Symbol
Name
ID

Mapk8
mitogen-activated protein kinase 8
MGI:1346861

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgE level	Cutaneous anergy	Decreased circulating iron concentration	Type II diabetes mellitus	Insulin resistance	Abnormality of temperature regulation	Hematuria
Disease(s) Associated with MAPK8	Increased circulating IgE level	Cutaneous anergy	Decreased circulating iron concentration	Type II diabetes mellitus	Insulin resistance	Abnormality of temperature regulation	Hematuria
chronic mucocutaneous candidiasis
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

increased response of heart to induced stress

decreased insulin secretion

decreased susceptibility to diet-induced obesity

decreased circulating glucose level

decreased circulating insulin level

decreased circulating insulin-like growth factor I level

decreased circulating leptin level

decreased circulating growth hormone level

increased circulating triiodothyronine level

increased oxygen consumption

increased respiratory quotient

abnormal glucose homeostasis

improved glucose tolerance

increased insulin sensitivity

increased circulating adiponectin level

decreased liver triglyceride level

abnormal enzyme/coenzyme activity

increased incidence of tumors by chemical induction

Availability

Mouse Genotype

Mapk8^tm1.1Jcbr/Mapk8^tm1.1Jcbr

Mapk8^tm1Flv/Mapk8^tm1Flv

Mapk8^tm1Wag/Mapk8^tm1Wag

Mapk8^tm1Jcbr/Mapk8^tm1Jcbr
Tg(Nes-cre)1Kln/0 (conditional)

Mapk8^tm1Jcbr/Mapk8^tm1Jcbr
Tg(Ckmm-cre)5Khn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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