All Phenotypes Myc<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myc⁺
wild type
MGI:2182123

Summary

20 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Myc^tm1Atp/Myc⁺	B6.129P2-Myc^tm1Atp	MGI:3811831
ht2	Myc^{em1(IMPC)Kmpc}/Myc⁺	C57BL/6NTac-Myc^{em1(IMPC)Kmpc}/Kmpc	MGI:7472115
ht3	Myc^tm3(Tcrb)Fwa/Myc⁺	involves: 129	MGI:3775398
ht4	Myc^tm2.1Atp/Myc⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:3811817
ht5	Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * FVB/N	MGI:3811816
ht6	Myc^tm1Lbox/Myc⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3603015
ht7	Myc^tm1Brd/Myc⁺	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2182124
ht8	Myc^tm37Mnz/Myc⁺	involves: C57BL/6	MGI:3836393
ht9	Myc^tm39Mnz/Myc⁺	involves: C57BL/6	MGI:3836390
cn10	Myc^tm2Fwa/Myc⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1	MGI:7485842
cn11	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836397
cn12	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836396
cn13	Myc^tm2Fwa/Myc⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:3720194
cx14	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811821
cx15	Cdkn1b^tm1Mlf/Cdkn1b⁺ Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:3811822
cx16	Il15^tm1Imx/Il15^tm1Imx Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3811834
cx17	Del(15Rr316124-Rr313939)2Fsp/+ Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:7411328
cx18	Il15^tm1Imx/Il15⁺ Myc^tm1Atp/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3811833
cx19	Apc^Min/Apc⁺ Myc^tm1Jlc/Myc⁺	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:3812011
cx20	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺	involves: C57BL/6 * CBA	MGI:3836398

Allelic Composition	Myc^tm1Atp/Myc⁺
Genetic Background	B6.129P2-Myc^tm1Atp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:132730 )

N	• thymocyte development is normal

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased between 2- and 3-fold compared to in wild-type mice

• however, steady state turnover and survival of memory T cells is normal

abnormal NK cell physiology ( J:132730 )

• NK cells exhibit a slight reduction in IL15 induced proliferation compared to similarly treated wild-type cells

• however, normal proliferation of NK cells was normal at high concentrations Il15

hematopoietic system

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased between 2- and 3-fold compared to in wild-type mice

• however, steady state turnover and survival of memory T cells is normal

abnormal NK cell physiology ( J:132730 )

• NK cells exhibit a slight reduction in IL15 induced proliferation compared to similarly treated wild-type cells

• however, normal proliferation of NK cells was normal at high concentrations Il15

cellular

decreased T cell proliferation ( J:132730 )

• 60% of activated T cells remain in a resting state compared to 30% in wild-type mice

• mice exhibit a 2-fold decreased in the number of dividing cells compared to in wild-type mice

• antigen-specific memory CD8+ T cells exhibit a cell autonomous impaired homeostatic proliferation compared to in wild-type mice

• memory CD44^high CD8+ T cells exhibit impaired proliferation in response to IL15 compared to similarly treated wild-type cells

Allelic Composition	Myc^{em1(IMPC)Kmpc}/Myc⁺
Genetic Background	C57BL/6NTac-Myc^{em1(IMPC)Kmpc}/Kmpc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^{em1(IMPC)Kmpc} mutation (0 available); any Myc mutation (42 available)

Data Sources

IMPC Data for Myc

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased fluid intake ( J:211773 )

IMPC - KMPC

increased startle reflex ( J:211773 )

IMPC - KMPC

increased grip strength ( J:211773 )

IMPC - KMPC

growth/size/body

decreased body length ( J:211773 )

IMPC - KMPC

nervous system

decreased prepulse inhibition ( J:211773 )

IMPC - KMPC

skeleton

abnormal bone structure ( J:211773 )

IMPC - KMPC

decreased bone mineral content ( J:211773 )

IMPC - KMPC

decreased bone mineral density ( J:211773 )

IMPC - KMPC

Allelic Composition	Myc^tm3(Tcrb)Fwa/Myc⁺
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm3(Tcrb)Fwa mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )

• the knocked in gene segments have substantial recombination in T and B cells but not in the kidney

hematopoietic system

abnormal T cell receptor beta chain V(D)J recombination ( J:131995 )

• the knocked in gene segments have substantial recombination in T and B cells but not in the kidney

Allelic Composition	Myc^tm2.1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm2.1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

growth/size/body

decreased body weight ( J:73369 )

• mice exhibit decreased weight compared to wild-type mice that is not as severe as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 63% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle then in wild-type samples

Allelic Composition	Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

spleen hypoplasia ( J:73369 )

lymph node hypoplasia ( J:73369 )

small lymphoid organs ( J:73369 )

• thymus, spleen, lymph node and bone marrow organ to body weight ratios are reduced compared to in wild-type mice

lymphoid hypoplasia ( J:73369 )

• in the spleen, lymph nodes and bone marrow

growth/size/body

decreased body size ( J:73369 )

• at birth

decreased body weight ( J:73369 )

• adult mice are 18% to 22% smaller than wild-type mice by weight

postnatal growth retardation ( J:73369 )

decreased fetal size ( J:73369 )

• at E16.5

cellular

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

decreased fibroblast proliferation ( J:73369 )

• mouse embryonic fibroblasts exhibit decreased proliferation in culture compared to wild-type cells

adipose tissue

decreased white adipose tissue amount ( J:73369 )

limbs/digits/tail

short tail ( J:73369 )

hematopoietic system

decreased T cell proliferation ( J:73369 )

• the percent of T cells that proliferate in response to TCR stimulation is 43% compared to 69% in wild-type cells with fewer cells re-entering the cell cycle than in wild-type samples

decreased bone marrow cell number ( J:73369 )

spleen hypoplasia ( J:73369 )

Allelic Composition	Myc^tm1Lbox/Myc⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm1Lbox mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histopathological analysis of lymphomas in Myc^tm1Lbox/Myc^tm1Lbox and Myc^tm1Lbox/Myc⁺ mice

mortality/aging

premature death ( J:97900 )

• mean age of death is about 379 days

immune system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

• in young (6 weeks-3months) mutants, the percentage of B cells in the spleen is increased with a significant increase in the B220+IgM+IgD^low cell population and a slight increase in the B220+IgM+ cell population is seen in the bone marrow

enlarged lymph nodes ( J:97900 )

• around 12 months of age profound enlargement of the lymph nodes is seen

neoplasm

increased B cell derived lymphoma incidence ( J:97900 )

• B cell derived lymphomas with diffuse infiltration in the spleen and lymph nodes, varying degrees of infiltration into the lung, kidney, and intestine, and a 'starry sky' appearance characteristic of Burkitt's lymphoma are seen

hematopoietic system

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

increased B cell number ( J:97900 )

growth/size/body

enlarged spleen ( J:97900 )

• around 12 months of age profound enlargement of the spleen is seen

increased spleen weight ( J:97900 )

• around 12 months of age, a 5-12 fold increase in spleen weight seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Burkitt lymphoma		DOID:8584	OMIM:113970	J:97900

Allelic Composition	Myc^tm1Brd/Myc⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm1Brd mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reduced female fertility ( J:4556 )

• 14% of implanted embryos are resorbed in females

decreased litter size ( J:4556 )

• heterozygous female mice produce litters of 3.2 mice compared to a litter of 4.2 mice when males are heterozygous for the allele

Allelic Composition	Myc^tm37Mnz/Myc⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm37Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

induced chromosome breakage ( J:145691 )

• activated B cells transfected with yeast-derived I-SceI endonuclease have a 4-fold higher incidence of chromosomal translocations involving chromosomes 12 and 15 than do controls

Allelic Composition	Myc^tm39Mnz/Myc⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm39Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• in activated B cells, Myc/Igh translocations involving chromosomes 12 and 15 occur 10-fold less frequently with the mutant Myc allele than with the wild-type allele

Allelic Composition	Myc^tm2Fwa/Myc⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myc^tm2Fwa mutation (2 available); any Myc mutation (42 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Myc

mortality/aging

increased tumor-free survival time ( J:319454 )

• survival time is increased compared to mutant mice wild-type for Myc

skeleton

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Myc

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (58 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (41 available)
Myc^tm37Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (58 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (41 available)
Myc^tm39Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Allelic Composition	Myc^tm2Fwa/Myc⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)
Myc^tm2Fwa mutation (2 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

belly spot ( J:121871 )

• mutant mice display a clearly demarcated white belly spot

integument

belly spot ( J:121871 )

• mutant mice display a clearly demarcated white belly spot

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b^tm1Mlf Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1b^tm1Mlf mutation (2 available); any Cdkn1b mutation (26 available)
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

growth/size/body

decreased body size ( J:73369 )

• as in Myc^tm1Atp heterozygotes

hematopoietic system

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

cellular

decreased T cell proliferation ( J:73369 )

• as in Myc^tm1Atp heterozygotes

Allelic Composition	Cdkn1b^tm1Mlf/Cdkn1b⁺ Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:73369 )

• as in Myc^tm1Atp heterozygotes

Allelic Composition	Il15^tm1Imx/Il15^tm1Imx Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il15^tm1Imx mutation (5 available); any Il15 mutation (44 available)
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK cell number ( J:132730 )

decreased memory T cell number ( J:132730 )

• mice exhibit the same reduction in CD8+ CD44^high memory T cells as in Il15^tm1Imx Myc^tm1Atp heterozygotes

hematopoietic system

decreased NK cell number ( J:132730 )

decreased memory T cell number ( J:132730 )

• mice exhibit the same reduction in CD8+ CD44^high memory T cells as in Il15^tm1Imx Myc^tm1Atp heterozygotes

Allelic Composition	Del(15Rr316124-Rr313939)2Fsp/+ Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(15Rr316124-Rr313939)2Fsp mutation (0 available); any Del(15Rr316124-Rr313939)2Fsp mutation (0 available)
Myc^tm1Atp mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:257739 )

N	• normal number of MMP1, HSC and T cells and erythrocytes in bone marrow

increased myeloid cell number in bone marrow ( J:257739 )

• increased multipotent progenitor (MMP) populations 3 and 4

• normal number of MMP1 and HSC cells

decreased bone marrow cell number ( J:257739 )

• decreased B cell and granulocyte numbers

• normal number of MMP1 and HSC cells

increased megakaryocyte cell number ( J:257739 )

• increased megakaryocytic cell number in bone marrow

decreased granulocyte number ( J:257739 )

• in bone marrow

decreased B cell number ( J:257739 )

• in bone marrow

immune system

decreased granulocyte number ( J:257739 )

• in bone marrow

decreased B cell number ( J:257739 )

• in bone marrow

Allelic Composition	Il15^tm1Imx/Il15⁺ Myc^tm1Atp/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased compared to in wild-type mice or single heterogyzotes

immune system

decreased memory T cell number ( J:132730 )

• the number of CD8+ CD44^high memory T cells is decreased compared to in wild-type mice or single heterogyzotes

Allelic Composition	Apc^Min/Apc⁺ Myc^tm1Jlc/Myc⁺
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apc^Min mutation (12 available); any Apc mutation (156 available)
Myc^tm1Jlc mutation (0 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:134087 )

N	• mice exhibit a life span of 291 days compared to 169 days in Apc^Min heterozygotes

digestive/alimentary system

intestine polyps ( J:134087 )

• mice develop fewer and smaller polyps than in Apc^Min heterozygotes

abnormal digestive system physiology ( J:134087 )

• cell proliferation in polyps is decreased compared to in Apc^Min heterozygotes while levels of apoptosis are increased compared to in Apc^Min heterozygotes and wild-type mice

hematopoietic system

hematopoietic system phenotype ( J:134087 )

N	• unlike in Apc^Min heterozygotes, hematocrit levels and spleen size are normal

abnormal hematopoietic system morphology/development ( J:134087 )

• expression of angiogenic factors is decreased compared to in Apc^Min heterozygotes

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (58 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (41 available)
Myc^tm37Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

induced chromosome breakage ( J:145691 )

• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15

• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles

• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions

• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes

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