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Mapk3 Gene Detail
Summary
  • Symbol
    Mapk3
  • Name
    mitogen-activated protein kinase 3
  • Synonyms
    Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346859
    NCBI Gene: 26417
  • Gene Overview
    MyGene.info: MAPK3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:126759601-126765819 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      6219 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.25 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAPK3, mitogen-activated protein kinase 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
  • Links
    NCBI Gene ID: 5595
    neXtProt AC: NX_P27361
    UniProt: P27361

  • Chr Location
    16p11.2; chr16:30114105-30123309 (-)  GRCh38.p7
Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 8 genetic backgrounds
    36 phenotypes from multigenic genotypes
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    115
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    546
  • Tissues
    309
  • cDNA Data
    205
  • Literature Summary
    402
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016478 VEGA Gene Model | MGI Sequence Detail 6219 C57BL/6J ±  kb
    transcript OTTMUST00000039748 VEGA | MGI Sequence Detail 1267 Not Applicable  
    polypeptide OTTMUSP00000017737 VEGA | MGI Sequence Detail 380 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      10 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • EC
      2.7.11.24
    • InterPro Domains
      IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
      IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR008271 Serine/threonine-protein kinase, active site
    Molecular
    Reagents
    less
    • All nucleic 211
      Genomic 2
      cDNA 205
      Primer pair 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176
    References
    more
    • Summaries
      All 745
      Developmental Gene Expression 402
      Diseases 3
      Gene Ontology 32
      Phenotypes 98
    • Earliest
      J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
    • Latest
      J:263781 Choi JC, et al., Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival. Hum Mol Genet. 2018 Jul 1;27(13):2290-2305
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory