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Gene Ontology Browser
Term Detail
GO term:cytokine production
Synonym: interferon production
Synonym: interleukin production
GO id:GO:0001816
Definition:The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
CommentsNote that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules.
Number of paths to term: 2

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-aadult behavior +
                                is-aage-dependent behavioral decline
                                is-abeta-amyloid clearance +
                                is-abud dormancy process
                                is-acallus formation
                                part-ofcell recognition +
                                is-acircadian regulation of gene expression
                                is-acircadian regulation of heart rate +
                                is-acircadian regulation of translation
                                is-acoagulation +
                                is-acytokine production [GO:0001816] (488 genes, 1231 annotations)
                                        is-achemokine production +
                                        is-aconnective tissue growth factor production +
                                        part-ofcytokine biosynthetic process +
                                        is-acytokine production involved in immune response +
                                        is-acytokine production involved in inflammatory response +
                                        part-ofcytokine secretion +
                                        is-afibroblast growth factor production +
                                        is-agranulocyte colony-stimulating factor production +
                                        is-agranulocyte macrophage colony-stimulating factor production +
                                        is-ahepatocyte growth factor production +
                                        is-ainterferon-gamma production +
                                        is-ainterleukin-1 production +
                                        is-ainterleukin-10 production +
                                        is-ainterleukin-11 production +
                                        is-ainterleukin-12 production +
                                        is-ainterleukin-13 production +
                                        is-ainterleukin-14 production +
                                        is-ainterleukin-15 production +
                                        is-ainterleukin-16 production +
                                        is-ainterleukin-17 production +
                                        is-ainterleukin-18 production +
                                        is-ainterleukin-19 production +
                                        is-ainterleukin-2 production +
                                        is-ainterleukin-20 production +
                                        is-ainterleukin-21 production +
                                        is-ainterleukin-22 production +
                                        is-ainterleukin-23 production +
                                        is-ainterleukin-24 production +
                                        is-ainterleukin-25 production +
                                        is-ainterleukin-26 production +
                                        is-ainterleukin-27 production +
                                        is-ainterleukin-3 production +
                                        is-ainterleukin-30 production +
                                        is-ainterleukin-31 production +
                                        is-ainterleukin-32 production +
                                        is-ainterleukin-33 production +
                                        is-ainterleukin-35 production +
                                        is-ainterleukin-4 production +
                                        is-ainterleukin-5 production +
                                        is-ainterleukin-6 production +
                                        is-ainterleukin-7 production +
                                        is-ainterleukin-8 production +
                                        is-ainterleukin-9 production +
                                        is-amacrophage colony-stimulating factor production +
                                        is-amacrophage migration inhibitory factor production
                                        negatively-regulatesnegative regulation of cytokine production +
                                        is-aOncostatin M production
                                        is-aplatelet activating factor production +
                                        is-aplatelet-derived growth factor production +
                                        positively-regulatespositive regulation of cytokine production +
                                        regulatesregulation of cytokine production +
                                        is-aregulation of fibroblast growth factor production +
                                        is-atransforming growth factor beta production +
                                        is-atumor necrosis factor superfamily cytokine production +
                                        is-atype I interferon production +
                                        is-atype III interferon production +
                                        is-avascular endothelial growth factor production +
                                is-adetermination of adult lifespan +
                                is-adigestion +
                                is-ahatching behavior
                                is-ainnervation +
                                is-akeratinization +
                                is-alarval behavior +
                                is-amegagametogenesis +
                                is-ameristem determinacy +
                                is-ameristem maintenance +
                                is-amicrogametogenesis +
                                is-amidbrain-hindbrain boundary maturation during brain development
                                is-amidbrain-hindbrain boundary maturation during neural plate development
                                is-amolting cycle +
                                is-amolting cycle process +
                                is-amorphogenesis of a branching structure +
                                is-amulticellular organism adhesion +
                                is-amulticellular organism growth +
                                is-amulticellular organismal development +
                                is-amulticellular organismal homeostasis +
                                is-amulticellular organismal metabolic process +
                                is-amulticellular organismal movement +
                                is-amulticellular organismal response to stress +
                                is-amulticellular organismal signaling +
                                is-amuscle attachment +
                                negatively-regulatesnegative regulation of multicellular organismal process +
                                is-aneurotrophin production +
                                is-aorgan growth +
                                is-aorganism emergence from protective structure +
                                is-aossification +
                                is-aotolith tethering
                                is-apattern specification process +
                                is-aphotoreceptor cell maintenance
                                is-apigment accumulation in tissues +
                                is-aplasma lipoprotein particle clearance +
                                is-aplasma lipoprotein particle organization +
                                is-apollen germination
                                is-apolyphenic determination +
                                positively-regulatespositive regulation of multicellular organismal process +
                                is-apost-embryonic development +
                                is-aprimary growth
                                is-aproduction of molecular mediator involved in inflammatory response +
                                is-apseudocleavage +
                                is-apupariation
                                is-apupation
                                is-aregulation of body fluid levels +
                                is-arespiratory gaseous exchange +
                                is-aresponse to dietary excess +
                                is-ascab formation
                                is-asecretion by tissue +
                                is-aseed dormancy process +
                                is-aseed germination +
                                is-asleep +
                                is-astem cell maintenance +
                                is-asystem process +
                                is-atissue migration +
                                is-atissue remodeling +
                                is-atransforming growth factor beta activation +
                                is-atropism +
                                is-avascular transport +
                                is-avibrational conductance of sound to the inner ear
                                is-avisual behavior +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-aadult behavior +
                                is-aage-dependent behavioral decline
                                is-abeta-amyloid clearance +
                                is-abud dormancy process
                                is-acallus formation
                                part-ofcell recognition +
                                is-acircadian regulation of gene expression
                                is-acircadian regulation of heart rate +
                                is-acircadian regulation of translation
                                is-acoagulation +
                                is-acytokine production [GO:0001816] (488 genes, 1231 annotations)
                                        is-achemokine production +
                                        is-aconnective tissue growth factor production +
                                        part-ofcytokine biosynthetic process +
                                        is-acytokine production involved in immune response +
                                        is-acytokine production involved in inflammatory response +
                                        part-ofcytokine secretion +
                                        is-afibroblast growth factor production +
                                        is-agranulocyte colony-stimulating factor production +
                                        is-agranulocyte macrophage colony-stimulating factor production +
                                        is-ahepatocyte growth factor production +
                                        is-ainterferon-gamma production +
                                        is-ainterleukin-1 production +
                                        is-ainterleukin-10 production +
                                        is-ainterleukin-11 production +
                                        is-ainterleukin-12 production +
                                        is-ainterleukin-13 production +
                                        is-ainterleukin-14 production +
                                        is-ainterleukin-15 production +
                                        is-ainterleukin-16 production +
                                        is-ainterleukin-17 production +
                                        is-ainterleukin-18 production +
                                        is-ainterleukin-19 production +
                                        is-ainterleukin-2 production +
                                        is-ainterleukin-20 production +
                                        is-ainterleukin-21 production +
                                        is-ainterleukin-22 production +
                                        is-ainterleukin-23 production +
                                        is-ainterleukin-24 production +
                                        is-ainterleukin-25 production +
                                        is-ainterleukin-26 production +
                                        is-ainterleukin-27 production +
                                        is-ainterleukin-3 production +
                                        is-ainterleukin-30 production +
                                        is-ainterleukin-31 production +
                                        is-ainterleukin-32 production +
                                        is-ainterleukin-33 production +
                                        is-ainterleukin-35 production +
                                        is-ainterleukin-4 production +
                                        is-ainterleukin-5 production +
                                        is-ainterleukin-6 production +
                                        is-ainterleukin-7 production +
                                        is-ainterleukin-8 production +
                                        is-ainterleukin-9 production +
                                        is-amacrophage colony-stimulating factor production +
                                        is-amacrophage migration inhibitory factor production
                                        negatively-regulatesnegative regulation of cytokine production +
                                        is-aOncostatin M production
                                        is-aplatelet activating factor production +
                                        is-aplatelet-derived growth factor production +
                                        positively-regulatespositive regulation of cytokine production +
                                        regulatesregulation of cytokine production +
                                        is-aregulation of fibroblast growth factor production +
                                        is-atransforming growth factor beta production +
                                        is-atumor necrosis factor superfamily cytokine production +
                                        is-atype I interferon production +
                                        is-atype III interferon production +
                                        is-avascular endothelial growth factor production +
                                is-adetermination of adult lifespan +
                                is-adigestion +
                                is-ahatching behavior
                                is-ainnervation +
                                is-akeratinization +
                                is-alarval behavior +
                                is-amegagametogenesis +
                                is-ameristem determinacy +
                                is-ameristem maintenance +
                                is-amicrogametogenesis +
                                is-amidbrain-hindbrain boundary maturation during brain development
                                is-amidbrain-hindbrain boundary maturation during neural plate development
                                is-amolting cycle +
                                is-amolting cycle process +
                                is-amorphogenesis of a branching structure +
                                is-amulticellular organism adhesion +
                                is-amulticellular organism growth +
                                is-amulticellular organismal development +
                                is-amulticellular organismal homeostasis +
                                is-amulticellular organismal metabolic process +
                                is-amulticellular organismal movement +
                                is-amulticellular organismal response to stress +
                                is-amulticellular organismal signaling +
                                is-amuscle attachment +
                                negatively-regulatesnegative regulation of multicellular organismal process +
                                is-aneurotrophin production +
                                is-aorgan growth +
                                is-aorganism emergence from protective structure +
                                is-aossification +
                                is-aotolith tethering
                                is-apattern specification process +
                                is-aphotoreceptor cell maintenance
                                is-apigment accumulation in tissues +
                                is-aplasma lipoprotein particle clearance +
                                is-aplasma lipoprotein particle organization +
                                is-apollen germination
                                is-apolyphenic determination +
                                positively-regulatespositive regulation of multicellular organismal process +
                                is-apost-embryonic development +
                                is-aprimary growth
                                is-aproduction of molecular mediator involved in inflammatory response +
                                is-apseudocleavage +
                                is-apupariation
                                is-apupation
                                is-aregulation of body fluid levels +
                                is-arespiratory gaseous exchange +
                                is-aresponse to dietary excess +
                                is-ascab formation
                                is-asecretion by tissue +
                                is-aseed dormancy process +
                                is-aseed germination +
                                is-asleep +
                                is-astem cell maintenance +
                                is-asystem process +
                                is-atissue migration +
                                is-atissue remodeling +
                                is-atransforming growth factor beta activation +
                                is-atropism +
                                is-avascular transport +
                                is-avibrational conductance of sound to the inner ear
                                is-avisual behavior +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory