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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		H2-Ab1
histocompatibility 2, class II antigen A, beta 1
MGI:103070
66 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal neuron proliferation J:170591
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Doi/H2-Ab1b-tm1Doi
Lattm1.1Mal/Lattm1.1Mal
involves: 129P2/OlaHsd * 129S2/SvPas 		absent CD4-positive, alpha-beta T cells J:77098
absent CD8-positive, alpha-beta T cells J:77098
normal immune system phenotype J:77098
B2mtm1Unc/B2mtm1Unc
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-B2mtm1Unc H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		atrioventricular block J:113267
normal cardiovascular system phenotype J:113267
prolonged PR interval J:113267
Cd8atm1Asin/Cd8atm1Asin
Cd8b1tm1Litt/Cd8b1tm1Litt
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129 * FVB/N 		decreased CD4-positive, alpha-beta T cell number J:126026
increased CD8-positive, alpha-beta T cell number J:126026
Cd83tm1.1Lnjt/Cd83tm1.1Lnjt
H2-Ab1b-tm2Hpl/H2-Ab1b-tm2Hpl
involves: 129S4/SvJae * C57BL/6 * C57BL/6N 		normal immune system phenotype J:236611
Cx3cr1tm1Litt/Cx3cr1tm1Litt
H2-Ab1b-tm1Hpl/H2-Ab1+
involves: 129P2/OlaHsd * 129S4/SvJae 		abnormal response to infection J:95694
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Ighmtm1Cgn/Ighmtm1Cgn
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-Ighmtm1Cgn H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		abnormal PR interval J:113267
enlarged heart J:113267
heart inflammation J:113267
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-Rag1tm1Mom H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		abnormal response to transplant J:113267
normal cardiovascular system phenotype J:113267
enlarged heart J:113267
heart inflammation J:113267
increased autoantibody level J:113267
myocarditis J:113267
prolonged PR interval J:113267
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Rag1tm1Mom/Rag1tm1Mom
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
NOD.Cg-Rag1tm1Mom H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl 		abnormal response to transplant J:88055
myocarditis J:88055
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Runx1tm1Toku/Runx1tm1Toku
Runx3tm1Itan/Runx3tm1Itan
Tg(Cd4-cre)1Cwi/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA/2 		abnormal interferon secretion J:131081
increased CD4-positive, alpha-beta T cell number J:131081
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tespa1tm1Smoc/Tespa1tm1Smoc
involves: 129 * 129S2/SvPas * C57BL/6 		absent CD4-positive, alpha-beta T cells J:186446
decreased CD8-positive, alpha-beta T cell number J:186446
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell/Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell
NOD.Cg-H2-Ab1b-tm1Gru Tg(CD2-CD4,HLA-DQA1,HLA-DQB1)1Ell 		abnormal heart electrocardiography waveform feature J:86540
abnormal pulmonary vein morphology J:86540
atrioventricular block J:86540
autoimmune response J:86540, J:87013
cardiac fibrosis J:86540
decreased susceptibility to autoimmune disorder J:87013
decreased ventricle muscle contractility J:86540
dilated cardiomyopathy J:86540
heart inflammation J:86540, J:87013
normal hematopoietic system phenotype J:87013
normal homeostasis/metabolism phenotype J:87013
normal immune system phenotype J:87013
increased autoantibody level J:113267
lung inflammation J:86540
mitral valve regurgitation J:86540
myocardium necrosis J:86540
myositis J:86540
premature death J:86540
prolonged PR interval J:113267
salivary gland inflammation J:86540
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell/Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
NOD.Cg-H2-Ab1b-tm1Gru Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell 		normal cardiovascular system phenotype J:113267
enlarged thyroid gland J:113509
normal immune system phenotype J:113267
increased autoantibody level J:113509
increased circulating thyroid-stimulating hormone level J:113509
thyroid gland inflammation J:113509
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA * SJL 		abnormal CD4-positive, alpha beta T cell morphology J:68641
abnormal CD8-positive, alpha beta T cell morphology J:68641
decreased susceptibility to autoimmune diabetes J:68641
salivary gland inflammation J:68641
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
B6.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv 		increased circulating glucose level J:59245
increased susceptibility to autoimmune diabetes J:59245
increased urine glucose level J:59245
salivary gland inflammation J:59245
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)1Dv/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * C57BL/10SnJ * CBA 		decreased interleukin-6 secretion J:68641
increased circulating glucose level J:68641
increased interferon-gamma secretion J:68641
increased susceptibility to autoimmune diabetes J:68641
increased urine glucose level J:68641
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)70Myl/0
NOD.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl 		heart inflammation J:88055
increased autoantibody level J:88055
insulitis J:88055
myocarditis J:88055
myocardium necrosis J:88055
salivary gland inflammation J:88055
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)73Myl/0
NOD.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)73Myl 		abnormal atrial thrombosis J:88055
abnormal breathing pattern J:88055
abnormal heart ventricle morphology J:88055
abnormal liver morphology J:88055
abnormal myocardial fiber morphology J:88055
congestive heart failure J:88055
cyanosis J:88055
edema J:88055
enlarged heart J:88055
enlarged liver J:88055
heart inflammation J:88055
increased autoantibody level J:88055
insulitis J:88055
lethargy J:88055
liver hemorrhage J:88055
myocardial fiber degeneration J:88055
myocarditis J:88055
myocardium necrosis J:88055
pleural effusion J:88055
premature death J:88055
salivary gland inflammation J:88055
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DRB1)31Dmz/0
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * CBA * SJL 		abnormal CD4-positive, alpha beta T cell morphology J:68641
abnormal CD8-positive, alpha beta T cell morphology J:68641
decreased susceptibility to autoimmune diabetes J:68641
salivary gland inflammation J:68641
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(Ins2-CD80)3B7Flv/0
involves: 129S2/SvPas * C57BL/6 * CBA 		decreased susceptibility to autoimmune diabetes J:68641
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Themistm1Lov/Themistm1Lov
involves: 129 		abnormal negative T cell selection J:151075
H2-Ab1g7-em1Dvs/H2-Ab1g7-em1Dvs
H2-D1b-em5Dvs/H2-D1b-em5Dvs
H2-K1d-em1Dvs/H2-K1d-em1Dvs
NOD/ShiLtDvs-H2-K1d-em1Dvs H2-Ab1g7-em1Dvs H2-D1em5Dvs/Dvs 		abnormal T cell subpopulation ratio J:257229
decreased alpha-beta T cell number J:257229
decreased CD4-positive, alpha-beta T cell number J:257229
decreased susceptibility to autoimmune diabetes J:257229
Rr94tm3.2Litt/Rr94tm3.2Litt
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N 		abnormal T cell subpopulation ratio J:158962
decreased CD4-positive, alpha-beta T cell number J:158962
normal immune system phenotype J:158962
increased CD8-positive, alpha-beta T cell number J:158962
Rr96tm1.1Yzo/Rr96tm1.1Yzo
H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
involves: 129P2/OlaHsd * 129S2/SvPas 		abnormal T cell differentiation J:130559
Tg(H2-Aa)26Dim/?
Tg(H2-Ab1)62Dim/?
B6.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim 		abnormal antigen presentation via MHC class II J:110897
abnormal level of surface class II molecules J:110897
normal immune system phenotype J:110897
increased immunoglobulin level J:110897
Tg(H2-Aa)26Dim/?
Tg(H2-Ab1)62Dim/?
SJL.Cg-Tg(H2-Aa)26Dim Tg(H2-Ab1)62Dim 		abnormal level of surface class II molecules J:110897
normal immune system phenotype J:110897
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory