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Mapk3
Gene Detail
 Symbol
Name
ID
Mapk3
mitogen-activated protein kinase 3
MGI:1346859
Synonyms Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3
Feature Type protein coding gene
Genetic Map
Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:126759601-126765819 bp, + strand
From VEGA annotation of GRCm38

  6219 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55682  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk3

Human
homologs
Human Homolog MAPK3, mitogen-activated protein kinase 3
NCBI Gene ID 5595
neXtProt AC  NX_P27361
Human Synonyms  ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
Human Chr (Location)  16p11.2; chr16:30114105-30123309 (-)  GRCh38
Alleles
and
phenotypes
All alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process apoptotic process, BMP signaling pathway, ...
Component caveola, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (253 records)
Data Summary: Results (329)    Tissues (211)    Images (67)
Theiler Stages: 1, 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 61
RNA in situ 93
Western blot 76
RT-PCR 99
cDNA source data(204)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(210) Genomic(2) cDNA(204) Primer pair(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016478 (Evidence)
Ensembl Gene ModelENSMUSG00000063065 (Evidence)
Entrez Gene26417 (Evidence)
UniGene8385
DFCITC1574602
DoTSDT.101408309, DT.535611
EC2.7.11.24
Consensus CDS ProjectCCDS21841.1
International Mouse Knockout Project StatusMapk3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016478 VEGA Gene Model | MGI Sequence Detail 6219 C57BL/6J ±  kb
transcript OTTMUST00000039748 VEGA | MGI Sequence Detail 1267 Not Applicable 
polypeptide OTTMUSP00000017737 VEGA | MGI Sequence Detail 380 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR008349 Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000000104 mitogen-activated protein kinase 3
References (Earliest) J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
(Latest) J:208421 Klimova L, et al., Stage-dependent requirement of neuroretinal Pax6 for lens and retina development. Development. 2014 Mar;141(6):1292-302
All references(450)
Other
accession IDs
MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory