Mapk3 MGI Mouse Gene Detail - MGI:1346859 - mitogen-activated protein kinase 3

Symbol

Mapk3
Name

mitogen-activated protein kinase 3
Synonyms

Erk-1, Erk1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3

Feature Type

protein coding gene
IDs

MGI:1346859
NCBI Gene: 26417
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr7:126358798-126364988 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.25 cM
Mapping Data

4 experiments

SNPs within 2kb

223 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1346859	protein coding gene	Chr7:126358773-126364991 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032995	protein coding gene	Chr7:131055372-131061583 (+)
A/J	MGP_AJ_G0032978	protein coding gene	Chr7:127585384-127591600 (+)
AKR/J	MGP_AKRJ_G0032910	protein coding gene	Chr7:130815857-130822070 (+)
BALB/cJ	MGP_BALBcJ_G0032983	protein coding gene	Chr7:127245865-127252082 (+)
C3H/HeJ	MGP_C3HHeJ_G0032693	protein coding gene	Chr7:130755973-130762194 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033489	protein coding gene	Chr7:136152065-136158573 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030461	protein coding gene	Chr7:128777581-128783772 (+)
CAST/EiJ	MGP_CASTEiJ_G0032022	protein coding gene	Chr7:122538785-122545075 (+)
CBA/J	MGP_CBAJ_G0032666	protein coding gene	Chr7:140735785-140741996 (+)
DBA/2J	MGP_DBA2J_G0032818	protein coding gene	Chr7:125559264-125565357 (+)
FVB/NJ	MGP_FVBNJ_G0032771	protein coding gene	Chr7:125406154-125412327 (+)
LP/J	MGP_LPJ_G0032912	protein coding gene	Chr7:132526687-132532898 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032803	protein coding gene	Chr7:141915708-141923330 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033508	protein coding gene	Chr7:129825229-129831445 (+)
PWK/PhJ	MGP_PWKPhJ_G0031729	protein coding gene	Chr7:118553857-118560088 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031575	protein coding gene	Chr7:116676150-116682330 (+)
WSB/EiJ	MGP_WSBEiJ_G0032134	protein coding gene	Chr7:130805165-130812123 (+)

Human Ortholog

MAPK3, mitogen-activated protein kinase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK3, mitogen-activated protein kinase 3
Synonyms

ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
Links

HGNC:6877

NCBI Gene ID: 5595

UniProt: P27361
Chr Location

16p11.2; chr16:30114105-30123506 (-) GRCh38

MGI Vertebrate Homology

Mapk3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPK3
Gene Tree

Mapk3

Diseases

6 with human MAPK3 associations

				Human Disease	Mouse Models
				colon adenocarcinoma IDs colon adenocarcinoma DOID:234 MESH:D003110 NCI:C4349 UMLS_CUI:C0338106
				colorectal adenocarcinoma IDs colorectal adenocarcinoma DOID:0050861 NCI:C5105 UMLS_CUI:C1319315
				endometrial adenocarcinoma IDs endometrial adenocarcinoma DOID:2870 DOID:5827 DOID:6650 NCI:C6287 NCI:C6290 NCI:C7359 UMLS_CUI:C0279763 UMLS_CUI:C1153706 UMLS_CUI:C1336905
				pancreatic ductal carcinoma IDs pancreatic ductal carcinoma DOID:3587 DOID:10023 ICD10CM:C25.3 ICD9CM:157.3 MESH:D021441 UMLS_CUI:C0153461 UMLS_CUI:C0887833
				Parkinson's disease IDs Parkinson's disease DOID:14330 ICD10CM:G20 ICD9CM:332 ICD9CM:332.0 KEGG:05012 MESH:D010300 NCI:C26845 OMIM:PS168600 ORDO:2828 UMLS_CUI:C0030567
				pulmonary hypertension IDs pulmonary hypertension DOID:6432 ICD10CM:I27.20 MESH:D006976 NCI:C3120 UMLS_CUI:C0020542

Click on a disease name to see all genes associated with that disease.

References

3 with disease annotations

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Phenotype Summary

19 phenotypes from 3 alleles in 10 genetic backgrounds
42 phenotypes from multigenic genotypes
161 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (ENU)

1
Endonuclease-mediated

4
Gene trapped

5
Targeted

9
Genomic Mutations

6 involving Mapk3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities. Adult mice heterozygous for a knock-out allele show no significant brain neuroanatomical phenotypes or male-specific behavioral deficits.

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All GO Annotations

208
GO References

49

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1727
Tissues

410
cDNA Data

205
Literature Summary

625

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN mapk3

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All Sequences

51
RefSeq

2
UniProt

6
CCDS

CCDS21841.1

Ensembl

ENSMUSG00000063065 (Evidence)
NCBI Gene

26417

			Length	Strain/Species	Flank
genomic	26417	NCBI Gene Model \| MGI Sequence Detail	6191	C57BL/6J	± kb
transcript	NM_011952	RefSeq \| MGI Sequence Detail	1772	FVB/N
polypeptide	Q63844	UniProt \| EBI \| MGI Sequence Detail	380	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000000104 mitogen-activated protein kinase 3

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 213

Genomic 2

cDNA 205

Primer pair 6

Microarray probesets 3

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MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176

Summaries

All 1066

Developmental Gene Expression 625

Diseases 3

Gene Ontology 49

Phenotypes 161
Earliest

J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
Latest

J:365984 Ju J, et al., The "don't eat me" signal CD47 is associated with microglial phagocytosis defects and autism-like behaviors in 16p11.2 deletion mice. Proc Natl Acad Sci U S A. 2025 Apr 22;122(16):e2411080122

TSS for Mapk3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69058	Chr7:126358770-126358780 (+)	-23 bp
Tssr69059	Chr7:126358785-126358823 (+)	6 bp
Tssr69060	Chr7:126358854-126358882 (+)	70 bp
Tssr69061	Chr7:126358901-126358934 (+)	120 bp
Tssr69062	Chr7:126358952-126358961 (+)	159 bp
Tssr69063	Chr7:126359763-126359771 (+)	969 bp
Tssr69064	Chr7:126359819-126359825 (+)	1,024 bp
Tssr69065	Chr7:126359870-126359916 (+)	1,095 bp
Tssr69066	Chr7:126361389-126361393 (+)	2,593 bp
Tssr69067	Chr7:126362041-126362054 (+)	3,250 bp
Tssr69068	Chr7:126362056-126362072 (+)	3,266 bp
Tssr69069	Chr7:126362076-126362098 (+)	3,289 bp
Tssr69070	Chr7:126362305-126362320 (+)	3,515 bp
Tssr69071	Chr7:126362942-126362968 (+)	4,157 bp
Tssr69072	Chr7:126362974-126362989 (+)	4,184 bp
Tssr69073	Chr7:126363455-126363467 (+)	4,663 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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