Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes ATF6
  • Mouse genes Atf6
  • Rat genes Atf6
  • Zfish genes atf6
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Atf6

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ATF6	IDA		Human	PMID:14973138
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ATF6	IDA		Human	PMID:11163209
Molecular Function	GO:0042802	identical protein binding	ATF6	IPI	UniProtKB:P18850	Human	PMID:20102225
Molecular Function	GO:0042802	identical protein binding	ATF6	IPI	UniProtKB:P18850	Human	PMID:23661758
Molecular Function	GO:0042802	identical protein binding	ATF6	IPI	UniProtKB:P18850	Human	PMID:25609649
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:Q68CJ9	Human	PMID:16469704
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:Q3U182	Human	PMID:19543265
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:Q53ET0	Human	PMID:19543265
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:P17861	Human	PMID:20102225
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:P35443	Human	PMID:22682248
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:P17861	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:Q99941	Human	PMID:23661758
Molecular Function	GO:0005515	protein binding	ATF6	IPI	UniProtKB:P11021	Human	PMID:27238082
Molecular Function	GO:0005515	protein binding	Atf6	IPI	UniProtKB:P35441|UniProtKB:Q9Z1T2	Mouse	MGI:MGI:5431143|PMID:22682248
Molecular Function	GO:0005515	protein binding	Atf6	IPI	UniProtKB:Q3U182	Mouse	MGI:MGI:3851621|PMID:19543265
Molecular Function	GO:0005515	protein binding	Atf6	IPI	UniProtKB:Q9Z1T2	Mouse	MGI:MGI:5431143|PMID:22682248
Molecular Function	GO:0005515	protein binding	Atf6	IPI	UniProtKB:E9PT53	Rat	PMID:20160352|RGD:10047363
Molecular Function	GO:0046982	protein heterodimerization activity	ATF6	IPI	UniProtKB:Q68CJ9	Human	PMID:16469704
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ATF6	IDA		Human	PMID:24269637
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ATF6	IDA		Human	PMID:11779464
Molecular Function	GO:0043565	sequence-specific DNA binding	ATF6	IDA		Human	PMID:28473536
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ATF6	IDA		Human	PMID:28473536
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ATF6	IDA		Human	PMID:16469704
Cellular Component	GO:0005737	cytoplasm	Atf6	IDA		Rat	PMID:16912310|RGD:32733622
Cellular Component	GO:0005783	endoplasmic reticulum	ATF6	IDA		Human	PMID:11256944
Cellular Component	GO:0005783	endoplasmic reticulum	ATF6	IDA		Human	PMID:16236796
Cellular Component	GO:0005789	endoplasmic reticulum membrane	ATF6	IDA		Human	PMID:10564271
Cellular Component	GO:0005794	Golgi apparatus	ATF6	IDA		Human	PMID:16236796
Cellular Component	GO:0016020	membrane	ATF6	IDA		Human	PMID:11163209
Cellular Component	GO:0005634	nucleus	ATF6	IDA		Human	PMID:11163209
Cellular Component	GO:0005634	nucleus	ATF6	IDA		Human	PMID:11256944
Cellular Component	GO:0005634	nucleus	ATF6	IDA		Human	PMID:16236796
Cellular Component	GO:0005634	nucleus	Atf6	IDA		Mouse	MGI:MGI:5431143|PMID:22682248
Cellular Component	GO:0005634	nucleus	Atf6	IDA		Rat	PMID:15942958|RGD:1598733
Cellular Component	GO:0005634	nucleus	Atf6	IDA		Rat	PMID:22682248|RGD:8554640
Cellular Component	GO:0090575	RNA polymerase II transcription regulator complex	ATF6	IPI		Human	PMID:23661758
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	atf6	IMP	ZFIN:ZDB-MRPHLNO-130206-2	Zfish	PMID:22917923
Biological Process	GO:0030968	endoplasmic reticulum unfolded protein response	atf6	IMP	ZFIN:ZDB-MRPHLNO-120906-7	Zfish	PMID:21538441
Biological Process	GO:0001654	eye development	ATF6	IMP		Human	PMID:26029869
Biological Process	GO:0043065	positive regulation of apoptotic process	ATF6	IDA		Human	PMID:14752510
Biological Process	GO:1903893	positive regulation of ATF6-mediated unfolded protein response	ATF6	IDA		Human	PMID:9837962
Biological Process	GO:0010508	positive regulation of autophagy	ATF6	IMP		Human	PMID:28747345
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ATF6	IDA		Human	PMID:14973138
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	Atf6	IDA		Mouse	PMID:19615339
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF6	IDA		Human	PMID:11163209
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF6	IDA		Human	PMID:11256944
Biological Process	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress	ATF6	IDA		Human	PMID:16469704
Biological Process	GO:0001666	response to hypoxia	atf6	IDA		Zfish	PMID:25814654
Biological Process	GO:0007601	visual perception	ATF6	IMP		Human	PMID:26029869

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern