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Mapk3 Gene Detail
Summary
  • Symbol
    Mapk3
  • Name
    mitogen-activated protein kinase 3
  • Synonyms
    Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346859
    NCBI Gene: 26417
  • Gene Overview
    MyGene.info: MAPK3
Location & Maps
more
  • Sequence Map
    Chr7:126759601-126765819 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      6219 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
  • Links
    NCBI Gene ID: 5595
    neXtProt AC: NX_P27361

  • Chr Location
    16p11.2; chr16:30114105-30123309 (-)  GRCh38.p2
Human Diseases
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  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 8 genetic backgrounds
    36 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Chemically induced (ENU)
    1
  • Gene trapped
    6
  • Targeted
    6
  • Genomic Mutations
    3 involving Mapk3
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    94
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    474
  • Tissues
    288
  • cDNA Data
    204
  • Literature Summary
    320
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016478 VEGA Gene Model | MGI Sequence Detail 6219 C57BL/6J ±  kb
transcript OTTMUST00000039748 VEGA | MGI Sequence Detail 1267 Not Applicable  
polypeptide OTTMUSP00000017737 VEGA | MGI Sequence Detail 380 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • RFLP
    1
Protein
Information
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  • UniProt
    6 Sequences
  • EC
    2.7.11.24
  • InterPro Domains
    IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
    IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 210
    Genomic 2
    cDNA 204
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176
References
more
  • Summaries
    All 530
    Developmental Gene Expression 320
    Diseases 6
    Gene Ontology 27
    Phenotypes 77
  • Earliest
    J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
  • Latest
    J:233686 Jia WJ, et al., Geranylgeranyl Diphosphate Synthase Modulates Fetal Lung Branching Morphogenesis Possibly through Controlling K-Ras Prenylation. Am J Pathol. 2016 Jun;186(6):1454-65
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/27/2016
MGI 6.05 		The Jackson Laboratory