Mmp12
Gene Detail

Symbol Name ID

Mmp12 matrix metallopeptidase 12 MGI:97005

Synonyms

macrophage elastase, Mmel, MMP12

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr9:7344381-7369499 bp, + strand From VEGA annotation of GRCm38   25119 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20547  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: matrix metalloproteinase, stromelysin type
Gene Tree: Mmp12

Human homologs

Human Homolog		MMP12, matrix metallopeptidase 12 (macrophage elastase)
NCBI Gene ID		4321
neXtProt AC		NX_P39900
Human Synonyms		HME, ME, MME, MMP-12
Human Chr (Location)		11q22.3; chr11:102733464-102745764 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit decreased sensitivity to cigarette smoke, decreased littler size, abnormal myelination, abnormal macrophage physiology, and decreased oligodedrocytes.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	positive regulation of epithelial cell proliferation involved in wound healing, proteolysis, ...
Component	extracellular matrix, extracellular region, ...
Function	calcium ion binding, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (5)    Tissues (3)   
Theiler Stages: 19, 28

Assay Type	Results
RT-PCR	5

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(4) cDNA(56) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027381 (Evidence)
Ensembl Gene Model	ENSMUSG00000049723 (Evidence)
Entrez Gene	17381 (Evidence)
UniGene	2055
DFCI	TC1573624, TC1596006
DoTS	DT.101135750, DT.101164333, DT.101312843, DT.101323612, DT.101346217, DT.101407043, DT.101407055, DT.101407068, DT.101407084, DT.97402107
NIA Mouse Gene Index	U010022
EC	3.4.24.65
Consensus CDS Project	CCDS22804.1
International Mouse Knockout Project Status	Mmp12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027381	VEGA Gene Model | MGI Sequence Detail	25119	C57BL/6J
transcript	OTTMUST00000067718	VEGA | MGI Sequence Detail	3607	Not Applicable
polypeptide	OTTMUSP00000034108	VEGA | MGI Sequence Detail	473	Not Applicable

All sequences(95) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(35 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000585	Hemopexin/matrixin
InterPro	IPR018486	Hemopexin/matrixin, conserved site
InterPro	IPR018487	Hemopexin/matrixin, repeat
InterPro	IPR024079	Metallopeptidase, catalytic domain
InterPro	IPR021158	Peptidase M10A, cysteine switch, zinc binding site
InterPro	IPR021190	Peptidase M10A, matrix metallopeptidase
InterPro	IPR016293	Peptidase M10A, matrix metallopeptidase, stromelysin type
InterPro	IPR001818	Peptidase M10, metallopeptidase
InterPro	IPR006026	Peptidase, metallopeptidase
InterPro	IPR002477	Peptidoglycan binding-like
Protein Ontology	PR:000010472	macrophage metalloelastase

References

(Earliest) J:11522 Denis M, et al., Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am J Respir Cell Mol Biol. 1991 Nov;5(5):477-83
(Latest) J:181974 Seo S, et al., Forkhead box transcription factor FoxC1 preserves corneal transparency by regulating vascular growth. Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2015-20
All references(87)

Other accession IDs

MGD-MRK-12275, MGI:2143275