Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes A2M
  • Mouse genes A2m
  • Rat genes A2m
  • Zfish genes a2ml,sb:cb37,si:ch211-212c13.10,si:dkey-105h12.2,zgc:165453
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set A2m

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0048403	brain-derived neurotrophic factor binding	A2m	IDA		Rat	PMID:11813239|RGD:10046023
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:E1BGJ0	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P04083	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P07355	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P08133	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P09525	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P12429	Human	PMID:15226301
Molecular Function	GO:0048306	calcium-dependent protein binding	A2M	IPI	UniProtKB:P79134	Human	PMID:15226301
Molecular Function	GO:0004866	endopeptidase inhibitor activity	A2m	IDA		Rat	PMID:19240864|RGD:7411612
Molecular Function	GO:0019899	enzyme binding	A2M	IPI	UniProtKB:P04180	Human	PMID:11435418
Molecular Function	GO:0019838	growth factor binding	A2M	IDA		Human	PMID:9398211
Molecular Function	GO:0042802	identical protein binding	A2m	IPI	RGD:2004	Rat	PMID:94834|RGD:10046030
Molecular Function	GO:0019966	interleukin-1 binding	A2M	IDA		Human	PMID:9714181
Molecular Function	GO:0019959	interleukin-8 binding	A2M	IPI	UniProtKB:P10145	Human	PMID:10880251
Molecular Function	GO:0048406	nerve growth factor binding	A2m	IDA		Rat	PMID:11813239|RGD:10046023
Molecular Function	GO:0002020	protease binding	A2M	IPI	UniProtKB:P58397	Human	PMID:18485748
Molecular Function	GO:0002020	protease binding	A2M	IPI	UniProtKB:Q9UKP4	Human	PMID:18485748
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UKR3	Human	PMID:14687906
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:A4FUJ8	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:O75558	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:O75616	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:O75626-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:O75925	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P04141	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P04271	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P07948	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P09017	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P0C0S5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P10599	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P27986-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P28347-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P35222	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P41218	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P43405-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P57729	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P60409	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P63010-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P68431	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q16637-3	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q6DN90-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q6GQQ9-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q6PCB6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q6PIV2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q7L576	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q7Z6I5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q86WT6-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8IUC2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8N4C7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8N895	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8TBB1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8TDB4	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8WUW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q8WVJ9	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q92478	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q92993	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q92993-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q96AX1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q96D59	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q96FW1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q99497	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q99KR7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9BVJ6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9H147	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9NR90-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UBQ0-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UHI6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UII2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9ULV1	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9ULX5	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UNE7	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UNS2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9UPM6	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9Y261-2	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:Q9Y605	Human	PMID:32814053
Molecular Function	GO:0005515	protein binding	A2M	IPI	UniProtKB:P35030	Human	PMID:6698368
Molecular Function	GO:0005515	protein binding	A2m	IPI	PR:Q91ZX7	Mouse	PMID:17920016
Molecular Function	GO:0004867	serine-type endopeptidase inhibitor activity	A2M	IDA		Human	PMID:12538697
Molecular Function	GO:0005102	signaling receptor binding	A2M	IMP		Human	PMID:15226301
Molecular Function	GO:0043120	tumor necrosis factor binding	A2M	IDA		Human	PMID:9714181
Cellular Component	GO:0072562	blood microparticle	A2M	HDA		Human	PMID:22516433
Cellular Component	GO:0062023	collagen-containing extracellular matrix	A2M	HDA		Human	PMID:28327460
Cellular Component	GO:0062023	collagen-containing extracellular matrix	A2M	HDA		Human	PMID:25037231
Cellular Component	GO:0062023	collagen-containing extracellular matrix	A2M	HDA		Human	PMID:28675934
Cellular Component	GO:0070062	extracellular exosome	A2M	HDA		Human	PMID:20458337
Cellular Component	GO:0070062	extracellular exosome	A2M	HDA		Human	PMID:21362503
Cellular Component	GO:0070062	extracellular exosome	A2M	HDA		Human	PMID:23533145
Cellular Component	GO:0005615	extracellular space	A2m	IDA		Rat	PMID:2442306|RGD:10046028
Biological Process	GO:0002438	acute inflammatory response to antigenic stimulus	A2m	IEP		Rat	PMID:6202298|RGD:10046045
Biological Process	GO:0006953	acute-phase response	A2m	IEP		Rat	PMID:2468362|RGD:67925
Biological Process	GO:1990402	embryonic liver development	A2m	IEP		Rat	PMID:2450021|RGD:10046029
Biological Process	GO:0001889	liver development	a2ml	IMP	ZFIN:ZDB-MRPHLNO-090212-1	Zfish	PMID:19011686
Biological Process	GO:0001889	liver development	a2ml	IMP	ZFIN:ZDB-MRPHLNO-090212-2	Zfish	PMID:19011686
Biological Process	GO:0001553	luteinization	A2m	IEP		Rat	PMID:2479532|RGD:10046034
Biological Process	GO:0001869	negative regulation of complement activation, lectin pathway	A2M	IDA		Human	PMID:12538697
Biological Process	GO:0010951	negative regulation of endopeptidase activity	A2m	IDA		Rat	PMID:19240864|RGD:7411612
Biological Process	GO:0010037	response to carbon dioxide	A2m	IEP		Rat	PMID:12042906|RGD:1598710
Biological Process	GO:0051384	response to glucocorticoid	A2m	IEP		Rat	PMID:2436819|RGD:1598511
Biological Process	GO:0007584	response to nutrient	A2m	IEP		Rat	PMID:9446838|RGD:1598510
Biological Process	GO:0034695	response to prostaglandin E	A2m	IEP		Rat	PMID:6202298|RGD:10046045
Biological Process	GO:0048863	stem cell differentiation	A2m	IDA		Mouse	PMID:19796622

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern