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A2m Gene Detail
Summary
  • Symbol
    A2m
  • Name
    alpha-2-macroglobulin
  • Synonyms
    A2mp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449119
    NCBI Gene: 232345
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:121636166-121679238 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.49 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    523 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2449119
protein coding gene Chr6:121635376-121679238 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031219
protein coding gene Chr6:124595355-124636498 (+)
A/J MGP_AJ_G0031188
protein coding gene Chr6:119796913-119836547 (+)
AKR/J MGP_AKRJ_G0031119
protein coding gene Chr6:123027278-123066904 (+)
BALB/cJ MGP_BALBcJ_G0031199
protein coding gene Chr6:119565552-119607493 (+)
C3H/HeJ MGP_C3HHeJ_G0030917
protein coding gene Chr6:123048497-123089307 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031657
protein coding gene Chr6:127775561-127822575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028817
protein coding gene Chr6:116710814-116713350 (+)
CAST/EiJ MGP_CASTEiJ_G0030306
protein coding gene Chr6:123512191-123551538 (+)
CBA/J MGP_CBAJ_G0030882
protein coding gene Chr6:132856140-132899046 (+)
DBA/2J MGP_DBA2J_G0031038
protein coding gene Chr6:118678411-118720803 (+)
FVB/NJ MGP_FVBNJ_G0030990
protein coding gene Chr6:117820950-117861296 (+)
LP/J MGP_LPJ_G0031117
protein coding gene Chr6:124574628-124617169 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031024
protein coding gene Chr6:136791057-136840453 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031686
protein coding gene Chr6:123062655-123102310 (+)
PWK/PhJ MGP_PWKPhJ_G0030021
protein coding gene Chr6:117727604-117769536 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029850
protein coding gene Chr6:121799928-121840754 (+)
WSB/EiJ MGP_WSBEiJ_G0030389
protein coding gene Chr6:123359706-123400819 (+)



Homology
more
  • Human Ortholog
    A2M, alpha-2-macroglobulin
  • Vertebrate Orthologs
    26
  • Human Ortholog
    A2M, alpha-2-macroglobulin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A2MD, CPAMD5, FWP007, S863-7
  • Links
    NCBI Gene ID: 2
    neXtProt AC: NX_P01023
    UniProt: P01023

  • Chr Location
    12p13.31; chr12:9067708-9115962 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human A2M associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 232345 NCBI Gene Model | MGI Sequence Detail 43073 C57BL/6J ±  kb
transcript NM_175628 RefSeq | MGI Sequence Detail 4687 C57BL/6  
polypeptide Q6GQT1 UniProt | EBI | MGI Sequence Detail 1474 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000024845 alpha-2-macroglobulin
  • InterPro Domains
    IPR001599 Alpha-2-macroglobulin
    IPR019742 Alpha-2-macroglobulin, conserved site
    IPR002890 Alpha-2-macroglobulin, N-terminal
    IPR011625 Alpha-2-macroglobulin, N-terminal 2
    IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
    IPR011626 Alpha-macroglobulin complement component
    IPR009048 Alpha-macroglobulin, receptor-binding
    IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Molecular
Reagents
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  • All nucleic 58
    cDNA 57
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 57
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:30080 Hudson NW, et al., Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue. Biochim Biophys Acta. 1982 Jun 4;704(2):290-303
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory