Epha4 MGI Mouse Gene Detail - MGI:98277

Symbol

Epha4
Name

Eph receptor A4
Synonyms

2900005C20Rik, Cek8, Hek8, rb, Sek, Sek1, Tyro1

Feature Type

protein coding gene
IDs

MGI:98277
NCBI Gene: 13838
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:77343822-77491725 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 39.55 cM, cytoband C1-C5
Mapping Data

5 experiments

SNPs within 2kb

3387 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98277	protein coding gene	Chr1:77343819-77491763 (-)
129S1/SvImJ	ENSMUSG00200035116	protein coding gene	Chr1:75027458-75162921 (-)
A/J	ENSMUSG00195010009	protein coding gene	Chr1:74440380-74576210 (-)
AKR/J	ENSMUSG00220010048	protein coding gene	Chr1:74586705-74729042 (-)
BALB/cJ	ENSMUSG00180019687	protein coding gene	Chr1:74702972-74838755 (-)
C3H/HeJ	ENSMUSG00175015850	protein coding gene	Chr1:74845353-74981148 (-)
C57BL/6NJ	ENSMUSG00215023036	protein coding gene	Chr1:74749446-74891781 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014307	protein coding gene	Chr1:70779309-70925699 (-)
CAST/EiJ	ENSTCUG00005027521	protein coding gene	Chr1:74452317-74588215 (-)
CBA/J	ENSMUSG00210033027	protein coding gene	Chr1:74537617-74679830 (-)
DBA/2J	ENSMUSG00185028345	protein coding gene	Chr1:75624156-75766452 (-)
FVB/NJ	ENSMUSG00205027147	protein coding gene	Chr1:74170067-74305559 (-)
JF1/MsJ	ENSUMUG00000004366	protein coding gene	Chr1:74509005-74646023 (-)
LP/J	ENSMUSG00230010991	protein coding gene	Chr1:75618119-75753563 (-)
NOD/ShiLtJ	ENSMUSG00190026332	protein coding gene	Chr1:74771941-74914293 (-)
NZO/HlLtJ	ENSMUSG00225039013	protein coding gene	Chr1:78825906-78968155 (-)
PWK/PhJ	ENSLUMG00010012567	protein coding gene	Chr1:74105744-74243100 (-)
SPRET/EiJ	ENSMSPG00010016658	protein coding gene	Chr1:76221503-76358547 (-)
WSB/EiJ	ENSIUOG00005012384	protein coding gene	Chr1:74367952-74503408 (-)

Human Ortholog

EPHA4, EPH receptor A4

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHA4, EPH receptor A4
Synonyms

EK8, HEK8, SEK, TYRO1
Links

HGNC:3388

NCBI Gene ID: 2043

UniProt: P54764
Chr Location

2q36.1; chr2:221418027-221574202 (-) GRCh38

MGI Vertebrate Homology

Epha4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EPHA4
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Epha4

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Phenotype Summary

37 phenotypes from 14 alleles in 21 genetic backgrounds
15 phenotypes from multigenic genotypes
2 images
123 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

79
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

5
Gene trapped

52
Radiation induced

1
Spontaneous

2
Targeted

17
Genomic Mutations

2 involving Epha4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations show loss of limb alternation in locomotion and axon guidance defects of the corticospinal tract within medulla and spinal cord, resulting in aberrant midline projections resulting in a hopping gait. Heterozygotes show a less severe phenotype.

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All GO Annotations

177
GO References

31

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1862
Tissues

631
cDNA Data

43
Literature Summary

233

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EPHA4

Xenbase epha4

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All Sequences

61
RefSeq

8
UniProt

6
CCDS

CCDS35627.1

Ensembl

ENSMUSG00000026235 (Evidence)
NCBI Gene

13838

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026235	Ensembl Gene Model \| MGI Sequence Detail	147904	C57BL/6J	± kb
transcript	ENSMUST00000188797	Ensembl \| MGI Sequence Detail	3612	Not Applicable
polypeptide	ENSMUSP00000140954	Ensembl \| MGI Sequence Detail	986	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000007124 ephrin type-A receptor 4

(term hierarchy)
PDB

1B0X, 2HEL, 2XYU, 2Y6M, 2Y6O
EC

2.7.10.1
InterPro Domains

IPR061283 Ephrin, cysteine rich domain

IPR001090 Ephrin, ligand binding domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR027936 Ephrin, transmembrane domain

IPR034270 Ephrin type-A receptor 4, ligand binding domain

IPR030602 Ephrin type-A receptor 4, SAM domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

Q03137 6 sites, 5 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 86

cDNA 50

Primer pair 6

Other 30

Antibodies 25

Microarray probesets 8

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MGD-MRK-14356, MGD-MRK-38166, MGI:109122, MGI:1920161, MGI:2138218

Summaries

All 404

Developmental Gene Expression 233

Gene Ontology 31

Phenotypes 123
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:387125 Jiang Y, et al., ECM-Syndecan-4-FAK signaling is associated with epithelial invagination and buccolingual asymmetry during mandibular molar development. Front Physiol. 2026;17:1805860

TSS for Epha4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr12418	Chr1:77491685-77491739 (-)	13 bp
Tssr12417	Chr1:77465334-77465338 (-)	26,389 bp
Tssr12416	Chr1:77433901-77433909 (-)	57,820 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24