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Gene Ontology Browser
Term Detail
GO term:dendritic spine
Synonym: branched dendritic spine
Synonym: dendrite spine
Synonym: mushroom dendritic spine
Synonym: sessile dendritic spine
Synonym: stubby dendritic spine
Synonym: thin dendritic spine
GO id:GO:0043197
Definition:Protrusion from a dendrite. Spines are specialised subcellular compartments involved in the synaptic transmission. They are linked to the dendritic shaft by a restriction. Because of their bulb shape, they function as a biochemical and an electrical compartment. Spine remodeling is though to be involved in synaptic plasticity.
Number of paths to term: 21

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection
                                        part-ofcell projection part
                                                is-aactin fusion focus
                                                is-aaxon part +
                                                is-abacterial-type flagellum part +
                                                is-acell projection cytoplasm +
                                                is-acell projection membrane +
                                                is-aciliary part +
                                                is-acytoplasmic side of dendritic spine plasma membrane
                                                is-acytoskeleton of dendritic spine
                                                is-adeep fiber
                                                is-adendrite terminus +
                                                is-adendritic branch
                                                is-adendritic branch point
                                                is-adendritic filopodium
                                                is-adendritic lamellar body
                                                is-adendritic microtubule
                                                is-adendritic shaft
                                                is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                is-adendritic spine head
                                                is-adendritic spine neck
                                                is-afilopodium tip
                                                is-agrowth cone +
                                                is-agrowth cone filopodium
                                                is-agrowth cone lamellipodium
                                                is-agrowth cone membrane
                                                is-ainaD signaling complex
                                                is-aintegral component of muscle cell projection membrane
                                                is-aleft lateral basal body pair
                                                is-aleft middle basal body pair
                                                is-aleft tetrad
                                                is-amacropinocytic cup cytoskeleton
                                                is-amating projection base
                                                is-amating projection septin band
                                                is-amating projection septin ring
                                                is-amating projection tip +
                                                is-amating projection tip membrane
                                                is-amating projection tip polarisome
                                                is-amicrovillar actin bundle
                                                is-aneuron projection terminus +
                                                is-aneuronal postsynaptic density
                                                is-aneuronal ribonucleoprotein granule
                                                is-apilus part +
                                                is-apollen tube tip
                                                is-aproximal dendrite
                                                is-arhabdomere microvillus +
                                                is-aright lateral basal body pair
                                                is-aright middle basal body pair
                                                is-aright tetrad
                                                is-aroot hair tip
                                                is-aspine apparatus
                                                is-astereocilia tip-link density +
                                                is-asubrhabdomeral cisterna
                                                is-aunicellular trichome apex +
                                                is-aunicellular trichome branch
                                                is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection
                                        is-aneuron projection
                                                is-adendrite
                                                        is-aapical dendrite
                                                        is-abasilar dendrite
                                                        is-aCA3 pyramidal cell dendrite
                                                        part-ofdendrite cytoplasm
                                                        part-ofdendrite terminus +
                                                        part-ofdendritic branch
                                                        part-ofdendritic branch point
                                                        part-ofdendritic filopodium
                                                        part-ofdendritic lamellar body
                                                        part-ofdendritic microtubule
                                                        part-ofdendritic shaft
                                                        part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                                part-ofcytoskeleton of dendritic spine
                                                                part-ofdendritic spine head
                                                                part-ofdendritic spine neck
                                                                is-athorny excrescence
                                                        part-ofproximal dendrite
                                                        is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection
                                        is-aneuron projection
                                                is-aneuron spine
                                                        is-aaxonal spine
                                                        is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                                part-ofcytoskeleton of dendritic spine
                                                                part-ofdendritic spine head
                                                                part-ofdendritic spine neck
                                                                is-athorny excrescence
                                                        is-asomatic spine
                                                        part-ofspine apparatus


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-acell projection part
                                        is-aactin fusion focus
                                        is-aaxon part +
                                        is-abacterial-type flagellum part +
                                        is-acell projection cytoplasm +
                                        is-acell projection membrane +
                                        is-aciliary part +
                                        is-acytoplasmic side of dendritic spine plasma membrane
                                        is-acytoskeleton of dendritic spine
                                        is-adeep fiber
                                        is-adendrite terminus +
                                        is-adendritic branch
                                        is-adendritic branch point
                                        is-adendritic filopodium
                                        is-adendritic lamellar body
                                        is-adendritic microtubule
                                        is-adendritic shaft
                                        is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                part-ofcytoskeleton of dendritic spine
                                                part-ofdendritic spine head
                                                part-ofdendritic spine neck
                                                is-athorny excrescence
                                        is-adendritic spine head
                                        is-adendritic spine neck
                                        is-afilopodium tip
                                        is-agrowth cone +
                                        is-agrowth cone filopodium
                                        is-agrowth cone lamellipodium
                                        is-agrowth cone membrane
                                        is-ainaD signaling complex
                                        is-aintegral component of muscle cell projection membrane
                                        is-aleft lateral basal body pair
                                        is-aleft middle basal body pair
                                        is-aleft tetrad
                                        is-amacropinocytic cup cytoskeleton
                                        is-amating projection base
                                        is-amating projection septin band
                                        is-amating projection septin ring
                                        is-amating projection tip +
                                        is-amating projection tip membrane
                                        is-amating projection tip polarisome
                                        is-amicrovillar actin bundle
                                        is-aneuron projection terminus +
                                        is-aneuronal postsynaptic density
                                        is-aneuronal ribonucleoprotein granule
                                        is-apilus part +
                                        is-apollen tube tip
                                        is-aproximal dendrite
                                        is-arhabdomere microvillus +
                                        is-aright lateral basal body pair
                                        is-aright middle basal body pair
                                        is-aright tetrad
                                        is-aroot hair tip
                                        is-aspine apparatus
                                        is-astereocilia tip-link density +
                                        is-asubrhabdomeral cisterna
                                        is-aunicellular trichome apex +
                                        is-aunicellular trichome branch
                                        is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aneuron part
                                        is-aneuron projection
                                                is-adendrite
                                                        is-aapical dendrite
                                                        is-abasilar dendrite
                                                        is-aCA3 pyramidal cell dendrite
                                                        part-ofdendrite cytoplasm
                                                        part-ofdendrite terminus +
                                                        part-ofdendritic branch
                                                        part-ofdendritic branch point
                                                        part-ofdendritic filopodium
                                                        part-ofdendritic lamellar body
                                                        part-ofdendritic microtubule
                                                        part-ofdendritic shaft
                                                        part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                                part-ofcytoskeleton of dendritic spine
                                                                part-ofdendritic spine head
                                                                part-ofdendritic spine neck
                                                                is-athorny excrescence
                                                        part-ofproximal dendrite
                                                        is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aneuron part
                                        is-aneuron projection
                                                is-aneuron spine
                                                        is-aaxonal spine
                                                        is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                                part-ofcytoskeleton of dendritic spine
                                                                part-ofdendritic spine head
                                                                part-ofdendritic spine neck
                                                                is-athorny excrescence
                                                        is-asomatic spine
                                                        part-ofspine apparatus


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-aneuron part
                                        is-asomatodendritic compartment
                                                part-ofdendrite
                                                        is-aapical dendrite
                                                        is-abasilar dendrite
                                                        is-aCA3 pyramidal cell dendrite
                                                        part-ofdendrite cytoplasm
                                                        part-ofdendrite terminus +
                                                        part-ofdendritic branch
                                                        part-ofdendritic branch point
                                                        part-ofdendritic filopodium
                                                        part-ofdendritic lamellar body
                                                        part-ofdendritic microtubule
                                                        part-ofdendritic shaft
                                                        part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                                part-ofcytoskeleton of dendritic spine
                                                                part-ofdendritic spine head
                                                                part-ofdendritic spine neck
                                                                is-athorny excrescence
                                                        part-ofproximal dendrite
                                                        is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell
                        part-ofcell part
                                is-apostsynapse
                                        part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                part-ofcytoskeleton of dendritic spine
                                                part-ofdendritic spine head
                                                part-ofdendritic spine neck
                                                is-athorny excrescence
                                        part-ofpostsynaptic density +
                                        part-ofpostsynaptic early endosome
                                        part-ofpostsynaptic endocytic zone +
                                        part-ofpostsynaptic endosome +
                                        part-ofpostsynaptic membrane +
                                        part-ofpostsynaptic recycling endosome


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection
                                part-ofcell projection part
                                        is-aactin fusion focus
                                        is-aaxon part +
                                        is-abacterial-type flagellum part +
                                        is-acell projection cytoplasm +
                                        is-acell projection membrane +
                                        is-aciliary part +
                                        is-acytoplasmic side of dendritic spine plasma membrane
                                        is-acytoskeleton of dendritic spine
                                        is-adeep fiber
                                        is-adendrite terminus +
                                        is-adendritic branch
                                        is-adendritic branch point
                                        is-adendritic filopodium
                                        is-adendritic lamellar body
                                        is-adendritic microtubule
                                        is-adendritic shaft
                                        is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                part-ofcytoskeleton of dendritic spine
                                                part-ofdendritic spine head
                                                part-ofdendritic spine neck
                                                is-athorny excrescence
                                        is-adendritic spine head
                                        is-adendritic spine neck
                                        is-afilopodium tip
                                        is-agrowth cone +
                                        is-agrowth cone filopodium
                                        is-agrowth cone lamellipodium
                                        is-agrowth cone membrane
                                        is-ainaD signaling complex
                                        is-aintegral component of muscle cell projection membrane
                                        is-aleft lateral basal body pair
                                        is-aleft middle basal body pair
                                        is-aleft tetrad
                                        is-amacropinocytic cup cytoskeleton
                                        is-amating projection base
                                        is-amating projection septin band
                                        is-amating projection septin ring
                                        is-amating projection tip +
                                        is-amating projection tip membrane
                                        is-amating projection tip polarisome
                                        is-amicrovillar actin bundle
                                        is-aneuron projection terminus +
                                        is-aneuronal postsynaptic density
                                        is-aneuronal ribonucleoprotein granule
                                        is-apilus part +
                                        is-apollen tube tip
                                        is-aproximal dendrite
                                        is-arhabdomere microvillus +
                                        is-aright lateral basal body pair
                                        is-aright middle basal body pair
                                        is-aright tetrad
                                        is-aroot hair tip
                                        is-aspine apparatus
                                        is-astereocilia tip-link density +
                                        is-asubrhabdomeral cisterna
                                        is-aunicellular trichome apex +
                                        is-aunicellular trichome branch
                                        is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection
                                is-aneuron projection
                                        is-adendrite
                                                is-aapical dendrite
                                                is-abasilar dendrite
                                                is-aCA3 pyramidal cell dendrite
                                                part-ofdendrite cytoplasm
                                                part-ofdendrite terminus +
                                                part-ofdendritic branch
                                                part-ofdendritic branch point
                                                part-ofdendritic filopodium
                                                part-ofdendritic lamellar body
                                                part-ofdendritic microtubule
                                                part-ofdendritic shaft
                                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                part-ofproximal dendrite
                                                is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection
                                is-aneuron projection
                                        is-aneuron spine
                                                is-aaxonal spine
                                                is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                is-asomatic spine
                                                part-ofspine apparatus


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-acell projection part
                                is-aactin fusion focus
                                is-aaxon part +
                                is-abacterial-type flagellum part +
                                is-acell projection cytoplasm +
                                is-acell projection membrane +
                                is-aciliary part +
                                is-acytoplasmic side of dendritic spine plasma membrane
                                is-acytoskeleton of dendritic spine
                                is-adeep fiber
                                is-adendrite terminus +
                                is-adendritic branch
                                is-adendritic branch point
                                is-adendritic filopodium
                                is-adendritic lamellar body
                                is-adendritic microtubule
                                is-adendritic shaft
                                is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                        part-ofcytoskeleton of dendritic spine
                                        part-ofdendritic spine head
                                        part-ofdendritic spine neck
                                        is-athorny excrescence
                                is-adendritic spine head
                                is-adendritic spine neck
                                is-afilopodium tip
                                is-agrowth cone +
                                is-agrowth cone filopodium
                                is-agrowth cone lamellipodium
                                is-agrowth cone membrane
                                is-ainaD signaling complex
                                is-aintegral component of muscle cell projection membrane
                                is-aleft lateral basal body pair
                                is-aleft middle basal body pair
                                is-aleft tetrad
                                is-amacropinocytic cup cytoskeleton
                                is-amating projection base
                                is-amating projection septin band
                                is-amating projection septin ring
                                is-amating projection tip +
                                is-amating projection tip membrane
                                is-amating projection tip polarisome
                                is-amicrovillar actin bundle
                                is-aneuron projection terminus +
                                is-aneuronal postsynaptic density
                                is-aneuronal ribonucleoprotein granule
                                is-apilus part +
                                is-apollen tube tip
                                is-aproximal dendrite
                                is-arhabdomere microvillus +
                                is-aright lateral basal body pair
                                is-aright middle basal body pair
                                is-aright tetrad
                                is-aroot hair tip
                                is-aspine apparatus
                                is-astereocilia tip-link density +
                                is-asubrhabdomeral cisterna
                                is-aunicellular trichome apex +
                                is-aunicellular trichome branch
                                is-aunicellular trichome tip


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aneuron part
                                is-aneuron projection
                                        is-adendrite
                                                is-aapical dendrite
                                                is-abasilar dendrite
                                                is-aCA3 pyramidal cell dendrite
                                                part-ofdendrite cytoplasm
                                                part-ofdendrite terminus +
                                                part-ofdendritic branch
                                                part-ofdendritic branch point
                                                part-ofdendritic filopodium
                                                part-ofdendritic lamellar body
                                                part-ofdendritic microtubule
                                                part-ofdendritic shaft
                                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                part-ofproximal dendrite
                                                is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aneuron part
                                is-aneuron projection
                                        is-aneuron spine
                                                is-aaxonal spine
                                                is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                is-asomatic spine
                                                part-ofspine apparatus


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-aneuron part
                                is-asomatodendritic compartment
                                        part-ofdendrite
                                                is-aapical dendrite
                                                is-abasilar dendrite
                                                is-aCA3 pyramidal cell dendrite
                                                part-ofdendrite cytoplasm
                                                part-ofdendrite terminus +
                                                part-ofdendritic branch
                                                part-ofdendritic branch point
                                                part-ofdendritic filopodium
                                                part-ofdendritic lamellar body
                                                part-ofdendritic microtubule
                                                part-ofdendritic shaft
                                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                        part-ofcytoskeleton of dendritic spine
                                                        part-ofdendritic spine head
                                                        part-ofdendritic spine neck
                                                        is-athorny excrescence
                                                part-ofproximal dendrite
                                                is-asensory dendrite


obsolete Gene_Ontology
        is-acellular_component
                is-acell part
                        is-apostsynapse
                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                        part-ofcytoskeleton of dendritic spine
                                        part-ofdendritic spine head
                                        part-ofdendritic spine neck
                                        is-athorny excrescence
                                part-ofpostsynaptic density +
                                part-ofpostsynaptic early endosome
                                part-ofpostsynaptic endocytic zone +
                                part-ofpostsynaptic endosome +
                                part-ofpostsynaptic membrane +
                                part-ofpostsynaptic recycling endosome


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofpostsynapse
                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                        part-ofcytoskeleton of dendritic spine
                                        part-ofdendritic spine head
                                        part-ofdendritic spine neck
                                        is-athorny excrescence
                                part-ofpostsynaptic density +
                                part-ofpostsynaptic early endosome
                                part-ofpostsynaptic endocytic zone +
                                part-ofpostsynaptic endosome +
                                part-ofpostsynaptic membrane +
                                part-ofpostsynaptic recycling endosome


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofsynapse part
                                is-aclathrin coat of synaptic vesicle
                                is-acytoplasmic side of dendritic spine plasma membrane
                                is-acytoskeleton of dendritic spine
                                is-acytoskeleton of presynaptic active zone
                                is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                        part-ofcytoskeleton of dendritic spine
                                        part-ofdendritic spine head
                                        part-ofdendritic spine neck
                                        is-athorny excrescence
                                is-adendritic spine head
                                is-adendritic spine membrane +
                                is-adendritic spine neck
                                is-aintegral component of synaptic vesicle membrane
                                is-aintrinsic component of synaptic vesicle membrane
                                is-apostsynapse +
                                is-apostsynaptic density +
                                is-apostsynaptic density membrane
                                is-apostsynaptic endocytic zone +
                                is-apostsynaptic endocytic zone membrane
                                is-apostsynaptic endosome +
                                is-apresynapse +
                                is-apresynaptic active zone +
                                is-apresynaptic active zone cytoplasmic component +
                                is-apresynaptic active zone dense projection
                                is-apresynaptic active zone membrane
                                is-apresynaptic endocytic zone +
                                is-apresynaptic endocytic zone membrane
                                is-apresynaptic endocytic zone, cytoplasmic component
                                is-apresynaptic endosome
                                is-apresynaptic grid
                                is-apresynaptic periactive zone
                                is-asubsynaptic reticulum
                                is-asynaptic cleft
                                is-asynaptic membrane +
                                is-asynaptic vesicle +
                                is-asynaptic vesicle lumen
                                is-asynaptic vesicle membrane +
                                is-asynaptic vesicle, readily releasable pool
                                is-asynaptic vesicle, recycling pool
                                is-asynaptic vesicle, resting pool
                                is-aterminal bouton +


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse
                        part-ofsynapse part
                                is-apostsynapse
                                        part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                                part-ofcytoskeleton of dendritic spine
                                                part-ofdendritic spine head
                                                part-ofdendritic spine neck
                                                is-athorny excrescence
                                        part-ofpostsynaptic density +
                                        part-ofpostsynaptic early endosome
                                        part-ofpostsynaptic endocytic zone +
                                        part-ofpostsynaptic endosome +
                                        part-ofpostsynaptic membrane +
                                        part-ofpostsynaptic recycling endosome


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse part
                        is-aclathrin coat of synaptic vesicle
                        is-acytoplasmic side of dendritic spine plasma membrane
                        is-acytoskeleton of dendritic spine
                        is-acytoskeleton of presynaptic active zone
                        is-adendritic spine [GO:0043197] (128 genes, 142 annotations)
                                part-ofcytoskeleton of dendritic spine
                                part-ofdendritic spine head
                                part-ofdendritic spine neck
                                is-athorny excrescence
                        is-adendritic spine head
                        is-adendritic spine membrane +
                        is-adendritic spine neck
                        is-aintegral component of synaptic vesicle membrane
                        is-aintrinsic component of synaptic vesicle membrane
                        is-apostsynapse +
                        is-apostsynaptic density +
                        is-apostsynaptic density membrane
                        is-apostsynaptic endocytic zone +
                        is-apostsynaptic endocytic zone membrane
                        is-apostsynaptic endosome +
                        is-apresynapse +
                        is-apresynaptic active zone +
                        is-apresynaptic active zone cytoplasmic component +
                        is-apresynaptic active zone dense projection
                        is-apresynaptic active zone membrane
                        is-apresynaptic endocytic zone +
                        is-apresynaptic endocytic zone membrane
                        is-apresynaptic endocytic zone, cytoplasmic component
                        is-apresynaptic endosome
                        is-apresynaptic grid
                        is-apresynaptic periactive zone
                        is-asubsynaptic reticulum
                        is-asynaptic cleft
                        is-asynaptic membrane +
                        is-asynaptic vesicle +
                        is-asynaptic vesicle lumen
                        is-asynaptic vesicle membrane +
                        is-asynaptic vesicle, readily releasable pool
                        is-asynaptic vesicle, recycling pool
                        is-asynaptic vesicle, resting pool
                        is-aterminal bouton +


obsolete Gene_Ontology
        is-acellular_component
                is-asynapse part
                        is-apostsynapse
                                part-ofdendritic spine [GO:0043197] (128 genes, 142 annotations)
                                        part-ofcytoskeleton of dendritic spine
                                        part-ofdendritic spine head
                                        part-ofdendritic spine neck
                                        is-athorny excrescence
                                part-ofpostsynaptic density +
                                part-ofpostsynaptic early endosome
                                part-ofpostsynaptic endocytic zone +
                                part-ofpostsynaptic endosome +
                                part-ofpostsynaptic membrane +
                                part-ofpostsynaptic recycling endosome


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory