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Klf4
Gene Detail
Symbol

Name
ID
Klf4
Kruppel-like factor 4 (gut)
MGI:1342287
Synonyms
EZF, Gklf, Zie
Feature Type
protein coding gene
Genetic Map
Chromosome 4
29.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:55527143-55532466 bp, - strand
From VEGA annotation of GRCm38

  5324 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: KLF4
Gene Tree: Klf4

Human
homologs
KLF4, Kruppel-like factor 4 (gut)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9314
neXtProt AC: NX_O43474

Human Synonyms: EZF, GKLF

Human Chr (Location): 9q31; chr9:107484852-107489766 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(4) Targeted(9) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die shortly after birth due to a skin defect that results in loss of fluids. Mutants also show a dramatic decrease in the number of goblet cells of the colon.
 
Interactions
Klf4 interacts with 298 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (84 annotations)
Process canonical Wnt signaling pathway, cell differentiation, ...
Component chromatin, nuclear chromatin, ...
Function beta-catenin binding, core promoter binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (37 records)
Data Summary: Results (371)    Tissues (152)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 229
Northern blot 21
RT-PCR 60
RNase protection 61
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA KLF4 ; Xenbase klf4 ; ZFIN klf4    NEW 
Molecular
reagents
All nucleic(106) cDNA(100) Primer pair(5) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000007231 (Evidence)
Ensembl Gene Model ENSMUSG00000003032 (Evidence)
Entrez Gene 16600 (Evidence)
UniGene 4325
DFCI TC1576153
DoTS DT.101302781, DT.494264
NIA Mouse Gene Index U025080
PDB 2WBS, 4M9E, 2WBU
Consensus CDS Project CCDS18195.2
International Mouse Phenotyping Consortium Status Klf4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007231 VEGA Gene Model | MGI Sequence Detail 5324 C57BL/6J ±  kb
transcript OTTMUST00000016677 VEGA | MGI Sequence Detail 3029 Not Applicable 
polypeptide OTTMUSP00000007677 VEGA | MGI Sequence Detail 483 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(51 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000009364 krueppel-like factor 4
References
(Earliest) J:34906 Shields JM, et al., Identification and characterization of a gene encoding a gut-enriched Kruppel-like factor expressed during growth arrest. J Biol Chem. 1996 Aug 16;271(33):20009-17
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(137)
Other
accession IDs
MGD-MRK-36140, MGD-MRK-37337, MGI:107568

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory