Myc^tm1Atp
Targeted Allele Detail

Summary

• Symbol: Myc^tm1Atp
• Name: myelocytomatosis oncogene; targeted mutation 1, Andreas Trumpp
• MGI ID: MGI:2177578
• Synonyms: c-myc^-, c-myc^deltaORF
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm1Atp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73369
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-Hprt expression cassette replaced the entire open reading frame. RNase protection assays using E9.5 embryo RNA did not detect expression in homozygous mutant embryos. (J:73369)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 42 strains or lines available

References

• Original: J:73369 Trumpp A, et al., c-Myc regulates mammalian body size by controlling cell number but not cell size. Nature. 2001 Dec 13;414(6865):768-73
• All: 8 reference(s)