Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes MAPK3
  • Mouse genes Mapk3
  • Rat genes Mapk3
  • Zfish genes mapk3
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Mapk3

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005524	ATP binding	Mapk3	IDA		Rat	PMID:15027896|RGD:1626220
Molecular Function	GO:0140297	DNA-binding transcription factor binding	MAPK3	IPI	UniProtKB:Q9BQW3	Human	PMID:35939714
Molecular Function	GO:0042802	identical protein binding	MAPK3	IPI	UniProtKB:P27361	Human	PMID:16627622
Molecular Function	GO:0042802	identical protein binding	MAPK3	IPI	UniProtKB:P27361	Human	PMID:22307056
Molecular Function	GO:0004707	MAP kinase activity	MAPK3	IDA		Human	PMID:8388392
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IDA		Mouse	PMID:1717989
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IDA		Mouse	PMID:15314156
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IMP		Mouse	PMID:11841548
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IDA		Rat	PMID:15027896|RGD:1626220
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IMP		Rat	PMID:16955078|RGD:8553011
Molecular Function	GO:0004707	MAP kinase activity	Mapk3	IDA		Rat	PMID:7889942|RGD:8554315
Molecular Function	GO:0004708	MAP kinase kinase activity	Mapk3	IMP		Mouse	PMID:26375174
Molecular Function	GO:0019902	phosphatase binding	MAPK3	IPI	UniProtKB:Q12913	Human	PMID:19494114
Molecular Function	GO:0001784	phosphotyrosine residue binding	Mapk3	IMP		Mouse	PMID:14636584
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q62132	Human	PMID:10066421
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q62132	Human	PMID:10419510
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P28562	Human	PMID:10617468
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q00613	Human	PMID:10747973
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16539	Human	PMID:11238443
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P23467	Human	PMID:12840032
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16828	Human	PMID:12840032
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P53355	Human	PMID:15616583
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P23396	Human	PMID:15950189
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P19419	Human	PMID:16291755
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P12270	Human	PMID:18794356
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P23467	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q12913	Human	PMID:19167335
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q02750	Human	PMID:19197339
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q12913	Human	PMID:19494114
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q08509	Human	PMID:19564905
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P28562	Human	PMID:20347885
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q14160	Human	PMID:20622900
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q15121	Human	PMID:21900206
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q60793	Human	PMID:22307056
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16539	Human	PMID:23397142
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q9EPI6	Human	PMID:23452857
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:23602568
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P14618-1	Human	PMID:24606918
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:24722188
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q9NXV6	Human	PMID:24825908
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q8N490	Human	PMID:25066297
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P19419	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P28562	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P53355	Human	PMID:25241761
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:25852190
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:26496610
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16828	Human	PMID:27880917
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16828	Human	PMID:31980649
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:O14978	Human	PMID:32051553
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q15121	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P49366	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q16828	Human	PMID:32707033
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:P13051-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q49AJ0-4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q6GQQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q96HT8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q96NJ5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q9HCU0	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	MAPK3	IPI	UniProtKB:Q9ULW8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	UniProtKB:Q60793	Mouse	MGI:MGI:5914636|PMID:22307056
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	PR:Q8VI36	Mouse	PMID:14636584
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	PR:O08663	Mouse	PMID:15544353
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	MGI:MGI:3525016	Mouse	PMID:15537391
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	RGD:620348	Rat	PMID:15781236|RGD:2300104
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	RGD:2157	Rat	PMID:19200235|RGD:5510003
Molecular Function	GO:0005515	protein binding	Mapk3	IPI	UniProtKB:B1PRL5	Rat	PMID:24567387|RGD:12907554
Molecular Function	GO:0004672	protein kinase activity	Mapk3	IDA		Mouse	PMID:15383658
Molecular Function	GO:0004674	protein serine/threonine kinase activity	MAPK3	IDA		Human	PMID:18391015
Molecular Function	GO:0097110	scaffold protein binding	Mapk3	IPI	UniProtKB:Q2IBC5	Rat	PMID:20455999|RGD:10047313
Cellular Component	GO:0005901	caveola	Mapk3	IDA		Rat	PMID:24567387|RGD:12907554
Cellular Component	GO:0005737	cytoplasm	Mapk3	IDA		Mouse	PMID:12223545
Cellular Component	GO:0005737	cytoplasm	Mapk3	IDA		Mouse	PMID:11726647
Cellular Component	GO:0005737	cytoplasm	Mapk3	IDA		Rat	PMID:24567387|RGD:12907554
Cellular Component	GO:0005829	cytosol	Mapk3	IDA		Mouse	PMID:22451653
Cellular Component	GO:0005829	cytosol	Mapk3	IDA		Rat	PMID:9779826|RGD:70317
Cellular Component	GO:0098978	glutamatergic synapse	Mapk3	IMP		Mouse	PMID:12062026
Cellular Component	GO:0098978	glutamatergic synapse	Mapk3	IDA		Mouse	PMID:12062026
Cellular Component	GO:0005635	nuclear envelope	MAPK3	IDA		Human	PMID:20455999
Cellular Component	GO:0005654	nucleoplasm	Mapk3	IDA		Rat	PMID:7889942|RGD:8554315
Cellular Component	GO:0005634	nucleus	Mapk3	IDA		Mouse	PMID:11726647
Cellular Component	GO:0005634	nucleus	Mapk3	IDA		Mouse	PMID:11254359
Cellular Component	GO:0005634	nucleus	Mapk3	IDA		Rat	PMID:17150373|RGD:1626219
Cellular Component	GO:0005886	plasma membrane	Mapk3	IDA		Rat	PMID:24567387|RGD:12907554
Cellular Component	GO:0032991	protein-containing complex	Mapk3	IDA		Rat	PMID:15781236|RGD:2300104
Cellular Component	GO:0031143	pseudopodium	Mapk3	IDA		Mouse	MGI:MGI:2673740|PMID:12821670
Biological Process	GO:0007568	aging	Mapk3	IDA		Rat	PMID:28515230|RGD:13800568
Biological Process	GO:0009887	animal organ morphogenesis	Mapk3	IDA		Mouse	PMID:11684667
Biological Process	GO:0019369	arachidonic acid metabolic process	Mapk3	IEP		Rat	PMID:15027896|RGD:1626220
Biological Process	GO:0060020	Bergmann glial cell differentiation	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:24431450
Biological Process	GO:0030509	BMP signaling pathway	MAPK3	IMP		Human	PMID:19664780
Biological Process	GO:0007420	brain development	mapk3	IMP	ZFIN:ZDB-MRPHLNO-121207-14	Zfish	PMID:22566537
Biological Process	GO:0061308	cardiac neural crest cell development involved in heart development	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0051216	cartilage development	Mapk3	IDA		Mouse	PMID:17644814
Biological Process	GO:0034198	cellular response to amino acid starvation	MAPK3	IDA		Human	PMID:11096076
Biological Process	GO:0071276	cellular response to cadmium ion	MAPK3	IMP		Human	PMID:26514923
Biological Process	GO:1903351	cellular response to dopamine	MAPK3	IMP		Human	PMID:24136195
Biological Process	GO:0071260	cellular response to mechanical stimulus	MAPK3	IEP		Human	PMID:19593445
Biological Process	GO:0034614	cellular response to reactive oxygen species	MAPK3	IMP		Human	PMID:26514923
Biological Process	GO:0071356	cellular response to tumor necrosis factor	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:24349514
Biological Process	GO:0021952	central nervous system projection neuron axonogenesis	mapk3	IMP	ZFIN:ZDB-MRPHLNO-121207-14	Zfish	PMID:22566537
Biological Process	GO:0043009	chordate embryonic development	mapk3	IMP	ZFIN:ZDB-MRPHLNO-080504-1	Zfish	PMID:17999625
Biological Process	GO:0043009	chordate embryonic development	mapk3	IMP	ZFIN:ZDB-MRPHLNO-080504-2	Zfish	PMID:17999625
Biological Process	GO:1904888	cranial skeletal system development	mapk3	IMP	ZFIN:ZDB-CRISPR-200506-3	Zfish	PMID:31553903
Biological Process	GO:1904888	cranial skeletal system development	mapk3	IGI	ZFIN:ZDB-CRISPR-200506-3,ZFIN:ZDB-CRISPR-200506-4	Zfish	PMID:31553903
Biological Process	GO:0046697	decidualization	Mapk3	IDA		Rat	PMID:21248290|RGD:8553214
Biological Process	GO:0006974	DNA damage response	Mapk3	IDA		Mouse	PMID:15383658
Biological Process	GO:0006351	DNA-templated transcription	Mapk3	IMP		Mouse	MGI:MGI:3793922|PMID:7889942
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:19047410
Biological Process	GO:0001654	eye development	mapk3	IMP	ZFIN:ZDB-MRPHLNO-121207-14	Zfish	PMID:22566537
Biological Process	GO:0060324	face development	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0008286	insulin receptor signaling pathway	Mapk3	IDA		Mouse	PMID:20889126
Biological Process	GO:0048009	insulin-like growth factor receptor signaling pathway	Mapk3	IDA		Mouse	PMID:14997210
Biological Process	GO:0070498	interleukin-1-mediated signaling pathway	MAPK3	IMP		Human	PMID:20018936
Biological Process	GO:0035556	intracellular signal transduction	Mapk3	IDA		Rat	PMID:12072413|RGD:625714
Biological Process	GO:0031663	lipopolysaccharide-mediated signaling pathway	Mapk3	IDA		Mouse	PMID:12872135
Biological Process	GO:0060425	lung morphogenesis	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:25100655
Biological Process	GO:0000165	MAPK cascade	Mapk3	IMP		Rat	PMID:17310240|RGD:1626216
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Mapk3	IDA		Mouse	PMID:12062026
Biological Process	GO:0050804	modulation of chemical synaptic transmission	Mapk3	IMP		Mouse	PMID:12062026
Biological Process	GO:2000657	negative regulation of apolipoprotein binding	Mapk3	IMP		Mouse	MGI:MGI:4460848|PMID:20037141
Biological Process	GO:0014032	neural crest cell development	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0042473	outer ear morphogenesis	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0018105	peptidyl-serine phosphorylation	Mapk3	IMP		Rat	PMID:16955078|RGD:8553011
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	MAPK3	IDA		Human	PMID:8388392
Biological Process	GO:0016310	phosphorylation	MAPK3	IDA		Human	PMID:15950189
Biological Process	GO:0031281	positive regulation of cyclase activity	MAPK3	IMP		Human	PMID:22027397
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	MAPK3	IMP		Human	PMID:19664780
Biological Process	GO:0010628	positive regulation of gene expression	MAPK3	IMP		Human	PMID:24136195
Biological Process	GO:0010759	positive regulation of macrophage chemotaxis	MAPK3	IGI	UniProtKB:P28482,UniProtKB:Q6ZMJ4	Human	PMID:26754294
Biological Process	GO:0120041	positive regulation of macrophage proliferation	MAPK3	IGI	UniProtKB:P28482,UniProtKB:Q6ZMJ4	Human	PMID:26754294
Biological Process	GO:0001934	positive regulation of protein phosphorylation	MAPK3	IMP		Human	PMID:19664780
Biological Process	GO:0051973	positive regulation of telomerase activity	MAPK3	IMP		Human	PMID:21531765
Biological Process	GO:1904355	positive regulation of telomere capping	MAPK3	IMP		Human	PMID:21531765
Biological Process	GO:0032212	positive regulation of telomere maintenance via telomerase	MAPK3	IMP		Human	PMID:21531765
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	MAPK3	IMP		Human	PMID:20018936
Biological Process	GO:0045727	positive regulation of translation	Mapk3	IMP		Rat	PMID:15027896|RGD:1626220
Biological Process	GO:1904417	positive regulation of xenophagy	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:22033934
Biological Process	GO:0006468	protein phosphorylation	MAPK3	IDA		Human	PMID:7687743
Biological Process	GO:0006468	protein phosphorylation	Mapk3	IDA		Mouse	PMID:11841548
Biological Process	GO:0006468	protein phosphorylation	Mapk3	IDA		Mouse	PMID:15383658
Biological Process	GO:0006468	protein phosphorylation	Mapk3	IDA		Rat	PMID:15027896|RGD:1626220
Biological Process	GO:0065003	protein-containing complex assembly	Mapk3	IMP		Rat	PMID:7889942|RGD:8554315
Biological Process	GO:0030641	regulation of cellular pH	Mapk3	IMP		Mouse	PMID:26375174
Biological Process	GO:0051090	regulation of DNA-binding transcription factor activity	Mapk3	IMP		Mouse	MGI:MGI:3793922|PMID:7889942
Biological Process	GO:0030278	regulation of ossification	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:20053668
Biological Process	GO:0070849	response to epidermal growth factor	MAPK3	IDA		Human	PMID:18794356
Biological Process	GO:0070849	response to epidermal growth factor	MAPK3	IDA		Human	PMID:21968647
Biological Process	GO:0043330	response to exogenous dsRNA	Mapk3	IDA		Mouse	PMID:12872135
Biological Process	GO:0032496	response to lipopolysaccharide	Mapk3	IDA		Mouse	PMID:12872135
Biological Process	GO:0009636	response to toxic substance	Mapk3	IDA		Rat	PMID:17651772|RGD:2314938
Biological Process	GO:0019233	sensory perception of pain	Mapk3	IMP		Mouse	MGI:MGI:1934687|PMID:11356865
Biological Process	GO:0042770	signal transduction in response to DNA damage	MAPK3	IDA		Human	PMID:17560175
Biological Process	GO:0051403	stress-activated MAPK cascade	MAPK3	IDA		Human	PMID:11096076
Biological Process	GO:0048538	thymus development	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0030878	thyroid gland development	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:18952847
Biological Process	GO:0060440	trachea formation	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:25100655
Biological Process	GO:0098792	xenophagy	Mapk3	IGI	MGI:MGI:1346858	Mouse	PMID:22033934

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern