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Klf4
Gene Detail
 Symbol
Name
ID
Klf4
Kruppel-like factor 4 (gut)
MGI:1342287
Synonyms EZF, Gklf, Zie
Feature Type protein coding gene
Genetic Map
Chromosome 4
29.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:55527143-55532466 bp, - strand
From VEGA annotation of GRCm38

  5324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Klf4

Human
homologs
Human Homolog KLF4, Kruppel-like factor 4 (gut)
NCBI Gene ID 9314
neXtProt AC  NX_O43474
Human Synonyms  EZF, GKLF
Human Chr (Location)  9q31; chr9:107484852-107489766 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die shortly after birth due to a skin defect that results in loss of fluids. Mutants also show a dramatic decrease in the number of goblet cells of the colon.
 
Interactions
Klf4 interacts with 299 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process cell differentiation, cellular response to growth factor stimulus, ...
Component chromatin, nuclear chromatin, ...
Function core promoter proximal region sequence-specific DNA binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (311)    Tissues (123)    Images (39)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 190
RT-PCR 60
RNase protection 61
cDNA source data(99)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(105) cDNA(99) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007231 (Evidence)
Ensembl Gene ModelENSMUSG00000003032 (Evidence)
Entrez Gene16600 (Evidence)
UniGene4325
DFCITC1576153
DoTSDT.101302781, DT.494264
NIA Mouse Gene IndexU025080
PDB2WBS, 2WBU, 4M9E
Consensus CDS ProjectCCDS18195.2
International Mouse Knockout Project StatusKlf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007231 VEGA Gene Model | MGI Sequence Detail 5324 C57BL/6J ±  kb
transcript OTTMUST00000016677 VEGA | MGI Sequence Detail 3029 Not Applicable 
polypeptide OTTMUSP00000007677 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009364 krueppel-like factor 4
References (Earliest) J:34906 Shields JM, et al., Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17
(Latest) J:206523 Abrigo M, et al., Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice. Carcinogenesis. 2014 Mar;35(3):662-9
All references(129)
Other
accession IDs
MGD-MRK-36140, MGD-MRK-37337, MGI:107568

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory