Cebpatm2Nerl
Targeted Allele Detail
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Symbol: |
Cebpatm2Nerl |
Name: |
CCAAT/enhancer binding protein alpha; targeted mutation 2, Claus Nerlov |
MGI ID: |
MGI:2387093 |
Synonyms: |
2n, BRM2 |
Gene: |
Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
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Alliance: |
Cebpatm2Nerl page
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Germline Transmission: |
Earliest citation of germline transmission:
J:72330
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Not Specified) |
Mutation: |
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Nucleotide substitutions
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Mutation details: A partial rat Cebpa gene carring an isoleucine to alanine substitution at position 294 (I294A) and an arginine to alanine substitution at position 297 (R297A) in the basic region alpha helix replaced the corresponding portion of the mouse gene via homologous recombination. A neo resistance marker was also introduced downstream of Cepba for positive selection.
(J:72330)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Cebpa Mutation: |
16 strains or lines available
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Original: |
J:72330 Porse BT, et al., E2f repression by c/ebpalpha is required for adipogenesis and granulopoiesis in vivo. Cell. 2001 Oct 19;107(2):247-58 |
All: |
5 reference(s) |
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