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Klf4 Gene Detail
Summary
  • Symbol
    Klf4
  • Name
    Kruppel-like factor 4 (gut)
  • Synonyms
    EZF, Gklf, Zie
  • Feature Type
    protein coding gene
  • IDs
    MGI:1342287
    NCBI Gene: 16600
  • Gene Overview
    MyGene.info: KLF4
Location & Maps
more
  • Sequence Map
    Chr4:55527143-55532466 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5324 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 29.76 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    KLF4, Kruppel like factor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KLF4, Kruppel like factor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EZF, GKLF
  • Links
    NCBI Gene ID: 9314
    neXtProt AC: NX_O43474

  • Chr Location
    9q31; chr9:107484852-107489766 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3123
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: KLF4
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 3 alleles in 6 genetic backgrounds
    20 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Gene trapped
    4
  • Targeted
    9
  • Transgenic
    3
  • Incidental Mutations
Homozygotes for targeted null mutations die shortly after birth due to a skin defect that results in loss of fluids. Mutants also show a dramatic decrease in the number of goblet cells of the colon.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007231 VEGA Gene Model | MGI Sequence Detail 5324 C57BL/6J ±  kb
transcript OTTMUST00000016677 VEGA | MGI Sequence Detail 3029 Not Applicable  
polypeptide OTTMUSP00000007677 VEGA | MGI Sequence Detail 483 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    48 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 106
    cDNA 100
    Primer pair 5
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36140, MGD-MRK-37337, MGI:107568
References
more
  • Summaries
    All 155
    Developmental Gene Expression 40
    Gene Ontology 24
    Phenotypes 72
  • Earliest
    J:34906 Shields JM, et al., Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17
  • Latest
    J:232707 Zhou Z, et al., Cerebral cavernous malformations arise from endothelial gain of MEKK3-KLF2/4 signalling. Nature. 2016 Apr 7;532(7597):122-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory