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Gene Ontology Browser
Term Detail
GO term:cellular response to oxidative stress
Synonym: adaptive response to oxidative stress
GO id:GO:0034599
Definition:Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
Number of paths to term: 7

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-aactivation of SoxR protein
                                        is-acell chemotaxis +
                                        is-acellular response to acid chemical +
                                        is-acellular response to alkane +
                                        is-acellular response to arsenic-containing substance +
                                        is-acellular response to boron-containing substance levels +
                                        is-acellular response to cisplatin
                                        is-acellular response to decane
                                        is-acellular response to dodecane
                                        is-acellular response to drug +
                                        is-acellular response to fluoride
                                        is-acellular response to food
                                        is-acellular response to inorganic substance +
                                        is-acellular response to isooctane
                                        is-acellular response to N-phenylthiourea
                                        is-acellular response to nitrogen compound +
                                        is-acellular response to nonane
                                        is-acellular response to nutrient +
                                        is-acellular response to organic substance +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to oxygen levels +
                                        is-acellular response to oxygen-containing compound +
                                        is-acellular response to salt
                                        is-acellular response to tacrolimus
                                        is-acellular response to topoisomerase inhibitor
                                        is-acellular response to toxic substance +
                                        is-acellular response to undecane
                                        is-acellular response to xenobiotic stimulus +
                                        is-achemoattraction of axon +
                                        is-achemorepulsion of axon +
                                        is-adetection of hypoxic conditions in blood by chemoreceptor signaling +
                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid chemical
                                        is-acellular stress response to acidic pH
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to chemical stimulus
                                        is-aactivation of SoxR protein
                                        is-acell chemotaxis +
                                        is-acellular response to acid chemical +
                                        is-acellular response to alkane +
                                        is-acellular response to arsenic-containing substance +
                                        is-acellular response to boron-containing substance levels +
                                        is-acellular response to cisplatin
                                        is-acellular response to decane
                                        is-acellular response to dodecane
                                        is-acellular response to drug +
                                        is-acellular response to fluoride
                                        is-acellular response to food
                                        is-acellular response to inorganic substance +
                                        is-acellular response to isooctane
                                        is-acellular response to N-phenylthiourea
                                        is-acellular response to nitrogen compound +
                                        is-acellular response to nonane
                                        is-acellular response to nutrient +
                                        is-acellular response to organic substance +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to oxygen levels +
                                        is-acellular response to oxygen-containing compound +
                                        is-acellular response to salt
                                        is-acellular response to tacrolimus
                                        is-acellular response to topoisomerase inhibitor
                                        is-acellular response to toxic substance +
                                        is-acellular response to undecane
                                        is-acellular response to xenobiotic stimulus +
                                        is-achemoattraction of axon +
                                        is-achemorepulsion of axon +
                                        is-adetection of hypoxic conditions in blood by chemoreceptor signaling +
                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid chemical
                                        is-acellular stress response to acidic pH
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to chemical
                                is-acellular response to chemical stimulus
                                        is-aactivation of SoxR protein
                                        is-acell chemotaxis +
                                        is-acellular response to acid chemical +
                                        is-acellular response to alkane +
                                        is-acellular response to arsenic-containing substance +
                                        is-acellular response to boron-containing substance levels +
                                        is-acellular response to cisplatin
                                        is-acellular response to decane
                                        is-acellular response to dodecane
                                        is-acellular response to drug +
                                        is-acellular response to fluoride
                                        is-acellular response to food
                                        is-acellular response to inorganic substance +
                                        is-acellular response to isooctane
                                        is-acellular response to N-phenylthiourea
                                        is-acellular response to nitrogen compound +
                                        is-acellular response to nonane
                                        is-acellular response to nutrient +
                                        is-acellular response to organic substance +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to oxygen levels +
                                        is-acellular response to oxygen-containing compound +
                                        is-acellular response to salt
                                        is-acellular response to tacrolimus
                                        is-acellular response to topoisomerase inhibitor
                                        is-acellular response to toxic substance +
                                        is-acellular response to undecane
                                        is-acellular response to xenobiotic stimulus +
                                        is-achemoattraction of axon +
                                        is-achemorepulsion of axon +
                                        is-adetection of hypoxic conditions in blood by chemoreceptor signaling +
                                        part-ofpositive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-acellular detoxification of nitrogen compound
                                        is-acellular response to anoxia
                                        is-acellular response to cell envelope stress
                                        is-acellular response to cold +
                                        is-acellular response to DNA damage stimulus +
                                        is-acellular response to fluid shear stress +
                                        is-acellular response to heat +
                                        is-acellular response to hydrostatic pressure +
                                        is-acellular response to hyperoxia
                                        is-acellular response to hypoxia +
                                        is-acellular response to immobilization stress
                                        is-acellular response to isolation stress
                                        is-acellular response to nitrosative stress +
                                        is-acellular response to osmotic stress +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-acellular response to starvation +
                                        is-acellular response to sterol depletion +
                                        is-acellular response to sugar-phosphate stress +
                                        is-acellular response to topologically incorrect protein +
                                        is-acellular response to water deprivation +
                                        is-acellular senescence +
                                        is-acellular stress response to acid chemical
                                        is-acellular stress response to acidic pH
                                        is-adefense response by cell wall thickening +
                                        is-aDNA protection
                                        is-aintracellular defense response
                                        is-anegative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress
                                        is-aneuron projection regeneration +
                                        is-aplant-type hypersensitive response +
                                        part-ofpriming of cellular response to stress
                                        regulatesregulation of cellular response to stress +
                                        is-aregulation of DNA-templated transcription in response to stress +
                                        part-ofregulation of mRNA stability involved in response to stress +
                                        is-aregulation of translation in response to stress +
                                        is-aresponse to endoplasmic reticulum stress +
                                        is-aSOS response
                                        is-astress-activated protein kinase signaling cascade +
                                        is-astress-induced mitochondrial fusion
                                        part-oftrehalose catabolic process involved in cellular response to stress
                                        is-atrehalose metabolism in response to stress +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-aresponse to oxidative stress
                                        is-aage-dependent response to oxidative stress +
                                        is-acellular response to oxidative stress [GO:0034599] (165 genes, 230 annotations)
                                                is-aage-dependent response to oxidative stress involved in chronological cell aging +
                                                is-aage-dependent response to oxidative stress involved in replicative cell aging +
                                                is-acell death in response to oxidative stress +
                                                is-acellular response to hydroperoxide +
                                                is-acellular response to reactive oxygen species +
                                                is-aintrinsic apoptotic signaling pathway in response to oxidative stress +
                                                negatively-regulatesnegative regulation of cellular response to oxidative stress +
                                                is-aoxidative stress-induced premature senescence
                                                positively-regulatespositive regulation of cellular response to oxidative stress +
                                                is-apositive regulation of transcription factor import into nucleus in response to oxidative stress
                                                regulatesregulation of cellular response to oxidative stress +
                                                is-aregulation of transcription from RNA polymerase II promoter in response to oxidative stress +
                                                is-aregulation of translation in response to oxidative stress +
                                        is-adetection of oxidative stress
                                        negatively-regulatesnegative regulation of response to oxidative stress +
                                        positively-regulatespositive regulation of response to oxidative stress +
                                        part-ofregulation of mRNA stability involved in response to oxidative stress
                                        regulatesregulation of response to oxidative stress +
                                        is-aresponse to hydroperoxide +
                                        is-aresponse to photooxidative stress
                                        is-aresponse to reactive oxygen species +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory