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Atf6
Gene Detail
Symbol

Name
ID
Atf6
activating transcription factor 6
MGI:1926157
Synonyms
9130025P16Rik, Atf6alpha, ESTM49
Feature Type
protein coding gene
Genetic Map
Chromosome 1
76.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:170704674-170867771 bp, - strand
From VEGA annotation of GRCm38

  163098 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32015  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ATF6
Gene Tree: Atf6

Human
homologs
ATF6, activating transcription factor 6
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 22926
neXtProt AC: NX_P18850

Human Synonyms: ATF6A

Human Chr (Location): 1q23.3; chr1:161766244-161964070 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit increased sensitivity to dithiothreitol, thapsigargin, and tunicamycin. Mice homozygous for a conditional allele activated in islet cells exhibit reduced sensitivity to TUDCA.
 
Interactions
Atf6 interacts with 452 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (10 records)
Data Summary: Results (114)    Tissues (113)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 94
In situ reporter (knock in) 2
Western blot 7
RT-PCR 3
cDNA source data(101)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ATF6 ; Xenbase atf6    NEW 
Molecular
reagents
All nucleic(103) cDNA(101) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000043564 (Evidence)
Ensembl Gene Model ENSMUSG00000026663 (Evidence)
Entrez Gene 226641 (Evidence)
UniGene 377046
DFCI TC1686546, TC1665478, TC1606785
DoTS DT.94333329, DT.94166642, DT.483934
NIA Mouse Gene Index U022038
Consensus CDS Project CCDS56653.1
International Mouse Phenotyping Consortium Status Atf6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043564 VEGA Gene Model | MGI Sequence Detail 163098 C57BL/6J ±  kb
transcript OTTMUST00000114360 VEGA | MGI Sequence Detail 7246 Not Applicable 
polypeptide OTTMUSP00000063822 VEGA | MGI Sequence Detail 656 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(7) UniProt(2)
Polymorphisms
SNPs within 2kb(1768 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000004402 cyclic AMP-dependent transcription factor ATF-6 alpha
References
(Earliest) J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
(Latest) J:218276 Yoshikawa A, et al., Deletion of Atf6alpha impairs astroglial activation and enhances neuronal death following brain ischemia in mice. J Neurochem. 2015 Feb;132(3):342-53
All references(72)
Other
accession IDs
MGI:1334425

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory