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Mmp12
Gene Detail
 Symbol
Name
ID
Mmp12
matrix metallopeptidase 12
MGI:97005
Synonyms macrophage elastase, Mmel, MMP12
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr9:7344381-7369499 bp, + strand
From VEGA annotation of GRCm38

  25119 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp12

Human
homologs
Human Homolog MMP12, matrix metallopeptidase 12 (macrophage elastase)
NCBI Gene ID 4321
neXtProt AC  NX_P39900
Human Synonyms  HME, ME, MME, MMP-12
Human Chr (Location)  11q22.3; chr11:102862733-102875034 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased sensitivity to cigarette smoke, decreased littler size, abnormal myelination, abnormal macrophage physiology, and decreased oligodedrocytes.
 
Interactions
Mmp12 interacts with 279 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process positive regulation of epithelial cell proliferation involved in wound healing, proteolysis, ...
Component extracellular matrix, extracellular region, ...
Function calcium ion binding, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (5)    Tissues (3)   
Theiler Stages: 19, 28
Assay TypeResults
RT-PCR 5
cDNA source data(58)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(4) cDNA(58) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027381 (Evidence)
Ensembl Gene ModelENSMUSG00000049723 (Evidence)
Entrez Gene17381 (Evidence)
UniGene2055
DFCITC1573624, TC1596006
DoTSDT.101135750, DT.101164333, DT.101312843, DT.101323612, DT.101346217, DT.101407043, DT.101407055, DT.101407068, DT.101407084, DT.97402107
NIA Mouse Gene IndexU010022
EC3.4.24.65
Consensus CDS ProjectCCDS22804.1
International Mouse Knockout Project StatusMmp12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027381 VEGA Gene Model | MGI Sequence Detail 25119 C57BL/6J ±  kb
transcript OTTMUST00000067718 VEGA | MGI Sequence Detail 3607 Not Applicable 
polypeptide OTTMUSP00000034108 VEGA | MGI Sequence Detail 473 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(4) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(73 from dbSNP Build 137)    SNPs within 2kb including multiple locations(75)
Protein-related
information
ResourceIDDescription
InterPro IPR018486 Hemopexin, conserved site
InterPro IPR000585 Hemopexin-like domain
InterPro IPR018487 Hemopexin-like repeats
InterPro IPR024079 Metallopeptidase, catalytic domain
InterPro IPR021190 Peptidase M10A
InterPro IPR021158 Peptidase M10A, cysteine switch, zinc binding site
InterPro IPR016293 Peptidase M10A, metazoans
InterPro IPR001818 Peptidase M10, metallopeptidase
InterPro IPR006026 Peptidase, metallopeptidase
InterPro IPR002477 Peptidoglycan binding-like
Protein Ontology PR:000010472 macrophage metalloelastase
References (Earliest) J:11522 Denis M, et al., Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am J Respir Cell Mol Biol. 1991 Nov;5(5):477-83
(Latest) J:204701 Fukuzawa T, et al., Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D. PLoS One. 2013;8(7):e69451
All references(92)
Other
accession IDs
MGD-MRK-12275, MGI:2143275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory