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Mmp12
Gene Detail
Symbol

Name
ID
Mmp12
matrix metallopeptidase 12
MGI:97005
Synonyms
macrophage elastase, Mmel, MMP12
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:7344381-7369499 bp, + strand
From VEGA annotation of GRCm38

  25119 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: MMP12
Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp12

Human
homologs
MMP12, matrix metallopeptidase 12
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4321
neXtProt AC: NX_P39900

Human Synonyms: HME, ME, MME, MMP-12

Human Chr (Location): 11q22.3; chr11:102862733-102875034 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased sensitivity to cigarette smoke, decreased littler size, abnormal myelination, abnormal macrophage physiology, and decreased oligodedrocytes.
 
Interactions
Mmp12 interacts with 278 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (5)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(4) cDNA(58) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027381 (Evidence)
Ensembl Gene Model ENSMUSG00000049723 (Evidence)
Entrez Gene 17381 (Evidence)
UniGene 2055
DFCI TC1573624, TC1596006
DoTS DT.101135750, DT.101164333, DT.101312843, DT.101323612, DT.101346217, DT.101407043, DT.101407055, DT.101407068, DT.101407084, DT.97402107
NIA Mouse Gene Index U010022
EC 3.4.24.65
Consensus CDS Project CCDS22804.1
International Mouse Phenotyping Consortium Status Mmp12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027381 VEGA Gene Model | MGI Sequence Detail 25119 C57BL/6J ±  kb
transcript OTTMUST00000067718 VEGA | MGI Sequence Detail 3607 Not Applicable 
polypeptide OTTMUSP00000034108 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(73 from dbSNP Build 137)    SNPs within 2kb including multiple locations(75)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010472 macrophage metalloelastase
References
(Earliest) J:11522 Denis M, et al., Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am J Respir Cell Mol Biol. 1991 Nov;5(5):477-83
(Latest) J:218540 Bellac CL, et al., Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis. Cell Rep. 2014 Oct 23;9(2):618-32
All references(94)
Other
accession IDs
MGD-MRK-12275, MGI:2143275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory