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Mapk8 Gene Detail
Summary
  • Symbol
    Mapk8
  • Name
    mitogen-activated protein kinase 8
  • Synonyms
    c-Jun N-terminal kinase, JNK1, Prkm8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346861
    NCBI Gene: 26419
  • Gene Overview
    MyGene.info: MAPK8
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:33377898-33447158 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      69261 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 20.22 cM, cytoband B
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    MAPK8, mitogen-activated protein kinase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAPK8, mitogen-activated protein kinase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c
  • Links
    NCBI Gene ID: 5599
    neXtProt AC: NX_P45983
    UniProt: P45983

  • Chr Location
    10q11.22; chr10:48306639-48439360 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 4 alleles in 9 genetic backgrounds
    75 phenotypes from multigenic genotypes
    4 images
    164 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018229 VEGA Gene Model | MGI Sequence Detail 69261 C57BL/6J ±  kb
    transcript OTTMUST00000044047 VEGA | MGI Sequence Detail 2587 Not Applicable  
    polypeptide OTTMUSP00000019791 VEGA | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      297 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • EC
    • InterPro Domains
      IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
      IPR008351 Mitogen-activated protein (MAP) kinase, JNK
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
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    • All nucleic 86
      Genomic 1
      cDNA 83
      Primer pair 2

      Microarray probesets 12
    Other
    Accession IDs
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    MGI:1328367, MGI:2145699
    References
    more
    • Summaries
      All 483
      Developmental Gene Expression 99
      Gene Ontology 38
      Phenotypes 164
    • Earliest
      J:41744 Tournier C, et al., Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7337-42
    • Latest
      J:257510 Zhu XJ, et al., Disruption of Wnt production in Shh lineage causes bone malformation in mice, mimicking human Malik-Percin-type syndactyly. FEBS Lett. 2018 Feb;592(3):356-368

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory