Errfi1 MGI Mouse Gene Detail - MGI:1921405 - ERBB receptor feedback inhibitor 1

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1921405	protein coding gene	Chr4:150938253-150953349 (+)
129S1/SvImJ	ENSMUSG00200041810	protein coding gene	Chr4:142005115-142019869 (+)
A/J	ENSMUSG00195014484	protein coding gene	Chr4:143637560-143652533 (+)
AKR/J	ENSMUSG00220023484	protein coding gene	Chr4:143223375-143238328 (+)
BALB/cJ	ENSMUSG00180015457	protein coding gene	Chr6:138524421-138527061 (+)
BALB/cJ	ENSMUSG00180044808	protein coding gene	Chr4:141320102-141335075 (+)
C3H/HeJ	ENSMUSG00175016385	protein coding gene	Chr4:144603662-144618613 (+)
C57BL/6NJ	ENSMUSG00215019443	protein coding gene	Chr4:143448560-143463529 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026832	protein coding gene	Chr4:140751980-140766907 (+)
CAST/EiJ	ENSTCUG00005028062	protein coding gene	Chr4:147313047-147327847 (+)
CBA/J	ENSMUSG00210004656	protein coding gene	Chr4:143255278-143270231 (+)
DBA/2J	ENSMUSG00185013854	protein coding gene	Chr4:146821250-146836228 (+)
FVB/NJ	ENSMUSG00205037292	protein coding gene	Chr4:141717674-141732652 (+)
JF1/MsJ	ENSUMUG00000007611	protein coding gene	Chr4:149826104-149840889 (+)
LP/J	ENSMUSG00230017707	protein coding gene	Chr4:153553284-153568262 (+)
NOD/ShiLtJ	ENSMUSG00190003586	protein coding gene	Chr4:142921032-142935985 (+)
NZO/HlLtJ	ENSMUSG00225023138	protein coding gene	Chr4:157548624-157563577 (+)
PWK/PhJ	ENSLUMG00010026199	protein coding gene	Chr4:142110968-142125704 (+)
SPRET/EiJ	ENSMSPG00010022680	protein coding gene	Chr4:144031459-144046227 (+)
WSB/EiJ	ENSIUOG00005043815	protein coding gene	Chr4:141092723-141107688 (+)

Length	Strain/Species	Flank
genomic	ENSMUSG00000028967	Ensembl Gene Model \| MGI Sequence Detail	14974	C57BL/6J	± kb
transcript	ENSMUST00000030811	Ensembl \| MGI Sequence Detail	3043	Not Applicable
polypeptide	ENSMUSP00000030811	Ensembl \| MGI Sequence Detail	461	Not Applicable

TSS for Errfi1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40443	Chr4:150937179-150937187 (+)	-1,193 bp
Tssr40444	Chr4:150938226-150938245 (+)	-140 bp
Tssr40445	Chr4:150938252-150938269 (+)	-115 bp
Tssr40446	Chr4:150938473-150938507 (+)	114 bp
Tssr40447	Chr4:150938510-150938520 (+)	139 bp
Tssr40448	Chr4:150938827-150938842 (+)	459 bp
Tssr40449	Chr4:150939521-150939538 (+)	1,154 bp
Tssr40450	Chr4:150949830-150949865 (+)	11,472 bp
Tssr40451	Chr4:150950833-150950853 (+)	12,467 bp
Tssr40452	Chr4:150950929-150950946 (+)	12,562 bp
Tssr40453	Chr4:150951010-150951030 (+)	12,644 bp
Tssr40454	Chr4:150951264-150951289 (+)	12,901 bp
Tssr40455	Chr4:150951423-150951445 (+)	13,058 bp
Tssr40456	Chr4:150951504-150951529 (+)	13,141 bp
Tssr40457	Chr4:150951546-150951558 (+)	13,176 bp
Tssr40458	Chr4:150951726-150951771 (+)	13,373 bp
Tssr40459	Chr4:150952739-150952757 (+)	14,372 bp

Errfi1 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Cdcs9	Chr4, 75.67 cM	Chr4:142230872-142230960	J:109420	Microarray analysis was used to identify candidate genes for colitis susceptibility QTLs. Messenger RNA was analyzed for expression differences between colitis susceptible inbred strain C3H/HeJBir-Il10 and colitis resistant inbred strain C57BL/6J-Il10. Capn3 (67.2 cM) on mouse Chromosome 2 is upregulated 1.5- to 2-fold in C3H/HeJBir-Il10 animals. This candidate gene maps to the Cdcs3 (cytokine deficiency colitis susceptibility 3) interval centered near 65 cM. Gbp1 (67.4 cM) on mouse Chromosome 3 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild type strains. Gbp1 maps to the Cdcs1 (cytokine deficiency colitis susceptibility 1) interval centered near 62 cM. Adh1 at 71.2 cM and Bglap2 at 42.6 cM also map to the same QTL interval. Adh1 is upregulated 1.5- to 2-fold, and Blgap2 is upregulated 2- to 5-fold, in C3H/HeJBir-Il10animals. Pla2g2a (68 cM) on mouse Chromosome 4 is upregulated over 15-fold in C3H/HeJBir-Il10 animals. This candidate gene is known to be polymorphic between C3H/HeJBir and C57BL/6J and exhibits expression differences in these parental wild typestrains. Pla2g2a maps to the Cdcs9 (cytokine deficiency colitis susceptibility 9) interval centered near 71 cM. Moreover, C57BL/6J animals are known to carry the frameshift mutation Pla2g2a resulting in multiple intestinal neoplasia. The human ortholog PLA2G2A maps near a irritable bowel disorder (IBD) susceptibility locus named IBD7. Gnb1 (79.4 cM) also maps to the Cdcs9 QTL interval and is upregulated 2- to 5-fold in C57BL/6J-Il10 animals. Errfi1 (formerly 1300002F13Rik) and Tceb3 also map to the Cdcs9 interval and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Areg (51 cM) on mouse Chromosome 5 maps near the Cdcs10 QTL interval centered around 45 cM. This candidate gene is upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals. Mtmr7 maps to mouse Chromosome 8 near the Cdcs4 interval centered around 21 cM. This candidate gene is upregulated over 15-fold in C57BL/6J-Il10 animals. Cd14 (31 cM) on mouse Chromosome 18 is upregulated 5- to 15-fold in C3H/HeJBir-Il10 animals. CD14 also exhibits expression differences in parental wild type strains C3H/HeJBir and C57BL/6J. This candidate gene maps to the Cdcs6 (cytokine deficiency colitis susceptibility 6) interval centered near 41 cM. The human ortholog CD14 maps near a human irritable bowel disorder (IBD) susceptibility locus named IBD5. Glo1 (16 cM) and Ly6g6c on mouse Chromosome 17 are upregulated 2- to 5-fold in C57BL/6J-Il10 animals. This candidate gene maps to the Cdcs5 (cytokine deficiency colitis susceptibility 5) interval centered near 19 cM. Hspa1a (18.9 cM) and Hspa1b (18.9 cM) also map to Cdcs5 and are upregulated 1.5- to 2-fold in C57BL/6J-Il10 animals.

*cM position of peak correlated region/marker

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Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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