| GO term: | hematopoietic stem cell differentiation |
| Synonym: | haematopoietic stem cell differentiation |
| Synonym: | haemopoietic stem cell differentiation |
| Synonym: | hemopoietic stem cell differentiation |
| GO id: | GO:0060218 |
| Definition: | The process in which a relatively unspecialized cell acquires specialized features of a hematopoietic stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells. |
| Number of paths to term: | 15 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processcellular processsingle-organism cellular processcellular developmental processcell differentiationstem cell differentiationcardioblast differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hepatoblast differentiationlimb basal epidermal cell differentiation +mesenchymal cell differentiation +mesenchymal stem cell differentiation +negative regulation of stem cell differentiation +neuroblast differentiation +positive regulation of stem cell differentiation +regulation of stem cell differentiation +satellite cell differentiation +stem cell development +stem cell fate commitment +biological_processdevelopmental processanatomical structure developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processdevelopmental processanatomical structure developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processdevelopmental processanatomical structure developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processdevelopmental processcellular developmental processcell differentiationstem cell differentiationcardioblast differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hepatoblast differentiationlimb basal epidermal cell differentiation +mesenchymal cell differentiation +mesenchymal stem cell differentiation +negative regulation of stem cell differentiation +neuroblast differentiation +positive regulation of stem cell differentiation +regulation of stem cell differentiation +satellite cell differentiation +stem cell development +stem cell fate commitment +biological_processdevelopmental processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processdevelopmental processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processdevelopmental processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processimmune system processimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processmulticellular organismal processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentimmune system developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processsingle-organism processsingle-multicellular organism processmulticellular organismal developmentsystem developmentorgan developmenthematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +biological_processsingle-organism processsingle-organism cellular processcellular developmental processcell differentiationstem cell differentiationcardioblast differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hepatoblast differentiationlimb basal epidermal cell differentiation +mesenchymal cell differentiation +mesenchymal stem cell differentiation +negative regulation of stem cell differentiation +neuroblast differentiation +positive regulation of stem cell differentiation +regulation of stem cell differentiation +satellite cell differentiation +stem cell development +stem cell fate commitment +biological_processsingle-organism processsingle-organism developmental processhematopoietic or lymphoid organ developmenthemopoiesisdefinitive hemopoiesis +embryonic hemopoiesis +fibroblast growth factor receptor signaling pathway involved in hemopoiesishematopoietic progenitor cell differentiation +hematopoietic stem cell differentiation [GO:0060218] (21 genes, 21 annotations)negative regulation of hematopoietic stem cell differentiationpositive regulation of hematopoietic stem cell differentiationregulation of hematopoietic stem cell differentiation +hematopoietic stem cell proliferation +leukocyte differentiation +myeloid cell differentiation +post-embryonic hemopoiesis +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/22/2013 MGI 5.13 |
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