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Atf6
Gene Detail
Symbol

Name
ID
Atf6
activating transcription factor 6
MGI:1926157
Synonyms
9130025P16Rik, Atf6alpha, ESTM49
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:170704674-170867771 bp, - strand
From VEGA annotation of GRCm38

  163098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32015  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Atf6

Human
homologs
Human Homolog ATF6, activating transcription factor 6
NCBI Gene ID 22926
neXtProt AC  NX_P18850
Human Synonyms  ATF6A
Human Chr (Location)  1q22-q23; chr1:161766244-161964070 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(28) : Gene trapped(26) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased sensitivity to dithiothreitol, thapsigargin, and tunicamycin.
 
Interactions
Atf6 interacts with 453 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (114)    Tissues (113)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 94
In situ reporter (knock in) 2
Western blot 7
RT-PCR 3
cDNA source data(101)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(103) cDNA(101) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000043564 (Evidence)
Ensembl Gene ModelENSMUSG00000026663 (Evidence)
Entrez Gene226641 (Evidence)
UniGene377046
DFCITC1665478, TC1606785, TC1686546
DoTSDT.94166642, DT.483934, DT.94333329
NIA Mouse Gene IndexU022038
Consensus CDS ProjectCCDS56653.1
International Mouse Knockout Project StatusAtf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043564 VEGA Gene Model | MGI Sequence Detail 163098 C57BL/6J ±  kb
transcript OTTMUST00000114360 VEGA | MGI Sequence Detail 7246 Not Applicable 
polypeptide OTTMUSP00000063822 VEGA | MGI Sequence Detail 656 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(9) UniProt(3)
Polymorphisms
SNPs within 2kb(1768 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000004402 cyclic AMP-dependent transcription factor ATF-6 alpha
References
(Earliest) J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
(Latest) J:212712 Liang G, et al., Endoplasmic reticulum stress-unfolding protein response-apoptosis cascade causes chondrodysplasia in a col2a1 p.Gly1170Ser mutated mouse model. PLoS One. 2014;9(1):e86894
All references(68)
Other
accession IDs
MGI:1334425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory