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Gene Detail
Eph receptor A4
Synonyms 2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1
Feature Type protein coding gene
Genetic Map
Chromosome 1
39.55 cM, cytoband C1-C5
Detailed Genetic Map ± 1 cM

Mapping data(4)
Sequence Map
Chr1:77367189-77515088 bp, - strand
From VEGA annotation of GRCm38

  147900 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:20933  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha4

Human Homolog EPHA4, EPH receptor A4
NCBI Gene ID 2043
neXtProt AC  NX_P54764
Human Synonyms  HEK8, SEK, TYRO1
Human Chr (Location)  2q36.1; chr2:221418027-221572290 (-)  GRCh38
alleles, and
All mutations/alleles(72) : Chemically induced (ENU)(1) Gene trapped(53) Spontaneous(2) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
Mutants are known for their "hopping gait". Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections. Heterozygotes show less severe phenotype.
Phenotype Images(2)
Epha4 interacts with 446 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
All GO classifications: (81 annotations)
Process adult walking behavior, axon guidance, ...
Component axon, axonal growth cone, ...
Function ATP binding, DH domain binding, ...
External Resources: FuncBase
Literature Summary: (167 records)
Data Summary: Results (807)    Tissues (452)    Images (191)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 354
RNA in situ 414
In situ reporter (knock in) 4
Northern blot 12
Western blot 4
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
All nucleic(61) cDNA(41) Primer pair(6) Other(14)
Microarray probesets(8)
Other database
VEGA Gene ModelOTTMUSG00000047778 (Evidence)
Ensembl Gene ModelENSMUSG00000026235 (Evidence)
Entrez Gene13838 (Evidence)
DFCITC1577795, TC1600031, TC1691778, TC1731535
DoTSDT.55281323, DT.94209730, DT.97361124
NIA Mouse Gene IndexU021506
PDB1B0X, 2HEL, 2I8J, 2XYU, 2Y6M, 2Y6O
Consensus CDS ProjectCCDS35627.1
International Mouse Knockout Project StatusEpha4
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047778 VEGA Gene Model | MGI Sequence Detail 147900 C57BL/6J ±  kb
transcript OTTMUST00000123012 VEGA | MGI Sequence Detail 6315 Not Applicable 
polypeptide OTTMUSP00000067292 VEGA | MGI Sequence Detail 986 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(831 from dbSNP Build 137)
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR011510 Sterile alpha motif, type 2
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007124 ephrin type-A receptor 4
References (Earliest) J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
(Latest) J:212169 Fu AK, et al., Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2014 Jul 8;111(27):9959-64
All references(274)
accession IDs
MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory