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Gene Ontology Browser
Term Detail
GO term:MAP kinase kinase activity
Synonym: ATP:protein phosphotransferase (MAPKKK-activated) activity
Synonym: ERK activator kinase activity
Synonym: MAP2K
Synonym: MAPK activator activity
Synonym: MAP kinase kinase 4 activity
Synonym: MAP kinase kinase 7 activity
Synonym: MAP kinase or ERK kinase activity
Synonym: MAPKK
Synonym: MAPKK1
Synonym: MAPKK activity
Synonym: MEK1
Synonym: MEK2
Synonym: MEK activity
Synonym: mitogen-activated protein kinase kinase activity
Synonym: MKK
Synonym: MKK2
Synonym: MKK4
Synonym: MKK6
Synonym: MKK7
Synonym: STK27
GO id:GO:0004708
Definition:Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-akinase activity
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine/tyrosine kinase activity
                                                                is-aMAP kinase kinase activity [GO:0004708] (22 genes, 36 annotations)
                                                                        is-aJUN kinase kinase activity
                                                                        is-aMAP kinase kinase activity involved in cell wall organization or biogenesis
                                                                        is-aMAP kinase kinase activity involved in conjugation with cellular fusion
                                                                        is-aMAP kinase kinase activity involved in innate immune response
                                                                        is-aMAP kinase kinase activity involved in osmosensory signaling pathway


Gene_Ontology
        is-amolecular_function
                is-acatalytic activity
                        is-atransferase activity
                                is-atransferase activity, transferring phosphorus-containing groups
                                        is-aphosphotransferase activity, alcohol group as acceptor
                                                is-aprotein kinase activity
                                                        is-aprotein serine/threonine/tyrosine kinase activity
                                                                is-aMAP kinase kinase activity [GO:0004708] (22 genes, 36 annotations)
                                                                        is-aJUN kinase kinase activity
                                                                        is-aMAP kinase kinase activity involved in cell wall organization or biogenesis
                                                                        is-aMAP kinase kinase activity involved in conjugation with cellular fusion
                                                                        is-aMAP kinase kinase activity involved in innate immune response
                                                                        is-aMAP kinase kinase activity involved in osmosensory signaling pathway


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory