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H2-Ab1 Gene Detail
Summary
  • Symbol
    H2-Ab1
  • Name
    histocompatibility 2, class II antigen A, beta 1
  • Synonyms
    A beta, Abeta, H2-Ab, H-2Ab, Ia-2, Ia2, I-Ab, IAb, I-Abeta, Rmcs1
  • Feature Type
    protein coding gene
  • IDs
    MGI:103070
    NCBI Gene: 14961
  • Alliance
    genome feature page
  • Transcription Start Sites
    28 TSS
  • Regulated by
    Rr206 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr17:34482201-34488392 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_103070
 protein coding gene Chr17:34476663-34488393 (+)
129S1/SvImJ ENSMUSG00200046440
 protein coding gene Chr17:30185171-30191651 (+)
A/J ENSMUSG00195046315
 protein coding gene Chr17:31039365-31046584 (+)
AKR/J ENSMUSG00220044474
 protein coding gene Chr17:30067006-30074225 (+)
BALB/cJ ENSMUSG00180028486
 protein coding gene Chr17:30428341-30434154 (+)
C3H/HeJ ENSMUSG00175052001
 protein coding gene Chr17:29953157-29960376 (+)
C57BL/6NJ ENSMUSG00215052290
 protein coding gene Chr17:30025355-30031838 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021452
 protein coding gene Chr17:31071247-31077676 (+)
CAST/EiJ ENSTCUG00005051223
 protein coding gene Chr17:30998226-31004091 (+)
CBA/J ENSMUSG00210039577
 protein coding gene Chr17:29775270-29782489 (+)
DBA/2J ENSMUSG00185052157
 protein coding gene Chr17:32447623-32453436 (+)
FVB/NJ ENSMUSG00205021176
 protein coding gene Chr17:30302835-30308640 (+)
JF1/MsJ ENSUMUG00000042750
 protein coding gene Chr17:31710688-31717010 (+)
LP/J ENSMUSG00230053632
 protein coding gene Chr17:33583503-33589986 (+)
NOD/ShiLtJ ENSMUSG00190051623
 protein coding gene Chr17:29926163-29931967 (+)
NZO/HlLtJ ENSMUSG00225054054
 protein coding gene Chr17:35615022-35622262 (+)
PWK/PhJ ENSLUMG00010046272
 protein coding gene Chr17:29563539-29569359 (+)
SPRET/EiJ ENSMSPG00010037645
 protein coding gene Chr17:30696294-30702670 (+)
WSB/EiJ ENSIUOG00005047374
 protein coding gene Chr17:30631368-30637626 (+)



Homology
more
  • Human Ortholog
    HLA-DQB1, major histocompatibility complex, class II, DQ beta 1
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DQB1, major histocompatibility complex, class II, DQ beta 1
  • Synonyms
    CELIAC1, HLA-DQB, IDDM1
  • Links
    NCBI Gene ID: 3119
    UniProt: P01920

  • Chr Location
    6p21.32; chr6:32659467-32668383 (-)  GRCh38
  • Human Ortholog
    HLA-DQB2, major histocompatibility complex, class II, DQ beta 2
  • Synonyms
    DQB2, HLA-DQB1, HLA-DXB
  • Links
    NCBI Gene ID: 3120
    UniProt: P05538

  • Chr Location
    6p21.32; chr6:32756094-32763543 (-)  GRCh38
Human Diseases
more
  • Diseases
    103 with human HLA-DQB1 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    65 phenotypes from 11 alleles in 15 genetic backgrounds
    70 phenotypes from multigenic genotypes
    1107 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit depletion of mature CD4+ T cells, deficiency in cell-mediated immune responses, and increased susceptibility to viral infections.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    626
  • Tissues
    23
  • cDNA Data
    155
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14961 NCBI Gene Model | MGI Sequence Detail 6192 C57BL/6J ±  kb
    transcript NM_207105 RefSeq | MGI Sequence Detail 1193 ZRU/MplStud  
    polypeptide P06342 UniProt | EBI | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 193
      Genomic 30
      cDNA 156
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10378, MGD-MRK-10491, MGD-MRK-11045, MGD-MRK-11050, MGD-MRK-23932, MGI:1890696, MGI:2146934
    References
    more
    • Summaries
      All 1241
      Developmental Gene Expression 12
      Diseases 5
      Gene Ontology 22
      Phenotypes 1107
    • Earliest
      J:5527 Shreffler DC, et al., The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization. Adv Immunol. 1975;20:125-95
    • Latest
      J:392235 Chi X, et al., TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation. Immunity. 2026 Jul 28;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory