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Atf6 Gene Detail
Summary
  • Symbol
    Atf6
  • Name
    activating transcription factor 6
  • Synonyms
    9130025P16Rik, Atf6alpha, ESTM49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926157
    NCBI Gene: 226641
  • Gene Overview
    MyGene.info: ATF6
Location & Maps
more
  • Sequence Map
    Chr1:170704674-170867771 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      163098 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.96 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATF6, activating transcription factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATF6, activating transcription factor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACHM7, ATF6A
  • Links
    NCBI Gene ID: 22926
    neXtProt AC: NX_P18850

  • Chr Location
    1q23.3; chr1:161766244-161964070 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 32015
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: ATF6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ATF6 associations

Human Disease Mouse Models
       Achromatopsia 7; ACHM7   OMIM: 616517
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    31
  • Chemically induced (other)
    2
  • Gene trapped
    26
  • Targeted
    3
  • Genomic Mutations
    2 involving Atf6
  • Incidental Mutations
Mice homozygous for a null allele exhibit increased sensitivity to dithiothreitol, thapsigargin, and tunicamycin. Mice homozygous for a conditional allele activated in islet cells exhibit reduced sensitivity to TUDCA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043564 VEGA Gene Model | MGI Sequence Detail 163098 C57BL/6J ±  kb
transcript OTTMUST00000114360 VEGA | MGI Sequence Detail 7246 Not Applicable  
polypeptide OTTMUSP00000063822 VEGA | MGI Sequence Detail 656 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1764 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000004402 cyclic AMP-dependent transcription factor ATF-6 alpha
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR029801 cAMP-dependent transcription factor ATF-6 alpha
Molecular
Reagents
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  • All nucleic 103
    cDNA 101
    Primer pair 2

    Microarray probesets 7
Other
Accession IDs
less
MGI:1334425
References
more
  • Summaries
    All 71
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 24
  • Earliest
    J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
  • Latest
    J:231780 Kohl S, et al., Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia. Nat Genet. 2015 Jul;47(7):757-65

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory