Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes LIPA
  • Mouse genes Lipa
  • Rat genes Lipa
  • Zfish genes lipf
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Lipa

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0016298	lipase activity	LIPA	IDA		Human	PMID:1718995
Molecular Function	GO:0016298	lipase activity	Lipa	IDA		Rat	PMID:11687729|RGD:1600623
Molecular Function	GO:0004771	sterol esterase activity	LIPA	IDA		Human	PMID:15269241
Molecular Function	GO:0004771	sterol esterase activity	LIPA	IDA		Human	PMID:1718995
Molecular Function	GO:0004771	sterol esterase activity	LIPA	IDA		Human	PMID:7204383
Molecular Function	GO:0004771	sterol esterase activity	LIPA	IDA		Human	PMID:8112342
Molecular Function	GO:0004771	sterol esterase activity	LIPA	IMP		Human	PMID:9633819
Molecular Function	GO:0004771	sterol esterase activity	Lipa	IDA		Rat	PMID:10419291|RGD:1626385
Cellular Component	GO:0005829	cytosol	LIPA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0001650	fibrillar center	LIPA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	LIPA	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005764	lysosome	Lipa	IDA		Mouse	PMID:21289032
Cellular Component	GO:0005764	lysosome	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:28402950
Cellular Component	GO:0005764	lysosome	Lipa	IDA		Rat	PMID:10419291|RGD:1626385
Cellular Component	GO:0005764	lysosome	Lipa	IDA		Rat	PMID:11687729|RGD:1600623
Cellular Component	GO:0005764	lysosome	Lipa	IDA		Rat	PMID:4062953|RGD:25671400
Cellular Component	GO:0005654	nucleoplasm	LIPA	IDA		Human	GO_REF:0000052
Biological Process	GO:0002526	acute inflammatory response	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:28402950
Biological Process	GO:1990845	adaptive thermogenesis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0060612	adipose tissue development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0006754	ATP biosynthetic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0048539	bone marrow development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0000902	cell morphogenesis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0008283	cell population proliferation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:22383970
Biological Process	GO:0008283	cell population proliferation	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0071838	cell proliferation in bone marrow	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0097384	cellular lipid biosynthetic process	Lipa	IMP		Mouse	PMID:28402950
Biological Process	GO:0097384	cellular lipid biosynthetic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:28402950
Biological Process	GO:0044255	cellular lipid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:28402950
Biological Process	GO:0006695	cholesterol biosynthetic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0006695	cholesterol biosynthetic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:0033344	cholesterol efflux	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:0008203	cholesterol metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24370824
Biological Process	GO:0008203	cholesterol metabolic process	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0010878	cholesterol storage	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24370824
Biological Process	GO:0010878	cholesterol storage	Lipa	IGI	MGI:MGI:1332226	Mouse	PMID:25450374
Biological Process	GO:0010878	cholesterol storage	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0030301	cholesterol transport	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:0035726	common myeloid progenitor cell proliferation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0001816	cytokine production	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0030421	defecation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0008340	determination of adult lifespan	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0006897	endocytosis	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0008333	endosome to lysosome transport	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0001935	endothelial cell proliferation	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0097009	energy homeostasis	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0050673	epithelial cell proliferation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0070341	fat cell proliferation	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0006631	fatty acid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0006631	fatty acid metabolic process	Lipa	IDA		Rat	PMID:10419291|RGD:1626385
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:22383970
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:31023823
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0010467	gene expression	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:33159889
Biological Process	GO:0006006	glucose metabolic process	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0006096	glycolytic process	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0002244	hematopoietic progenitor cell differentiation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0030097	hemopoiesis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0048872	homeostasis of number of cells	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:33159889
Biological Process	GO:0048873	homeostasis of number of cells within a tissue	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0006954	inflammatory response	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0006954	inflammatory response	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0055088	lipid homeostasis	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0140354	lipid import into cell	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0006629	lipid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0006629	lipid metabolic process	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:31023823
Biological Process	GO:0006629	lipid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:0019915	lipid storage	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:31023823
Biological Process	GO:0042159	lipoprotein catabolic process	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0001889	liver development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24370824
Biological Process	GO:0001889	liver development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0072576	liver morphogenesis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24370824
Biological Process	GO:0030324	lung development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0007040	lysosome organization	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0007040	lysosome organization	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0061519	macrophage homeostasis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0007005	mitochondrion organization	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0007005	mitochondrion organization	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0000278	mitotic cell cycle	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0000278	mitotic cell cycle	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:22383970
Biological Process	GO:0140962	multicellular organismal-level chemical homeostasis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:27354281
Biological Process	GO:0048871	multicellular organismal-level homeostasis	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0033028	myeloid cell apoptotic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0033028	myeloid cell apoptotic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0030099	myeloid cell differentiation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:20348241
Biological Process	GO:0030099	myeloid cell differentiation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0006638	neutral lipid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0050862	positive regulation of T cell receptor signaling pathway	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0012501	programmed cell death	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:21697390
Biological Process	GO:1903409	reactive oxygen species biosynthetic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0042391	regulation of membrane potential	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0051881	regulation of mitochondrial membrane potential	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0002536	respiratory burst involved in inflammatory response	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0009409	response to cold	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29374543
Biological Process	GO:0009409	response to cold	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0002021	response to dietary excess	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0002021	response to dietary excess	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:31023823
Biological Process	GO:0001666	response to hypoxia	lipf	IDA		Zfish	PMID:15994372
Biological Process	GO:0033993	response to lipid	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:29599133
Biological Process	GO:1901355	response to rapamycin	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0033189	response to vitamin A	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:31023823
Biological Process	GO:0009410	response to xenobiotic stimulus	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24370824
Biological Process	GO:0001523	retinoid metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:27354281
Biological Process	GO:0007264	small GTPase mediated signal transduction	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:22383970
Biological Process	GO:0048536	spleen development	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0016125	sterol metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:21289032
Biological Process	GO:0016125	sterol metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:21697390
Biological Process	GO:0016125	sterol metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:25147230
Biological Process	GO:0016125	sterol metabolic process	Lipa	IDA		Rat	PMID:10419291|RGD:1626385
Biological Process	GO:0070231	T cell apoptotic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0030217	T cell differentiation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0042098	T cell proliferation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:19179613
Biological Process	GO:0042098	T cell proliferation	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0048771	tissue remodeling	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:14644759
Biological Process	GO:0031929	TOR signaling	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:24287405
Biological Process	GO:0031929	TOR signaling	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:22383970
Biological Process	GO:0031929	TOR signaling	Lipa	IMP		Mouse	PMID:25807535
Biological Process	GO:0006641	triglyceride metabolic process	Lipa	IMP	MGI:MGI:5428633	Mouse	PMID:30639734
Biological Process	GO:0071830	triglyceride-rich lipoprotein particle clearance	Lipa	IMP	MGI:MGI:6364606	Mouse	PMID:33357458
Biological Process	GO:0006776	vitamin A metabolic process	Lipa	IMP	MGI:MGI:2451080	Mouse	PMID:27354281

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern