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Grik1 Gene Detail
Summary
  • Symbol
    Grik1
  • Name
    glutamate receptor, ionotropic, kainate 1
  • Synonyms
    A830007B11Rik, D16Ium24, D16Ium24e, GluK5, Glur-5, Glur5, Glurbeta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95814
    NCBI Gene: 14805
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87692788-88087153 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 50.23 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12022 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95814
 protein coding gene Chr16:87692788-88087751 (-)
129S1/SvImJ ENSMUSG00200036991
 protein coding gene Chr16:84563182-84962782 (-)
A/J ENSMUSG00195025950
 protein coding gene Chr16:84371242-84766113 (-)
AKR/J ENSMUSG00220015489
 protein coding gene Chr16:84563224-84954247 (-)
BALB/cJ ENSMUSG00180014470
 protein coding gene Chr16:84443816-84838248 (-)
C3H/HeJ ENSMUSG00175014395
 protein coding gene Chr16:84778855-85177673 (-)
C57BL/6NJ ENSMUSG00215024342
 protein coding gene Chr16:84573221-84968094 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020903
 protein coding gene Chr16:82403607-82559065 (-)
CAST/EiJ ENSTCUG00005017839
 protein coding gene Chr16:84134116-84527283 (-)
CBA/J ENSMUSG00210038269
 protein coding gene Chr16:84669592-85063994 (-)
DBA/2J ENSMUSG00185032522
 protein coding gene Chr16:84623433-85018402 (-)
FVB/NJ ENSMUSG00205016449
 protein coding gene Chr16:84422418-84816824 (-)
JF1/MsJ ENSUMUG00000016819
 protein coding gene Chr16:84753466-85164227 (-)
LP/J ENSMUSG00230033858
 protein coding gene Chr16:87124223-87523792 (-)
NOD/ShiLtJ ENSMUSG00190023660
 protein coding gene Chr16:84587991-84993908 (-)
NZO/HlLtJ ENSMUSG00225030760
 protein coding gene Chr16:90312678-90701682 (-)
PWK/PhJ ENSLUMG00010013557
 protein coding gene Chr16:84406683-84797232 (-)
SPRET/EiJ ENSMSPG00010026177
 protein coding gene Chr16:85504899-85913755 (-)
WSB/EiJ ENSIUOG00005018650
 protein coding gene Chr16:84569712-84960765 (-)



Homology
more
  • Human Ortholog
    GRIK1, glutamate ionotropic receptor kainate type subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK1, glutamate ionotropic receptor kainate type subunit 1
  • Synonyms
    EAA3, EEA3, GLR5, GluK1, gluR-5, GLUR5
  • Links
    NCBI Gene ID: 2897
    UniProt: P39086

  • Chr Location
    21q21.3; chr21:29536933-29940033 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIK1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    59 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    848
  • Tissues
    185
  • cDNA Data
    26
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022935 Ensembl Gene Model | MGI Sequence Detail 394366 C57BL/6J ±  kb
    transcript ENSMUST00000227986 Ensembl | MGI Sequence Detail 2942 Not Applicable  
    polypeptide ENSMUSP00000153786 Ensembl | MGI Sequence Detail 949 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      15 Sequences
    • Protein Ontology
      PR:000008240 glutamate receptor ionotropic, kainate 1
      (term hierarchy)
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      Q60934 9 sites, 9 N-linked glycans (6 sites)
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 27
      Primer pair 5
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10144, MGD-MRK-10151, MGD-MRK-10252, MGD-MRK-33850, MGI:106163, MGI:2443714
    References
    more
    • Summaries
      All 149
      Developmental Gene Expression 20
      Gene Ontology 26
      Phenotypes 59
    • Earliest
      J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
    • Latest
      J:387850 Rhee JK, et al., GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior. Transl Psychiatry. 2026 Apr 30;16(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory