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Epha4
Gene Detail
Symbol

Name
ID
Epha4
Eph receptor A4
MGI:98277
Synonyms
2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1
Feature Type
protein coding gene
Genetic Map
Chromosome 1
39.55 cM, cytoband C1-C5
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:77367189-77515088 bp, - strand
From VEGA annotation of GRCm38

  147900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHA4
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha4

Human
homologs
EPHA4, EPH receptor A4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2043
neXtProt AC: NX_P54764

Human Synonyms: HEK8, SEK, TYRO1

Human Chr (Location): 2q36.1; chr2:221418027-221574202 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Chemically induced (ENU)(1) Gene trapped(53) Spontaneous(2) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants are known for their "hopping gait". Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections. Heterozygotes show less severe phenotype.
 
Phenotype Images(2)
Interactions
Epha4 interacts with 445 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (81 annotations)
Process adult walking behavior, axon guidance, ...
Component axon, axonal growth cone, ...
Function ATP binding, DH domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (176 records)
Data Summary: Results (806)    Tissues (451)    Images (191)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 354
RNA in situ 413
In situ reporter (knock in) 4
Northern blot 12
Western blot 4
RT-PCR 19
cDNA source data(35)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA EPHA4 ; Xenbase epha4    NEW 
Molecular
reagents
All nucleic(61) cDNA(41) Primer pair(6) Other(14)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000047778 (Evidence)
Ensembl Gene Model ENSMUSG00000026235 (Evidence)
Entrez Gene 13838 (Evidence)
DFCI TC1577795, TC1600031, TC1731535, TC1691778
DoTS DT.94209730, DT.55281323, DT.97361124
NIA Mouse Gene Index U021506
EC 2.7.10.1
PDB 1B0X, 2XYU, 2I8J, 2HEL, 2Y6M, 2Y6O
Consensus CDS Project CCDS35627.1
International Mouse Phenotyping Consortium Status Epha4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047778 VEGA Gene Model | MGI Sequence Detail 147900 C57BL/6J ±  kb
transcript OTTMUST00000123013 VEGA | MGI Sequence Detail 3612 Not Applicable 
polypeptide OTTMUSP00000067293 VEGA | MGI Sequence Detail 986 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(6)
Polymorphisms
SNPs within 2kb(831 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007124 ephrin type-A receptor 4
References
(Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:219882 Kao TJ, et al., alpha2-chimaerin is required for Eph receptor-class-specific spinal motor axon guidance and coordinate activation of antagonistic muscles. J Neurosci. 2015 Feb 11;35(6):2344-57
All references(283)
Other
accession IDs
MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory