Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation
(1 available);
any
Cebpa mutation
(13 available)
Cebpbtm1Nerl mutation
(0 available);
any
Cebpb mutation
(22 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
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integument
|
N |
• mice have normal epidermis
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation
(1 available);
any
Cebpa mutation
(13 available)
Cebpatm2Nerl mutation
(0 available);
any
Cebpa mutation
(13 available)
Cebpbtm1Nerl mutation
(0 available);
any
Cebpb mutation
(22 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation
(1 available);
any
Cebpa mutation
(13 available)
Cebpatm9Nerl mutation
(0 available);
any
Cebpa mutation
(13 available)
Cebpbtm1Nerl mutation
(0 available);
any
Cebpb mutation
(22 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpatm1Gonz mutation
(1 available);
any
Cebpa mutation
(13 available)
Cebpbtm1Nerl mutation
(0 available);
any
Cebpb mutation
(22 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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mortality/aging
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• mice die within 5 to 8 hours of birth
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growth/size/body
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• at birth mice loss weight rapidly likely due to severe transepithelial water loss without lipophilic barrier dysfunction
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vision/eye
integument
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• the interfollicular epidermis exhibits an immature phenotype with fewer and smaller keratohyalin granules in the stratum granulosum and immature non-scaling stratum corneum and parakeratosis compared with wild-type mice
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cellular
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|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myd88tm1Aki mutation
(9 available);
any
Myd88 mutation
(44 available)
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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integument
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N |
• no skin lesions and normal epidermal thickness
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mortality/aging
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N |
• mice are born at Mendelian frequency and survive for over 2 years
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integument
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N |
• keratinocytes exhibit normal proliferation
• mice exhibit normal skin and hair
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|
• keratinocytes exhibit an increase in misshapen cell nuclei and nuclear blebs in culture compared with wild-type cells
• however, no polyploidy is observed
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb1tm1.1Sgy mutation
(1 available);
any
Lmnb1 mutation
(33 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
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mortality/aging
|
N |
• mice are born at Mendelian frequency and survive for over 2 years
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnb2tm1.1Sgy mutation
(1 available);
any
Lmnb2 mutation
(19 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
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mortality/aging
|
N |
• mice are born at Mendelian frequency and survive for over 2 years
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(39 available)
|
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integument
|
N |
• mice reach adulthood without showing inflammatory skin lesions
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Yhu mutation
(0 available);
any
Chuk mutation
(31 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
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integument
|
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• at birth, some mice resemble Chuktm1Mpa homozygotes
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• some mice exhibit epidermal hyperplasia after birth
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(39 available)
|
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immune system
|
N |
• normal circulating inflammatory cytokine and chemokine levels
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integument
|
N |
• no dermatitis and normal epidermal thickness up to age older than 40 weeks
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifnar1tm1Agt mutation
(11 available);
any
Ifnar1 mutation
(42 available)
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
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immune system
|
N |
• normal circulating inflammatory cytokine and chemokine levels in most mice
|
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• delineated inflamed skin lesions from age 6 weeks in some mice
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integument
|
N |
• no skin lesions and normal epidermal thickness in most mice
|
|
|
• delineated inflamed skin lesions from age 6 weeks in some mice
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm1Mak mutation
(2 available);
any
Tnfrsf1a mutation
(39 available)
|
|
|
integument
|
N |
• mice reach adulthood without showing inflammatory skin lesions
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(78 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
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pigmentation
|
N |
• mice never form white spots
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation
(1 available);
any
Rest mutation
(78 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
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pigmentation
|
N |
• mice never form white spots
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
Tnfrsf1atm2Gkl mutation
(1 available);
any
Tnfrsf1a mutation
(39 available)
|
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integument
|
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• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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• milder at P7 than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• skin lesions progressively develop to severe skin inflammation by 4 weeks
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immune system
|
|
• at P7
• skin lesions progressively develop to severe skin inflammation by 4 weeks
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuktm1Mpa mutation
(0 available);
any
Chuk mutation
(31 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
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mortality/aging
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• pups die within a few hours of birth
|
homeostasis/metabolism
growth/size/body
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• mice loose as much as 5% of their weight within 3 hours of birth
|
skeleton
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N |
• in contrast to Chuktm1.1Mpa homozygotes, mice do not have any skeletal abnormalities
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integument
|
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• skin on the limbs, tail and parts of the head show increased permeability
• however, skin on the body does not show increased permeability
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• epidermis had increased vascularisation
• blood vessel diameter is increased within the epidermis
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• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo
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• free fatty acids and ceramide content are decreased in the outer layer of the epidermis
• lipid composition within the stratum corneum is altered resulting in defective epidermal barrier and increased transepidermal water loss
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• at birth skin is shiny, sticky and taut
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cellular
|
|
• primary keratinocytes do not differentiate in medium with increased calcium
• however, keratinocytes differentiate normally in vivo
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulinem1Gvl mutation
(0 available);
any
Otulin mutation
(14 available)
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
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immune system
|
|
• delineated inflamed skin lesions on back
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integument
|
|
• delineated inflamed skin lesions on back
|
|
|
• delineated inflamed skin lesions on back
|
neoplasm
|
|
• verrucous carcinomas on back skin
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snap29tm1c(EUCOMM)Wtsi mutation
(0 available);
any
Snap29 mutation
(24 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
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mortality/aging
|
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• pups die within a few hours after birth
|
growth/size/body
|
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• slightly reduced body size
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behavior/neurological
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• none of the pups contain milk in their stomachs
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cellular
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• marker analysis indicates disturbed epidermal differentiation of the epidermis
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homeostasis/metabolism
integument
|
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• reduction of hair follicles down to 81% that of wild-type mice
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• skin shows decreased deposition of neutral lipids and glucosylceramide in the epidermis
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• marker analysis indicates disturbed epidermal differentiation of the epidermis
|
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• corneocytes appear inhomogeneously filled with remnants of nondegraded organelles and electron-lucent vesicle-like structures compared to homogenously filled wild-type corneocytes
|
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• stratum corneum is thickened and its structure is condensed
|
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• the basket-like structure of the stratum granulosum is condensed in the epidermis
|
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• reduction of lamellar body contents in the epidermis
• diminished formation, maturation, and secretion of lamellar bodies
|
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• the number of profilaggrin containing keratohyalin granules in the upper stratum granulosum is decreased in the epidermis
|
|
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• mice exhibit a congenital ichtyotic phenotype
|
|
|
• marker analysis indicates disturbed epidermal differentiation of the epidermis
|
|
|
• newborns show severe functional impairment of the epidermal barrier
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation
(0 available);
any
Fadd mutation
(12 available)
Mlkltm1.1Wsa mutation
(0 available);
any
Mlkl mutation
(20 available)
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
immune system
|
N |
• normal circulating inflammatory cytokine levels
|
integument
|
N |
• no skin lesions and normal epidermal thickness
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlkltm1.1Wsa mutation
(0 available);
any
Mlkl mutation
(20 available)
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
immune system
|
|
• delineated inflamed skin lesions on back
• no skin lesions in tail
|
integument
|
N |
• no skin lesions and normal epidermal thickness in tail
|
|
|
• delineated inflamed skin lesions on back
• no skin lesions in tail
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Otulintm1c(EUCOMM)Hmgu mutation
(0 available);
any
Otulin mutation
(14 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
integument
|
|
• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis
|
|
|
• in both skin lesions and non-lesional skin at age 7 weeks
|
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• hyperproliferation
• accelerated wound closure at day 2 and 4 post-wounding
• decelerated wound closure at day 8 post-wounding
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• hypersebacea at age 7 weeks
|
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• at wound sites after completion of re-epithelialization
|
|
|
• of back and tail skin lesions at age 7 weeks
• normal in non-lesional skin
|
|
|
• delineated inflamed skin lesions on back and tail from age P6 onwards
• infiltration of immune cells into lesional skin
|
|
|
• of back and tail skin lesions at age 7 weeks
• normal epidermal thickness of non-lesional skin
|
|
|
• tumor-like lesions at wound sites after completion of re-epithelialization
|
|
|
• delineated inflamed skin lesions on back and tail from age P6 onwards
|
|
|
• verrucous carcinoma developed from back and tail skin lesions
|
neoplasm
|
|
• verrucous carcinoma developed from back and tail skin lesions
|
immune system
|
|
• delineated inflamed skin lesions on back and tail from age P6 onwards
• infiltration of immune cells into lesional skin
|
cellular
|
|
• increased hair follicle stem cell (HFSC) and interfollicular epidermis (IFE) cell apoptosis
|
|
|
• in both skin lesions and non-lesional skin at age 7 weeks
|
|
|
• hyperproliferation
• accelerated wound closure at day 2 and 4 post-wounding
• decelerated wound closure at day 8 post-wounding
|
endocrine/exocrine glands
|
|
• hypersebacea at age 7 weeks
|
homeostasis/metabolism
growth/size/body
|
|
• at wound sites after completion of re-epithelialization
|
embryo
|
N |
• born at normal Mendelian ratios
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Il22ra1tm1Rsab mutation
(0 available);
any
Il22ra1 mutation
(21 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
mortality/aging
|
N |
• mice survive to adulthood
|
integument
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
|
|
|
• at P8, milder than in Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
|
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
|
immune system
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
• mild inflammation at 7 weeks
• cutaneous inflammation of variable degree on the abdomen, flanks and throat at 14 weeks
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Il20ratm1Rsab mutation
(0 available);
any
Il20ra mutation
(20 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
mortality/aging
|
|
• severe inflammation requiring euthanasia by P25 in some mice
|
integument
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
|
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
|
immune system
|
|
• delayed onset and decelerated development compared with Ikbkbtm1Cgn/Ikbkbtm1Cgn Tg(KRT14-cre)1Cgn
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Cgn mutation
(2 available)
Trim16tm1Gmma mutation
(0 available);
any
Trim16 mutation
(21 available)
|
|
|
neoplasm
|
|
• mice show increased incidence of DMBA and TPA-induced papillomas compared to wild-type mice and homozygotes
• 3 of 30 DMBA and TPA treated mice develop squamous cell carcinomas which are not seen in treated controls
• DMBA and TPA treated mice show an increase in the number of melanomas at 15 weeks compared to wild-type, with mice developing both small and large melanoma lesions after 21 weeks of TPA treatment compared to only small lesions in wild-type mice
|
|
|
• 6 of 33 DMBA/TPA-treated mice show pigmentation in a number of inguinal lymph nodes, suggesting metastatic melanoma
|
|
|
• DMBA and TPA treated mice show an increase in the development of papillomas at 13 and 15 weeks, but not weeks 18 and 21, indicating a decrease in latency of papilloma development
|
homeostasis/metabolism
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
integument
|
|
• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
|
|
|
• psoriasis-like skin inflammation
|
immune system
|
|
• psoriasis-like skin inflammation
• inflammatory infiltrate consists mainly of macrophages and dendritic cells rather than CD3+ T lymphocytes
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ikbkbtm1Cgn mutation
(0 available);
any
Ikbkb mutation
(36 available)
Il22tm1Jcrd mutation
(0 available);
any
Il22 mutation
(20 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
mortality/aging
integument
immune system
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)1Cgn mutation
(2 available)
Trim16tm1Gmma mutation
(0 available);
any
Trim16 mutation
(21 available)
|
|
|
neoplasm
|
N |
• mice show similar development of DMBA and TPA-induced papillomas as wild-type mice, with no development of squamous cell carcinoma
• mice show a similar incidence of DMBA/TPA-induced cutaneous melanomas as wild-type mice
|
|
|
• DMBA and TPA treated mice develop larger melanoma lesions than wild-type mice after 21 weeks of TPA treatment
|
behavior/neurological
|
N |
• mice exhibit normal food consumption
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbitm2.1Smdp mutation
(0 available);
any
Dbi mutation
(20 available)
Dbitm2.2Smdp mutation
(0 available);
any
Dbi mutation
(20 available)
Tg(KRT14-cre)1Cgn mutation
(2 available)
|
|
|
integument
|
|
• compromised epidermal barrier function at postnatal day 21
|
|
|
• greasy and tousled appearance identical to that in homozygous germ line null mice
|
adipose tissue
|
|
• elevated lypolysis in isolated inguinal WAT
|
homeostasis/metabolism
liver/biliary system
|
|
• greater accumulation of cholesteryl esters at P21
• accumulation is less than in homozygous germ line null mice
|
|
|
• expression analysis in fostered pups indicates a defect in liver adaptation to weaning
|
Analysis Tools
