About   Help   FAQ
Mapk3 Gene Detail
Summary
  • Symbol
    Mapk3
  • Name
    mitogen-activated protein kinase 3
  • Synonyms
    Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346859
    NCBI Gene: 26417
  • Gene Overview
    MyGene.info: MAPK3
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:126759626-126765816 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346859
 protein coding gene Chr7:126759601-126765819 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032995
 protein coding gene Chr7:131055372-131061583 (+)
A/J MGP_AJ_G0032978
 protein coding gene Chr7:127585384-127591600 (+)
AKR/J MGP_AKRJ_G0032910
 protein coding gene Chr7:130815857-130822070 (+)
BALB/cJ MGP_BALBcJ_G0032983
 protein coding gene Chr7:127245865-127252082 (+)
C3H/HeJ MGP_C3HHeJ_G0032693
 protein coding gene Chr7:130755973-130762194 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033489
 protein coding gene Chr7:136152065-136158573 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030461
 protein coding gene Chr7:128777581-128783772 (+)
CAST/EiJ MGP_CASTEiJ_G0032022
 protein coding gene Chr7:122538785-122545075 (+)
CBA/J MGP_CBAJ_G0032666
 protein coding gene Chr7:140735785-140741996 (+)
DBA/2J MGP_DBA2J_G0032818
 protein coding gene Chr7:125559264-125565357 (+)
FVB/NJ MGP_FVBNJ_G0032771
 protein coding gene Chr7:125406154-125412327 (+)
LP/J MGP_LPJ_G0032912
 protein coding gene Chr7:132526687-132532898 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032803
 protein coding gene Chr7:141915708-141923330 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033508
 protein coding gene Chr7:129825229-129831445 (+)
PWK/PhJ MGP_PWKPhJ_G0031729
 protein coding gene Chr7:118553857-118560088 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031575
 protein coding gene Chr7:116676150-116682330 (+)
WSB/EiJ MGP_WSBEiJ_G0032134
 protein coding gene Chr7:130805165-130812123 (+)



Homology
more
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
  • Links
    NCBI Gene ID: 5595
    neXtProt AC: NX_P27361
    UniProt: P27361

  • Chr Location
    16p11.2; chr16:30114105-30123309 (-)  GRCh38.p7
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 8 genetic backgrounds
    36 phenotypes from multigenic genotypes
    100 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    33
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    559
  • Tissues
    311
  • cDNA Data
    205
  • Literature Summary
    404
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 26417 NCBI Gene Model | MGI Sequence Detail 6191 C57BL/6J ±  kb
    transcript NM_011952 RefSeq | MGI Sequence Detail 1772 FVB/N  
    polypeptide Q63844 UniProt | EBI | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      2.7.11.24
    • InterPro Domains
      IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
      IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 2
      cDNA 205
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176
    References
    more
    • Summaries
      All 747
      Developmental Gene Expression 404
      Diseases 3
      Gene Ontology 33
      Phenotypes 100
    • Earliest
      J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
    • Latest
      J:263781 Choi JC, et al., Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival. Hum Mol Genet. 2018 Jul 1;27(13):2290-2305
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    11/06/2018
    MGI 6.13     		The Jackson Laboratory