Mmp2
Gene Detail

Symbol Name ID

Mmp2 matrix metallopeptidase 2 MGI:97009

Synonyms

72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2

Feature Type

protein coding gene

Genetic Map

Chromosome 8

44.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr8:92827328-92853417 bp, + strand From Ensembl annotation of GRCm38   26090 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3329  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: gelatinase A
Gene Tree: Mmp2

Human homologs

Human Homolog		MMP2, matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
NCBI Gene ID		4313
neXtProt AC		NX_P08253
Human Synonyms		CLG4, CLG4A, MMP-II, MONA, TBE-1
Human Chr (Location)		16q13-q21; chr16:55513081-55540586 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MMP2

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (47 annotations)

Process	angiogenesis, blood vessel maturation, ...
Component	cytoplasm, extracellular matrix, ...
Function	fibronectin binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (65 records)
Data Summary: Results (136)    Tissues (93)    Images (26)
Theiler Stages: 11, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	8
RNA in situ	88
Northern blot	14
Western blot	3
RT-PCR	23

cDNA source data(169)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(179) cDNA(169) Primer pair(6) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000031740 (Evidence)
Entrez Gene	17390 (Evidence)
UniGene	29564
DFCI	TC1571950
DoTS	DT.111178769, DT.495126, DT.91351894
NIA Mouse Gene Index	U009639
EC	3.4.24.24
Consensus CDS Project	CCDS22523.1
International Mouse Knockout Project Status	Mmp2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031740	Ensembl Gene Model | MGI Sequence Detail	26090	C57BL/6J
transcript	ENSMUST00000034187	Ensembl | MGI Sequence Detail	3038	Not Applicable
polypeptide	ENSMUSP00000034187	Ensembl | MGI Sequence Detail	662	Not Applicable

All sequences(69) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(235 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000562	Fibronectin, type II, collagen-binding
InterPro	IPR018486	Hemopexin, conserved site
InterPro	IPR000585	Hemopexin-like domain
InterPro	IPR018487	Hemopexin-like repeats
InterPro	IPR013806	Kringle-like fold
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021190	Peptidase M10A
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010479	72 kDa type IV collagenase

References

(Earliest) J:218 Bennett D, Brain hernia, a new recessive mutation in the mouse. J Hered. 1959;50:265-8
(Latest) J:195050 Wilson CL, et al., Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults. Mech Dev. 2013 Apr-May;130(4-5):272-89
All references(223)

Other accession IDs

MGD-MRK-12279, MGD-MRK-2013