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Gene Ontology Browser
Term Detail
GO term:MAP kinase activity
Synonym: ATP:protein phosphotransferase (MAPKK-activated) activity
Synonym: Dp38
Synonym: ERK
Synonym: ERK1
Synonym: ERK2
Synonym: extracellular signal-regulated kinase activity
Synonym: LeMPK3
Synonym: MAP-2 kinase activity
Synonym: MAPK
Synonym: MAP kinase 1 activity
Synonym: MAP kinase 2 activity
Synonym: MBP kinase I activity
Synonym: MBP kinase II activity
Synonym: mitogen activated kinase activity
Synonym: mitogen-activated protein kinase activity
Synonym: Mpk2
Synonym: MP kinase activity
Synonym: myelin basic protein kinase activity
Synonym: p38
Synonym: p38-2
Synonym: p38delta
Synonym: p42mapk
Synonym: p42 mitogen-activated protein kinase activity
Synonym: p44mpk
Synonym: PMK-1
Synonym: PMK-2
Synonym: PMK-3
Synonym: pp42
Synonym: pp44mapk
Synonym: SAPK2
Synonym: STK26
GO id:GO:0004707
Definition:Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine kinase activity
                                                                is-areceptor signaling protein serine/threonine kinase activity
                                                                        is-aMAP kinase activity [GO:0004707] (22 genes, 43 annotations)
                                                                                is-aMAP kinase activity involved in cell wall organization or biogenesis
                                                                                is-aMAP kinase activity involved in conjugation with cellular fusion
                                                                                is-aMAP kinase activity involved in innate immune response
                                                                                is-aMAP kinase activity involved in osmosensory signaling pathway
                                                                                is-aSAP kinase activity +
                                                                        is-aMAP kinase kinase kinase activity +
                                                                        is-aMAP kinase kinase kinase kinase activity +
                                                                        is-aNF-kappaB-inducing kinase activity
                                                                        is-apolo kinase kinase activity


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine kinase activity
                                                                is-areceptor signaling protein serine/threonine kinase activity
                                                                        is-aMAP kinase activity [GO:0004707] (22 genes, 43 annotations)
                                                                                is-aMAP kinase activity involved in cell wall organization or biogenesis
                                                                                is-aMAP kinase activity involved in conjugation with cellular fusion
                                                                                is-aMAP kinase activity involved in innate immune response
                                                                                is-aMAP kinase activity involved in osmosensory signaling pathway
                                                                                is-aSAP kinase activity +
                                                                        is-aMAP kinase kinase kinase activity +
                                                                        is-aMAP kinase kinase kinase kinase activity +
                                                                        is-aNF-kappaB-inducing kinase activity
                                                                        is-apolo kinase kinase activity


Gene_Ontology
        is-amolecular_function
                is-amolecular transducer activity
                        is-asignal transducer activity
                                is-areceptor signaling protein activity
                                        is-areceptor signaling protein serine/threonine kinase activity
                                                is-aMAP kinase activity [GO:0004707] (22 genes, 43 annotations)
                                                        is-aMAP kinase activity involved in cell wall organization or biogenesis
                                                        is-aMAP kinase activity involved in conjugation with cellular fusion
                                                        is-aMAP kinase activity involved in innate immune response
                                                        is-aMAP kinase activity involved in osmosensory signaling pathway
                                                        is-aSAP kinase activity +
                                                is-aMAP kinase kinase kinase activity +
                                                is-aMAP kinase kinase kinase kinase activity +
                                                is-aNF-kappaB-inducing kinase activity
                                                is-apolo kinase kinase activity


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory