Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes GRIK1
  • Mouse genes Grik1
  • Rat genes Grik1
  • Zfish genes grik1a,grik1b
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Grik1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0005234	extracellularly glutamate-gated ion channel activity	Grik1	IDA		Rat	PMID:1977421|RGD:61622
Molecular Function	GO:0016595	glutamate binding	Grik1	IDA		Rat	PMID:12533604|RGD:1642497
Molecular Function	GO:0016595	glutamate binding	Grik1	IDA		Rat	PMID:16540562|RGD:1642470
Molecular Function	GO:1901363	heterocyclic compound binding	Grik1	IPI	CHEBI:63631	Rat	PMID:12904467|RGD:731146
Molecular Function	GO:0042802	identical protein binding	Grik1	IPI	RGD:2732	Rat	PMID:16540562|RGD:1642470
Molecular Function	GO:0004970	ionotropic glutamate receptor activity	Grik1	IDA		Rat	PMID:17395219|RGD:1642466
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	GRIK1	IDA		Human	PMID:9335499
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IDA		Mouse	PMID:15483117
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:11985817
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:12223554
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IDA		Mouse	PMID:17174564
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:15509753
Molecular Function	GO:0015277	kainate selective glutamate receptor activity	Grik1	IDA		Rat	PMID:17395219|RGD:1642466
Molecular Function	GO:0005313	L-glutamate transmembrane transporter activity	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:14715943
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grik1	IDA		Rat	PMID:1373382|RGD:155230697
Molecular Function	GO:0099507	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	Grik1	IMP		Rat	PMID:1373382|RGD:155230697
Molecular Function	GO:0005515	protein binding	Grik1	IPI	PR:Q61626	Mouse	PMID:17174564
Molecular Function	GO:0005515	protein binding	Grik1	IPI	PR:Q8R4I7	Mouse	PMID:21734292
Molecular Function	GO:0005515	protein binding	Grik1	IPI	PR:P39087	Mouse	PMID:17174564
Molecular Function	GO:0005515	protein binding	Grik1	IPI	PR:Q8BNJ6	Mouse	PMID:21734292
Molecular Function	GO:0005515	protein binding	Grik1	IPI	RGD:1307709	Rat	PMID:12597860|RGD:152995391
Molecular Function	GO:0005515	protein binding	Grik1	IPI	UniProtKB:Q8K430	Rat	PMID:17062563|RGD:8553595
Molecular Function	GO:0097110	scaffold protein binding	Grik1	IDA		Rat	PMID:12597860|RGD:152995391
Molecular Function	GO:0000149	SNARE binding	Grik1	IPI	RGD:69437	Rat	PMID:12597860|RGD:152995391
Cellular Component	GO:0030425	dendrite	Grik1	IDA		Mouse	PMID:17174564
Cellular Component	GO:0030425	dendrite	Grik1	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0098978	glutamatergic synapse	Grik1	IDA		Rat	PMID:16360275|RGD:1642473
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	GRIK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0008328	ionotropic glutamate receptor complex	Grik1	IDA		Rat	PMID:16540562|RGD:1642470
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik1	IPI	PR:Q61626	Mouse	PMID:17174564
Cellular Component	GO:0032983	kainate selective glutamate receptor complex	Grik1	IPI	PR:P39087	Mouse	PMID:17174564
Cellular Component	GO:0016020	membrane	Grik1	IDA		Mouse	PMID:15014126
Cellular Component	GO:0043025	neuronal cell body	Grik1	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0005886	plasma membrane	GRIK1	IDA		Human	GO_REF:0000052
Cellular Component	GO:0014069	postsynaptic density	Grik1	IDA		Mouse	PMID:21734292
Cellular Component	GO:0014069	postsynaptic density	Grik1	IDA		Mouse	PMID:24069373
Cellular Component	GO:0042734	presynaptic membrane	Grik1	IDA		Mouse	PMID:11985817
Cellular Component	GO:0042734	presynaptic membrane	Grik1	IDA		Mouse	PMID:14724198
Cellular Component	GO:0042734	presynaptic membrane	Grik1	IDA		Rat	PMID:16360275|RGD:1642473
Cellular Component	GO:0043235	receptor complex	Grik1	IDA		Rat	PMID:10627597|RGD:8553571
Cellular Component	GO:0045202	synapse	Grik1	IDA		Mouse	PMID:21734292
Cellular Component	GO:0043195	terminal bouton	Grik1	IDA		Rat	PMID:15844209|RGD:1642495
Cellular Component	GO:0043195	terminal bouton	Grik1	IDA		Rat	PMID:16360275|RGD:1642473
Biological Process	GO:0030534	adult behavior	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0048266	behavioral response to pain	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:15673679
Biological Process	GO:0051649	establishment of localization in cell	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:14715943
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:14724198
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:11069933
Biological Process	GO:0060079	excitatory postsynaptic potential	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:11985817
Biological Process	GO:0014051	gamma-aminobutyric acid secretion	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:11144357
Biological Process	GO:0060080	inhibitory postsynaptic potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:12223554
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	Grik1	IDA		Rat	PMID:17395219|RGD:1642466
Biological Process	GO:0051899	membrane depolarization	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0098815	modulation of excitatory postsynaptic potential	Grik1	IMP		Rat	PMID:12597860|RGD:152995391
Biological Process	GO:0032229	negative regulation of synaptic transmission, GABAergic	Grik1	IDA		Rat	PMID:12533604|RGD:1642497
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:11985817
Biological Process	GO:0051967	negative regulation of synaptic transmission, glutamatergic	Grik1	IDA		Rat	PMID:17395219|RGD:1642466
Biological Process	GO:0007399	nervous system development	Grik1	IMP		Rat	PMID:1977421|RGD:61622
Biological Process	GO:0014054	positive regulation of gamma-aminobutyric acid secretion	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0032230	positive regulation of synaptic transmission, GABAergic	Grik1	IDA		Rat	PMID:12533604|RGD:1642497
Biological Process	GO:0099171	presynaptic modulation of chemical synaptic transmission	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:11985817
Biological Process	GO:0042391	regulation of membrane potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:12223554
Biological Process	GO:0042391	regulation of membrane potential	Grik1	IDA		Mouse	PMID:17174564
Biological Process	GO:0042391	regulation of membrane potential	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:15509753
Biological Process	GO:0042391	regulation of membrane potential	Grik1	IMP	MGI:MGI:3623113	Mouse	PMID:10516295
Biological Process	GO:0042391	regulation of membrane potential	Grik1	IMP		Mouse	PMID:15513934
Biological Process	GO:0048172	regulation of short-term neuronal synaptic plasticity	Grik1	IDA		Rat	PMID:17395219|RGD:1642466
Biological Process	GO:0051932	synaptic transmission, GABAergic	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:17245443
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik1	IMP	MGI:MGI:3623113	Mouse	PMID:15928066
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik1	IGI	MGI:MGI:95815	Mouse	PMID:15928066
Biological Process	GO:0035249	synaptic transmission, glutamatergic	Grik1	IMP	MGI:MGI:2176347	Mouse	PMID:15509753

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern