Phenotypes Associated with This Genotype

Genotype
MGI:3623405

• Allelic Composition: H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru; Tg(HLA-DQA1,HLA-DQB1)1Dv/0; Tg(Ins2-CD80)3B7Flv/0
• Genetic Background: B6.Cg-H2-Ab1^b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)1Dv Tg(Ins2-CD80)3B7Flv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

salivary gland inflammation ( J:59245 )

• diabetic transgenic mice display sialadenitis

increased susceptibility to autoimmune diabetes ( J:59245 )

• over 80% of transgenic mice develop diabetes (positive urine glucose test and >250 mg/dl blood glucose) beginning at 4 months of age

homeostasis/metabolism

increased circulating glucose level ( J:59245 )

• over 80% have blood glucose levels above 250 mg/dl

increased urine glucose level ( J:59245 )

• seen in over 80% of mice

digestive/alimentary system

salivary gland inflammation ( J:59245 )

• diabetic transgenic mice display sialadenitis

endocrine/exocrine glands

salivary gland inflammation ( J:59245 )

• diabetic transgenic mice display sialadenitis

renal/urinary system

increased urine glucose level ( J:59245 )

• seen in over 80% of mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:59245