Comparative GO Graph (mouse, human, rat)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MMP12
  • Mouse genes Mmp12
  • Rat genes Mmp12
  • Zfish genes
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mmp12

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005509	calcium ion binding	MMP12	IMP		Human	PMID:11575928
Molecular Function	GO:0005518	collagen binding	MMP12	IPI	UniProtKB:P02452	Human	PMID:19932771
Molecular Function	GO:0005518	collagen binding	MMP12	IPI	UniProtKB:P02461	Human	PMID:19932771
Molecular Function	GO:0005518	collagen binding	MMP12	IPI	UniProtKB:P08123	Human	PMID:19932771
Molecular Function	GO:0001046	core promoter sequence-specific DNA binding	MMP12	IMP		Human	PMID:24784232
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP12	IMP		Human	PMID:19932771
Molecular Function	GO:0004222	metalloendopeptidase activity	MMP12	IDA		Human	PMID:24784232
Molecular Function	GO:0043565	sequence-specific DNA binding	MMP12	IMP		Human	PMID:24784232
Molecular Function	GO:0008270	zinc ion binding	MMP12	IMP		Human	PMID:11575928
Cellular Component	GO:0005737	cytoplasm	MMP12	IDA		Human	PMID:24784232
Cellular Component	GO:0005615	extracellular space	MMP12	IMP		Human	PMID:24784232
Cellular Component	GO:0005615	extracellular space	Mmp12	HDA		Mouse	MGI:MGI:5640941|PMID:24006456
Cellular Component	GO:0005615	extracellular space	Mmp12	IDA		Mouse	MGI:MGI:5583923|PMID:24784232
Cellular Component	GO:0005634	nucleus	MMP12	IMP		Human	PMID:24784232
Cellular Component	GO:0005634	nucleus	Mmp12	IDA		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0060435	bronchiole development	Mmp12	IMP	MGI:MGI:1926484	Mouse	PMID:12634787
Biological Process	GO:0060435	bronchiole development	Mmp12	IMP	MGI:MGI:2386174	Mouse	PMID:12634787
Biological Process	GO:0060435	bronchiole development	Mmp12	IDA		Mouse	PMID:12634787
Biological Process	GO:0098586	cellular response to virus	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0060309	elastin catabolic process	MMP12	IDA		Human	PMID:29101312
Biological Process	GO:0048286	lung alveolus development	Mmp12	IMP	MGI:MGI:2386174	Mouse	PMID:12634787
Biological Process	GO:1904905	negative regulation of endothelial cell-matrix adhesion via fibronectin	MMP12	IDA		Human	PMID:29101312
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0060339	negative regulation of type I interferon-mediated signaling pathway	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Mmp12	IEP		Rat	PMID:15802269|RGD:1582367
Biological Process	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	MMP12	IDA		Human	PMID:15802269
Biological Process	GO:0010628	positive regulation of gene expression	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0032727	positive regulation of interferon-alpha production	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MMP12	IMP		Human	PMID:24784232
Biological Process	GO:0060340	positive regulation of type I interferon-mediated signaling pathway	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0006606	protein import into nucleus	MMP12	IMP		Human	PMID:24784232
Biological Process	GO:0006606	protein import into nucleus	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:0006508	proteolysis	MMP12	IMP		Human	PMID:19932771
Biological Process	GO:0006508	proteolysis	MMP12	IDA		Human	PMID:24784232
Biological Process	GO:0050691	regulation of defense response to virus by host	Mmp12	IMP		Mouse	MGI:MGI:5583923|PMID:24784232
Biological Process	GO:1901163	regulation of trophoblast cell migration	Mmp12	IMP		Rat	PMID:27807143|RGD:12910498
Biological Process	GO:0001666	response to hypoxia	Mmp12	IEP		Rat	PMID:27807143|RGD:12910498
Biological Process	GO:0014070	response to organic cyclic compound	Mmp12	IEP		Rat	PMID:15569474|RGD:1582369
Biological Process	GO:0009410	response to xenobiotic stimulus	Mmp12	IEP		Rat	PMID:12783419|RGD:1582362
Biological Process	GO:0035313	wound healing, spreading of epidermal cells	MMP12	IDA		Human	PMID:15802269

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern