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Mapk8
Gene Detail
Symbol

Name
ID
Mapk8
mitogen-activated protein kinase 8
MGI:1346861
Synonyms
c-Jun N-terminal kinase, JNK1, Prkm8
Feature Type
protein coding gene
Genetic Map
Chromosome 14
20.22 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:33377898-33447158 bp, - strand
From VEGA annotation of GRCm38

  69261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MAPK8
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk8

Human
homologs
MAPK8, mitogen-activated protein kinase 8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5599
neXtProt AC: NX_P45983

Human Synonyms: JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c

Human Chr (Location): 10q11.22; chr10:48306639-48439360 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(37) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology.
 
Phenotype Images(4)
Interactions
Mapk8 interacts with 453 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process cellular response to hydrogen peroxide, cellular response to lipopolysaccharide, ...
Component axon, cytoplasm, ...
Function ATP binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (203)    Tissues (71)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 124
Western blot 73
cDNA source data(80)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA MAPK8 ; Xenbase mapk8 ; ZFIN mapk8a, mapk8b    NEW 
Molecular
reagents
All nucleic(85) Genomic(1) cDNA(83) Primer pair(1)
Microarray probesets(12)
Other database
links
VEGA Gene Model OTTMUSG00000018229 (Evidence)
Ensembl Gene Model ENSMUSG00000021936 (Evidence)
Entrez Gene 26419 (Evidence)
UniGene 21495
DFCI TC1598120, TC1577892, TC1597850, TC1592768, TC1709918
DoTS DT.97390242, DT.55281756, DT.533449, DT.97398944, DT.60104612
NIA Mouse Gene Index U035398
EC 2.7.11.24
Consensus CDS Project CCDS36869.1
International Mouse Phenotyping Consortium Status Mapk8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018229 VEGA Gene Model | MGI Sequence Detail 69261 C57BL/6J ±  kb
transcript OTTMUST00000044047 VEGA | MGI Sequence Detail 2587 Not Applicable 
polypeptide OTTMUSP00000019791 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(10) UniProt(7)
Polymorphisms
SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002206 mitogen-activated protein kinase 8
References
(Earliest) J:51510 Dong C, et al., Defective T cell differentiation in the absence of Jnk1. Science. 1998 Dec 11;282(5396):2092-5
(Latest) J:221495 Tapia O, et al., Nuclear envelope protein Lem2 is required for mouse development and regulates MAP and AKT kinases. PLoS One. 2015;10(3):e0116196
All references(338)
Other
accession IDs
MGI:1328367, MGI:2145699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory