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Gene Ontology Browser
Term Detail
GO term:cell differentiation
GO id:GO:0030154
Definition:The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Number of paths to term: 3

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (2729 genes, 7038 annotations)
                                                is-aangioblast cell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-acumulus cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aenteroendocrine cell differentiation
                                                is-aepidermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-agranulosa cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahemangioblast cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-ahepatocyte differentiation +
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-alens fiber cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesenchymal cell differentiation +
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneuroblast differentiation +
                                                is-aneuroendocrine cell differentiation +
                                                is-aneuroepithelial cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aodontoblast differentiation +
                                                is-aoenocyte differentiation +
                                                is-aolfactory bulb interneuron differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic A cell differentiation +
                                                is-apancreatic D cell differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apancreatic PP cell differentiation +
                                                is-aparenchymal cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                is-aradial glial cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-aSertoli cell differentiation +
                                                is-asieve cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-asorocarp stalk cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-athyroid-stimulating hormone-secreting cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-atype B pancreatic cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-acellular developmental process
                                is-aascospore release from ascus +
                                is-acell dedifferentiation
                                is-acell development +
                                is-acell differentiation [GO:0030154] (2729 genes, 7038 annotations)
                                        is-aangioblast cell differentiation
                                        is-aanther wall tapetum cell differentiation +
                                        is-aantipodal cell differentiation +
                                        is-acardiocyte differentiation +
                                        part-ofcell development +
                                        is-acell differentiation in hindbrain +
                                        is-acell differentiation in spinal cord +
                                        is-acell differentiation involved in embryonic placenta development +
                                        is-acell differentiation involved in kidney development +
                                        is-acell differentiation involved in salivary gland development +
                                        is-acell differentiation involved in spore germination
                                        part-ofcell fate commitment +
                                        is-achondroblast differentiation
                                        is-achondrocyte differentiation +
                                        is-achorionic trophoblast cell differentiation +
                                        is-acollenchyma cell differentiation
                                        is-acompound eye cone cell differentiation +
                                        is-acorticotropin hormone secreting cell differentiation +
                                        is-acumulus cell differentiation +
                                        is-aectodermal cell differentiation +
                                        is-aembryo sac central cell differentiation +
                                        is-aembryo sac egg cell differentiation +
                                        is-aendodermal cell differentiation +
                                        is-aenteroendocrine cell differentiation
                                        is-aepidermal cell differentiation +
                                        is-aepithelial cell differentiation +
                                        is-afat cell differentiation +
                                        is-afoam cell differentiation +
                                        is-afollicular dendritic cell differentiation
                                        part-ofG1 to G0 transition involved in cell differentiation
                                        is-agenerative cell differentiation
                                        is-aglial cell differentiation +
                                        is-agranulosa cell differentiation +
                                        is-aguard mother cell differentiation
                                        is-ahemangioblast cell differentiation
                                        is-ahematopoietic progenitor cell differentiation +
                                        is-ahemocyte differentiation +
                                        is-ahepatic stellate cell differentiation
                                        is-ahepatocyte differentiation +
                                        is-aheterocyst differentiation
                                        is-ahypothalamus cell differentiation +
                                        is-ainner cell mass cell differentiation +
                                        is-alens fiber cell differentiation +
                                        is-aleukocyte differentiation +
                                        is-aLeydig cell differentiation
                                        is-alung cell differentiation +
                                        is-aMalpighian tubule tip cell differentiation
                                        is-amesenchymal cell differentiation +
                                        is-amesodermal cell differentiation +
                                        is-amicrosporocyte differentiation
                                        is-amuscle cell differentiation +
                                        is-amyeloid cell differentiation +
                                        is-amystery cell differentiation
                                        negatively-regulatesnegative regulation of cell differentiation +
                                        is-aneuroblast differentiation +
                                        is-aneuroendocrine cell differentiation +
                                        is-aneuroepithelial cell differentiation +
                                        is-aneurogenesis +
                                        is-aneuromast mantle cell differentiation +
                                        is-aneuromast support cell differentiation +
                                        is-aneuron differentiation +
                                        is-anotochord cell differentiation +
                                        is-aodontoblast differentiation +
                                        is-aoenocyte differentiation +
                                        is-aolfactory bulb interneuron differentiation +
                                        is-aoocyte differentiation +
                                        is-aosteoblast differentiation +
                                        is-apancreatic A cell differentiation +
                                        is-apancreatic D cell differentiation +
                                        is-apancreatic epsilon cell differentiation +
                                        is-apancreatic PP cell differentiation +
                                        is-aparenchymal cell differentiation +
                                        is-apigment cell differentiation +
                                        is-apigment cell precursor differentiation
                                        is-apollen sperm cell differentiation
                                        positively-regulatespositive regulation of cell differentiation +
                                        is-aprolactin secreting cell differentiation +
                                        is-aradial glial cell differentiation +
                                        regulatesregulation of cell differentiation +
                                        is-arenal filtration cell differentiation +
                                        is-arhombomere cell differentiation
                                        is-asclerenchyma cell differentiation
                                        is-aSertoli cell differentiation +
                                        is-asieve cell differentiation
                                        is-asomatotropin secreting cell differentiation +
                                        is-asorocarp spore cell differentiation +
                                        is-asorocarp stalk cell differentiation +
                                        is-aspermatid differentiation +
                                        is-asporocyte differentiation
                                        is-asporulation resulting in formation of a cellular spore +
                                        is-astem cell differentiation +
                                        is-asynergid differentiation +
                                        is-atendon cell differentiation +
                                        is-athyroid-stimulating hormone-secreting cell differentiation +
                                        is-atransdifferentiation
                                        is-atrophectodermal cell differentiation +
                                        is-atype B pancreatic cell differentiation +
                                        is-avasculogenesis +
                                        is-avegetative cell differentiation
                                        is-axylem vessel member cell differentiation
                                is-acell fate commitment +
                                is-acell fate determination +
                                is-acell fate specification +
                                is-acell maturation +
                                is-acellular component morphogenesis +
                                is-acentrosomal and pronuclear rotation
                                is-acreation of an inductive signal +
                                is-adevelopmental programmed cell death +
                                is-adonor selection +
                                is-afruiting body development in cellular response to starvation
                                is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                is-aplant-type spore development +
                                is-astomatal lineage progression +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (2729 genes, 7038 annotations)
                                                is-aangioblast cell differentiation
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-acumulus cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aenteroendocrine cell differentiation
                                                is-aepidermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-agranulosa cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahemangioblast cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-ahepatocyte differentiation +
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-alens fiber cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesenchymal cell differentiation +
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneuroblast differentiation +
                                                is-aneuroendocrine cell differentiation +
                                                is-aneuroepithelial cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aodontoblast differentiation +
                                                is-aoenocyte differentiation +
                                                is-aolfactory bulb interneuron differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic A cell differentiation +
                                                is-apancreatic D cell differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apancreatic PP cell differentiation +
                                                is-aparenchymal cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                is-aradial glial cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-aSertoli cell differentiation +
                                                is-asieve cell differentiation
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-asorocarp stalk cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-athyroid-stimulating hormone-secreting cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-atype B pancreatic cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/08/2013
MGI 5.13
The Jackson Laboratory