A2m
Gene Detail

Symbol Name ID

A2m alpha-2-macroglobulin MGI:2449119

Synonyms

A2mp

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)

Sequence Map

Chr6:121636173-121679237 bp, + strand From Ensembl annotation of GRCm38   43065 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37248  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 15 zebrafish

Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: A2m

Human homologs

Human Homolog		A2M, alpha-2-macroglobulin
NCBI Gene ID		2
neXtProt AC		NX_P01023
Human Synonyms		A2MD, CPAMD5, FWP007, S863-7
Human Chr (Location)		12p13.31; chr12:9220304-9268558 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human A2M

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	female pregnancy, negative regulation of complement activation, lectin pathway, ...
Component	extracellular region, extracellular space, ...
Function	endopeptidase inhibitor activity, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (250)    Tissues (46)    Images (38)
Theiler Stages: 11, 19, 23, 28

Assay Type	Results
RNA in situ	248
RT-PCR	2

cDNA source data(55)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(56) cDNA(55) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030111 (Evidence)
Entrez Gene	232345 (Evidence)
UniGene	30151
DFCI	TC1578162
DoTS	DT.101372319, DT.97396488
NIA Mouse Gene Index	U042766
Consensus CDS Project	CCDS39617.1
International Mouse Knockout Project Status	A2m

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030111	Ensembl Gene Model | MGI Sequence Detail	43065	C57BL/6J
transcript	ENSMUST00000032203	Ensembl | MGI Sequence Detail	4670	Not Applicable
polypeptide	ENSMUSP00000032203	Ensembl | MGI Sequence Detail	1474	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(414 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001599	Alpha-2-macroglobulin
InterPro	IPR019742	Alpha-2-macroglobulin, conserved site
InterPro	IPR002890	Alpha-2-macroglobulin, N-terminal
InterPro	IPR011625	Alpha-2-macroglobulin, N-terminal 2
InterPro	IPR019565	Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro	IPR009048	Alpha-macroglobulin, receptor-binding
InterPro	IPR011626	A-macroglobulin complement component
InterPro	IPR008930	Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology	PR:000003514	alpha-2-macroglobulin-P

References

(Earliest) J:30080 Hudson NW, et al., Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue. Biochim Biophys Acta. 1982 Jun 4;704(2):290-303
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(47)