Mapk3
Gene Detail

Symbol Name ID

Mapk3 mitogen-activated protein kinase 3 MGI:1346859

Synonyms

Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:126759601-126765819 bp, + strand From VEGA annotation of GRCm38   6219 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55682  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk3

Human homologs

Human Homolog		MAPK3, mitogen-activated protein kinase 3
NCBI Gene ID		5595
neXtProt AC		NX_P27361
Human Synonyms		ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
Human Chr (Location)		16p11.2; chr16:30125426-30134630 (-)  GRCh37.p13

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)
 

Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (78 annotations)

Process	apoptotic process, BMP signaling pathway, ...
Component	caveola, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (244 records)

Data Summary: Results (318)    Tissues (205)    Images (65)
Theiler Stages: 1, 2, 3, 4, 5, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	59
RNA in situ	93
Western blot	67
RT-PCR	99

cDNA source data(204)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(210) Genomic(2) cDNA(204) Primer pair(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016478 (Evidence)
Ensembl Gene Model	ENSMUSG00000063065 (Evidence)
Entrez Gene	26417 (Evidence)
UniGene	8385
DFCI	TC1574602
DoTS	DT.101408309, DT.535611
EC	2.7.11.24
Consensus CDS Project	CCDS21841.1
International Mouse Knockout Project Status	Mapk3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016478	VEGA Gene Model | MGI Sequence Detail	6219	C57BL/6J
transcript	OTTMUST00000039748	VEGA | MGI Sequence Detail	1267	Not Applicable
polypeptide	OTTMUSP00000017737	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(38) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008349	Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000000104	mitogen-activated protein kinase 3

References

(Earliest) J:11434 De Miguel C, et al., Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain. DNA Cell Biol. 1991 Sep;10(7):505-14
(Latest) J:203125 Wu W, et al., Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation. Hum Mol Genet. 2014 Jan 1;23(1):1-11
All references(436)

Other accession IDs

MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176