About   Help   FAQ
Mapk8
Gene Detail
 Symbol
Name
ID
Mapk8
mitogen-activated protein kinase 8
MGI:1346861
Synonyms c-Jun N-terminal kinase, JNK1, Prkm8
Feature Type protein coding gene
Genetic Map
Chromosome 14
20.22 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:33377898-33447158 bp, - strand
From VEGA annotation of GRCm38

  69261 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk8

Human
homologs
Human Homolog MAPK8, mitogen-activated protein kinase 8
NCBI Gene ID 5599
neXtProt AC  NX_P45983
Human Synonyms  JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c
Human Chr (Location)  10q11.22; chr10:48306639-48439360 (+)  GRCh38
Alleles
and
phenotypes
All alleles(43) : Targeted(6) Gene trapped(37)
 
Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology.
 
Phenotype Images(4)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process cellular response to hydrogen peroxide, cellular response to lipopolysaccharide, ...
Component axon, cytoplasm, ...
Function ATP binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (183)    Tissues (67)    Images (43)
Theiler Stages: 15, 17, 19, 20, 21, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 124
Western blot 53
cDNA source data(80)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(85) Genomic(1) cDNA(83) Primer pair(1)
Microarray probesets(12)
Other database
links
VEGA Gene ModelOTTMUSG00000018229 (Evidence)
Ensembl Gene ModelENSMUSG00000021936 (Evidence)
Entrez Gene26419 (Evidence)
UniGene21495
DFCITC1577892, TC1592768, TC1597850, TC1598120, TC1709918
DoTSDT.533449, DT.55281756, DT.60104612, DT.97390242, DT.97398944
NIA Mouse Gene IndexU035398
EC2.7.11.24
Consensus CDS ProjectCCDS36869.1
International Mouse Knockout Project StatusMapk8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018229 VEGA Gene Model | MGI Sequence Detail 69261 C57BL/6J ±  kb
transcript OTTMUST00000044048 VEGA | MGI Sequence Detail 1528 Not Applicable 
polypeptide OTTMUSP00000019792 VEGA | MGI Sequence Detail 427 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(10) UniProt(7)
Polymorphisms SNPs within 2kb(298 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008351 Mitogen-activated protein (MAP) kinase, JNK
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000002206 mitogen-activated protein kinase 8
References (Earliest) J:51510 Dong C, et al., Defective T cell differentiation in the absence of Jnk1. Science. 1998 Dec 11;282(5396):2092-5
(Latest) J:205449 Dauphinee SM, et al., SASH1 is a scaffold molecule in endothelial TLR4 signaling. J Immunol. 2013 Jul 15;191(2):892-901
All references(316)
Other
accession IDs
MGI:1328367, MGI:2145699

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/08/2014
MGI 5.17
The Jackson Laboratory