Phenotypes associated with this allele

• Allele Symbol: Mapt⁺
• Allele Name: wild type
• Allele ID: MGI:2152802
• Summary: 22 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mapt^tm1.1(FUS)Neas/Mapt^+	B6J.129P2(129S)-Mapt^tm1.1(FUS)Neas	MGI:5823842
ht2	Mapt^tm2.1(FUS)Neas/Mapt^+	B6J.129P2(129S)-Mapt^tm2.1(FUS)Neas	MGI:5823847
ht3	Mapt^tm3.1(FUS)Neas/Mapt^+	B6J.129P2(129S)-Mapt^tm3.1(FUS)Neas	MGI:5823860
ht4	Mapt^tm2.1(RHOA*)Klt/Mapt^+	involves: 129S4/SvJae * C57BL/6 * FVB/N	MGI:4442966
ht5	Mapt^tm1(Mecp2)Jae/Mapt^+	involves: 129/Sv * C57BL/6	MGI:3043298
ht6	Mapt^tm1Hnd/Mapt^+	involves: 129X1/SvJ * C57BL/6	MGI:3718365
cn7	Chat^tm2(cre)Lowl/Chat^+ Mapt^tm2(FUS)Neas/Mapt^+	B6.129-Mapt^tm2(FUS)Neas Chat^tm2(cre)Lowl	MGI:5823845
cn8	Chat^tm2(cre)Lowl/Chat^+ Mapt^tm3(FUS)Neas/Mapt^+	B6.129-Mapt^tm3(FUS)Neas Chat^tm2(cre)Lowl	MGI:5823858
cn9	Fus^tm1a(EUCOMM)Wtsi/Fus^tm1c(EUCOMM)Wtsi Mapt^tm3.1(FUS)Neas/Mapt^+ Ndor1^Tg(UBC-cre/ERT2)1Ejb/0	involves: 129 * C3H * C57BL/6 * C57BL/6N	MGI:5824116
cn10	Lbx1^tm2Cbm/Lbx1^tm3.1(cre)Cbm Mapt^tm2Arbr/Mapt^+	involves: 129P2/OlaHsd	MGI:3710960
cn11	Mapt^tm2Arbr/Mapt^+ Neurod6^tm1(cre)Kan/Neurod6^+ Trim67^tm1.1Slgu/Trim67^tm1.1Slgu	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:6259603
cn12	Isl1^tm1(cre)Tmj/Isl1^+ Mapt^tm1(Ewsr1/Etv4)Arbr/Mapt^+	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716103
cn13	Mapt^tm1(Ewsr1/Etv4)Arbr/Mapt^+ Mnx1^tm4(cre)Tmj/Mnx1^+	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6	MGI:3716107
cn14	Mapt^tm2Arbr/Mapt^+ Shox2^tm1.1(cre)Oki/Shox2^+ Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J	MGI:5576701
cn15	Mapt^tm2Arbr/Mapt^+ Pvalb^tm1(cre)Arbr/Pvalb^+	involves: 129P2/OlaHsd * C57BL/6	MGI:3716104
cn16	Bdnf^tm1Msd/Bdnf^tm1Msd Mapt^tm1(cre)Nagy/Mapt^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3809587
cn17	Bdnf^tm1Yab/Bdnf^tm1Yab Mapt^tm1(cre)Nagy/Mapt^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:4443030
cn18	Mapt^tm1(Setdb1)Akba/Mapt^+ Mecp2^tm1Jae/Y Tg(Nes-cre)1Atp/0	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N	MGI:5299159
cn19	Smc3^tm1.1Toshi/Smc3^+ Mapt^tm2(cre)Aha/Mapt^+	involves: C57BL/6J	MGI:7489855
cn20	Mapt^tm1(Sema3e)Yuyo/Mapt^+ Olig2^tm1(cre)Tmj/Olig2^+	Not Specified	MGI:5550524
cx21	Mapt^tm1(Mecp2)Jae/Mapt^+ Mecp2^tm1.1Jae/Mecp2^+	involves: 129S4/SvJae * C57BL/6	MGI:3043301
cx22	Mapt^tm1Hnd/Mapt^+ Zbtb20^Tg(PDGFB-APPSwInd)20Lms/0	involves: 129X1/SvJ * C57BL/6 * DBA/2	MGI:3718361

Genotype
MGI:5823842

ht1

• Allelic Composition: Mapt^{tm1.1(FUS)Neas}/Mapt⁺
• Genetic Background: B6J.129P2(129S)-Mapt^{tm1.1(FUS)Neas}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:232167 )

N • mice do not exhibit loss of lumbar level 5 motor neurons or denervation of the tibialis anterior, gastrocnemius, or soleus muscles

Genotype
MGI:5823847

ht2

• Allelic Composition: Mapt^{tm2.1(FUS)Neas}/Mapt⁺
• Genetic Background: B6J.129P2(129S)-Mapt^{tm2.1(FUS)Neas}

nervous system

astrocytosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

abnormal motor neuron innervation pattern ( J:232167 )

• by P40, before motor neuron loss, a significant number of neuromuscular junctions in the tibialis anterior has no associated input, indicating early retraction of motor axons

motor neuron degeneration ( J:232167 )

• loss of motor neurons at lumber level 5 (L5) is first seen at P60 and progresses steadily to P360

• however, no loss of parvalbumin-positive, proprioceptive sensory neurons in the L5 dorsal root ganglia is seen or of motor neuron loss in oculomotor nucleus at P360

abnormal neuromuscular synapse morphology ( J:232167 )

• by P40, denervation of the tibialis anterior neuromuscular junctions are seen before motor neuron loss

• denervation of the gastrocnemius muscle is seen at P90 when about 10% of neuromuscular junctions are vacant

• denervation in both the tibialis anterior and gastrocnemius muscles progresses steadily so that by P360, 30.2% and 13.9% of endplates are vacant in the respective muscles

• however, no denervation of the slow sloeus muscle is seen at 1 year

hematopoietic system

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

immune system

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

cellular

astrocytosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

Genotype
MGI:5823860

ht3

• Allelic Composition: Mapt^{tm3.1(FUS)Neas}/Mapt⁺
• Genetic Background: B6J.129P2(129S)-Mapt^{tm3.1(FUS)Neas}

behavior/neurological

paraparesis ( J:232167 )

• hind-limb weakness; wire hang analysis of P360 mice shows that the average latency to fall is about half that of the controls

hematopoietic system

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

immune system

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

muscle

abnormal tibialis anterior morphology ( J:232167 )

• internal nuclei and decreased fiber diameter are seen in the tibialis anterior muscle

• sarcomere length in tibialis anterior muscle is reduced

abnormal sarcomere morphology ( J:232167 )

• sarcomere length in tibialis anterior muscle is reduced

nervous system

astrocytosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

abnormal motor neuron innervation pattern ( J:232167 )

• by P20, before motor neuron loss, 11.4% of neuromuscular junctions in the tibialis anterior have no associated input, indicating early retraction of motor axons

motor neuron degeneration ( J:232167 )

• loss of motor neurons at lumber level 5 (L5) is first seen at P30 and progresses steadily to P360

• however, no loss of parvalbumin-positive, proprioceptive sensory neurons in the L5 dorsal root ganglia is seen or of motor neuron loss in oculomotor nucleus at P360

• increase in spontaneous activity in motor neurons, a sign of active denervation of neurogenic origin

abnormal synaptic bouton morphology ( J:232167 )

• in the axon terminals of motor neurons, the number of morphologically normal mitochondria is decreased and the remaining mitochondria appear dilated and vacuolated with disorganized cristae and membranes

abnormal neuromuscular synapse morphology ( J:232167 )

• by P20, before motor neuron loss, 11.4% of neuromuscular junctions in the tibialis anterior have no associated input, indicating early retraction of motor axons

• denervation of the gastrocnemius muscle is seen at P90 when about 10% of neuromuscular junctions are vacant

• denervation in both the tibialis anterior and gastrocnemius muscles progresses steadily so that by P360, 36.7% and 19.3% of endplates are vacant in the respective muscles

• by P360, 36.7% and 19.3% of neuromuscular junctions are denervated in the tibialis anterior and gastrocnemius muscles, respectively

• by P360, only 10% of slow soleus muscle motor terminals are vacant

• at P30, neuromuscular junctions (NMJs) show pre-synaptic abnormalities, including a 40% reduction in the density of synaptic vesicles in the pre-synaptic terminals

• however, the number of active zones-the main apparatus for synaptic vesicle release-is unchanged

• in the axon terminals of motor neurons, the number of morphologically normal mitochondria is decreased and the remaining mitochondria appear dilated and vacuolated with disorganized cristae and membranes, while on the postsynaptic side of NMJs, abnormal mitochondria are seen

abnormal synaptic transmission ( J:232167 )

• at 50 Hz, a 45% reduction of the motor response amplitude in the tibialis anterior, suggesting that motor neurons cannot sustain reliable neurotransmission at the NMJs and exhibit abnormal synaptic depression

• at 100 Hz, mice exhibit synaptic depression, however the motor response in tibialis anterior motor neurons is often completely absent, indicating failure of neurotransmission

abnormal synaptic depression ( J:232167 )

• motor neurons exhibit abnormal synaptic depression

limbs/digits/tail

abnormal tibialis anterior morphology ( J:232167 )

• internal nuclei and decreased fiber diameter are seen in the tibialis anterior muscle

• sarcomere length in tibialis anterior muscle is reduced

cellular

astrocytosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

microgliosis ( J:232167 )

• motor neuron degeneration is associated with astrocytosis and microgliosis

Genotype
MGI:4442966

ht4

• Allelic Composition: Mapt^{tm2.1(RHOA*)Klt}/Mapt⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * FVB/N

nervous system

nervous system phenotype ( J:159220 )

N • mice exhibit normal cortical anatomy and neuronal migration and cell type specification of cortical neuron

decreased neuron apoptosis ( J:159220 )

• in the somatosensory cortex at P5

abnormal somatosensory cortex morphology ( J:159220 )

• at P24, mice exhibit an increase in number and density of neurons in the somatosensory neurons compared with wild-type mice

• however, the density of interneurons in the somatosensory cortex is normal

increased neuron number ( J:159220 )

• at P24, mice exhibit an increase in number and density of neurons in the somatosensory neurons compared with wild-type mice

cellular

decreased neuron apoptosis ( J:159220 )

• in the somatosensory cortex at P5

Genotype
MGI:3043298

ht5

• Allelic Composition: Mapt^{tm1(Mecp2)Jae}/Mapt⁺
• Genetic Background: involves: 129/Sv * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:89593 )

• heterozygous mice are fertile and healthy with no obvious abnormalities

Genotype
MGI:3718365

ht6

• Allelic Composition: Mapt^tm1Hnd/Mapt⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6

behavior/neurological

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• severity is reduced and seizure onset is delayed after pentylenetetrazole treatment compared to wild-type mice

• mice are resistant to kainate-induced seizures over a larger range of doses than wild-type mice

Genotype
MGI:5823845

cn7

• Allelic Composition: Chat^tm2(cre)Lowl/Chat⁺; Mapt^tm2(FUS)Neas/Mapt⁺
• Genetic Background: B6.129-Mapt^tm2(FUS)Neas Chat^tm2(cre)Lowl

nervous system

motor neuron degeneration ( J:232167 )

• motor neuron loss is seen at P60 but not P30, when 10% of lumbar level 5 (L5) motor neurons are lost and by P360, there are 18.6% fewer motor neurons overall in the L5 segment

abnormal neuromuscular synapse morphology ( J:232167 )

• about 10% denervation of the tibialis anterior neuromuscular junctions (NMJs), first seen at P60 which progresses with age such that at P360, about 25% of NMJs are denervated

• denervation is first noted at P120 in the gastrocnemius muscle where about 10% of NMJs are denervated

• however, even at P360, no denervation is seen in the soleus muscle NMJs

Genotype
MGI:5823858

cn8

• Allelic Composition: Chat^tm2(cre)Lowl/Chat⁺; Mapt^tm3(FUS)Neas/Mapt⁺
• Genetic Background: B6.129-Mapt^tm3(FUS)Neas Chat^tm2(cre)Lowl

nervous system

motor neuron degeneration ( J:232167 )

• significant motor neuron loss is seen at P30 but not P10, and by P360, there are 22.6% fewer motor neurons overall in the lumbar level 5 (L5) segment

abnormal neuromuscular synapse morphology ( J:232167 )

• about 10% denervation of the tibialis anterior neuromuscular junctions, first seen at P20 which progresses with age such that at P360, about 30% of NMJs are denervated

• denervation is first noted at P120 in the gastrocnemius muscle where about 13% of NMJs are denervated

• however, even at P360, no denervation is seen in the soleus muscle NMJs

Genotype
MGI:5824116

cn9

• Allelic Composition: Fus^{tm1a(EUCOMM)Wtsi}/Fus^{tm1c(EUCOMM)Wtsi}; Mapt^{tm3.1(FUS)Neas}/Mapt⁺; Ndor1^{Tg(UBC-cre/ERT2)1Ejb}/0
• Genetic Background: involves: 129 * C3H * C57BL/6 * C57BL/6N
• Cell Lines: EPD0667_5_C04

nervous system

abnormal neuromuscular synapse morphology ( J:232167 )

• mice treated with tamoxifen postnatally show denervation in the tibialis anterior muscle where about 12% of neuromuscular junctions are denervated

Genotype
MGI:3710960

cn10

• Allelic Composition: Lbx1^tm2Cbm/Lbx1^{tm3.1(cre)Cbm}; Mapt^tm2Arbr/Mapt⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal brainstem morphology ( J:121332 )

• spinal trigeminal nucleus (SpV, trigeminal somatosensory relay nucleus) does not form; Lmx1b+ and Tlx3+ neurons cannot be detected at E14 and 18 in lateral medulla, but such neurons ar abundant in control SpV

abnormal medulla oblongata morphology ( J:121332 )

• ectopic dB3* and dBLb3* neurons are assembled in a broad dorsal band

• absence of SpV causes shape abnormalities in medulla

abnormal neuron morphology ( J:121332 )

• mutants have increased number of tyrosine hydroxylase-positive neurons in dorsal medulla

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• neurons expressing Phox2b, Lmx1b, and Tlx3, thus diplaying identity of dA3 neurons, arise early in neurogenesis at positions where dB3 neurons are normally generated, and are designated dB3* neurons

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice

increased sensory neuron number ( J:121332 )

abnormal neuron specification ( J:121332 )

• dB3 and dBLb neurons are misspecified, and an increased number of ectopic dB3* and dBLb3* neurons with the molecular characteristics of dA3 neurons Lmx1b are seen in mutants vs controls at E14 and settle like dA3 neurons in a broad band in dorsal medulla close to solitary tract

cellular

abnormal neuron differentiation ( J:121332 )

• many ectopic neurons are observed in the ventral alar plate at E10.5

• neurons expressing Phox2b, Lmx1b, and Tlx3, thus diplaying identity of dA3 neurons, arise early in neurogenesis at positions where dB3 neurons are normally generated, and are designated dB3* neurons

• such ectopic neurons (DBLb*) also arise during the late phase of neurogenesis, at the expense of dBLb (late-born dB neurons) whereas Phox2b+ neurons are only generated early in control mice

Genotype
MGI:6259603

cn11

• Allelic Composition: Mapt^tm2Arbr/Mapt⁺; Neurod6^tm1(cre)Kan/Neurod6⁺; Trim67^tm1.1Slgu/Trim67^tm1.1Slgu
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

decreased corpus callosum size ( J:266702 )

• thinner

Genotype
MGI:3716103

cn12

• Allelic Composition: Isl1^tm1(cre)Tmj/Isl1⁺; Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

abnormal sensory neuron morphology ( J:100886 )

• while sensory axons reach the skin only rudimentary sensory axon branching is established within the skin

abnormal sensory neuron innervation pattern ( J:100886 )

• sensory afferents fail to invade the spinal cord and are found in an extreme lateral position at the dorsal root entry zone

• sensory afferents are bifurcated at the entry point

• sensory afferent fibers fail to approach the midline at the distal segments and continue to occupy an extreme lateral position

abnormal dorsal root ganglion morphology ( J:100886 )

• unlike wild-type cells, dorsal root ganglia neurons survive in culture without the addition of neurotrophic agents

• whole dorsal root ganglia require neurotrophin-3 for survival

muscle

decreased muscle spindle number ( J:100886 )

• mice have 25% of the wild-type number of muscle spindles

Genotype
MGI:3716107

cn13

• Allelic Composition: Mapt^{tm1(Ewsr1/Etv4)Arbr}/Mapt⁺; Mnx1^tm4(cre)Tmj/Mnx1⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6

nervous system

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

cellular

abnormal axon extension ( J:100886 )

• mice have very few dorsal root ganglia neurons at brachial levels and increasingly more neurons progressing caudally undergo recombination

Genotype
MGI:5576701

cn14

• Allelic Composition: Mapt^tm2Arbr/Mapt⁺; Shox2^{tm1.1(cre)Oki}/Shox2⁺; Slc17a6^tm1.1Thna/Slc17a6^tm1.2Edw
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

nervous system

abnormal nervous system physiology ( J:209344 )

• frequencies of locomotor activity induced in isolated spinal cords increase with increasing NMDA concentrations, but are significantly lower than those observed in control spinal cords

• locomotor burst duration increases but duty cycle is not changed in mutant preparations (increased interburst interval)

• coefficients of variation of main locomotor parameters (cycle period, burst duration, amplitude, duty cycle) are increased compared to controls

• spinal cords from mutants display lower drug-evoked and stimulus-evoked locomotor frequencies

• flexor-extensor coupling is not significantly changed at any locomotor frequency

Genotype
MGI:3716104

cn15

• Allelic Composition: Mapt^tm2Arbr/Mapt⁺; Pvalb^tm1(cre)Arbr/Pvalb⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal dorsal root ganglion morphology ( J:100886 )

• whole dorsal root ganglia require neurotrophin-3 for survival

Genotype
MGI:3809587

cn16

• Allelic Composition: Bdnf^tm1Msd/Bdnf^tm1Msd; Mapt^tm1(cre)Nagy/Mapt⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

mortality/aging ( J:131394 )

N • mice survive for several months after birth

nervous system

nervous system phenotype ( J:131394 )

N • long term depression is normal

reduced long-term potentiation ( J:131394 )

Genotype
MGI:4443030

cn17

• Allelic Composition: Bdnf^tm1Yab/Bdnf^tm1Yab; Mapt^tm1(cre)Nagy/Mapt⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

mortality/aging

postnatal lethality, complete penetrance ( J:157932 )

• mice exhibiting zygotic cre expression die within a week of birth

• however, remaining mice survive at least 8 months

nervous system

decreased brain size ( J:157932 )

• slightly at 2 months

decreased brain weight ( J:157932 )

• at 2 months

decreased striatum size ( J:157932 )

• striatum volume is reduced compared to in wild-type mice

abnormal neuron morphology ( J:157932 )

• striatal neurons are smaller than in wild-type mice with smaller cell bodies

abnormal dendrite morphology ( J:157932 )

• dendritic complexity, number, length, and volume occupied in striatal neurons are reduced compared to in wild-type mice

• dendritic spine densities and total number of spines of striatal neurons are decreased compared to in wild-type mice

• CA1 hippocampal neuron exhibit reduced apical dendrite complexity and reduced proportion of mushroom spines where as mice exhibit an increased in the number of thin spines compared to in wild-type mice

abnormal optic nerve morphology ( J:157932 )

• the optic nerve is hypomyelinated and axonal diameters are reduced compared to in wild-type mice

• however, mice exhibit normal optic nerve cross-sectional area and axon numbers

behavior/neurological

increased anxiety-related response ( J:157932 )

• light/dark exploration is impaired compared to in wild-type mice

limb grasping ( J:157932 )

• at 8 weeks

abnormal locomotor activation ( J:157932 )

• mice exhibit bursts of hyperactivity followed by periods of inactivity that were longer than normal

growth/size/body

decreased body weight ( J:157932 )

• at 8 weeks, male mice are slightly lighter than wild-type mice

• however, by 4 weeks male mice exhibit normal body weight

increased body weight ( J:157932 )

• by 6 weeks and there after, female mice exhibit mild to severe obesity with a 43% increased in body weight compared with wild-type mice

postnatal growth retardation ( J:157932 )

vision/eye

abnormal optic nerve morphology ( J:157932 )

• the optic nerve is hypomyelinated and axonal diameters are reduced compared to in wild-type mice

• however, mice exhibit normal optic nerve cross-sectional area and axon numbers

Genotype
MGI:5299159

cn18

• Allelic Composition: Mapt^{tm1(Setdb1)Akba}/Mapt⁺; Mecp2^tm1Jae/Y; Tg(Nes-cre)1Atp/0
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N

mortality/aging

premature death ( J:178512 )

♂ • most mice die between 8 weeks and 24 weeks of age

behavior/neurological

impaired coordination ( J:178512 )

♂

Genotype
MGI:7489855

cn19

• Allelic Composition: Smc3^tm1.1Toshi/Smc3⁺; Mapt^tm2(cre)Aha/Mapt⁺
• Genetic Background: involves: C57BL/6J

behavior/neurological

increased anxiety-related response ( J:242006 )

♂ • in the novelty-induced hypophagia test, adult males show a significantly longer latency to drink milk in a novel, brightly lit cage as well as reduced milk consumption relative to controls, indicating increased anxiety

♂ • however, no significant differences are noted in the light/dark transition or marble-burying tests

nervous system

decreased CNS synapse formation ( J:242006 )

• at P21, Stat1 expression in the cortex is significantly higher than in controls

Genotype
MGI:5550524

cn20

• Allelic Composition: Mapt^{tm1(Sema3e)Yuyo}/Mapt⁺; Olig2^tm1(cre)Tmj/Olig2⁺
• Genetic Background: Not Specified

nervous system

nervous system phenotype ( J:205528 )

N • normal proprioceptive sensory axonal projection to the ventral spinal cord

abnormal sensory neuron innervation pattern ( J:205528 )

• decrease in monosynaptic sensory-motor connections from sensory neurons innervating the hamstring knee flexor muscle

abnormal synaptic bouton morphology ( J:205528 )

• number of boutons on the soma of motor neurons innervating the hamstring knee flexor muscle are reduced while the density of boutons in the vicinity remains normal

• normal vGlut+ boutons on Glu motor neurons

abnormal excitatory postsynaptic potential ( J:205528 )

• mean amplitudes of the monosynaptic EPSPs in motor neurons innervating the hamstring knee flexor muscle are reduced comparing to wild-type

Genotype
MGI:3043301

cx21

• Allelic Composition: Mapt^{tm1(Mecp2)Jae}/Mapt⁺; Mecp2^tm1.1Jae/Mecp2⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

behavior/neurological

behavior/neurological phenotype ( J:89593 )

♀N • mutant activity as measured by exploratory response and total nocturnal activity does not differ from wild-type mice

growth/size/body

growth/size/body region phenotype ( J:89593 )

♀N • mutants display normal body weight

nervous system

nervous system phenotype ( J:89593 )

♀N • mutants display normal brain weight

Genotype
MGI:3718361

cx22

• Allelic Composition: Mapt^tm1Hnd/Mapt⁺; Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

behavior/neurological

behavior/neurological phenotype ( J:121330 )

N • mice show no signs of hyperactivity

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

abnormal spatial learning ( J:121330 )

• in the hidden platform version of the Morris water maze, non-trangenic controls, regardless of Mapt genotype learn the task over 3 days, whereas transgenic mice heterozygous for Mapt^tm1Hnd show show impaired learning compared to controls but less impairment than transgenic mice with normal Mapt expression

• in probe trials where the platform is removed, mice show delayed learning, compared to non transgenic controls or transgenic mice with wild-type Mapt, with more target than non-target crossings after 5 days of training

nervous system

decreased susceptibility to pharmacologically induced seizures ( J:121330 )

• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt

abnormal neuron morphology ( J:121330 )

• mice show neuritic dystrophy around amyloid plaques

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

cellular

abnormal neuron differentiation ( J:121330 )

• aberrant sprouting of hippocampal axons is observed in transgenic mice

homeostasis/metabolism

amyloid beta deposits ( J:121330 )

• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt