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Gene Ontology Browser
Term Detail
GO term:core promoter sequence-specific DNA binding
GO id:GO:0001046
Definition:Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region composed of the transcription start site and binding sites for the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon.
CommentsThe word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
Number of paths to term: 10

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter binding
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-acore promoter proximal region sequence-specific DNA binding +
                                                                is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                        is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                        is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                is-aenhancer sequence-specific DNA binding +
                                                                is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter binding
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter binding
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-acore promoter proximal region sequence-specific DNA binding +
                                                                is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                        is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                        is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                is-aenhancer sequence-specific DNA binding +
                                                                is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-acore promoter binding
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding [GO:0001046] (70 genes, 79 annotations)
                                                                                is-abacterial-type RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-amitochondrial RNA polymerase core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase I CORE element sequence-specific DNA binding
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding +
                                                                        is-atranscription termination site sequence-specific DNA binding +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory