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Comparative GO Graph (mouse, human, rat, zebrafish)
Source
Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Mapk8

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

Molecular Function


Cellular Component


Biological Process



Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mapk8
Category ID Classification term Gene Evidence Inferred from Organism Reference
Molecular FunctionGO:0008047enzyme activator activityMAPK8IDAHumanPMID:27568560
Molecular FunctionGO:0019899enzyme bindingMAPK8IPIUniProtKB:P12821HumanPMID:14615289
Molecular FunctionGO:0042826histone deacetylase bindingMAPK8IPIUniProtKB:Q96EB6HumanPMID:20027304
Molecular FunctionGO:0035033histone deacetylase regulator activityMAPK8IMPHumanPMID:20027304
Molecular FunctionGO:0004705JUN kinase activityMAPK8IDAHumanPMID:21095239
Molecular FunctionGO:0004705JUN kinase activityMAPK8IDAHumanPMID:8654373
Molecular FunctionGO:0004705JUN kinase activityMapk8IDAMouseMGI:MGI:1855744|PMID:10811224
Molecular FunctionGO:0004705JUN kinase activityMapk8IDAMousePMID:19289495
Molecular FunctionGO:0004705JUN kinase activityMapk8IDAMousePMID:15579909
Molecular FunctionGO:0004705JUN kinase activityMapk8IDARatPMID:11849756|RGD:2298565
Molecular FunctionGO:0004705JUN kinase activityMapk8IDARatPMID:17064355|RGD:2298577
Molecular FunctionGO:0016301kinase activityMapk8IDAMousePMID:15767678
Molecular FunctionGO:0016301kinase activityMapk8IDAMousePMID:15483136
Molecular FunctionGO:0016301kinase activityMapk8IDAMousePMID:12808090
Molecular FunctionGO:0019894kinesin bindingMapk8IPIRGD:621559RatPMID:18932217|RGD:9587790
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P05412HumanPMID:10393177
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q13387HumanPMID:10490659
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q00613HumanPMID:10747973
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q03112HumanPMID:10856240
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q9WVI9-1HumanPMID:11517249
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q61823HumanPMID:15334056
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P05412HumanPMID:15894542
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P05412HumanPMID:16291755
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:O14733-2HumanPMID:16533805
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P45985HumanPMID:16533805
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q9UQF2HumanPMID:16840345
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P22681HumanPMID:16982329
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P27986HumanPMID:16982329
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P05412HumanPMID:18003900
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q9UQF2HumanPMID:18286207
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:O00213HumanPMID:19234442
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P16104HumanPMID:19234442
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P05412HumanPMID:19527717
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q9NRA8HumanPMID:22966201
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P27986HumanPMID:25284480
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:Q8N122HumanPMID:27043084
Molecular FunctionGO:0005515protein bindingMAPK8IPIUniProtKB:P45985HumanPMID:32707033
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:Q9WVI9MouseMGI:MGI:2182167|PMID:11562351
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P19157MouseMGI:MGI:5009191|PMID:11279197
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P05627MouseMGI:MGI:1928254|PMID:10581243
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:Q9ESN9MouseMGI:MGI:1890011|PMID:10523642
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P05627MouseMGI:MGI:5508610|PMID:17255944
Molecular FunctionGO:0005515protein bindingMapk8IPIPR:Q9DBR4MousePMID:12855407
Molecular FunctionGO:0005515protein bindingMapk8IPIPR:Q9JJP2MousePMID:15483136
Molecular FunctionGO:0005515protein bindingMapk8IPIPR:Q99KG5MousePMID:24889144
Molecular FunctionGO:0005515protein bindingMapk8IPIPR:Q6NS57MousePMID:10471813
Molecular FunctionGO:0005515protein bindingMapk8IPIRGD:68947RatPMID:16618812|RGD:1582322
Molecular FunctionGO:0005515protein bindingMapk8IPIRGD:70937RatPMID:17348686|RGD:2298766
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P17325RatPMID:18046461|RGD:8554794
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P50232RatPMID:18046461|RGD:8554794
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P19491-3RatPMID:18188153|RGD:8553460
Molecular FunctionGO:0005515protein bindingMapk8IPIUniProtKB:P19493RatPMID:18188153|RGD:8553460
Molecular FunctionGO:0005515protein bindingMapk8IPIRGD:621227RatPMID:18932217|RGD:9587790
Molecular FunctionGO:0005515protein bindingMapk8IPIRGD:62081RatPMID:22302822|RGD:9685391
Molecular FunctionGO:0004672protein kinase activityMapk8IDAMousePMID:24889144
Molecular FunctionGO:0019903protein phosphatase bindingMAPK8IPIUniProtKB:Q9BY84HumanPMID:11489891
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:14967141
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:15850461
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:20027304
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:21095239
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:22966201
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:27568560
Molecular FunctionGO:0004674protein serine/threonine kinase activityMAPK8IDAHumanPMID:28943315
Molecular FunctionGO:0004674protein serine/threonine kinase activityMapk8IDAMouseMGI:MGI:6106673|PMID:28943315
Molecular FunctionGO:0004674protein serine/threonine kinase activityMapk8IDAMousePMID:24127566
Molecular FunctionGO:0004674protein serine/threonine kinase activityMapk8IDAMousePMID:24889144
Molecular FunctionGO:0120283protein serine/threonine kinase bindingMAPK8IPIUniProtKB:P27448HumanPMID:11865055
Molecular FunctionGO:0004712protein serine/threonine/tyrosine kinase activityMapk8IMPMouseMGI:MGI:6148490|PMID:29153991
Cellular ComponentGO:0030424axonMapk8IMPMouseMGI:MGI:5462161|PMID:22683681
Cellular ComponentGO:0030424axonMapk8IDARatPMID:9714150|RGD:2293331
Cellular ComponentGO:0097441basal dendriteMapk8IMPMouseMGI:MGI:5462161|PMID:22683681
Cellular ComponentGO:0005737cytoplasmMapk8IMPMouseMGI:MGI:6148490|PMID:29153991
Cellular ComponentGO:0005737cytoplasmMapk8IDAMousePMID:24127566
Cellular ComponentGO:0005737cytoplasmMapk8IDAMousePMID:15030387
Cellular ComponentGO:0005737cytoplasmMapk8IDAMousePMID:29078390
Cellular ComponentGO:0005737cytoplasmMapk8IDARatPMID:10773432|RGD:1582317
Cellular ComponentGO:0005737cytoplasmMapk8IDARatPMID:15504737|RGD:2298783
Cellular ComponentGO:0005829cytosolMapk8IDAMousePMID:11884367
Cellular ComponentGO:0032839dendrite cytoplasmMapk8IDARatPMID:9714150|RGD:2293331
Cellular ComponentGO:0005739mitochondrionMapk8IDAMousePMID:11884367
Cellular ComponentGO:0005739mitochondrionMapk8IDARatPMID:15504737|RGD:2298783
Cellular ComponentGO:0043005neuron projectionMapk8IDAMousePMID:29078390
Cellular ComponentGO:0005634nucleusMAPK8IDAHumanPMID:20027304
Cellular ComponentGO:0005634nucleusMAPK8IDAHumanPMID:30878395
Cellular ComponentGO:0005634nucleusMapk8IDAMousePMID:24127566
Cellular ComponentGO:0005634nucleusMapk8IDAMousePMID:15483136
Cellular ComponentGO:0005634nucleusMapk8IDAMousePMID:15030387
Cellular ComponentGO:0005634nucleusMapk8IDARatPMID:10773432|RGD:1582317
Cellular ComponentGO:0005634nucleusMapk8IDARatPMID:15504737|RGD:2298783
Cellular ComponentGO:0005634nucleusMapk8IDARatPMID:16699462|RGD:1582310
Cellular ComponentGO:0043204perikaryonMapk8IDARatPMID:9714150|RGD:2293331
Cellular ComponentGO:0002102podosomeMapk8IDAMousePMID:24127566
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseMapk8IMPMousePMID:17284179
Cellular ComponentGO:0098685Schaffer collateral - CA1 synapseMapk8IDAMousePMID:17284179
Cellular ComponentGO:0045202synapseMapk8IDARatPMID:29166604|RGD:15023486
Cellular ComponentGO:0031982vesicleMapk8IDARatPMID:16618812|RGD:1582322
Biological ProcessGO:0097190apoptotic signaling pathwayMapk8IGIMGI:MGI:1346862MousePMID:16458303
Biological ProcessGO:0034198cellular response to amino acid starvationMAPK8IDAHumanPMID:11096076
Biological ProcessGO:1904646cellular response to amyloid-betaMapk8IEPRatPMID:12534344|RGD:10412678
Biological ProcessGO:0071216cellular response to biotic stimulusMapk8IMPMousePMID:23262141
Biological ProcessGO:0071276cellular response to cadmium ionMAPK8IMPHumanPMID:26514923
Biological ProcessGO:0070301cellular response to hydrogen peroxideMapk8IDAMousePMID:20808772
Biological ProcessGO:0071347cellular response to interleukin-1Mapk8IEPRatPMID:9513050|RGD:10412698
Biological ProcessGO:0071222cellular response to lipopolysaccharideMAPK8IDAHumanPMID:23776175
Biological ProcessGO:0071260cellular response to mechanical stimulusMAPK8IEPHumanPMID:19593445
Biological ProcessGO:0071732cellular response to nitric oxideMapk8IMPMousePMID:18007661
Biological ProcessGO:0034599cellular response to oxidative stressMAPK8IDAHumanPMID:27568560
Biological ProcessGO:0034614cellular response to reactive oxygen speciesMAPK8IMPHumanPMID:26514923
Biological ProcessGO:0048813dendrite morphogenesisMapk8IMPMouseMGI:MGI:3582133|PMID:16000625
Biological ProcessGO:0048263determination of dorsal identitymapk8bIMPZFIN:ZDB-MRPHLNO-071126-2ZfishPMID:17681137
Biological ProcessGO:0048484enteric nervous system developmentmapk8aIGIZFIN:ZDB-CRISPR-230208-18,ZFIN:ZDB-CRISPR-230208-19ZfishPMID:34358225
Biological ProcessGO:0048484enteric nervous system developmentmapk8bIGIZFIN:ZDB-CRISPR-230208-18,ZFIN:ZDB-CRISPR-230208-19ZfishPMID:34358225
Biological ProcessGO:0034349glial cell apoptotic processMapk8IEPRatPMID:14997384|RGD:10412686
Biological ProcessGO:0006954inflammatory responseMapk8IDARatPMID:11435459|RGD:1582329
Biological ProcessGO:0007254JNK cascadeMAPK8IDAHumanPMID:8654373
Biological ProcessGO:0007254JNK cascadeMapk8IDAMouseMGI:MGI:1855744|PMID:10811224
Biological ProcessGO:0007254JNK cascademapk8bIMPZfishPMID:17681137|ZFIN:ZDB-PUB-070813-12
Biological ProcessGO:0007258JUN phosphorylationMAPK8IDAHumanPMID:14967141
Biological ProcessGO:0007258JUN phosphorylationMAPK8IDAHumanPMID:21095239
Biological ProcessGO:0007258JUN phosphorylationMapk8IMPMGI:MGI:2384141MousePMID:14967141
Biological ProcessGO:0050804modulation of chemical synaptic transmissionMapk8IMPMousePMID:17284179
Biological ProcessGO:0050804modulation of chemical synaptic transmissionMapk8IDAMousePMID:17284179
Biological ProcessGO:0043066negative regulation of apoptotic processMAPK8IDAHumanPMID:14967141
Biological ProcessGO:0043066negative regulation of apoptotic processMAPK8IDAHumanPMID:21095239
Biological ProcessGO:0043066negative regulation of apoptotic processMapk8IDARatPMID:15309413|RGD:1582311
Biological ProcessGO:0032091negative regulation of protein bindingMAPK8IDAHumanPMID:21095239
Biological ProcessGO:0048666neuron developmentMapk8IEPRatPMID:17568197|RGD:2304232
Biological ProcessGO:0001764neuron migrationMapk8IMPMouseMGI:MGI:4946347|PMID:21297631
Biological ProcessGO:0031175neuron projection developmentMapk8IMPRatPMID:16618812|RGD:1582322
Biological ProcessGO:0097150neuronal stem cell population maintenanceMapk8IGIUniProtKB:Q5M9F2RatPMID:24388750|RGD:10047173
Biological ProcessGO:0097150neuronal stem cell population maintenanceMapk8IMPRatPMID:24388750|RGD:10047173
Biological ProcessGO:0001503ossificationMapk8IMPMousePMID:15820682
Biological ProcessGO:0018105peptidyl-serine phosphorylationMAPK8IDAHumanPMID:15850461
Biological ProcessGO:0018105peptidyl-serine phosphorylationMAPK8IDAHumanPMID:20027304
Biological ProcessGO:0018105peptidyl-serine phosphorylationMAPK8IDAHumanPMID:21095239
Biological ProcessGO:0018105peptidyl-serine phosphorylationMAPK8IDAHumanPMID:22966201
Biological ProcessGO:0018105peptidyl-serine phosphorylationMapk8IMPMouseMGI:MGI:6148490|PMID:29153991
Biological ProcessGO:0018105peptidyl-serine phosphorylationMapk8IDAMousePMID:24889144
Biological ProcessGO:0018107peptidyl-threonine phosphorylationMAPK8IMPHumanPMID:20027304
Biological ProcessGO:0018107peptidyl-threonine phosphorylationMAPK8IDAHumanPMID:21095239
Biological ProcessGO:0018107peptidyl-threonine phosphorylationMapk8IMPMGI:MGI:2384141MousePMID:14967141
Biological ProcessGO:0043065positive regulation of apoptotic processMapk8IEPRatPMID:16699462|RGD:1582310
Biological ProcessGO:2001235positive regulation of apoptotic signaling pathwayMapk8IGIMGI:MGI:1346862MousePMID:16458303
Biological ProcessGO:0010666positive regulation of cardiac muscle cell apoptotic processMapk8IMPRatPMID:11259632|RGD:10412677
Biological ProcessGO:0030335positive regulation of cell migrationMapk8IDARatPMID:12853963|RGD:1582328
Biological ProcessGO:0031281positive regulation of cyclase activityMAPK8IMPHumanPMID:22027397
Biological ProcessGO:0090045positive regulation of deacetylase activityMAPK8IMPHumanPMID:20027304
Biological ProcessGO:2000017positive regulation of determination of dorsal identityMapk8IDAMousePMID:18316368
Biological ProcessGO:0045740positive regulation of DNA replicationMapk8IMPRatPMID:9487126|RGD:2293350
Biological ProcessGO:0010628positive regulation of gene expressionMAPK8IMPHumanPMID:22065586
Biological ProcessGO:0034352positive regulation of glial cell apoptotic processMapk8IMPRatPMID:14997384|RGD:10412686
Biological ProcessGO:0031116positive regulation of microtubule polymerizationMapk8IMPRatPMID:16618812|RGD:1582322
Biological ProcessGO:0002052positive regulation of neuroblast proliferationMapk8IMPRatPMID:24388750|RGD:10047173
Biological ProcessGO:0043525positive regulation of neuron apoptotic processMapk8IMPRatPMID:12534344|RGD:10412678
Biological ProcessGO:2001224positive regulation of neuron migrationMapk8IMPRatPMID:24388750|RGD:10047173
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyMAPK8IDAHumanPMID:28943315
Biological ProcessGO:1900227positive regulation of NLRP3 inflammasome complex assemblyMapk8IDAMouseMGI:MGI:6106673|PMID:28943315
Biological ProcessGO:0071803positive regulation of podosome assemblyMapk8IMPMousePMID:24127566
Biological ProcessGO:0051247positive regulation of protein metabolic processMAPK8IMPHumanPMID:22027397
Biological ProcessGO:0031398positive regulation of protein ubiquitinationMapk8IMPMouseMGI:MGI:6148490|PMID:29153991
Biological ProcessGO:1901485positive regulation of transcription factor catabolic processMapk8IMPMouseMGI:MGI:6148490|PMID:29153991
Biological ProcessGO:0097300programmed necrotic cell deathMapk8IMPMousePMID:18007661
Biological ProcessGO:0061833protein localization to tricellular tight junctionMapk8IMPMousePMID:24889144
Biological ProcessGO:0006468protein phosphorylationMAPK8IDAHumanPMID:21856198
Biological ProcessGO:0006468protein phosphorylationMAPK8IMPHumanPMID:22441692
Biological ProcessGO:0006468protein phosphorylationMapk8IMPMouseMGI:MGI:5431019|PMID:22441692
Biological ProcessGO:0006468protein phosphorylationMapk8IDAMousePMID:24889144
Biological ProcessGO:0006468protein phosphorylationMapk8IDAMousePMID:15767678
Biological ProcessGO:0046605regulation of centrosome cycleMapk8IMPRatPMID:24388750|RGD:10047173
Biological ProcessGO:0042752regulation of circadian rhythmMapk8IMPMouseMGI:MGI:5431019|PMID:22441692
Biological ProcessGO:1904809regulation of dense core granule transportMapk8IDARatPMID:29166604|RGD:15023486
Biological ProcessGO:1902595regulation of DNA replication origin bindingMAPK8IMPHumanPMID:21856198
Biological ProcessGO:0006355regulation of DNA-templated transcriptionMapk8IDARatPMID:12011047|RGD:625500
Biological ProcessGO:0010468regulation of gene expressionMapk8IMPMousePMID:19289495
Biological ProcessGO:0045664regulation of neuron differentiationMapk8IMPRatPMID:24388750|RGD:10047173
Biological ProcessGO:0032880regulation of protein localizationMAPK8IDAHumanPMID:20027304
Biological ProcessGO:0046686response to cadmium ionMapk8IGIMGI:MGI:1346862MousePMID:16458303
Biological ProcessGO:0009408response to heatMapk8IDARatPMID:10772775|RGD:1582333
Biological ProcessGO:0042542response to hydrogen peroxideMapk8IDARatPMID:14707549|RGD:1582326
Biological ProcessGO:0006970response to osmotic stressMapk8IDARatPMID:10781376|RGD:1582332
Biological ProcessGO:0006979response to oxidative stressMAPK8IDAHumanPMID:22966201
Biological ProcessGO:0048545response to steroid hormoneMapk8IEPRatPMID:14512437|RGD:1582327
Biological ProcessGO:0009411response to UVMAPK8IDAHumanPMID:14967141
Biological ProcessGO:0007165signal transductionMapk8IDARatPMID:12011047|RGD:625500
Biological ProcessGO:0051403stress-activated MAPK cascadeMAPK8IDAHumanPMID:11096076
Biological ProcessGO:0097050type B pancreatic cell apoptotic processMapk8IMPRatPMID:24475223|RGD:10047243

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment
  IDA Inferred from direct assay
  IEP Inferred from expression pattern
  IGI Inferred from genetic interaction
  IMP Inferred from mutant phenotype
  IPI Inferred from physical interaction
  HTP Inferred from High Throughput Experiment
  HDA Inferred from High Throughput Direct Assay
  HMP Inferred from High Throughput Mutant Phenotype
  HGI Inferred from High Throughput Genetic Interaction
  HEP Inferred from High Throughput Expression Pattern

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory