Phenotypes associated with this allele

• Allele Symbol: Myc^tm1Brd
• Allele Name: targeted mutation 1, Allan Bradley
• Allele ID: MGI:2178196
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myc^tm1Brd/Myc^tm1Brd	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2182121
ht2	Myc^tm1Brd/Myc^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:2182124

Genotype
MGI:2182121

hm1

• Allelic Composition: Myc^tm1Brd/Myc^tm1Brd
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:4556 )

• embryos die between E9.5 and E10.5

cardiovascular system

enlarged heart ( J:4556 )

distended pericardium ( J:4556 )

• dilated pericardium

embryo

abnormal embryo turning ( J:4556 )

embryonic growth retardation ( J:4556 )

• generalized developmental delay

open neural tube ( J:4556 )

• failure of neural tube closure

nervous system

open neural tube ( J:4556 )

• failure of neural tube closure

growth/size/body

enlarged heart ( J:4556 )

embryonic growth retardation ( J:4556 )

• generalized developmental delay

Genotype
MGI:2182124

ht2

• Allelic Composition: Myc^tm1Brd/Myc⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

reproductive system

reduced female fertility ( J:4556 )

♀ • 14% of implanted embryos are resorbed in females

decreased litter size ( J:4556 )

• heterozygous female mice produce litters of 3.2 mice compared to a litter of 4.2 mice when males are heterozygous for the allele