All Phenotypes Cebpa<tm2Nerl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cebpa^tm2Nerl
targeted mutation 2, Claus Nerlov
MGI:2387093

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cebpa^tm2Nerl/Cebpa^tm2Nerl	involves: 129P2/OlaHsd * C57BL/6	MGI:3809498
cn2	Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2	MGI:4366855

Allelic Composition	Cebpa^tm2Nerl/Cebpa^tm2Nerl
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^tm2Nerl mutation (0 available); any Cebpa mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:72330 )

• fewer than expected mice are alive at 8 weeks of age

adipose tissue

decreased white adipose tissue amount ( J:72330 )

• mice have little to no white adipose tissue unlike in wild-type mice

abnormal gonadal fat pad morphology ( J:72330 )

• the gonadal fat pad is hypotrophic and adipocytes within it are smaller than normal

hematopoietic system

abnormal granulocyte morphology ( J:72330 )

• granulocytes are large and dysplastic

decreased granulocyte number ( J:72330 )

• in the bone marrow and peripheral blood

immune system

immune system phenotype ( J:72330 )

N	• despite the defects in granulocytes, other hematopoietic lineages are normal

abnormal granulocyte morphology ( J:72330 )

• granulocytes are large and dysplastic

decreased granulocyte number ( J:72330 )

• in the bone marrow and peripheral blood

Allelic Composition	Cebpa^tm1Gonz/Cebpa^tm2Nerl Cebpb^tm1Nerl/Cebpb^tm1Nerl Tg(KRT14-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cebpa^tm1Gonz mutation (1 available); any Cebpa mutation (18 available)
Cebpa^tm2Nerl mutation (0 available); any Cebpa mutation (18 available)
Cebpb^tm1Nerl mutation (0 available); any Cebpb mutation (26 available)
Tg(KRT14-cre)1Cgn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

increased keratinocyte proliferation ( J:154022 )

abnormal epidermis stratum corneum morphology ( J:154022 )

• intermediate phenotype

abnormal epidermis stratum granulosum morphology ( J:154022 )

• intermediate phenotype

shiny skin ( J:154022 )

cellular

increased keratinocyte proliferation ( J:154022 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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