Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Epha4

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EPHA4
- Mouse genes Epha4
- Rat genes Epha4
- Zfish genes epha4a,epha4l
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epha4

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0097161	DH domain binding	EPHA4	IDA		Human	PMID:12775584
Molecular Function	GO:0046875	ephrin receptor binding	Epha4	IDA		Rat	PMID:10366629\|RGD:2301959
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	Epha4	IMP		Mouse	MGI:MGI:3696283\|PMID:17143272
Molecular Function	GO:0005004	GPI-linked ephrin receptor activity	Epha4	IMP		Mouse	MGI:MGI:3772555\|PMID:18094260
Molecular Function	GO:0042802	identical protein binding	Epha4	IPI	UniProtKB:Q03137	Mouse	MGI:MGI:5508623\|PMID:16977320
Molecular Function	GO:0016301	kinase activity	EPHA4	IGI	UniProtKB:P20827\|UniProtKB:P52797	Human	PMID:24217950
Molecular Function	GO:0042731	PH domain binding	EPHA4	IPI	UniProtKB:O94989	Human	PMID:12775584
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:O94989	Human	PMID:12775584
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:O43921	Human	PMID:19836338
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:P52799	Human	PMID:19836338
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:P52803	Human	PMID:19836338
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:P52803	Human	PMID:23812375
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:Q15768	Human	PMID:23812375
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:Q15768	Human	PMID:28514442
Molecular Function	GO:0005515	protein binding	EPHA4	IPI	UniProtKB:P29323	Human	PMID:35384245
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q91V57-2	Mouse	MGI:MGI:3767884\|PMID:17785183
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q91V57-1	Mouse	MGI:MGI:3759704\|PMID:17719550
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:P54763\|UniProtKB:Q03145	Mouse	MGI:MGI:5508623\|PMID:16977320
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q8C0T5	Mouse	MGI:MGI:3772555\|PMID:18094260
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q8CHT1	Mouse	MGI:MGI:3696283\|PMID:17143272
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q91V57	Mouse	MGI:MGI:3759704\|PMID:17719550
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:O95292\|UniProtKB:P52800	Mouse	MGI:MGI:3810017\|PMID:18555774
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q921Q7	Mouse	MGI:MGI:6092541\|PMID:18723684
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:A0A0G2JTU0	Rat	PMID:12775584\|RGD:8554375
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:D3ZPJ8	Rat	PMID:12775584\|RGD:8554375
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:P61810	Rat	PMID:17143272\|RGD:8554385
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:Q03114	Rat	PMID:17143272\|RGD:8554385
Molecular Function	GO:0005515	protein binding	Epha4	IPI	UniProtKB:P00520	Rat	PMID:24658113\|RGD:12911004
Molecular Function	GO:0004672	protein kinase activity	EPHA4	IDA		Human	PMID:12775584
Molecular Function	GO:1990782	protein tyrosine kinase binding	EPHA4	IPI	UniProtKB:P07948	Human	PMID:24217950
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	Epha4	IDA		Mouse	MGI:MGI:7432482\|PMID:31439799
Molecular Function	GO:0005005	transmembrane-ephrin receptor activity	Epha4	IDA		Mouse	MGI:MGI:3759704\|PMID:17719550
Cellular Component	GO:0030424	axon	Epha4	IDA		Mouse	MGI:MGI:3696283\|PMID:17143272
Cellular Component	GO:0043679	axon terminus	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0044295	axonal growth cone	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0044297	cell body	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0042995	cell projection	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0009986	cell surface	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0005737	cytoplasm	Epha4	IDA		Rat	PMID:12775584\|RGD:8554375
Cellular Component	GO:0030425	dendrite	Epha4	IDA		Mouse	MGI:MGI:3696283\|PMID:17143272
Cellular Component	GO:0030425	dendrite	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0043198	dendritic shaft	Epha4	IDA		Rat	PMID:24658113\|RGD:12911004
Cellular Component	GO:0043197	dendritic spine	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0043197	dendritic spine	Epha4	IDA		Rat	PMID:24658113\|RGD:12911004
Cellular Component	GO:0031901	early endosome membrane	Epha4	IDA		Mouse	MGI:MGI:3696283\|PMID:17143272
Cellular Component	GO:0005783	endoplasmic reticulum	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0030175	filopodium	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IDA		Mouse	PMID:18410519
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IEP		Mouse	PMID:18410519
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IMP		Mouse	PMID:12496762
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	EXP		Mouse	PMID:12496762
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IDA		Mouse	PMID:12496762
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	EXP		Rat	PMID:17143272\|RGD:8554385
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IDA		Rat	PMID:17143272\|RGD:8554385
Cellular Component	GO:0098978	glutamatergic synapse	Epha4	IMP		Rat	PMID:17143272\|RGD:8554385
Cellular Component	GO:0005794	Golgi apparatus	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0005741	mitochondrial outer membrane	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0031594	neuromuscular junction	Epha4	IDA		Rat	PMID:11414792\|RGD:2301728
Cellular Component	GO:0043204	perikaryon	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0005886	plasma membrane	Epha4	IDA		Mouse	MGI:MGI:3696283\|PMID:17143272
Cellular Component	GO:0005886	plasma membrane	Epha4	IDA		Rat	PMID:17143272\|RGD:8554385
Cellular Component	GO:0005886	plasma membrane	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0014069	postsynaptic density	Epha4	IDA		Rat	PMID:17143272\|RGD:8554385
Cellular Component	GO:0014069	postsynaptic density	Epha4	IDA		Rat	PMID:19086003\|RGD:5688744
Cellular Component	GO:0045211	postsynaptic membrane	Epha4	IDA		Mouse	PMID:18410519
Cellular Component	GO:0045211	postsynaptic membrane	Epha4	IEP		Mouse	PMID:18410519
Cellular Component	GO:0042734	presynaptic membrane	Epha4	IDA		Mouse	PMID:18410519
Cellular Component	GO:0042734	presynaptic membrane	Epha4	IEP		Mouse	PMID:18410519
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Epha4	IEP		Mouse	PMID:18410519
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	Epha4	IDA		Mouse	PMID:18410519
Biological Process	GO:0034332	adherens junction organization	Epha4	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Biological Process	GO:0007628	adult walking behavior	Epha4	IMP	MGI:MGI:2654411	Mouse	PMID:12649481
Biological Process	GO:0009952	anterior/posterior pattern specification	epha4a	IMP	ZFIN:ZDB-MRPHLNO-050522-1	Zfish	PMID:15797022
Biological Process	GO:0007411	axon guidance	Epha4	IGI	MGI:MGI:2679336	Mouse	PMID:23144223
Biological Process	GO:0007411	axon guidance	Epha4	IMP	MGI:MGI:2654411	Mouse	PMID:12649481
Biological Process	GO:0009988	cell-cell recognition	epha4a	IMP	ZFIN:ZDB-MRPHLNO-050522-1	Zfish	PMID:15797022
Biological Process	GO:1904646	cellular response to amyloid-beta	Epha4	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5588508\|PMID:24658113
Biological Process	GO:0090102	cochlea development	Epha4	IMP		Mouse	MGI:MGI:6316556\|PMID:30639848
Biological Process	GO:0021957	corticospinal tract morphogenesis	Epha4	IMP		Mouse	MGI:MGI:1306963\|PMID:9789074
Biological Process	GO:0048013	ephrin receptor signaling pathway	EPHA4	IGI	UniProtKB:P20827\|UniProtKB:P52797	Human	PMID:24217950
Biological Process	GO:0097156	fasciculation of motor neuron axon	Epha4	IMP		Mouse	MGI:MGI:3783924\|PMID:18403711
Biological Process	GO:0097155	fasciculation of sensory neuron axon	Epha4	IMP		Mouse	MGI:MGI:3783924\|PMID:18403711
Biological Process	GO:0030900	forebrain development	epha4a	IMP		Zfish	PMID:8692269
Biological Process	GO:0008347	glial cell migration	Epha4	IMP		Rat	PMID:20335460\|RGD:5688742
Biological Process	GO:0008045	motor neuron axon guidance	Epha4	IMP		Mouse	MGI:MGI:3767884\|PMID:17785183
Biological Process	GO:0030517	negative regulation of axon extension	epha4a	IGI	ZFIN:ZDB-MRPHLNO-051026-3,ZFIN:ZDB-MRPHLNO-121114-1	Zfish	PMID:22922411
Biological Process	GO:0030517	negative regulation of axon extension	epha4a	IGI	ZFIN:ZDB-GENE-990415-258,ZFIN:ZDB-MRPHLNO-121114-1	Zfish	PMID:22922411
Biological Process	GO:0048681	negative regulation of axon regeneration	Epha4	IMP		Mouse	MGI:MGI:3530975\|PMID:15537875
Biological Process	GO:0048681	negative regulation of axon regeneration	Epha4	IMP		Rat	PMID:17970742\|RGD:5688750
Biological Process	GO:0007162	negative regulation of cell adhesion	EPHA4	IMP		Human	PMID:29093007
Biological Process	GO:0030336	negative regulation of cell migration	EPHA4	IMP		Human	PMID:22996586
Biological Process	GO:0030336	negative regulation of cell migration	EPHA4	IMP		Human	PMID:29093007
Biological Process	GO:1900038	negative regulation of cellular response to hypoxia	EPHA4	IMP		Human	PMID:31150684
Biological Process	GO:0048685	negative regulation of collateral sprouting of intact axon in response to injury	epha4a	IGI	ZFIN:ZDB-GENE-990415-258,ZFIN:ZDB-MRPHLNO-121114-1	Zfish	PMID:22922411
Biological Process	GO:0010719	negative regulation of epithelial to mesenchymal transition	EPHA4	IMP		Human	PMID:29093007
Biological Process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	EPHA4	IDA		Human	PMID:29093007
Biological Process	GO:1900272	negative regulation of long-term synaptic potentiation	Epha4	IGI	ComplexPortal:CPX-1134,UniProtKB:P00520	Mouse	MGI:MGI:5588508\|PMID:24658113
Biological Process	GO:0010977	negative regulation of neuron projection development	Epha4	IDA		Mouse	MGI:MGI:5905552\|PMID:12761826
Biological Process	GO:1903051	negative regulation of proteolysis involved in protein catabolic process	EPHA4	IGI	UniProtKB:P20827	Human	PMID:24217950
Biological Process	GO:0072178	nephric duct morphogenesis	Epha4	IGI	MGI:MGI:95276	Mouse	PMID:25139858
Biological Process	GO:0106030	neuron projection fasciculation	Epha4	IDA		Mouse	MGI:MGI:5905552\|PMID:12761826
Biological Process	GO:0097485	neuron projection guidance	Epha4	IDA		Mouse	MGI:MGI:5905552\|PMID:12761826
Biological Process	GO:0003404	optic vesicle morphogenesis	epha4a	IGI	ZFIN:ZDB-MRPHLNO-050522-1,ZFIN:ZDB-MRPHLNO-050523-1,ZFIN:ZDB-MRPHLNO-131219-1	Zfish	PMID:24026122
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	EPHA4	IDA		Human	PMID:12775584
Biological Process	GO:1902004	positive regulation of amyloid-beta formation	EPHA4	IGI	UniProtKB:P20827	Human	PMID:24217950
Biological Process	GO:1902961	positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	EPHA4	IGI	UniProtKB:P20827\|UniProtKB:P52797	Human	PMID:24217950
Biological Process	GO:0045785	positive regulation of cell adhesion	EPHA4	IMP		Human	PMID:22996586
Biological Process	GO:0030335	positive regulation of cell migration	EPHA4	IDA		Human	PMID:28795314
Biological Process	GO:0008284	positive regulation of cell population proliferation	EPHA4	IGI	RNAcentral:URS0000237AF9_9606	Human	PMID:28795314
Biological Process	GO:0050775	positive regulation of dendrite morphogenesis	Epha4	IMP		Rat	PMID:19414612\|RGD:5688776
Biological Process	GO:0043507	positive regulation of JUN kinase activity	Epha4	IDA		Mouse	MGI:MGI:1890011\|PMID:10523642
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	Epha4	IGI	ComplexPortal:CPX-1134	Mouse	MGI:MGI:5588508\|PMID:24658113
Biological Process	GO:2001108	positive regulation of Rho guanyl-nucleotide exchange factor activity	EPHA4	IDA		Human	PMID:12775584
Biological Process	GO:0046777	protein autophosphorylation	EPHA4	IDA		Human	PMID:12775584
Biological Process	GO:0050821	protein stabilization	EPHA4	IGI	UniProtKB:P20827	Human	PMID:24217950
Biological Process	GO:0048710	regulation of astrocyte differentiation	Epha4	IMP		Mouse	MGI:MGI:3530975\|PMID:15537875
Biological Process	GO:0050770	regulation of axonogenesis	Epha4	IMP		Mouse	MGI:MGI:3530975\|PMID:15537875
Biological Process	GO:0061001	regulation of dendritic spine morphogenesis	Epha4	IMP		Mouse	MGI:MGI:3696283\|PMID:17143272
Biological Process	GO:0043087	regulation of GTPase activity	Epha4	IDA		Mouse	MGI:MGI:3759704\|PMID:17719550
Biological Process	GO:0043087	regulation of GTPase activity	Epha4	IMP		Mouse	MGI:MGI:3772555\|PMID:18094260
Biological Process	GO:0043087	regulation of GTPase activity	Epha4	IDA		Rat	PMID:17143272\|RGD:8554385
Biological Process	GO:1905244	regulation of modification of synaptic structure	Epha4	IGI	ComplexPortal:CPX-1134,UniProtKB:P00520	Mouse	MGI:MGI:5588508\|PMID:24658113
Biological Process	GO:1905244	regulation of modification of synaptic structure	Epha4	IGI	ComplexPortal:CPX-1134	Rat	PMID:24658113\|RGD:12911004
Biological Process	GO:0031641	regulation of myelination	epha4a	IMP	ZFIN:ZDB-MRPHLNO-121114-1	Zfish	PMID:29350423
Biological Process	GO:0031641	regulation of myelination	epha4a	IMP	ZFIN:ZDB-MRPHLNO-050522-2	Zfish	PMID:29350423
Biological Process	GO:1905806	regulation of synapse pruning	Epha4	EXP		Rat	PMID:17143272\|RGD:8554385
Biological Process	GO:1905806	regulation of synapse pruning	Epha4	IDA		Rat	PMID:17143272\|RGD:8554385
Biological Process	GO:1905806	regulation of synapse pruning	Epha4	IEP		Rat	PMID:17143272\|RGD:8554385
Biological Process	GO:1905806	regulation of synapse pruning	Epha4	IMP		Rat	PMID:17143272\|RGD:8554385
Biological Process	GO:0021654	rhombomere boundary formation	epha4a	IMP	ZFIN:ZDB-MRPHLNO-050522-1	Zfish	PMID:22764046
Biological Process	GO:0021654	rhombomere boundary formation	epha4a	IMP	ZFIN:ZDB-MRPHLNO-050522-1	Zfish	PMID:15797022
Biological Process	GO:0021654	rhombomere boundary formation	epha4a	IGI	ZFIN:ZDB-MRPHLNO-050522-1,ZFIN:ZDB-MRPHLNO-050523-1	Zfish	PMID:15797022
Biological Process	GO:0021654	rhombomere boundary formation	epha4a	IGI	ZFIN:ZDB-MRPHLNO-050522-1,ZFIN:ZDB-MRPHLNO-050712-3	Zfish	PMID:19135438
Biological Process	GO:0061053	somite development	epha4a	IGI	ZFIN:ZDB-GENE-020416-5	Zfish	PMID:13678588
Biological Process	GO:0098883	synapse pruning	Epha4	IMP		Mouse	PMID:12496762
Biological Process	GO:0098883	synapse pruning	Epha4	IDA		Mouse	PMID:12496762
Biological Process	GO:0098883	synapse pruning	Epha4	EXP		Mouse	PMID:12496762

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.