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Grik1
Gene Detail
 Symbol
Name
ID
Grik1
glutamate receptor, ionotropic, kainate 1
MGI:95814
Synonyms A830007B11Rik, D16Ium24, D16Ium24e, GluK5, Glur5, Glur-5, Glurbeta1
Feature Type protein coding gene
Genetic Map
Chromosome 16
50.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr16:87896196-88056176 bp, - strand
From Ensembl annotation of GRCm38

  159981 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik1

Human
homologs
Human Homolog GRIK1, glutamate receptor, ionotropic, kainate 1
NCBI Gene ID 2897
neXtProt AC  NX_P39086
Human Synonyms  EAA3, EEA3, GLR5, GluK1, GLUR5
Human Chr (Location)  21q22.11; chr21:29536933-29939964 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Genomic Mutations involving Grik1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced.
 
Interactions
Grik1 interacts with 97 markers (Mir10a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process adult behavior, behavioral response to pain, ...
Component cell junction, dendrite, ...
Function drug binding, extracellular-glutamate-gated ion channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (184)    Tissues (150)    Images (17)
Theiler Stages: 13, 14, 15, 17, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 166
RT-PCR 18
cDNA source data(25)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(25) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022935 (Evidence)
Entrez Gene14805 (Evidence)
UniGene5134
DFCITC1582409, TC1586532, TC1592943, TC1596903, TC1602124, TC1608344, TC1613293, TC1624364, TC1756461
DoTSDT.101286834, DT.101343989, DT.101703385, DT.101736192, DT.101736193, DT.101736194, DT.110718140, DT.40139317, DT.60103161, DT.91330182, DT.94189737
NIA Mouse Gene IndexU037256
International Mouse Knockout Project StatusGrik1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022935 Ensembl Gene Model | MGI Sequence Detail 159981 C57BL/6J ±  kb
transcript ENSMUST00000072256 Ensembl | MGI Sequence Detail 2688 Not Applicable 
polypeptide ENSMUSP00000072107 Ensembl | MGI Sequence Detail 895 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(22) UniProt(11)
Polymorphisms RFLP(2) : SNPs within 2kb(3273 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008240 glutamate receptor ionotropic, kainate 1
References (Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:210617 Fritsch B, et al., Role of GluK1 kainate receptors in seizures, epileptic discharges, and epileptogenesis. J Neurosci. 2014 Apr 23;34(17):5765-75
All references(95)
Other
accession IDs
MGD-MRK-10144, MGD-MRK-10151, MGD-MRK-10252, MGD-MRK-33850, MGI:106163, MGI:2443714

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory