Myc^tm1Brd
Targeted Allele Detail

Summary

• Symbol: Myc^tm1Brd
• Name: myelocytomatosis oncogene; targeted mutation 1, Allan Bradley
• MGI ID: MGI:2178196
• Synonyms: c-myc -
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:4556
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into the second exon. Western blot analysis on doubly targeted ES cells demonstrated that no detectable protein was expressed from this allele. (J:4556)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:4556 Davis AC, et al., A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev. 1993 Apr;7(4):671-82
• All: 2 reference(s)