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Klf4 Gene Detail
Summary
  • Symbol
    Klf4
  • Name
    Kruppel-like factor 4 (gut)
  • Synonyms
    EZF, Gklf, Zie
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342287
    NCBI Gene: 16600
  • Gene Overview
    MyGene.info: KLF4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:55527143-55532466 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 29.76 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    48 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1342287
protein coding gene Chr4:55527137-55532475 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028306
protein coding gene Chr4:54241406-54248871 (-)
A/J MGP_AJ_G0028267
protein coding gene Chr4:52156425-52161421 (-)
AKR/J MGP_AKRJ_G0028216
protein coding gene Chr4:53569668-53574494 (-)
BALB/cJ MGP_BALBcJ_G0028286
protein coding gene Chr4:52319280-52324641 (-)
C3H/HeJ MGP_C3HHeJ_G0028007
protein coding gene Chr4:54099566-54105373 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028727
protein coding gene Chr4:56199518-56205320 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026035
protein coding gene Chr4:49024556-49029575 (-)
CAST/EiJ MGP_CASTEiJ_G0027445
protein coding gene Chr4:53797957-53803723 (-)
CBA/J MGP_CBAJ_G0027972
protein coding gene Chr4:58122495-58138096 (-)
DBA/2J MGP_DBA2J_G0028122
protein coding gene Chr4:52081499-52086387 (-)
FVB/NJ MGP_FVBNJ_G0028089
protein coding gene Chr4:51311180-51316498 (-)
LP/J MGP_LPJ_G0028221
protein coding gene Chr4:54322566-54327479 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028113
protein coding gene Chr4:61304249-61312164 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028763
protein coding gene Chr4:53806005-53812886 (-)
PWK/PhJ MGP_PWKPhJ_G0027170
protein coding gene Chr4:52059139-52065901 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026998
protein coding gene Chr4:53064961-53070557 (-)
WSB/EiJ MGP_WSBEiJ_G0027523
protein coding gene Chr4:53709108-53715434 (-)



Homology
more
  • Human Ortholog
    KLF4, Kruppel like factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF4, Kruppel like factor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EZF, GKLF
  • Links
    NCBI Gene ID: 9314
    neXtProt AC: NX_O43474
    UniProt: O43474

  • Chr Location
    9q31.2; chr9:107484852-107489720 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3123
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KLF4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 3 alleles in 7 genetic backgrounds
    20 phenotypes from multigenic genotypes
    111 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die shortly after birth due to a skin defect that results in loss of fluids. Mutants also show a dramatic decrease in the number of goblet cells of the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003032 Ensembl Gene Model | MGI Sequence Detail 5324 C57BL/6J ±  kb
    transcript ENSMUST00000107619 Ensembl | MGI Sequence Detail 3029 Not Applicable  
    polypeptide ENSMUSP00000103245 Ensembl | MGI Sequence Detail 483 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 109
      cDNA 102
      Primer pair 6
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36140, MGD-MRK-37337, MGI:107568
    References
    more
    • Summaries
      All 247
      Developmental Gene Expression 55
      Gene Ontology 29
      Phenotypes 111
    • Earliest
      J:34906 Shields JM, et al., Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17
    • Latest
      J:265943 Muthiah A, et al., Biologically anchored knowledge expansion approach uncovers KLF4 as a novel insulin signaling regulator. PLoS One. 2018;13(9):e0204100

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory