| GO term: | T cell differentiation |
| Synonym: | T cell development |
| Synonym: | T-cell differentiation |
| Synonym: | T lymphocyte differentiation |
| Synonym: | T-lymphocyte differentiation |
| GO id: | GO:0030217 |
| Definition: | The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex. |
| Comments | This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. |
| Number of paths to term: | 21 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processcellular processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activation +establishment of T cell polaritygamma-delta T cell activation +memory T cell activation +negative regulation of T cell activation +positive regulation of T cell activation +regulation of T cell activation +T cell activation involved in immune response +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +T cell proliferation +biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processimmune system processleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processimmune system processleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activation +establishment of T cell polaritygamma-delta T cell activation +memory T cell activation +negative regulation of T cell activation +positive regulation of T cell activation +regulation of T cell activation +T cell activation involved in immune response +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +T cell proliferation +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processsingle-organism processsingle-organism cellular processcell activationleukocyte activationlymphocyte activationT cell activationalpha-beta T cell activation +establishment of T cell polaritygamma-delta T cell activation +memory T cell activation +negative regulation of T cell activation +positive regulation of T cell activation +regulation of T cell activation +T cell activation involved in immune response +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +T cell proliferation +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisleukocyte differentiationlymphocyte differentiationB cell differentiation +natural killer cell differentiation +negative regulation of lymphocyte differentiation +positive regulation of lymphocyte differentiation +regulation of lymphocyte differentiation +T cell differentiation [GO:0030217] (181 genes, 314 annotations)alpha-beta T cell differentiation +cytotoxic T cell differentiation +extrathymic T cell differentiation +gamma-delta T cell differentiation +negative regulation of T cell differentiation +positive regulation of T cell differentiation +pro-T cell differentiation +regulation of T cell differentiation +regulatory T cell differentiation +somatic diversification of T cell receptor genes +T cell differentiation in thymus +T cell differentiation involved in immune response +T cell lineage commitment +T cell selection +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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