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Gene Ontology Browser
Term Detail
GO term:cell differentiation
GO id:GO:0030154
Definition:The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
Number of paths to term: 4

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (3241 genes, 8227 annotations)
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-asieve cell differentiation
                                                is-askeletal muscle cell differentiation +
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


Gene_Ontology
        is-abiological_process
                is-adevelopmental process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (3241 genes, 8227 annotations)
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-asieve cell differentiation
                                                is-askeletal muscle cell differentiation +
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (3241 genes, 8227 annotations)
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-asieve cell differentiation
                                                is-askeletal muscle cell differentiation +
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism developmental process
                                is-acellular developmental process
                                        is-aascospore release from ascus +
                                        is-acell dedifferentiation
                                        is-acell development +
                                        is-acell differentiation [GO:0030154] (3241 genes, 8227 annotations)
                                                is-aanther wall tapetum cell differentiation +
                                                is-aantipodal cell differentiation +
                                                is-acardiocyte differentiation +
                                                part-ofcell development +
                                                is-acell differentiation in hindbrain +
                                                is-acell differentiation in spinal cord +
                                                is-acell differentiation involved in embryonic placenta development +
                                                is-acell differentiation involved in kidney development +
                                                is-acell differentiation involved in salivary gland development +
                                                is-acell differentiation involved in spore germination
                                                part-ofcell fate commitment +
                                                is-achondroblast differentiation
                                                is-achondrocyte differentiation +
                                                is-achorionic trophoblast cell differentiation +
                                                is-acollenchyma cell differentiation
                                                is-acompound eye cone cell differentiation +
                                                is-acorticotropin hormone secreting cell differentiation +
                                                is-aectodermal cell differentiation +
                                                is-aembryo sac central cell differentiation +
                                                is-aembryo sac egg cell differentiation +
                                                is-aendodermal cell differentiation +
                                                is-aepithelial cell differentiation +
                                                is-afat cell differentiation +
                                                is-afoam cell differentiation +
                                                is-afollicular dendritic cell differentiation
                                                part-ofG1 to G0 transition involved in cell differentiation
                                                is-agenerative cell differentiation
                                                is-aglial cell differentiation +
                                                is-aguard mother cell differentiation
                                                is-ahematopoietic progenitor cell differentiation +
                                                is-ahemocyte differentiation +
                                                is-ahepatic stellate cell differentiation
                                                is-aheterocyst differentiation
                                                is-ahypothalamus cell differentiation +
                                                is-ainner cell mass cell differentiation +
                                                is-aleukocyte differentiation +
                                                is-aLeydig cell differentiation
                                                is-alung cell differentiation +
                                                is-aMalpighian tubule tip cell differentiation
                                                is-amesodermal cell differentiation +
                                                is-amicrosporocyte differentiation
                                                is-amuscle cell differentiation +
                                                is-amyeloid cell differentiation +
                                                is-amyofibroblast differentiation
                                                is-amystery cell differentiation
                                                negatively-regulatesnegative regulation of cell differentiation +
                                                is-aneurogenesis +
                                                is-aneuromast mantle cell differentiation +
                                                is-aneuromast support cell differentiation +
                                                is-aneuron differentiation +
                                                is-anotochord cell differentiation +
                                                is-aoenocyte differentiation +
                                                is-aoocyte differentiation +
                                                is-aosteoblast differentiation +
                                                is-apancreatic epsilon cell differentiation +
                                                is-apigment cell differentiation +
                                                is-apigment cell precursor differentiation
                                                is-aplant parenchymal cell differentiation +
                                                is-apollen sperm cell differentiation
                                                positively-regulatespositive regulation of cell differentiation +
                                                is-aprolactin secreting cell differentiation +
                                                regulatesregulation of cell differentiation +
                                                is-arenal filtration cell differentiation +
                                                is-arhombomere cell differentiation
                                                is-asclerenchyma cell differentiation
                                                is-asieve cell differentiation
                                                is-askeletal muscle cell differentiation +
                                                is-asomatotropin secreting cell differentiation +
                                                is-asorocarp spore cell differentiation +
                                                is-aspermatid differentiation +
                                                is-asporocyte differentiation +
                                                is-asporulation resulting in formation of a cellular spore +
                                                is-astem cell differentiation +
                                                is-asynergid differentiation +
                                                is-atendon cell differentiation +
                                                is-atransdifferentiation
                                                is-atrophectodermal cell differentiation +
                                                is-avasculogenesis +
                                                is-avegetative cell differentiation
                                                is-axylem vessel member cell differentiation
                                        is-acell fate commitment +
                                        is-acell fate determination +
                                        is-acell fate specification +
                                        is-acell maturation +
                                        is-acellular component morphogenesis +
                                        is-acentrosomal and pronuclear rotation
                                        is-acreation of an inductive signal +
                                        is-adevelopmental programmed cell death +
                                        is-adonor selection +
                                        is-afruiting body development in cellular response to starvation
                                        is-ainitiation of movement involved in cerebral cortex radial glia guided migration +
                                        is-aplant-type spore development +
                                        is-astomatal lineage progression +


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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory