Phenotypes associated with this allele

• Allele Symbol: Ighg1⁺
• Allele Name: wild type
• Allele ID: MGI:2431049
• Summary: 26 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Ighg1^tm1.1Pyu/Ighg1^+	B6.C(Cg)-Ighg1^tm1.1Pyu	MGI:5502732
ht2	Ighg1^tm2Cgn/Ighg1^+	(C57BL/6 x 129P2/OlaHsd)F1	MGI:3837938
ht3	Ighg1^tm3Cgn/Ighg1^+	involves: 129P2/OlaHsd * BALB/c * C57BL/6	MGI:4850031
ht4	Ighg1^tm1Ksho/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2669548
ht5	Ighg1^tm1.1Ksho/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2669547
cn6	Gt(ROSA)26Sor^tm1(gp80)Eces/Gt(ROSA)26Sor^+ Ighg1^tm1(cre)Cgn/Ighg1^+	either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)	MGI:5004803
cn7	Ezh2^tm1Tara/Ezh2^tm1Tara Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd	MGI:5519931
cn8	Ighg1^tm1(cre)Cgn/Ighg1^+ Irf4^tm1Rdf/Irf4^tm1.1Rdf	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:3712440
cn9	Col1a1^tm1(CAG-Ezh2*)Meln/Col1a1^+ Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5519929
cn10	Gt(ROSA)26Sor^tm13(CAG-MYC,-CD2*)Rsky/Gt(ROSA)26Sor^+ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444673
cn11	Gt(ROSA)26Sor^tm12(CD2*)Rsky/Gt(ROSA)26Sor^+ Myc^tm2Fwa/Myc^tm2Fwa Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:5444672
cn12	Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor^+ Ighg1^tm1(cre)Cgn/Ighg1^+ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * 129X1/SvJ	MGI:5762939
cn13	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5780068
cn14	Gt(ROSA)26Sor^tm7(Pik3ca*,-EGFP)Rsky/Gt(ROSA)26Sor^tm13(CAG-MYC,-CD2*)Rsky Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5463978
cn15	Gt(ROSA)26Sor^tm4(Ikbkb)Rsky/Gt(ROSA)26Sor^+ Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5762937
cn16	Gt(ROSA)26Sor^tm4(Ikbkb)Rsky/Gt(ROSA)26Sor^+ Ighg1^tm1(cre)Cgn/Ighg1^+ Prdm1^tm2Masu/Prdm1^tm2Masu	involves: 129P2/OlaHsd * C57BL/6	MGI:5762938
cn17	Mir146^tm1.1Lfl/Mir146^tm1.1Lfl Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:6360061
cn18	Kmt2d^tm1.1Kaig/Kmt2d^+ Ighg1^tm1(cre)Cgn/Ighg1^+ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780072
cn19	Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig Ighg1^tm1(cre)Cgn/Ighg1^+ Tg(Vav-BCL2)69Jad/0	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:5780071
cn20	Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl	MGI:5461329
cn21	Gm614^tm1.1Cya/Gm614^tm1.1Cya Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:6727909
cn22	Ighg1^tm1(cre)Cgn/Ighg1^+ Tbl1xr1^tm1c(EUCOMM)Hmgu/Tbl1xr1^tm1c(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550774
cn23	Ighg1^tm1(cre)Cgn/Ighg1^+ Tbl1xr1^tm1.1Meln/Tbl1xr1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:7550771
cn24	Ighg1^tm1(cre)Cgn/Ighg1^+ Myd88^em1.1Rsky/Myd88^+	involves: 129P2/OlaHsd * C57BL/6NTac	MGI:7281484
cn25	Ebf1^tm1.1Rug/Ebf1^tm1.1Rug Ighg1^tm1(cre)Cgn/Ighg1^+	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5316375
cx26	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^+	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502736

Genotype
MGI:5502732

ht1

• Allelic Composition: Ighg1^tm1.1Pyu/Ighg1⁺
• Genetic Background: B6.C(Cg)-Ighg1^tm1.1Pyu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:198154 )

N • unchallenged mice exhibit normal production of IgG1 and IgG2b

N • challenged mice exhibit normal production of IgM

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

hematopoietic system

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Genotype
MGI:3837938

ht2

• Allelic Composition: Ighg1^tm2Cgn/Ighg1⁺
• Genetic Background: (C57BL/6 x 129P2/OlaHsd)F1

immune system

abnormal class switch recombination ( J:146428 )

• B cells activated in vitro with LPS and IL-4 have a 95% reduction in IgG1 class switch recombination for the mutant 129P2/OlaHsd allele

• absence of class switching in these cultures leads to a doubling in the percentage of B cells expressing IgM from the 129P2/OlaHsd allele

• IgG1 class switch recombination for the wild-type C57BL/6 allele is normal in these cultures

decreased IgG1 level ( J:146428 )

• sera levels of IgG1 expressed from the mutant 129P2/OlaHsd allele (IgG1^a) is 2% of that in controls

• no antigen specific IgG1^a antibodies are detected in mice after immunization with NP antigen compared to high levels in controls

• sera levels of IgG1 expressed from the wild-type C57BL/6 allele (IgG1^b) is normal

hematopoietic system

abnormal class switch recombination ( J:146428 )

• B cells activated in vitro with LPS and IL-4 have a 95% reduction in IgG1 class switch recombination for the mutant 129P2/OlaHsd allele

• absence of class switching in these cultures leads to a doubling in the percentage of B cells expressing IgM from the 129P2/OlaHsd allele

• IgG1 class switch recombination for the wild-type C57BL/6 allele is normal in these cultures

decreased IgG1 level ( J:146428 )

• sera levels of IgG1 expressed from the mutant 129P2/OlaHsd allele (IgG1^a) is 2% of that in controls

• no antigen specific IgG1^a antibodies are detected in mice after immunization with NP antigen compared to high levels in controls

• sera levels of IgG1 expressed from the wild-type C57BL/6 allele (IgG1^b) is normal

Genotype
MGI:4850031

ht3

• Allelic Composition: Ighg1^tm3Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6

immune system

abnormal class switch recombination ( J:166887 )

• no serum IgG1a

• reduced IgG1b

decreased IgG1 level ( J:166887 )

• no serum IgG1a

• reduced IgG1b

hematopoietic system

abnormal class switch recombination ( J:166887 )

• no serum IgG1a

• reduced IgG1b

decreased IgG1 level ( J:166887 )

• no serum IgG1a

• reduced IgG1b

Genotype
MGI:2669548

ht4

• Allelic Composition: Ighg1^tm1Ksho/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is less pronounced than in Ighg1^tm1.1Ksho homozygotes

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG), produce less NP-specific IgG1

hematopoietic system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is less pronounced than in Ighg1^tm1.1Ksho homozygotes

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin coupled to 4-hydroxy-3-nitro-phenylacetyl (NP-CG), produce less NP-specific IgG1

Genotype
MGI:2669547

ht5

• Allelic Composition: Ighg1^tm1.1Ksho/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is more pronounced than in Ighg1^tm1Ksho mutant mice

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin (CG) coupled to 4-hydroxy-3-nitro-phenylacetyl (NP), produce less NP-specific IgG1

hematopoietic system

abnormal B cell physiology ( J:39568 )

• B cells are unable to mount efficient primary and secondary IgG1 responses

• the impairment is more pronounced than in Ighg1^tm1Ksho mutant mice

decreased IgG1 level ( J:39568 )

• mutants immunized with a T cell-dependent antigen, chicken gamma-globulin (CG) coupled to 4-hydroxy-3-nitro-phenylacetyl (NP), produce less NP-specific IgG1

Genotype
MGI:5004803

cn6

• Allelic Composition: Gt(ROSA)26Sor^{tm1(gp80)Eces}/Gt(ROSA)26Sor⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * BALB/c * C57BL/6)

Splenomegaly and lack of germinal center formation in Gt(ROSA)26Sor^{tm1(gp80)Eces}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ (left) and Gt(ROSA)26Sor^{tm1(gp80)Eces}/Gt(ROSA)26Sor⁺ Ighg1^tm1(cre)Cgn/Ighg1⁺ mice (right)

growth/size/body

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

mortality/aging

decreased tumor-free survival time ( J:172031 )

• mice succumb to tumors between 7 and 19 months of age

immune system

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

abnormal class switch recombination ( J:172031 )

decreased B cell number ( J:172031 )

• mice exhibit fewer IgG1+ B cells compared to in wild-type mice

decreased germinal center B cell number ( J:172031 )

decreased follicular B cell number ( J:172031 )

decreased plasma cell number ( J:172031 )

increased B cell number ( J:172031 )

• in the spleen with a slight reduction in the splenic B to T cell ratio

increased marginal zone B cell number ( J:172031 )

increased macrophage cell number ( J:172031 )

absent spleen germinal center ( J:172031 )

• in non-immunized and immunized mice

decreased IgA level ( J:172031 )

• NP-stimulated

increased IgE level ( J:172031 )

• resting and NP-stimulated

decreased IgG1 level ( J:172031 )

• resting and NP-stimulated

decreased IgG2a level ( J:172031 )

• resting and NP-stimulated

decreased IgG2b level ( J:172031 )

• resting and NP-stimulated

decreased IgG3 level ( J:172031 )

• resting and NP-stimulated

neoplasm

increased tumor incidence ( J:172031 )

• mice develop tumors in lymphoid tissues including nasopharynx, armpit, and inguinal region

increased sarcoma incidence ( J:172031 )

• histocytic/dendritic cell sarcoma

increased histiocytic sarcoma incidence ( J:172031 )

hematopoietic system

enlarged spleen ( J:172031 )

• in non-immunized and immunized mice starting at 2 to 3 months of age

increased spleen weight ( J:172031 )

abnormal class switch recombination ( J:172031 )

decreased B cell number ( J:172031 )

• mice exhibit fewer IgG1+ B cells compared to in wild-type mice

decreased germinal center B cell number ( J:172031 )

decreased follicular B cell number ( J:172031 )

decreased plasma cell number ( J:172031 )

increased B cell number ( J:172031 )

• in the spleen with a slight reduction in the splenic B to T cell ratio

increased marginal zone B cell number ( J:172031 )

increased macrophage cell number ( J:172031 )

absent spleen germinal center ( J:172031 )

• in non-immunized and immunized mice

decreased IgA level ( J:172031 )

• NP-stimulated

increased IgE level ( J:172031 )

• resting and NP-stimulated

decreased IgG1 level ( J:172031 )

• resting and NP-stimulated

decreased IgG2a level ( J:172031 )

• resting and NP-stimulated

decreased IgG2b level ( J:172031 )

• resting and NP-stimulated

decreased IgG3 level ( J:172031 )

• resting and NP-stimulated

Genotype
MGI:5519931

cn7

• Allelic Composition: Ezh2^tm1Tara/Ezh2^tm1Tara; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd

immune system

immune system phenotype ( J:199122 )

N • mice exhibit normal marginal zone and follicular B cells

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

decreased germinal center B cell number ( J:199122 )

• following injection of antigen sheep red blood cells or immunization with NP-KLH

decreased spleen germinal center number ( J:199122 )

• following injection of antigen sheep red blood cells

decreased spleen germinal center size ( J:199122 )

• following injection of antigen sheep red blood cells

decreased IgG1 level ( J:199122 )

• following immunization with NP-KLH

decreased IgG2b level ( J:199122 )

• following immunization with NP-KLH

decreased IgG3 level ( J:199122 )

• following immunization with NP-KLH

hematopoietic system

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

decreased germinal center B cell number ( J:199122 )

• following injection of antigen sheep red blood cells or immunization with NP-KLH

decreased spleen germinal center number ( J:199122 )

• following injection of antigen sheep red blood cells

decreased spleen germinal center size ( J:199122 )

• following injection of antigen sheep red blood cells

decreased IgG1 level ( J:199122 )

• following immunization with NP-KLH

decreased IgG2b level ( J:199122 )

• following immunization with NP-KLH

decreased IgG3 level ( J:199122 )

• following immunization with NP-KLH

cellular

decreased B cell proliferation ( J:199122 )

• reduced germinal center B cell compartment proliferation following injection of antigen sheep red blood cells

Genotype
MGI:3712440

cn8

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Irf4^tm1Rdf/Irf4^tm1.1Rdf
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

immune system

immune system phenotype ( J:112643 )

N • mice form germinal centers and have similar numbers of PNA^hi, B220+ B cells in spleen

abnormal class switch recombination ( J:112643 )

• following CD40 and Il-4 stimulation, mice have smaller fraction of class-switched cells than control mice (7.4% vs 26.3%); defect appears to be downstream of Cgamma1 germline transcription

absent plasma cells ( J:112643 )

• 14 days after immunization with sheep red blood cells, mutants are observed to lack plasma cells, as recognized by CD138 expression, in spleen, peripheral blood and bone marrow

abnormal memory B cell morphology ( J:112643 )

• memory B cell generation occurs in mutants after immunization with NP-KLH, but the population is maintained only partly over time; numbers of NP-binding cells are much lower 42 days after immunization compared to controls

• mice receiving a secondary immunization with antigen lack plasmablasts in the spleen that bind NP, are CD138 +ve and have low B220 expression, indicating that memory B cells cannot differentiate into plasma B cells upon antigen restimulation; B cells also lack IgG1 secretion after restimulation

decreased IgG1 level ( J:112643 )

• mice have much lower titer of IgG1 specific for the hapten NP (nitrophenylacetyl) than controls after immunization with NP coupled to keyhole limpet hemocyanin, but titers of other immunoglobulin classes are similar to levels in controls

hematopoietic system

abnormal class switch recombination ( J:112643 )

• following CD40 and Il-4 stimulation, mice have smaller fraction of class-switched cells than control mice (7.4% vs 26.3%); defect appears to be downstream of Cgamma1 germline transcription

absent plasma cells ( J:112643 )

• 14 days after immunization with sheep red blood cells, mutants are observed to lack plasma cells, as recognized by CD138 expression, in spleen, peripheral blood and bone marrow

abnormal memory B cell morphology ( J:112643 )

• memory B cell generation occurs in mutants after immunization with NP-KLH, but the population is maintained only partly over time; numbers of NP-binding cells are much lower 42 days after immunization compared to controls

• mice receiving a secondary immunization with antigen lack plasmablasts in the spleen that bind NP, are CD138 +ve and have low B220 expression, indicating that memory B cells cannot differentiate into plasma B cells upon antigen restimulation; B cells also lack IgG1 secretion after restimulation

decreased IgG1 level ( J:112643 )

• mice have much lower titer of IgG1 specific for the hapten NP (nitrophenylacetyl) than controls after immunization with NP coupled to keyhole limpet hemocyanin, but titers of other immunoglobulin classes are similar to levels in controls

Genotype
MGI:5519929

cn9

• Allelic Composition: Col1a1^{tm1(CAG-Ezh2*)Meln}/Col1a1⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

immune system

immune system phenotype ( J:199122 )

N • mice exhibit normal marginal zone and follicular B cells

increased germinal center B cell number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center size ( J:199122 )

• following immunization with NP-KLH

neoplasm

neoplasm ( J:199122 )

N • mice exhibit normal marginal zone and follicular B cells

hematopoietic system

increased germinal center B cell number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center number ( J:199122 )

• following immunization with NP-KLH

increased spleen germinal center size ( J:199122 )

• following immunization with NP-KLH

Genotype
MGI:5444673

cn10

• Allelic Composition: Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}/Gt(ROSA)26Sor⁺; Myc^tm2Fwa/Myc^tm2Fwa; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

immune system

immune system phenotype ( J:188564 )

N • enforced expression of human MYC rescues germinal center formation

Genotype
MGI:5444672

cn11

• Allelic Composition: Gt(ROSA)26Sor^{tm12(CD2*)Rsky}/Gt(ROSA)26Sor⁺; Myc^tm2Fwa/Myc^tm2Fwa; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

immune system

decreased spleen germinal center size ( J:188564 )

• almost complete ablation of germinal centers in response to T cell dependent immunization

• the few remaining germinal center B cells have escaped cre mediated recombination

hematopoietic system

decreased spleen germinal center size ( J:188564 )

• almost complete ablation of germinal centers in response to T cell dependent immunization

• the few remaining germinal center B cells have escaped cre mediated recombination

Genotype
MGI:5762939

cn12

• Allelic Composition: Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺; Prdm1^tm2Masu/Prdm1^tm2Masu
• Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

hematopoietic system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

enlarged lymph nodes ( J:167612 )

• occasional lymphadenopathy

liver/biliary system

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

mortality/aging

decreased survivor rate ( J:167612 )

• shortened survival

premature death ( J:167612 )

• shortened survival

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• spleens and lymph nodes show presence of large cells with a diffuse growth pattern, resembling diffuse large B cell lymphoma (DLBCL)

• lymphoproliferations are of clonal origin

• 5 of 6 DLBCLs are consistent with activated B cell-DLBCL

growth/size/body

enlarged liver ( J:167612 )

• hepatomegaly in one mouse

enlarged spleen ( J:167612 )

• splenomegaly in all terminally ill mice

Genotype
MGI:5780068

cn13

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

immune system phenotype ( J:228913 )

♀N • unimmunized mice exhibit normal germinal center size and number, IgG1+ B cell numbers, plasma cells, total IgG1 serum levels and induced B cell proliferation

Genotype
MGI:5463978

cn14

• Allelic Composition: Gt(ROSA)26Sor^{tm7(Pik3ca*,-EGFP)Rsky}/Gt(ROSA)26Sor^{tm13(CAG-MYC,-CD2*)Rsky}; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:191824 )

• when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells, median survival is 227 days

immune system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

neoplasm

increased B cell derived lymphoma incidence ( J:191824 )

• of germinal center B cell origin when bone marrow is used to reconstitute Rag2 and Il2rg null mice stimulated with sheep red blood cells

hematopoietic system

abnormal class switch recombination ( J:191824 )

• impaired

increased germinal center B cell number ( J:191824 )

• in the Peyer's patches and spleen

Genotype
MGI:5762937

cn15

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

decreased germinal center B cell number ( J:167612 )

• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization

increased B cell number ( J:167612 )

• hyperplasia of B cells in the spleen and bone marrow at 550-600 days

increased plasma cell number ( J:167612 )

• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days

• clonal or oligoclonal plasma cell expansions

abnormal spleen morphology ( J:167612 )

• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

increased IgG1 level ( J:167612 )

increased IgM level ( J:167612 )

immune system

decreased germinal center B cell number ( J:167612 )

• mice show some reduction in the germinal center B cell fraction at day 10 after primary and secondary immunization

increased B cell number ( J:167612 )

• hyperplasia of B cells in the spleen and bone marrow at 550-600 days

increased plasma cell number ( J:167612 )

• hyperplasia of plasma cells in the spleen and bone marrow at 550-600 days

• clonal or oligoclonal plasma cell expansions

abnormal spleen morphology ( J:167612 )

• large numbers of cells expressing intracellular Ig and the plasma cell marker CD138 are seen in spleens

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

increased IgG1 level ( J:167612 )

increased IgM level ( J:167612 )

growth/size/body

enlarged spleen ( J:167612 )

• enlarged spleens in mice 550-600 days of age

Genotype
MGI:5762938

cn16

• Allelic Composition: Gt(ROSA)26Sor^{tm4(Ikbkb)Rsky}/Gt(ROSA)26Sor⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺; Prdm1^tm2Masu/Prdm1^tm2Masu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

hematopoietic system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

immune system

abnormal plasma cell differentiation ( J:167612 )

• plasma cell formation is severely impeded 10 days after primary and secondary immunization

increased germinal center B cell number ( J:167612 )

• mice show increased numbers of germinal center B cells at day 10 after primary immunizations

abnormal germinal center B cell physiology ( J:167612 )

• small, but significant, increase of the fraction of germinal center B cells in the S and G2 phases of the cell cycle

decreased IgG1 level ( J:167612 )

• reduction in total as well as sheep red blood cell-specific IgG1, but not IgM, antibodies 10 days after primary and secondary immunization

mortality/aging

decreased survivor rate ( J:167612 )

premature death ( J:167612 )

• shortened survival, with 40% survival at around 500 days of age

neoplasm

increased B cell derived lymphoma incidence ( J:167612 )

• mice succumb to a B cell-derived lymphoproliferative disease affecting spleen and lymph nodes, resembling human diffuse large B cell lymphoma

• mice develop clonal lymphomas consistent with activated B cell-diffuse large B cell lymphoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
non-Hodgkin lymphoma		DOID:0060060	OMIM:605027	J:167612

Genotype
MGI:6360061

cn17

• Allelic Composition: Mir146^tm1.1Lfl/Mir146^tm1.1Lfl; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

immune system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

hematopoietic system

increased germinal center B cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

increased T follicular helper cell number ( J:266124 )

• mild day 28 post immunization with sheep red blood cells

Genotype
MGI:5780072

cn18

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d⁺; Ighg1^tm1(cre)Cgn/Ighg1⁺; Tg(Vav-BCL2)69Jad/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

mortality/aging

premature death ( J:228913 )

♀ • mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

♀ • diffuse large B cell lymphoma as in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

♀ • more so than in Tg(Vav-BCL2)1Jad mice

Genotype
MGI:5780071

cn19

• Allelic Composition: Kmt2d^tm1.1Kaig/Kmt2d^tm1.1Kaig; Ighg1^tm1(cre)Cgn/Ighg1⁺; Tg(Vav-BCL2)69Jad/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

mortality/aging

premature death ( J:228913 )

♀ • mice die around 13 months of age as in Tg(Vav-BCL2)1Jad mice

neoplasm

increased B cell derived lymphoma incidence ( J:228913 )

♀ • diffuse large B cell lymphoma more so than in Tg(Vav-BCL2)1Jad mice

increased follicular lymphoma incidence ( J:228913 )

♀ • more so than in Tg(Vav-BCL2)1Jad mice

Genotype
MGI:5461329

cn20

• Allelic Composition: Bcl6^tm1.1Mtto/Bcl6^tm1.1Mtto; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JJcl

immune system

immune system phenotype ( J:190943 )

N • mice immunized with NP-CG exhibit normal development of memory B cells

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

hematopoietic system

decreased germinal center B cell number ( J:190943 )

• in mice immunized with NP-CG at day 7 and 40 with deletion of early GC B cells

Genotype
MGI:6727909

cn21

• Allelic Composition: Gm614^tm1.1Cya/Gm614^tm1.1Cya; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N

immune system

immune system phenotype ( J:307345 )

N • normal total IgG levels after pristane injection

N • normal CD86^loCXCR4^hi dark zone (DZ) and CD86^hiCXCR4^lo light zone (LZ) B cells ratio after pristane injection

N • normal B cell cell cycle after pristane injection

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

decreased susceptibility to systemic lupus erythematosus ( J:307345 )

• reduced inflammatory cell infiltration in kidney and normal glomerular morphology after pristane injection

• reduced levels of IgM and IgG anti-nucleic antibodies and anti-nucleosome IgG after pristane injection

hematopoietic system

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

cellular

increased B cell apoptosis ( J:307345 )

• in germinal center after pristane injection

Genotype
MGI:7550774

cn22

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Tbl1xr1^{tm1c(EUCOMM)Hmgu}/Tbl1xr1^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

Genotype
MGI:7550771

cn23

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Tbl1xr1^tm1.1Meln/Tbl1xr1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

hematopoietic system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

immune system

abnormal B cell differentiation ( J:292118 )

• decreased number and proportion of FAS+ GL7+and FAS+ CD38- germinal center B cells (GCBs) after immunization with sheep red blood cells (SRBC)

• normal B cell abundance

abnormal spleen morphology ( J:292118 )

• smaller germinal centers (GCs) after immunization with sheep red blood cells (SRBC)

• normal follicular structure and number of GCs after immunization with sheep red blood cells (SRBC)

Genotype
MGI:7281484

cn24

• Allelic Composition: Ighg1^tm1(cre)Cgn/Ighg1⁺; Myd88^em1.1Rsky/Myd88⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6NTac

hematopoietic system

hematopoietic system phenotype ( J:308792 )

N • normal Ig class switching in germinal center B cells after immunization with hapten-carrier conjugate NP-CGG

N • normal rise and fall of hapten-specific IgG levels after immunization with hapten-carrier conjugate NP-CGG

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

immune system

abnormal somatic hypermutation frequency ( J:308792 )

• increased frequency in IgM+ plasma cells

increased germinal center B cell number ( J:308792 )

• increased frequency and number

increased plasma cell number ( J:308792 )

• persistently high number of hapten-specific IgM+ plasma cells in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• high total plasma cell numbers in spleen and bone marrow for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

abnormal splenic cell ratio ( J:308792 )

• increased frequency and number of plasma cells and germinal center B cells

increased IgM level ( J:308792 )

• high total IgM serum levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

• persistently high hapten-specific IgM levels for at least 50 weeks after immunization with hapten-carrier conjugate NP-CGG

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
monoclonal gammopathy of uncertain significance		DOID:7442		J:308792

Genotype
MGI:5316375

cn25

• Allelic Composition: Ebf1^tm1.1Rug/Ebf1^tm1.1Rug; Ighg1^tm1(cre)Cgn/Ighg1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

immune system

decreased germinal center B cell number ( J:182210 )

• 2 to 3 times in immunized mice

hematopoietic system

decreased germinal center B cell number ( J:182210 )

• 2 to 3 times in immunized mice

Genotype
MGI:5502736

cx26

• Allelic Composition: Fcer2a^tm1Max/Fcer2a^tm1Max; Ighg1^tm1.1Pyu/Ighg1⁺
• Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin