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Mmp2
Gene Detail
Symbol

Name
ID
Mmp2
matrix metallopeptidase 2
MGI:97009
Synonyms
72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2
Feature Type
protein coding gene
Genetic Map
Chromosome 8
44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr8:92827328-92853417 bp, + strand
From Ensembl annotation of GRCm38

  26090 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3329  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: gelatinase A
Gene Tree: Mmp2

Human
homologs
Human Homolog MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
NCBI Gene ID 4313
neXtProt AC  NX_P08253
Human Synonyms  CLG4, CLG4A, MMP-II, MONA, TBE-1
Human Chr (Location)  16q13-q21; chr16:55479169-55506674 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human MMP2
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from APF )
 
Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.
 
Human Diseases Modeled Using Mouse Mmp2 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Mmp2 interacts with 154 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process angiogenesis, blood vessel maturation, ...
Component cytoplasm, extracellular matrix, ...
Function fibronectin binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (138)    Tissues (96)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 88
Northern blot 14
Western blot 3
RT-PCR 23
cDNA source data(171)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(181) cDNA(171) Primer pair(6) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000031740 (Evidence)
Entrez Gene17390 (Evidence)
UniGene29564
DFCITC1571950
DoTSDT.111178769, DT.495126, DT.91351894
NIA Mouse Gene IndexU009639
EC3.4.24.24
Consensus CDS ProjectCCDS22523.1
International Mouse Knockout Project StatusMmp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031740 Ensembl Gene Model | MGI Sequence Detail 26090 C57BL/6J ±  kb
transcript ENSMUST00000034187 Ensembl | MGI Sequence Detail 3038 Not Applicable 
polypeptide ENSMUSP00000034187 Ensembl | MGI Sequence Detail 662 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(430 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000562 Fibronectin, type II, collagen-binding
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR013806 Kringle-like fold
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010479 72 kDa type IV collagenase
References
(Earliest) J:218 Bennett D, Brain hernia, a new recessive mutation in the mouse. J Hered. 1959;50:265-8
(Latest) J:211036 Korol A, et al., Matrix Metalloproteinase-9-Null Mice Are Resistant to TGF-beta-Induced Anterior Subcapsular Cataract Formation. Am J Pathol. 2014 Jul;184(7):2001-12
All references(235)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-12279, MGD-MRK-2013

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory