Grik1
Gene Detail

Symbol Name ID

Grik1 glutamate receptor, ionotropic, kainate 1 MGI:95814

Synonyms

A830007B11Rik, D16Ium24, D16Ium24e, GluK5, Glur5, Glur-5, Glurbeta1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

50.23 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr16:87896196-88056176 bp, - strand From Ensembl annotation of GRCm38   159981 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68992  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik1

Human homologs

Human Homolog		GRIK1, glutamate receptor, ionotropic, kainate 1
NCBI Gene ID		2897
neXtProt AC		NX_P39086
Human Synonyms		EAA3, EEA3, GLR5, GluK1, GLUR5
Human Chr (Location)		21q22.11; chr21:30909254-31312282 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	adult behavior, behavioral response to pain, ...
Component	cell junction, dendrite, ...
Function	drug binding, extracellular-glutamate-gated ion channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (184)    Tissues (149)    Images (17)
Theiler Stages: 13, 14, 15, 17, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	166
RT-PCR	18

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(30) Genomic(1) cDNA(26) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000022935 (Evidence)
Entrez Gene	14805 (Evidence)
UniGene	5134
DFCI	TC1582409, TC1586532, TC1592943, TC1596903, TC1602124, TC1608344, TC1613293, TC1624364, TC1756461
DoTS	DT.101286834, DT.101343989, DT.101703385, DT.101736192, DT.101736193, DT.101736194, DT.110718140, DT.40139317, DT.60103161, DT.91330182, DT.94189737
NIA Mouse Gene Index	U037256
International Mouse Knockout Project Status	Grik1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022935	Ensembl Gene Model | MGI Sequence Detail	159981	C57BL/6J
transcript	ENSMUST00000072256	Ensembl | MGI Sequence Detail	2688	Not Applicable
polypeptide	ENSMUSP00000072107	Ensembl | MGI Sequence Detail	895	Not Applicable

All sequences(65) RefSeq(4) UniProt(11)

Polymorphisms

RFLP(2) : SNPs(2284 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008240	glutamate receptor, ionotropic kainate 1

References

(Earliest) J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
(Latest) J:193538 Cui S, et al., Developmental expression patterns of kainate receptors in the mouse spinal cord. Neuroreport. 2012 Dec 5;23(17):1012-6
All references(90)

Other accession IDs

MGD-MRK-10144, MGD-MRK-10151, MGD-MRK-10252, MGD-MRK-33850, MGI:106163, MGI:2443714