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Atf6 Gene Detail
Summary
  • Symbol
    Atf6
  • Name
    activating transcription factor 6
  • Synonyms
    9130025P16Rik, Atf6alpha, ESTM49
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926157
    NCBI Gene: 226641
  • Gene Overview
    MyGene.info: ATF6
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:170704674-170867771 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 76.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1764 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926157
protein coding gene Chr1:170704457-170867787 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016733
protein coding gene Chr1:176430602-176614305 (-)
A/J MGP_AJ_G0016713
protein coding gene Chr1:169242102-169418485 (-)
AKR/J MGP_AKRJ_G0016679
protein coding gene Chr1:174302476-174485528 (-)
BALB/cJ MGP_BALBcJ_G0016674
protein coding gene Chr1:169711605-169873917 (-)
C3H/HeJ MGP_C3HHeJ_G0016497
protein coding gene Chr1:174560648-174740964 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017135
protein coding gene Chr1:182263895-182442256 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014844
protein coding gene Chr1:160959568-161129366 (-)
CAST/EiJ MGP_CASTEiJ_G0016078
protein coding gene Chr1:174195480-174378034 (-)
CBA/J MGP_CBAJ_G0016472
protein coding gene Chr1:188761038-188945325 (-)
DBA/2J MGP_DBA2J_G0016579
protein coding gene Chr1:168091588-168255880 (-)
FVB/NJ MGP_FVBNJ_G0016576
protein coding gene Chr1:166453387-166625469 (-)
LP/J MGP_LPJ_G0016650
protein coding gene Chr1:177552131-177733354 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016602
protein coding gene Chr1:196080286-196263085 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017172
protein coding gene Chr1:174212827-174388729 (-)
PWK/PhJ MGP_PWKPhJ_G0015864
protein coding gene Chr1:167331608-167508748 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015648
protein coding gene Chr1:172960570-173137941 (-)
WSB/EiJ MGP_WSBEiJ_G0016140
protein coding gene Chr1:174327601-174507624 (-)



Homology
more
  • Human Ortholog
    ATF6, activating transcription factor 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATF6, activating transcription factor 6
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACHM7, ATF6A
  • Links
    NCBI Gene ID: 22926
    neXtProt AC: NX_P18850
    UniProt: P18850

  • Chr Location
    1q23.3; chr1:161766244-161964070 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 32015
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATF6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human ATF6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit increased sensitivity to dithiothreitol, thapsigargin, and tunicamycin. Mice homozygous for a conditional allele activated in islet cells exhibit reduced sensitivity to TUDCA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026663 Ensembl Gene Model | MGI Sequence Detail 163098 C57BL/6J ±  kb
    transcript ENSMUST00000027974 Ensembl | MGI Sequence Detail 7246 Not Applicable  
    polypeptide ENSMUSP00000027974 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004402 cyclic AMP-dependent transcription factor ATF-6 alpha
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR029801 cAMP-dependent transcription factor ATF-6 alpha
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 102
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1334425
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 16
      Gene Ontology 8
      Phenotypes 29
    • Earliest
      J:52606 Eddleston J, et al., Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp). Genomics. 1999 Mar 1;56(2):149-59
    • Latest
      J:264541 Sasaki T, et al., The exercise-inducible bile acid receptor Tgr5 improves skeletal muscle function in mice. J Biol Chem. 2018 Jun 29;293(26):10322-10332

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory