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Gene Ontology Browser
Term Detail
GO term:RNA polymerase II regulatory region sequence-specific DNA binding
GO id:GO:0000977
Definition:Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
CommentsThe word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding".
Number of paths to term: 10

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding +
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-acore promoter proximal region sequence-specific DNA binding +
                                                                is-acore promoter sequence-specific DNA binding +
                                                                is-aenhancer sequence-specific DNA binding +
                                                                is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                        is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aheterocyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding +
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding +
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                        is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aDNA binding
                                                is-asequence-specific DNA binding
                                                        is-atranscription regulatory region sequence-specific DNA binding
                                                                is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-acore promoter proximal region sequence-specific DNA binding +
                                                                is-acore promoter sequence-specific DNA binding +
                                                                is-aenhancer sequence-specific DNA binding +
                                                                is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                        is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                        is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                        is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                is-atranscription termination site sequence-specific DNA binding +


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-aRNA polymerase II regulatory region DNA binding
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding


Gene_Ontology
        is-amolecular_function
                is-abinding
                        is-aorganic cyclic compound binding
                                is-anucleic acid binding
                                        is-aregulatory region nucleic acid binding
                                                is-aregulatory region DNA binding
                                                        is-atranscription regulatory region DNA binding
                                                                is-atranscription regulatory region sequence-specific DNA binding
                                                                        is-abacterial-type RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-acore promoter proximal region sequence-specific DNA binding +
                                                                        is-acore promoter sequence-specific DNA binding +
                                                                        is-aenhancer sequence-specific DNA binding +
                                                                        is-amitochondrial RNA polymerase regulatory region sequence-specific DNA binding +
                                                                        is-apolymerase III regulatory region sequence-specific DNA binding +
                                                                        is-aRNA polymerase II regulatory region sequence-specific DNA binding [GO:0000977] (296 genes, 392 annotations)
                                                                                is-aRNA polymerase II core promoter proximal region sequence-specific DNA binding +
                                                                                is-aRNA polymerase II core promoter sequence-specific DNA binding
                                                                                is-aRNA polymerase II distal enhancer sequence-specific DNA binding
                                                                                is-aRNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
                                                                        is-atranscription termination site sequence-specific DNA binding +


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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory