Mapk3
Gene Detail

Symbol

Name
ID

Mapk3
mitogen-activated protein kinase 3
MGI:1346859

Synonyms

Erk1, Erk-1, Esrk1, Mtap2k, p44erk1, p44mapk, p44 MAP kinase, Prkm3

Feature Type

protein coding gene

Genetic Map

Chromosome 7
69.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:126759601-126765819 bp, + strand From VEGA annotation of GRCm38   6219 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:55682  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Mapk3

Human
homologs

Human Homolog		MAPK3, mitogen-activated protein kinase 3
NCBI Gene ID		5595
neXtProt AC		NX_P27361
Human Synonyms		ERK1, ERK-1, ERT2, HS44KDAP, HUMKER1A, p44-ERK1, P44ERK1, p44-MAPK, P44MAPK, PRKM3
Human Chr (Location)		16p11.2; chr16:30114105-30123309 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(12) : Gene trapped(6) Targeted(6)
Genomic Mutations involving Mapk3 (3)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a targeted null mutation are hyperactive with impaired T cell maturation and proliferation. Mice homozygous for a knock-out allele on a CD-1 background exhibit normal Mendelian ratios, growth, and no obvious abnormalities.

 
Mutations Annotated to Human Diseases (2)   

Interactions

Mapk3 interacts with 123 markers (Mir1a-1, Mir1a-2, Mir15a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (83 annotations)

Process	apoptotic process, BMP signaling pathway, ...
Component	caveola, cytoplasm, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (268 records)

Data Summary: Results (332)    Tissues (211)    Images (69)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	61
RNA in situ	93
Western blot	82
RT-PCR	96

cDNA source data(204)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(210) Genomic(2) cDNA(204) Primer pair(4)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000016478 (Evidence)
Ensembl Gene Model	ENSMUSG00000063065 (Evidence)
Entrez Gene	26417 (Evidence)
UniGene	8385
DFCI	TC1574602
DoTS	DT.101408309, DT.535611
EC	2.7.11.24
Consensus CDS Project	CCDS21841.1
International Mouse Knockout Project Status	Mapk3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016478	VEGA Gene Model | MGI Sequence Detail	6219	C57BL/6J
transcript	OTTMUST00000039746	VEGA | MGI Sequence Detail	1800	Not Applicable
polypeptide	OTTMUSP00000017735	VEGA | MGI Sequence Detail	380	Not Applicable

All sequences(41) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR003527	Mitogen-activated protein (MAP) kinase, conserved site
InterPro	IPR008349	Mitogen-activated protein (MAP) kinase, ERK1/2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000000104	mitogen-activated protein kinase 3

References

(Earliest) J:202303 Owens WE, et al., Bacterial translocation from the gastrointestinal tract of athymic (nu/nu) mice. Infect Immun. 1980 Feb;27(2):461-7
(Latest) J:216228 Inoue S, et al., New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome. Hum Mol Genet. 2014 Dec 15;23(24):6553-66
All references(468)

Other
accession IDs

MGD-MRK-12586, MGD-MRK-33597, MGD-MRK-9583, MGD-MRK-9654, MGI:105920, MGI:95451, MGI:97176