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A2m Gene Detail
Summary
  • Symbol
    A2m
  • Name
    alpha-2-macroglobulin
  • Synonyms
    A2mp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2449119
    NCBI Gene: 232345
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:121635376-121679227 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.49 cM
  • Mapping Data
    12 experiments
Homology
more
  • Human Ortholog
    A2M, alpha-2-macroglobulin
  • Vertebrate Orthologs
    26
  • Human Ortholog
    A2M, alpha-2-macroglobulin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A2MD, CPAMD5, FWP007, S863-7
  • Links
    NCBI Gene ID: 2
    neXtProt AC: NX_P01023
    UniProt: P01023

  • Chr Location
    12p13.31; chr12:9067708-9115962 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human A2M associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056872 VEGA Gene Model | MGI Sequence Detail 43852 C57BL/6J ±  kb
transcript OTTMUST00000140274 VEGA | MGI Sequence Detail 4605 Not Applicable  
polypeptide OTTMUSP00000073543 VEGA | MGI Sequence Detail 1474 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    534 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000024845 alpha-2-macroglobulin
  • InterPro Domains
    IPR001599 Alpha-2-macroglobulin
    IPR019742 Alpha-2-macroglobulin, conserved site
    IPR002890 Alpha-2-macroglobulin, N-terminal
    IPR011625 Alpha-2-macroglobulin, N-terminal 2
    IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
    IPR011626 Alpha-macroglobulin complement component
    IPR009048 Alpha-macroglobulin, receptor-binding
    IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily
    IPR014756 Immunoglobulin E-set
    IPR013783 Immunoglobulin-like fold
    IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Molecular
Reagents
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  • All nucleic 57
    cDNA 56
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 56
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 3
  • Earliest
    J:30080 Hudson NW, et al., Subunit and primary structure of a mouse alpha-macroglobulin, a human alpha 2-macroglobulin homologue. Biochim Biophys Acta. 1982 Jun 4;704(2):290-303
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory