Process	GO:0048246	macrophage chemotaxis	Mmp2	IDA		Rat	PMID:20110414\|RGD:4142798
Biological Process	GO:0007162	negative regulation of cell adhesion	Mmp2	IDA		Rat	PMID:14645107\|RGD:1582607
Biological Process	GO:0045906	negative regulation of vasoconstriction	Mmp2	IDA		Rat	PMID:19482300\|RGD:2325737
Biological Process	GO:0001541	ovarian follicle development	Mmp2	IDA		Rat	PMID:15617683\|RGD:1582601
Biological Process	GO:0001542	ovulation from ovarian follicle	Mmp2	IEP		Rat	PMID:14668206\|RGD:1582606
Biological Process	GO:0007567	parturition	Mmp2	IEP		Rat	PMID:19923067\|RGD:2325701
Biological Process	GO:0014012	peripheral nervous system axon regeneration	Mmp2	IDA		Rat	PMID:15026117\|RGD:1582605
Biological Process	GO:0043065	positive regulation of apoptotic process	Mmp2	IDA		Rat	PMID:16857167\|RGD:1582632
Biological Process	GO:0030335	positive regulation of cell migration	Mmp2	IMP		Rat	PMID:21637818\|RGD:7207287
Biological Process	GO:0048661	positive regulation of smooth muscle cell proliferation	Mmp2	IMP		Mouse	PMID:17561096
Biological Process	GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	mmp2	IMP	ZFIN:ZDB-MRPHLNO-200827-1	Zfish	PMID:32004993
Biological Process	GO:1904707	positive regulation of vascular associated smooth muscle cell proliferation	MMP2	IMP		Human	PMID:18667463
Biological Process	GO:0060740	prostate gland epithelium morphogenesis	Mmp2	IMP		Rat	PMID:20108352\|RGD:2325693
Biological Process	GO:0030163	protein catabolic process	Mmp2	IDA		Rat	PMID:16899336\|RGD:1601417
Biological Process	GO:0006508	proteolysis	MMP2	IDA		Human	PMID:15863497
Biological Process	GO:0006508	proteolysis	Mmp2	IDA		Rat	PMID:20110414\|RGD:4142798
Biological Process	GO:0014823	response to activity	Mmp2	IEP		Rat	PMID:19685505\|RGD:2325729
Biological Process	GO:1904645	response to amyloid-beta	Mmp2	IDA		Mouse	MGI:MGI:6294206\|PMID:28912710
Biological Process	GO:0034097	response to cytokine	Mmp2	IEP		Rat	PMID:17822627\|RGD:2290405
Biological Process	GO:0051602	response to electrical stimulus	Mmp2	IEP		Rat	PMID:19660200\|RGD:2325730
Biological Process	GO:0043627	response to estrogen	Mmp2	IDA		Rat	PMID:16765374\|RGD:1582613
Biological Process	GO:0042542	response to hydrogen peroxide	Mmp2	IDA		Rat	PMID:16934674\|RGD:1582595
Biological Process	GO:0055093	response to hyperoxia	Mmp2	IEP		Rat	PMID:19099751\|RGD:5129684
Biological Process	GO:0001666	response to hypoxia	Mmp2	IDA		Mouse	PMID:17382917
Biological Process	GO:0001666	response to hypoxia	Mmp2	IDA		Rat	PMID:16980344\|RGD:1582594
Biological Process	GO:0009612	response to mechanical stimulus	Mmp2	IDA		Rat	PMID:15350851\|RGD:1582602
Biological Process	GO:0035094	response to nicotine	Mmp2	IEP		Rat	PMID:19879865\|RGD:2325822
Biological Process	GO:0006979	response to oxidative stress	Mmp2	IDA		Rat	PMID:15642321\|RGD:1582600
Biological Process	GO:0009314	response to radiation	Mmp2	IEP		Rat	PMID:19922364\|RGD:2325703
Biological Process	GO:0032526	response to retinoic acid	Mmp2	IEP		Rat	PMID:19099751\|RGD:5129684
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp2	IDA		Rat	PMID:16846501\|RGD:1582611
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp2	IEP		Rat	PMID:19874802\|RGD:2325709
Biological Process	GO:0060041	retina development in camera-type eye	mmp2	IMP	ZFIN:ZDB-CRISPR-191009-76,ZFIN:ZDB-CRISPR-191009-77	Zfish	PMID:30924555
Biological Process	GO:0031290	retinal ganglion cell axon guidance	mmp2	IGI	ZFIN:ZDB-MRPHLNO-081029-4,ZFIN:ZDB-MRPHLNO-130220-4	Zfish	PMID:23326364
Biological Process	GO:0048705	skeletal system morphogenesis	Mmp2	IGI	MGI:MGI:88467	Mouse	PMID:17440987
Biological Process	GO:0048771	tissue remodeling	Mmp2	IDA		Rat	PMID:16740171\|RGD:1582597

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.