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Grik1 Gene Detail
Summary
  • Symbol
    Grik1
  • Name
    glutamate receptor, ionotropic, kainate 1
  • Synonyms
    A830007B11Rik, D16Ium24, D16Ium24e, GluK5, Glur5, Glur-5, Glurbeta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95814
    NCBI Gene: 14805
  • Gene Overview
    MyGene.info: GRIK1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87895900-88290265 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 50.23 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3254 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95814
protein coding gene Chr16:87895897-88290601 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022982
protein coding gene Chr16:88647688-88841725 (-)
A/J MGP_AJ_G0022950
protein coding gene Chr16:84557698-84743987 (-)
AKR/J MGP_AKRJ_G0022920
protein coding gene Chr16:87131139-87309487 (-)
BALB/cJ MGP_BALBcJ_G0022952
protein coding gene Chr16:85086861-85270339 (-)
C3H/HeJ MGP_C3HHeJ_G0022714
protein coding gene Chr16:87695898-87853531 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023399
protein coding gene Chr16:91516487-91704030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020903
protein coding gene Chr16:82403607-82559065 (-)
CAST/EiJ MGP_CASTEiJ_G0022236
protein coding gene Chr16:88089648-88295753 (-)
CBA/J MGP_CBAJ_G0022683
protein coding gene Chr16:95435069-95646628 (-)
DBA/2J MGP_DBA2J_G0022817
protein coding gene Chr16:84489796-84670976 (-)
FVB/NJ MGP_FVBNJ_G0022792
protein coding gene Chr16:83582067-83771989 (-)
LP/J MGP_LPJ_G0022886
protein coding gene Chr16:88330505-88523773 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022811
protein coding gene Chr16:99992615-100193948 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023417
protein coding gene Chr16:87608715-87800339 (-)
PWK/PhJ MGP_PWKPhJ_G0021979
protein coding gene Chr16:84595113-84806694 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021809
protein coding gene Chr16:87150785-87340049 (-)
WSB/EiJ MGP_WSBEiJ_G0022284
protein coding gene Chr16:87839918-88033002 (-)



Homology
more
  • Human Ortholog
    GRIK1, glutamate ionotropic receptor kainate type subunit 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GRIK1, glutamate ionotropic receptor kainate type subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EAA3, EEA3, GLR5, GluK1, gluR-5, GLUR5
  • Links
    NCBI Gene ID: 2897
    neXtProt AC: NX_P39086
    UniProt: P39086

  • Chr Location
    21q21.3; chr21:29536933-29940052 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022935 Ensembl Gene Model | MGI Sequence Detail 394366 C57BL/6J ±  kb
    transcript ENSMUST00000227986 Ensembl | MGI Sequence Detail 2942 Not Applicable  
    polypeptide ENSMUSP00000153786 Ensembl | MGI Sequence Detail 949 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • Protein Ontology
      PR:000008240 glutamate receptor ionotropic, kainate 1
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10144, MGD-MRK-10151, MGD-MRK-10252, MGD-MRK-33850, MGI:106163, MGI:2443714
    References
    more
    • Summaries
      All 115
      Developmental Gene Expression 14
      Gene Ontology 23
      Phenotypes 40
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    06/11/2019
    MGI 6.14
    The Jackson Laboratory