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A2m
Gene Detail
Symbol

Name
ID
A2m
alpha-2-macroglobulin
MGI:2449119
Synonyms
A2mp
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr6:121636173-121679237 bp, + strand
From Ensembl annotation of GRCm38

  43065 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37248  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 15 zebrafish

HCOP human homology predictions: A2M
Protein SuperFamily: alpha-2-macroglobulin
Gene Tree: A2m

Human
homologs
A2M, alpha-2-macroglobulin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2
neXtProt AC: NX_P01023

Human Synonyms: A2MD, CPAMD5, FWP007, S863-7

Human Chr (Location): 12p13.31; chr12:9067708-9115962 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human A2M

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Interactions
A2m interacts with 75 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (250)    Tissues (46)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 248
RT-PCR 2
cDNA source data(55)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase a2m    NEW 
Molecular
reagents
All nucleic(56) cDNA(55) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000030111 (Evidence)
Entrez Gene 232345 (Evidence)
UniGene 30151
DFCI TC1578162
DoTS DT.101372319, DT.97396488
NIA Mouse Gene Index U042766
Consensus CDS Project CCDS39617.1
International Mouse Phenotyping Consortium Status A2m
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030111 Ensembl Gene Model | MGI Sequence Detail 43065 C57BL/6J ±  kb
transcript ENSMUST00000032203 Ensembl | MGI Sequence Detail 4670 Not Applicable 
polypeptide ENSMUSP00000032203 Ensembl | MGI Sequence Detail 1474 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(547 from dbSNP Build 137)    SNPs within 2kb including multiple locations(571)
Protein-related
information
ResourceIDDescription
InterPro IPR001599 Alpha-2-macroglobulin
InterPro IPR019742 Alpha-2-macroglobulin, conserved site
InterPro IPR002890 Alpha-2-macroglobulin, N-terminal
InterPro IPR011625 Alpha-2-macroglobulin, N-terminal 2
InterPro IPR019565 Alpha-2-macroglobulin, thiol-ester bond-forming
InterPro IPR011626 Alpha-macroglobulin complement component
InterPro IPR009048 Alpha-macroglobulin, receptor-binding
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
Protein Ontology PR:000024845 alpha-2-macroglobulin
References
(Earliest) J:15557 Van Leuven F, et al., The alpha-macroglobulin family of proteinase inhibitors and the A/LRP receptor. Fifth International Workshop on Mouse Genome Mapping. 1991;:55
(Latest) J:189624 Son EJ, et al., Developmental gene expression profiling along the tonotopic axis of the mouse cochlea. PLoS One. 2012;7(7):e40735
All references(48)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory