Mapk8
Gene Detail

Symbol Name ID

Mapk8 mitogen-activated protein kinase 8 MGI:1346861

Synonyms

c-Jun N-terminal kinase, JNK1, Prkm8

Feature Type

protein coding gene

Genetic Map

Chromosome 14

20.22 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr14:33377898-33447158 bp, - strand From VEGA annotation of GRCm38   69261 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:56760  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk8

Human homologs

Human Homolog		MAPK8, mitogen-activated protein kinase 8
NCBI Gene ID		5599
neXtProt AC		NX_P45983
Human Synonyms		JNK, JNK1, JNK1A2, JNK21B1/2, JNK-46, PRKM8, SAPK1, SAPK1c
Human Chr (Location)		10q11.22; chr10:49609687-49643183 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(42) : Targeted(5) Gene trapped(37)
 

Mice homozygous for a knock-out allele exhibit abnormal T cell differentiation and proliferation, cardiac morphology and physiology, and chemically-induced tumorigenesis. Mice homozygous for another knock-out allele exhibit abnormal glucose homeostasis and T cell physiology.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (74 annotations)

Process	determination of dorsal identity, inflammatory response, ...
Component	axon part, cytoplasm, ...
Function	ATP binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (64 records)
Data Summary: Results (179)    Tissues (66)    Images (41)
Theiler Stages: 15, 17, 19, 20, 21, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	124
Western blot	49

cDNA source data(81)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(86) Genomic(1) cDNA(84) Primer pair(1)
Microarray probesets(12)

Other database links

VEGA Gene Model	OTTMUSG00000018229 (Evidence)
Ensembl Gene Model	ENSMUSG00000021936 (Evidence)
Entrez Gene	26419 (Evidence)
UniGene	21495
DFCI	TC1577892, TC1592768, TC1597850, TC1598120, TC1709918
DoTS	DT.533449, DT.55281756, DT.60104612, DT.97390242, DT.97398944
NIA Mouse Gene Index	U035398
EC	2.7.11.24
Consensus CDS Project	CCDS36869.1
International Mouse Knockout Project Status	Mapk8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018229	VEGA Gene Model | MGI Sequence Detail	69261	C57BL/6J
transcript	OTTMUST00000044047	VEGA | MGI Sequence Detail	2587	Not Applicable
polypeptide	OTTMUSP00000019791	VEGA | MGI Sequence Detail	427	Not Applicable

All sequences(77) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(225 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008351	Mitogen-activated protein (MAP) kinase, JNK
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000002206	mitogen-activated protein kinase 8

References

(Earliest) J:51510 Dong C, et al., Defective T cell differentiation in the absence of Jnk1. Science. 1998 Dec 11;282(5396):2092-5
(Latest) J:192551 Han MS, et al., JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science. 2013 Jan 11;339(6116):218-22
All references(300)

Other accession IDs

MGI:1328367, MGI:2145699