Comparative GO Graph (mouse, human, rat, zebrafish)

Source

Alliance of Genome Resources

Compare experimental GO annotations for Human-Mouse-Rat-Zebrafish orthologs to Mouse Epas1

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

This class contains
- Human genes EPAS1
- Mouse genes Epas1
- Rat genes Epas1
- Zfish genes epas1a,epas1b
Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Epas1

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	Epas1	IDA		Mouse	PMID:12464608
Molecular Function	GO:0050897	cobalt ion binding	Epas1	IDA		Rat	PMID:11688986\|RGD:10395380
Molecular Function	GO:0003677	DNA binding	Epas1	IDA		Mouse	PMID:17404621
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	Epas1	IDA		Mouse	PMID:21856340
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Epas1	IDA		Mouse	PMID:12464608
Molecular Function	GO:0003700	DNA-binding transcription factor activity	Epas1	IDA		Rat	PMID:11237857\|RGD:68201
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:11018023
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:14668441
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:16181639
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P08047	Human	PMID:17024177
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P60228	Human	PMID:17324924
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q9GZT9	Human	PMID:17353276
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P61244	Human	PMID:17418410
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q96RK4	Human	PMID:18000879
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:19129502
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P40337	Human	PMID:19208626
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q9GZT9	Human	PMID:19208626
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:O60573	Human	PMID:22678294
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q9BWF3-1	Human	PMID:22678294
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P40337,UniProtKB:P62877,UniProtKB:Q13617	Human	PMID:23401859
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:23434853
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P40818	Human	PMID:24378640
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:24981860
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:P09467	Human	PMID:25043030
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q9GZT9	Human	PMID:30487161
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:A0A024R8A9	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:O00327-8	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	EPAS1	IPI	UniProtKB:Q8WYA1-3	Human	PMID:32296183
Molecular Function	GO:0005515	protein binding	Epas1	IPI	UniProtKB:Q0VBL6	Mouse	MGI:MGI:5526927\|PMID:21546903
Molecular Function	GO:0005515	protein binding	Epas1	IPI	PR:P53762	Mouse	PMID:9113979
Molecular Function	GO:0005515	protein binding	Epas1	IPI	PR:P53762	Mouse	PMID:26245371
Molecular Function	GO:0046982	protein heterodimerization activity	EPAS1	IDA		Human	PMID:16181639
Molecular Function	GO:0046982	protein heterodimerization activity	EPAS1	IPI	UniProtKB:P27540	Human	PMID:9079689
Molecular Function	GO:0046982	protein heterodimerization activity	Epas1	IDA		Mouse	MGI:MGI:5927132\|PMID:26245371
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	Epas1	IGI	MGI:MGI:88071	Mouse	PMID:9113979
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	EPAS1	IPI	UniProtKB:P27540	Human	PMID:9079689
Molecular Function	GO:0043565	sequence-specific DNA binding	EPAS1	IDA		Human	PMID:9079689
Molecular Function	GO:0043565	sequence-specific DNA binding	Epas1	IDA		Mouse	MGI:MGI:5927132\|PMID:26245371
Molecular Function	GO:0043565	sequence-specific DNA binding	Epas1	IDA		Rat	PMID:12675925\|RGD:632652
Molecular Function	GO:0000976	transcription cis-regulatory region binding	epas1b	IDA		Zfish	PMID:25000307
Molecular Function	GO:0001223	transcription coactivator binding	EPAS1	IPI	UniProtKB:Q09472	Human	PMID:15261140
Molecular Function	GO:0008134	transcription factor binding	Epas1	IPI	PR:P27577	Mouse	PMID:12464608
Cellular Component	GO:0005737	cytoplasm	Epas1	IDA		Mouse	PMID:12832481
Cellular Component	GO:0005737	cytoplasm	Epas1	IDA		Rat	PMID:11313887\|RGD:1581932
Cellular Component	GO:0016607	nuclear speck	Epas1	IDA		Mouse	MGI:MGI:5526927\|PMID:21546903
Cellular Component	GO:0005634	nucleus	Epas1	IDA		Mouse	MGI:MGI:5526927\|PMID:21546903
Cellular Component	GO:0005634	nucleus	Epas1	IDA		Mouse	PMID:12464608
Cellular Component	GO:0005634	nucleus	Epas1	IDA		Rat	PMID:11313887\|RGD:1581932
Cellular Component	GO:0005667	transcription regulator complex	EPAS1	IDA		Human	PMID:9000051
Cellular Component	GO:0005667	transcription regulator complex	Epas1	IDA		Mouse	PMID:12464608
Biological Process	GO:0001525	angiogenesis	Epas1	IMP	MGI:MGI:2386334	Mouse	PMID:15851592
Biological Process	GO:0001525	angiogenesis	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:15728559
Biological Process	GO:0001525	angiogenesis	Epas1	IMP	MGI:MGI:2663583	Mouse	PMID:12053176
Biological Process	GO:0001974	blood vessel remodeling	Epas1	IMP	MGI:MGI:2386334	Mouse	PMID:10880563
Biological Process	GO:0030154	cell differentiation	Epas1	IGI	MGI:MGI:106918	Mouse	PMID:16287860
Biological Process	GO:0071456	cellular response to hypoxia	EPAS1	IDA		Human	PMID:11573933
Biological Process	GO:0071456	cellular response to hypoxia	Epas1	IEP		Rat	PMID:12099714\|RGD:11041576
Biological Process	GO:0071347	cellular response to interleukin-1	Epas1	IEP		Rat	PMID:12099714\|RGD:11041576
Biological Process	GO:0071222	cellular response to lipopolysaccharide	Epas1	IEP		Rat	PMID:12099714\|RGD:11041576
Biological Process	GO:0048565	digestive tract development	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:25000307
Biological Process	GO:1990402	embryonic liver development	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:25000307
Biological Process	GO:0001892	embryonic placenta development	Epas1	IGI	MGI:MGI:106918	Mouse	PMID:16287860
Biological Process	GO:0002070	epithelial cell maturation	Epas1	IMP	MGI:MGI:2663583	Mouse	PMID:12053176
Biological Process	GO:0030218	erythrocyte differentiation	Epas1	IMP	MGI:MGI:3710344	Mouse	PMID:17284606
Biological Process	GO:0031017	exocrine pancreas development	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:25000307
Biological Process	GO:0010467	gene expression	Epas1	IMP		Mouse	PMID:18635823
Biological Process	GO:0010467	gene expression	Epas1	IMP		Mouse	PMID:25414188
Biological Process	GO:0060218	hematopoietic stem cell differentiation	epas1a	IMP	ZFIN:ZDB-GENO-190221-3	Zfish	PMID:29339404
Biological Process	GO:0060218	hematopoietic stem cell differentiation	epas1a	IGI	ZFIN:ZDB-GENE-060607-11	Zfish	PMID:29339404
Biological Process	GO:0060218	hematopoietic stem cell differentiation	epas1b	IGI	ZFIN:ZDB-GENE-030131-4490	Zfish	PMID:29339404
Biological Process	GO:0060218	hematopoietic stem cell differentiation	epas1b	IMP	ZFIN:ZDB-GENO-190221-3	Zfish	PMID:29339404
Biological Process	GO:0030097	hemopoiesis	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:12750163
Biological Process	GO:0030097	hemopoiesis	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:15626745
Biological Process	GO:0030324	lung development	Epas1	IMP	MGI:MGI:2663583	Mouse	PMID:12053176
Biological Process	GO:0007005	mitochondrion organization	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:14608355
Biological Process	GO:0042789	mRNA transcription by RNA polymerase II	Epas1	IDA		Mouse	PMID:18635823
Biological Process	GO:0060586	multicellular organismal-level iron ion homeostasis	Epas1	IGI	MGI:MGI:109169	Mouse	PMID:22128145
Biological Process	GO:0048625	myoblast fate commitment	Epas1	IMP		Mouse	MGI:MGI:4867337\|PMID:21106753
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	Epas1	IMP		Rat	PMID:20496369\|RGD:5147880
Biological Process	GO:0051402	neuron apoptotic process	epas1b	IGI	ZFIN:ZDB-MRPHLNO-100414-7,ZFIN:ZDB-MRPHLNO-100414-8,ZFIN:ZDB-MRPHLNO-100610-11	Zfish	PMID:19123687
Biological Process	GO:0030182	neuron differentiation	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:21546908
Biological Process	GO:0030182	neuron differentiation	epas1b	IMP	ZFIN:ZDB-MRPHLNO-111117-1	Zfish	PMID:21546908
Biological Process	GO:0097150	neuronal stem cell population maintenance	epas1b	IGI	ZFIN:ZDB-GENE-080917-47,ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:27323909
Biological Process	GO:0097150	neuronal stem cell population maintenance	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:27323909
Biological Process	GO:0042421	norepinephrine biosynthetic process	Epas1	IMP		Rat	PMID:19457096\|RGD:5128877
Biological Process	GO:0042415	norepinephrine metabolic process	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:9808618
Biological Process	GO:0007219	Notch signaling pathway	epas1b	IGI	ZFIN:ZDB-GENE-030131-4490	Zfish	PMID:29339404
Biological Process	GO:0007219	Notch signaling pathway	epas1a	IMP	ZFIN:ZDB-GENO-190221-3	Zfish	PMID:29339404
Biological Process	GO:0007219	Notch signaling pathway	epas1b	IMP	ZFIN:ZDB-GENO-190221-3	Zfish	PMID:29339404
Biological Process	GO:0007219	Notch signaling pathway	epas1a	IGI	ZFIN:ZDB-GENE-060607-11	Zfish	PMID:29339404
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	Epas1	IMP		Mouse	MGI:MGI:5803933\|PMID:26572826
Biological Process	GO:1903181	positive regulation of dopamine biosynthetic process	Epas1	IMP		Rat	PMID:19457096\|RGD:5128877
Biological Process	GO:1904655	positive regulation of lung alveolus development	Epas1	IEP		Rat	PMID:23962064\|RGD:10395379
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	EPAS1	IDA		Human	PMID:11573933
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IDA		Mouse	PMID:12464608
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IGI	MGI:MGI:88071	Mouse	PMID:9113979
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IGI	MGI:MGI:95455	Mouse	PMID:12464608
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IDA		Mouse	PMID:17322295
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IMP	MGI:MGI:3526731	Mouse	PMID:17404621
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Epas1	IDA		Rat	PMID:11237857\|RGD:68201
Biological Process	GO:0002027	regulation of heart rate	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:9808618
Biological Process	GO:0043523	regulation of neuron apoptotic process	epas1b	IMP	ZFIN:ZDB-MRPHLNO-100414-8	Zfish	PMID:21546908
Biological Process	GO:0043523	regulation of neuron apoptotic process	epas1b	IMP	ZFIN:ZDB-MRPHLNO-111117-1	Zfish	PMID:21546908
Biological Process	GO:2000434	regulation of protein neddylation	EPAS1	IMP		Human	PMID:23401859
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	Epas1	IDA		Mouse	PMID:14608355
Biological Process	GO:0043619	regulation of transcription from RNA polymerase II promoter in response to oxidative stress	Epas1	IMP	MGI:MGI:3710344	Mouse	PMID:17284606
Biological Process	GO:0014823	response to activity	epas1b	IEP		Zfish	PMID:21343420
Biological Process	GO:0001666	response to hypoxia	EPAS1	IDA		Human	PMID:11782478
Biological Process	GO:0001666	response to hypoxia	Epas1	IMP		Mouse	PMID:25414188
Biological Process	GO:0001666	response to hypoxia	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:15626745
Biological Process	GO:0001666	response to hypoxia	Epas1	IDA		Rat	PMID:12675925\|RGD:632652
Biological Process	GO:0001666	response to hypoxia	epas1b	IEP		Zfish	PMID:21343420
Biological Process	GO:0006979	response to oxidative stress	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:14608355
Biological Process	GO:0006979	response to oxidative stress	Epas1	IGI	MGI:MGI:98352	Mouse	PMID:17322295
Biological Process	GO:0043129	surfactant homeostasis	Epas1	IMP	MGI:MGI:2663583	Mouse	PMID:12053176
Biological Process	GO:0006366	transcription by RNA polymerase II	Epas1	IMP	MGI:MGI:3526731	Mouse	PMID:17404621
Biological Process	GO:0007601	visual perception	Epas1	IMP	MGI:MGI:1861921	Mouse	PMID:15728559

Gene Ontology Evidence Code Abbreviations:

EXP Inferred from experiment

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

HTP Inferred from High Throughput Experiment

HDA Inferred from High Throughput Direct Assay

HMP Inferred from High Throughput Mutant Phenotype

HGI Inferred from High Throughput Genetic Interaction

HEP Inferred from High Throughput Expression Pattern

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/21/2024 MGI 6.23

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023. Complete table of the annotations represented in this image is provided below.

Molecular Function

Cellular Component

Biological Process

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.