Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes KLF4
  • Mouse genes Klf4
  • Rat genes Klf4
  • Zfish genes klf4
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Klf4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0008013	beta-catenin binding	Klf4	IPI	UniProtKB:Q02248	Mouse	MGI:MGI:5428344|PMID:22723415
Molecular Function	GO:0031490	chromatin DNA binding	Klf4	IDA		Mouse	PMID:32467224
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	KLF4	IMP		Human	PMID:21539536
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Klf4	IMP		Mouse	MGI:MGI:5428344|PMID:22723415
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Klf4	IDA		Mouse	PMID:22306741
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Klf4	IDA		Rat	PMID:17659301|RGD:1643591
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf4	IDA		Mouse	PMID:17130451
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Klf4	IDA		Rat	PMID:12034813|RGD:619591
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	Klf4	IDA		Mouse	MGI:MGI:6377804|PMID:28262547
Molecular Function	GO:0003690	double-stranded DNA binding	Klf4	IDA		Rat	PMID:12034813|RGD:619591
Molecular Function	GO:0042826	histone deacetylase binding	Klf4	IPI	RGD:619976	Rat	PMID:19486889|RGD:9590233
Molecular Function	GO:0035014	phosphatidylinositol 3-kinase regulator activity	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Molecular Function	GO:1990841	promoter-specific chromatin binding	KLF4	IDA		Human	PMID:27907090
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:Q13363	Human	PMID:19751731
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:O95983	Human	PMID:24048479
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:A0A024R8L2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:O14964	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:O75031	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:P13807	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:P55771	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:Q08117-2	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	KLF4	IPI	UniProtKB:Q92997	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:P20263|UniProtKB:P48432	Mouse	MGI:MGI:4887542|PMID:19816951
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:Q3ULA2	Mouse	MGI:MGI:6149282|PMID:29593216
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:P27361|UniProtKB:Q63844|UniProtKB:Q9UKB1|UniProtKB:Q9Y297	Mouse	MGI:MGI:5914636|PMID:22307056
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:O95793	Mouse	MGI:MGI:6114918|PMID:29374155
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:Q62315	Mouse	MGI:MGI:5887185|PMID:26523946
Molecular Function	GO:0005515	protein binding	Klf4	IPI	UniProtKB:O88895	Mouse	PMID:32467224
Molecular Function	GO:0005515	protein binding	Klf4	IPI	PR:E9Q6W4	Mouse	PMID:24161396
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	KLF4	IDA		Human	PMID:21539536
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Klf4	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Molecular Function	GO:0001010	RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity	Klf4	IDA		Mouse	MGI:MGI:4887558|PMID:18396140
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	KLF4	IPI	UniProtKB:Q92793	Human	PMID:21539536
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Klf4	IPI	UniProtKB:P08152	Mouse	MGI:MGI:4887558|PMID:18396140
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	Klf4	IPI	PR:P42227	Mouse	PMID:24129709
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf4	IDA		Mouse	PMID:8940147
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf4	IDA		Mouse	PMID:22306741
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf4	IDA		Rat	PMID:12034813|RGD:619591
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf4	IDA		Rat	PMID:15632413|RGD:1643534
Molecular Function	GO:0043565	sequence-specific DNA binding	Klf4	IDA		Rat	PMID:17659301|RGD:1643591
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	KLF4	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Klf4	IDA		Mouse	MGI:MGI:4887334|PMID:16954384
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Klf4	IDA		Mouse	PMID:24161396
Molecular Function	GO:0000976	transcription cis-regulatory region binding	Klf4	IDA		Rat	PMID:19531492|RGD:8553301
Molecular Function	GO:0001221	transcription coregulator binding	Klf4	IPI	RGD:620036	Rat	PMID:21252119|RGD:7364714
Cellular Component	GO:0000785	chromatin	KLF4	IDA		Human	PMID:21539536
Cellular Component	GO:0000785	chromatin	Klf4	IDA		Rat	PMID:15632413|RGD:1643534
Cellular Component	GO:0005737	cytoplasm	Klf4	IDA		Mouse	PMID:24129709
Cellular Component	GO:0005829	cytosol	KLF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0000791	euchromatin	Klf4	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Cellular Component	GO:0015630	microtubule cytoskeleton	KLF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005654	nucleoplasm	KLF4	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005634	nucleus	Klf4	IPI	UniProtKB:O88895	Mouse	PMID:32467224
Cellular Component	GO:0005634	nucleus	Klf4	IDA		Mouse	PMID:19796622
Cellular Component	GO:0005634	nucleus	Klf4	IDA		Mouse	PMID:24161396
Cellular Component	GO:0005634	nucleus	Klf4	IDA		Mouse	PMID:24129709
Cellular Component	GO:0005634	nucleus	Klf4	IDA		Rat	PMID:15632413|RGD:1643534
Cellular Component	GO:0005667	transcription regulator complex	Klf4	IDA		Mouse	MGI:MGI:5428344|PMID:22723415
Cellular Component	GO:0005667	transcription regulator complex	Klf4	IDA		Rat	PMID:15632413|RGD:1643534
Biological Process	GO:0060070	canonical Wnt signaling pathway	Klf4	IMP		Mouse	MGI:MGI:5428344|PMID:22723415
Biological Process	GO:0071409	cellular response to cycloheximide	Klf4	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071363	cellular response to growth factor stimulus	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0070301	cellular response to hydrogen peroxide	Klf4	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071499	cellular response to laminar fluid shear stress	KLF4	IMP		Human	PMID:22430140
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	Klf4	IEP		Mouse	PMID:20439489
Biological Process	GO:0071407	cellular response to organic cyclic compound	Klf4	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:1901653	cellular response to peptide	Klf4	IEP		Rat	PMID:18406357|RGD:2316543
Biological Process	GO:0071300	cellular response to retinoic acid	Klf4	IEP		Rat	PMID:19486889|RGD:9590233
Biological Process	GO:0002357	defense response to tumor cell	KLF4	IMP		Human	PMID:30429596
Biological Process	GO:0006351	DNA-templated transcription	Klf4	IMP		Mouse	MGI:MGI:5485298|PMID:23372771
Biological Process	GO:0009913	epidermal cell differentiation	Klf4	IMP	MGI:MGI:2183936	Mouse	PMID:10431239
Biological Process	GO:0008544	epidermis development	Klf4	IMP	MGI:MGI:2183917	Mouse	PMID:32467224
Biological Process	GO:0048730	epidermis morphogenesis	Klf4	IMP	MGI:MGI:2183936	Mouse	PMID:10431239
Biological Process	GO:0061436	establishment of skin barrier	Klf4	IMP	MGI:MGI:2183917	Mouse	PMID:32467224
Biological Process	GO:0045444	fat cell differentiation	Klf4	IMP		Mouse	MGI:MGI:4887558|PMID:18396140
Biological Process	GO:0045444	fat cell differentiation	Klf4	IMP		Mouse	PMID:22306741
Biological Process	GO:0010467	gene expression	Klf4	IMP		Mouse	PMID:27208706
Biological Process	GO:0010467	gene expression	Klf4	IMP	MGI:MGI:2183917	Mouse	PMID:32467224
Biological Process	GO:0002067	glandular epithelial cell differentiation	Klf4	IMP	MGI:MGI:2183917,MGI:MGI:3045749	Mouse	PMID:17060454
Biological Process	GO:0016525	negative regulation of angiogenesis	KLF4	IDA		Human	PMID:23867820
Biological Process	GO:0030336	negative regulation of cell migration	Klf4	IMP		Mouse	MGI:MGI:5445064|PMID:22491752
Biological Process	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0008285	negative regulation of cell population proliferation	Klf4	IDA		Mouse	PMID:8702718
Biological Process	GO:0008285	negative regulation of cell population proliferation	klf4	IMP	ZFIN:ZDB-MRPHLNO-111014-1,ZFIN:ZDB-MRPHLNO-111014-2	Zfish	PMID:21687630
Biological Process	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	Klf4	IMP		Mouse	PMID:24129709
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	KLF4	IDA		Human	PMID:9422764
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	KLF4	IDA		Human	PMID:23867820
Biological Process	GO:0010629	negative regulation of gene expression	KLF4	IGI	RNAcentral:URS00003768C5_9606	Human	PMID:22267480
Biological Process	GO:0034115	negative regulation of heterotypic cell-cell adhesion	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0032717	negative regulation of interleukin-8 production	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:1904998	negative regulation of leukocyte adhesion to arterial endothelial cell	KLF4	IGI	RNAcentral:URS00003768C5_9606	Human	PMID:22267480
Biological Process	GO:0014740	negative regulation of muscle hyperplasia	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:0051898	negative regulation of protein kinase B signaling	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:0060761	negative regulation of response to cytokine stimulus	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Klf4	IDA		Rat	PMID:17659301|RGD:1643591
Biological Process	GO:0048662	negative regulation of smooth muscle cell proliferation	Klf4	IMP		Rat	PMID:19531492|RGD:8553301
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	KLF4	IDA		Human	PMID:20551324
Biological Process	GO:1904798	positive regulation of core promoter binding	Klf4	IMP		Mouse	MGI:MGI:5428344|PMID:22723415
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	KLF4	IDA		Human	PMID:27431648
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf4	IDA		Mouse	MGI:MGI:4887334|PMID:16954384
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	Klf4	IDA		Mouse	MGI:MGI:4887542|PMID:19816951
Biological Process	GO:0010628	positive regulation of gene expression	KLF4	IGI	RNAcentral:URS00003768C5_9606	Human	PMID:22267480
Biological Process	GO:0046985	positive regulation of hemoglobin biosynthetic process	KLF4	IMP		Human	PMID:21539536
Biological Process	GO:1902895	positive regulation of miRNA transcription	KLF4	IDA		Human	PMID:23867820
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	KLF4	IMP		Human	PMID:22430140
Biological Process	GO:0051247	positive regulation of protein metabolic process	KLF4	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0051247	positive regulation of protein metabolic process	KLF4	IMP		Human	PMID:22430140
Biological Process	GO:1903672	positive regulation of sprouting angiogenesis	KLF4	IGI	RNAcentral:URS0000591950_9606	Human	PMID:27431648
Biological Process	GO:0051973	positive regulation of telomerase activity	KLF4	IDA		Human	PMID:20629177
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF4	IGI	UniProtKB:Q62862	Human	PMID:20551324
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF4	IMP		Human	PMID:22430140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF4	IMP		Human	PMID:22723415
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	KLF4	IMP		Human	PMID:27907090
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IMP		Mouse	MGI:MGI:5428344|PMID:22723415
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Mouse	MGI:MGI:6377809|PMID:26691508
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IMP		Mouse	MGI:MGI:4887558|PMID:18396140
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IMP		Mouse	PMID:22306741
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Mouse	PMID:24161396
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Mouse	PMID:17130451
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Mouse	PMID:17060454
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Rat	PMID:12034813|RGD:619591
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Klf4	IDA		Rat	PMID:17659301|RGD:1643591
Biological Process	GO:0031077	post-embryonic camera-type eye development	Klf4	IMP	MGI:MGI:2183917,MGI:MGI:3045749	Mouse	PMID:17060454
Biological Process	GO:0035166	post-embryonic hemopoiesis	KLF4	IMP		Human	PMID:21539536
Biological Process	GO:0048679	regulation of axon regeneration	Klf4	IGI	MGI:MGI:103038	Mouse	PMID:24129709
Biological Process	GO:0048679	regulation of axon regeneration	Klf4	IMP		Mouse	PMID:24129709
Biological Process	GO:0120222	regulation of blastocyst development	Klf4	IMP	MGI:MGI:6392146	Mouse	PMID:29593216
Biological Process	GO:0045595	regulation of cell differentiation	Klf4	IDA		Mouse	MGI:MGI:4887542|PMID:19816951
Biological Process	GO:0042127	regulation of cell population proliferation	Klf4	IGI	MGI:MGI:88039	Mouse	PMID:17671182
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	Klf4	IDA		Mouse	PMID:19796622
Biological Process	GO:0010033	response to organic substance	Klf4	IDA		Mouse	PMID:18400104
Biological Process	GO:0032526	response to retinoic acid	Klf4	IDA		Mouse	PMID:18400104
Biological Process	GO:0035019	somatic stem cell population maintenance	Klf4	IDA		Mouse	PMID:15358627
Biological Process	GO:0019827	stem cell population maintenance	Klf4	IDA		Mouse	MGI:MGI:4887542|PMID:19816951
Biological Process	GO:0072089	stem cell proliferation	klf4	IMP	ZFIN:ZDB-GENO-200220-22	Zfish	PMID:30933982
Biological Process	GO:0006366	transcription by RNA polymerase II	Klf4	IMP		Mouse	PMID:22306741

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern